By Dr Rajesh Kuppusamy

Journal articles

Sara M; Kuppusamy R; Enninful G; Suresh D; Vasilev K; Mackenzie D; Dehghani F; Hui A; Wong EHH; Yasir M; Kumar N; Willcox M, 2026, 'Antimicrobial activity of a short guanidine mimic immobilised on contact lenses', Journal of Materials Science Materials in Medicine, 37, http://dx.doi.org/10.1007/s10856-025-06998-w

Mishra SK; Shen J; Akter T; Tigabu A; Urmi UL; Damtie MA; Mekonen ES; Kuppusamy R; Sørensen K; Lin JS; Wong EHH; Hui A; Barron AE; Willcox M, 2026, 'Peptoid-based antimicrobial strategies against polymyxin-resistant Gram-negative bacteria', Journal of Applied Microbiology, 137, http://dx.doi.org/10.1093/jambio/lxag093

Enninful GN; Kuppusamy R; Tiburu E; Kumar N; Willcox MDP, 2026, 'Assessing the Effect of Substitution of Arginine with Homoarginine in Two Antimicrobial Peptides', International Journal of Peptide Research and Therapeutics, 32, http://dx.doi.org/10.1007/s10989-026-10804-8

Kuppusamy R; Manoharan A; Moshkanbaryans L; Das T; Glasbey T; Moore K; Triccas J; Whiteley G, 2026, '191 | Investigating the criteria for biofilm disruption of blocked urinary catheters', Continence, 19, pp. 102668, http://dx.doi.org/10.1016/j.cont.2026.102668

Bahatheg G; Kuppusamy R; Hartmann LM; Cranfield CG; Black DSC; Willcox M; Kumar N, 2025, 'Antibacterial peptidomimetics based on guanidine-functionalized di-tertiary amides', Rsc Medicinal Chemistry, 16, pp. 6333 - 6350, http://dx.doi.org/10.1039/d5md00688k

Manoharan A; Whiteley G; Kuppusamy R; Jensen S; Glasbey T; Chen Z; Moshkanbaryans L; Moore KH; Das T; Manos J, 2025, 'Combating biofilm formation and bacterial killing: N-acetylcysteine's efficacy against Pseudomonas aeruginosa in urinary catheters', Biofilm, 10, http://dx.doi.org/10.1016/j.bioflm.2025.100296

Attard ST; Aldilla VR; Kuppusamy R; Chen R; Black DSC; Thordarson P; Willcox MDP; Kumar N, 2025, 'Tuning the Structure–Functional Properties Within Peptide-Mimicking Antimicrobial Hydrogels', Antibiotics, 14, http://dx.doi.org/10.3390/antibiotics14111118

Urmi UL; Willcox MDP; Kuppusamy R; Attard S; Kumar N; Islam S; Chen H; Ren X; Vijay AK, 2025, 'Antiviral activity of peptide and peptide mimic coated surfaces', Applied Surface Science, 702, http://dx.doi.org/10.1016/j.apsusc.2025.163242

Urmi UL; Vijay AK; Kuppusamy R; Attard S; Hartmann LM; Bridge S; Soundararajan S; Holt SA; Sarwat S; Islam S; Cranfield CG; Kumar N; Willcox MDP, 2025, 'Synergistic effects of peptide mimics against enveloped viruses', Virology, 610, http://dx.doi.org/10.1016/j.virol.2025.110599

Bahatheg G; Kuppusamy R; Yasir M; Mishra SK; Black DSC; Willcox M; Kumar N, 2025, 'Functionalized Phenyl Peptoids with Enhanced Antibacterial Potency', ACS Infectious Diseases, 11, pp. 1648 - 1661, http://dx.doi.org/10.1021/acsinfecdis.5c00148

Aziz MA; Maulvi F; Desai DT; Kuppusamy R; Mazumder K; Hui A; Stapleton F; Willcox M, 2025, 'Designing a contact lens with atropine base using a microemulsion technique', Contact Lens and Anterior Eye, 48, http://dx.doi.org/10.1016/j.clae.2025.102381

Mishra SK; Kuppusamy R; Nguyen C; Doeur J; Atwal H; Attard S; Sørensen K; Lin JS; Wong EHH; Hui A; Barron AE; Kumar N; Willcox M, 2025, 'Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance', Journal of Fungi, 11, http://dx.doi.org/10.3390/jof11050370

Suresh D; Yu TT; Kuppusamy R; Sabir S; Das T; Black DSC; Willcox MDP; Kumar N, 2025, 'Novel cationic dihydropyrrol-2-one compounds as antimicrobial agents and quorum sensing inhibitors', Bioorganic and Medicinal Chemistry, 122, http://dx.doi.org/10.1016/j.bmc.2025.118137

Maulvi FA; Sahu A; Ren X; Desai DT; Kalaiselvan P; Yasir MA; Kuppusamy R; Shah DO; Willcox MDP, 2025, 'Mel4-coated hyaluronic acid-laden etafilcon A contact lenses: Improved wettability with retained antimicrobial properties', International Journal of Biological Macromolecules, 304, http://dx.doi.org/10.1016/j.ijbiomac.2025.140701

Mishra SK; Yasir M; Kuppusamy R; Wong EHH; Hui A; Sørensen K; Lin JS; Jenssen H; Barron AE; Willcox M, 2025, 'Antimicrobial activity of peptoids against Metallo-β-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris', Journal of Applied Microbiology, 136, http://dx.doi.org/10.1093/jambio/lxaf031

Abdullah Aziz M; Kuppusamy R; Mazumder K; Hui A; Maulvi F; Stapleton F; Willcox M, 2024, 'Absorption and attachment of atropine to etafilcon A contact lenses', Contact Lens and Anterior Eye, 47, http://dx.doi.org/10.1016/j.clae.2024.102246

Urmi UL; Vijay AK; Willcox MDP; Attard S; Enninful G; Kumar N; Islam S; Kuppusamy R, 2024, 'Exploring the Efficacy of Peptides and Mimics against Influenza A Virus, Adenovirus, and Murine Norovirus', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms25137030

Hong Z; Yu TT; Yasir M; Sara M; Black DSC; Willcox MDP; Kuppusamy R; Kumar N, 2024, 'Daidzein-Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti-Biofilm Activity', Chemistryselect, 9, http://dx.doi.org/10.1002/slct.202400502

Bahatheg G; Kuppusamy R; Yasir M; Bridge S; Mishra SK; Cranfield CG; StC. Black D; Willcox M; Kumar N, 2024, 'Dimeric peptoids as antibacterial agents', Bioorganic Chemistry, 147, http://dx.doi.org/10.1016/j.bioorg.2024.107334

Maulvi FA; Desai DT; Kalaiselvan P; Dumpati S; Kuppusamy R; Masoudi S; Shah DO; Willcox MDP, 2024, 'Lipid-based eye drop formulations for the management of evaporative dry eyes', Contact Lens and Anterior Eye, 47, http://dx.doi.org/10.1016/j.clae.2024.102154

Enninful GN; Kuppusamy R; Tiburu EK; Kumar N; Willcox MDP, 2024, 'Non-canonical amino acid bioincorporation into antimicrobial peptides and its challenges', Journal of Peptide Science, 30, http://dx.doi.org/10.1002/psc.3560

Sara M; Yasir M; Kalaiselvan P; Hui A; Kuppusamy R; Kumar N; Chakraborty S; Yu TT; