By Dr Rajesh Kuppusamy

Journal articles

Bahatheg G; Kuppusamy R; Yasir M; Bridge S; Mishra SK; Cranfield CG; StC. Black D; Willcox M; Kumar N, 2024, 'Dimeric peptoids as antibacterial agents', Bioorganic Chemistry, 147, http://dx.doi.org/10.1016/j.bioorg.2024.107334

Sara M; Yasir M; Kalaiselvan P; Hui A; Kuppusamy R; Kumar N; Chakraborty S; Yu TT; Wong EHH; Molchanova N; Jenssen H; Lin JS; Barron AE; Willcox M, 2024, 'The activity of antimicrobial peptoids against multidrug-resistant ocular pathogens', Contact Lens and Anterior Eye, 47, http://dx.doi.org/10.1016/j.clae.2024.102124

Enninful GN; Kuppusamy R; Tiburu EK; Kumar N; Willcox MDP, 2024, 'Non-canonical amino acid bioincorporation into antimicrobial peptides and its challenges', Journal of Peptide Science, http://dx.doi.org/10.1002/psc.3560

Browne K; Kuppusamy R; Walsh WR; Black DSC; Willcox MDP; Kumar N; Chen R, 2023, 'Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms241914966

Urmi UL; Attard S; Vijay AK; Willcox MDP; Kumar N; Islam S; Kuppusamy R, 2023, 'Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus', Antibiotics, 12, pp. 1436, http://dx.doi.org/10.3390/antibiotics12091436

Urmi UL; Vijay AK; Kuppusamy R; Islam S; Willcox MDP, 2023, 'A review of the antiviral activity of cationic antimicrobial peptides', Peptides, 166, http://dx.doi.org/10.1016/j.peptides.2023.171024

Urmi UL; Willcox MDP; Islam S; Kuppusamy R; Vijay AK, 2023, 'Ocular signs and symptoms of monkeypox virus infection, and possible role of the eye in transmission of the virus', Contact Lens and Anterior Eye, 46, pp. 101808, http://dx.doi.org/10.1016/j.clae.2022.101808

Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585, http://dx.doi.org/10.3390/antibiotics12030585

Willcox MDP; Bahatheg G; Carnt N; Kalaiselvan P; Kumar N; Kuppusamy R; Rayamajhee B; Sara M; Stapleton F; Vijay AK; Yasir M; Yu TT, 2023, 'Biofilms and contact lenses: problems and solutions', Microbiology Australia, 44, pp. 96 - 99, http://dx.doi.org/10.1071/MA23027

Sabir S; Das T; Kuppusamy R; Yu TT; Willcox MD; Black DSC; Kumar N, 2023, 'Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa', Bioorganic Chemistry, 130, pp. 106226, http://dx.doi.org/10.1016/j.bioorg.2022.106226

Kuppusamy R; Browne K; Suresh D; Do Rosario RM; Chakraborty S; Yang S; Willcox M; Black D; Chen R; Kumar N, 2023, 'Transition Towards Antibiotic Hybrid Vehicles: The Next Generation Antibacterials', Current Medicinal Chemistry, 30, pp. 104 - 125, http://dx.doi.org/10.2174/0929867329666220613105424

Aldilla VR; Chen R; Kuppusamy R; Chakraborty S; Willcox MDP; Black DSC; Thordarson P; Martin AD; Kumar N, 2022, 'Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-26426-1

Peguda HK; Carnt NA; Gu Z; Kumar N; Willcox MDP; Kuppusamy R, 2022, 'The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii', Microorganisms, 10, pp. 2377, http://dx.doi.org/10.3390/microorganisms10122377

Bahatheg G; Kuppusamy R; Yasir M; Black DSC; Willcox M; Kumar N, 2022, 'Short Tryptamine-Based Peptoids as Potential Therapeutics for Microbial Keratitis: Structure-Function Correlation Studies', Antibiotics, 11, pp. 1074, http://dx.doi.org/10.3390/antibiotics11081074

Wu J; Yu TT; Kuppusamy R; Hassan MM; Alghalayini A; Cranfield CG; Willcox MDP; Black DS; Kumar N, 2022, 'Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents', International Journal of Molecular Sciences, 23, pp. 4623, http://dx.doi.org/10.3390/ijms23094623

Kalaiselvan P; Yasir M; Kuppusamy R; Willcox M; Vijay AK, 2022, 'Ability of Essential Oil Vapours to Reduce Numbers of Culturable Aerosolised Coronavirus, Bacteria and Fungi', Antibiotics, 11, pp. 393, http://dx.doi.org/10.3390/antibiotics11030393

