By Dr Lennart Kuck

Journal articles

Kuck L; Griffith TA; McNamee AP; Peart JN; Wilson JH; Sharma A; Sharma LA; Robertson K; Du Toit EF; Simmonds MJ, 2025, 'Insulin facilitates entry of calcium ions into human and murine erythrocytes via Piezo1: a newly identified mechanism with implications for type 2 diabetes', FEBS Journal, 292, pp. 5457 - 5474, http://dx.doi.org/10.1111/febs.70157

Kuck L; Frappa FA; McNamee AP; Simmonds MJ, 2025, 'Storage temperature and anticoagulant choice determine the short-term stability of blood rheological parameters.', Clin Hemorheol Microcirc, pp. 13860291251376503, http://dx.doi.org/10.1177/13860291251376503

Kuck L, 2025, 'Piezo1: the Force Awakens—How Red Blood Cells Sense and Respond to Mechanical Stress', Physiology, 40, pp. 117, http://dx.doi.org/10.1152/physiol.00058.2024

Kuck L; Kaestner L; Egée S; Lew VL; Simmonds MJ, 2025, 'Mechanotransduction mechanisms in human erythrocytes: Fundamental physiology and clinical significance', Channels, 19, http://dx.doi.org/10.1080/19336950.2025.2556105

Kuck L; McNamee AP; Bordukova M; Sadafi A; Marr C; Peart JN; Simmonds MJ, 2024, 'Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal', Proceedings of the National Academy of Sciences of the United States of America, 121, http://dx.doi.org/10.1073/pnas.2407765121

McNamee AP; Griffith TA; Smith AG; Kuck L; Simmonds MJ, 2023, 'Accelerated Hemocompatibility Testing of Rotary Blood Pumps', ASAIO Journal, 69, pp. 918 - 923, http://dx.doi.org/10.1097/MAT.0000000000001995

Leo JA; Sabapathy S; Kuck L; Simmonds MJ, 2023, 'Modulation of red blood cell nitric oxide synthase phosphorylation in the quiescent and exercising human forearm', American Journal of Physiology Regulatory Integrative and Comparative Physiology, 325, pp. R260 - R268, http://dx.doi.org/10.1152/ajpregu.00017.2023

Bent Z; Kuck L; Sabapathy S; Sriram KB; McNamee AP; Simmonds MJ, 2023, 'Single-night continuous positive airway pressure treatment improves blood fluid properties in individuals recently diagnosed with obstructive sleep apnoea', Microvascular Research, 148, http://dx.doi.org/10.1016/j.mvr.2023.104549

Grau M; Kuck L, 2023, 'Immunostaining-Based Detection of Dynamic Alterations in Red Blood Cell Proteins', Journal of Visualized Experiments, 2023, http://dx.doi.org/10.3791/64843

Kuck L; Peart JN; Simmonds MJ, 2022, 'Piezo1 regulates shear-dependent nitric oxide production in human erythrocytes', American Journal of Physiology Heart and Circulatory Physiology, 323, pp. H24 - H37, http://dx.doi.org/10.1152/AJPHEART.00185.2022

McNamee AP; Kuck L; Simmonds MJ, 2022, 'Bovine erythrocytes are poor surrogates for human when exposed to sublethal shear stress', International Journal of Artificial Organs, 45, pp. 580 - 587, http://dx.doi.org/10.1177/03913988221095581

Kuck L; McNamee AP; Simmonds MJ, 2022, 'Impact of small fractions of abnormal erythrocytes on blood rheology', Microvascular Research, 139, http://dx.doi.org/10.1016/j.mvr.2021.104261

Kuck L; Simmonds MJ; Chan CHH; Pauls JP; Tansley GD; Feldmann F; McNamee AP, 2021, 'Ex vivo assessment of erythrocyte tolerance to the HeartWare ventricular assist device operated in three discrete configurations', Artificial Organs, 45, pp. E146 - E157, http://dx.doi.org/10.1111/aor.13877

Horobin JT; Sabapathy S; Kuck L; Simmonds MJ, 2021, 'Shear stress and rbc-nos serine1177 phosphorylation in humans: A dose response', Life, 11, pp. 1 - 13, http://dx.doi.org/10.3390/life11010036

Grau M; Kuck L; Dietz T; Bloch W; Simmonds MJ, 2021, 'Sub-fractions of red blood cells respond differently to shear exposure following superoxide treatment', Biology, 10, pp. 1 - 13, http://dx.doi.org/10.3390/biology10010047

Kuck L; Peart JN; Simmonds MJ, 2020, 'Calcium dynamically alters erythrocyte mechanical response to shear', Biochimica Et Biophysica Acta Molecular Cell Research, 1867, http://dx.doi.org/10.1016/j.bbamcr.2020.118802

Richardson KJ; Kuck L; Michael J S, 2020, 'Beyond oxygen transport: active role of erythrocytes in the regulation of blood flow', American Journal of Physiology Heart and Circulatory Physiology, 319, pp. H866 - H872, http://dx.doi.org/10.1152/AJPHEART.00441.2020

Kuck L; Peart JN; Simmonds MJ, 2020, 'Active modulation of human erythrocyte mechanics', American Journal of Physiology Cell Physiology, 319, pp. C250 - C257, http://dx.doi.org/10.1152/ajpcell.00210.2020

Brotherton E; Simmonds M; Richardson K; Kuck L; Turner J; McNamee A; Balmain B; Sabapathy S, 2020, 'Evidence That Women With Polycystic Ovary Syndrome Exhibit Altered Vascular Function To High-intensity Exercise', Medicine & Science in Sports & Exercise, 52, pp. 704 - 704, http://dx.doi.org/10.1249/01.mss.0000682856.65629.ed

McNamee AP; Richardson K; Horobin J; Kuck L; Simmonds MJ, 2019, 'Susceptibility of density-fractionated erythrocytes to subhaemolytic mechanical shear stress', International Journal of Artificial Organs, 42, pp. 151 - 157, http://dx.doi.org/10.1177/0391398818790334

Kuck L; Grau M; Bloch W; Simmonds MJ, 2019, 'Shear stress ameliorates superoxide impairment to erythrocyte deformability with concurrent nitric oxide synthase activation', Frontiers in Physiology, 10, http://dx.doi.org/10.3389/fphys.2019.00036

Kuck L; Grau M; Simmonds MJ, 2018, 'Recovery time course of erythrocyte deformability following exposure to shear is dependent upon conditioning shear stress', Biorheology, 54, pp. 141 - 152, http://dx.doi.org/10.3233/BIR-17151

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