By Dr Osvaldo Contreras

Preprints

Thekkedam C; Humphreys D; Naval-Sanchez M; Nicks A; Harvey R; Contreras O, 2026, A scalable MNase-seq framework for reproducible nucleosome profiling across pluripotent stem cell and cardiomyocyte models, http://dx.doi.org/10.64898/2026.06.08.731013

Thorpe J; Perry MD; Contreras O; Hurley E; Parker G; Harvey RP; Hill AP; Vandenberg JI, Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia, http://dx.doi.org/10.21203/rs.3.rs-2744099/v1

Contreras O; Thekkedam C; Zaunders J; Aguirre-MacLennan I; Murray NJ; Gonzalez-Cordero A; Harvey RP, OpenEMMU: a versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics, http://dx.doi.org/10.1101/2025.01.17.633495

Contreras O; Smith GD; Santiago C; Dey M; Thekkedam C; Chand R; González-Rajal Á; Zhong L; Lock JG; Wong E; Fatkin D; Harvey RP, Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia, http://dx.doi.org/10.64898/2026.01.11.698907

Contreras O; Harvey RP, Single-Cell Transcriptome Dynamics of the Autotaxin-Lysophosphatidic Acid Axis During Muscle Regeneration Reveal Proliferative Effects in Mesenchymal Fibro-Adipogenic Progenitors, http://dx.doi.org/10.1101/2022.07.02.498539

Hancock SE; Garthwaite L; Harellis K; Susetio M; Ding E; Choong L; Contreras O; Nguyen A; Lising J; Hansen FK; Wongsomboon P; Menzel JP; Poad BL; Mitchell TW; Blanksby SJ; Turner N, Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma, http://dx.doi.org/10.1101/2024.12.18.628624

Theret M; Low M; Rempel L; Li FF; Tung LW; Contreras O; Chang C-K; Wu A; Soliman H; Rossi FMV, Targeting fibrosis in the Duchenne Muscular Dystrophy mice model: an uphill battle, http://dx.doi.org/10.1101/2021.01.20.427485

Contreras O; Soliman H; Theret M; Rossi FMV; Brandan E, TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts, http://dx.doi.org/10.1101/2020.01.05.895334

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