Browne K; Kuppusamy R; Chen R; Willcox MDP; Walsh WR; Black DS; Kumar N, 2022, 'Bioinspired Polydopamine Coatings Facilitate Attachment of Antimicrobial Peptidomimetics with Broad-Spectrum Antibacterial Activity', International Journal of Molecular Sciences, 23, pp. 2952, http://dx.doi.org/10.3390/ijms23062952

Kalaiselvan P; Kuppusamy R; Kumar N; Willcox M, 2022, 'Antimicrobial activity of RK-7 peptide mimic against Staphylococcus aureus in solution and when immobilised onto contact lenses', Contact Lens and Anterior Eye, 45, pp. 101607 - 101607, http://dx.doi.org/10.1016/j.clae.2022.101607

Chakraborty S; Kuppusamy R; Roohani I; Walsh WR; Willcox MDP; Kumar N; Chen R, 2021, 'Antibacterial peptidomimetic and characterization of its efficacy as an antibacterial and biocompatible coating for bioceramic-based bone substitutes', Materials Advances, 2, pp. 6369 - 6379, http://dx.doi.org/10.1039/d1ma00648g

Yu TT; Kuppusamy R; Yasir M; Hassan MM; Sara M; Ho J; Willcox MDP; Black DS; Kumar N, 2021, 'Polyphenylglyoxamide‐based amphiphilic small molecular peptidomimetics as antibacterial agents with anti‐biofilm activity', International Journal of Molecular Sciences, 22, pp. 7344, http://dx.doi.org/10.3390/ijms22147344

Tummanapalli SS; Kuppusamy R; Yeo JH; Kumar N; New EJ; Willcox MDP, 2021, 'The role of nitric oxide in ocular surface physiology and pathophysiology', Ocular Surface, 21, pp. 37 - 51, http://dx.doi.org/10.1016/j.jtos.2021.04.007

Sabir S; Yu TT; Kuppusamy R; Almohaywi B; Iskander G; Das T; Willcox MDP; Black DS; Kumar N, 2021, 'Novel seleno-and thio-urea-containing dihydropyrrol-2-one analogues as antibacterial agents', Antibiotics, 10, pp. 321, http://dx.doi.org/10.3390/antibiotics10030321

Yu TT; Bhadbhade M; Kuppusamy R; Black DSC; Kumar N, 2020, 'A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics', Tetrahedron Letters, 61, http://dx.doi.org/10.1016/j.tetlet.2020.152560

Yu TT; Kuppusamy R; Yasir M; Hassan MM; Alghalayini A; Gadde S; Deplazes E; Cranfield C; Willcox MDP; Black DS; Kumar N, 2020, 'Design, synthesis and biological evaluation of biphenylglyoxamide-based small molecular antimicrobial peptide mimics as antibacterial agents', International Journal of Molecular Sciences, 21, pp. 1 - 38, http://dx.doi.org/10.3390/ijms21186789

Yasir M; Dutta D; Hossain KR; Chen R; Ho KKK; Kuppusamy R; Clarke RJ; Kumar N; Willcox MDP, 2020, 'Mechanism of Action of Surface Immobilized Antimicrobial Peptides Against Pseudomonas aeruginosa', Frontiers in Microbiology, 10, pp. 3053, http://dx.doi.org/10.3389/fmicb.2019.03053

Kuppusamy R; Willcox M; Black DSC; Kumar N, 2019, 'Short cationic peptidomimetic antimicrobials', Antibiotics, 8, pp. 44, http://dx.doi.org/10.3390/antibiotics8020044

Kuppusamy R; Yasir M; Berry T; Cranfield CG; Nizalapur S; Yee E; Kimyon O; Taunk A; Ho KKK; Cornell B; Manefield M; Willcox M; Black DSC; Kumar N, 2018, 'Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents', European Journal of Medicinal Chemistry, 143, pp. 1702 - 1722, http://dx.doi.org/10.1016/j.ejmech.2017.10.066

Kuppusamy R; Yasir M; Yee E; Willcox M; Black DSC; Kumar N, 2018, 'Guanidine functionalized anthranilamides as effective antibacterials with biofilm disruption activity', Organic and Biomolecular Chemistry, 16, pp. 5871 - 5888, http://dx.doi.org/10.1039/c8ob01699b

Chittimalla SK; Koodalingam M; Bandi C; Putturu S; Kuppusamy R, 2016, 'Expedient Baylis-Hillman reaction protocol to functionalize cyclohexa-2,4-dienones', RSC Advances, 6, pp. 1460 - 1465, http://dx.doi.org/10.1039/c5ra21842j

Devasthale P; Wang W; Mignone J; Renduchintala K; Radhakrishnan S; Dhanapal J; Selvaraj J; Kuppusamy R; Pelleymounter MA; Longhi D; Huang N; Flynn N; Azzara AV; Rohrbach K; Devenny J; Rooney S; Thomas M; Glick S; Godonis H; Harvey S; Cullen MJ; Zhang H; Caporuscio C; Stetsko P; Grubb M; Huang C; Zhang L; Freeden C; Murphy BJ; Robl JA; Washburn WN, 2015, 'Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies', Bioorganic and Medicinal Chemistry Letters, 25, pp. 4412 - 4418, http://dx.doi.org/10.1016/j.bmcl.2015.09.018

Chittimalla SK; Kuppusamy R; Akavaram N, 2015, 'Palladium-catalyzed regioselective synthesis of oxygenated biphenyls', Synlett, 26, http://dx.doi.org/10.1055/s-0034-1379987

Chittimalla SK; Laxmi S; Ming Liing AC; Kai Jun JL; Kuppusamy R; Putturu S; Bandi C, 2015, 'An approach towards expanding the scope of masked o-benzoquinone dimers to generate diverse compound libraries', RSC Advances, 5, pp. 29391 - 29396, http://dx.doi.org/10.1039/c5ra03627e

Chittimalla SK; Kuppusamy R; Bandi C, 2014, 'A detour route for meta functionalization of phenols', Synlett, 25, pp. 1991 - 1996, http://dx.doi.org/10.1055/s-0034-1378395

Chittimalla SK; Bandi C; Putturu S; Kuppusamy R; Boellaard KC; Tan DCA; Lum DMJ, 2014, 'Access to 3-arylindoles through a tandem one-pot protocol involving dearomatization, a regioselective michael addition reaction, and rearomatization', European Journal of Organic Chemistry, 2014, pp. 2565 - 2575, http://dx.doi.org/10.1002/ejoc.201400079

Chittimalla SK; Kuppusamy R; Thiyagarajan K; Bandi C, 2013, 'Reaction of nitrile oxides with masked o-benzoquinones; Synthesis of highly functionalized isoxazolines', European Journal of Organic Chemistry, pp. 2715 - 2723, http://dx.doi.org/10.1002/ejoc.201201670

Chittimalla SK; Kuppusamy R; Chakrabarti A, 2012, '[3+2] Cycloaddition of masked o-benzoquinones with azomethine ylides', Synlett, 23, pp. 1901 - 1906, http://dx.doi.org/10.1055/s-0031-129043

Conference Papers

Sara M; Alex H; Chen R; Kumar N; Rajesh K; Kumar Mishara SK; Barron A; Yasir MUHAMMAD; Willcox M; Yasir M, 2022, 'Antimicrobial activity of peptoids against clinical pathogens.', in Antimicrobial activity of peptoids against clinical pathogens., USA, presented at peptoidsummit2022, USA, 11 August 2022 - 12 August 2022

Peguda HK; Kuppusamy R; Kumar N; Willcox MDP, 2022, 'Anti-amoebic activity of RK-7 peptide mimic against Acanthamoeba spp trophozoites', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000844437003302&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wang W; Devasthale P; Longhi D; Azzara A; Devenny J; Cullen MJ; Zhang M; Caporuscio C; Zhang L; Huang C; Rampulla R; Mathur A; Shi H; Sun L; Levesque P; Apedo A; Moore D; Hicks M; Krishna K; Radhakrishnan S; Kuppusamy R; Selvaraj J; Dhanapal J; Washburn W; Robl J; Murphy B, 2013, 'Discovery of pyrazolopyrrolidinone-derived melanin concentrating hormone receptor-1 antagonists as anti-obesity agents', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, IN, Indianapolis, presented at 246th National Meeting of the American-Chemical-Society (ACS), IN, Indianapolis, 08 September 2013 - 12 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329618405018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Sara M; Kuppusamy R; Afzal M; Khan M; Yasir M; Kalaiselvan P; Hui A; Kumar N; Willcox M, 2021, 'Synergistic activity of a peptide mimic with quinolones and cephalosporins against Staphylococcus aureus', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vol. 62, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000690760500400&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Patents

Kumar N; Willcox M; Nizalapur S; Black D; Yu TT; Kuppusamy R, 2021, Antimicrobial compounds, Patent No. United States 2021 pat no. 10988444

Preprints

Urmi UL; Attard S; Vijay AK; Willcox M; Kumar N; Islam S; Kuppusamy R, 2023, Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus, , http://dx.doi.org/10.20944/preprints202308.2017.v1

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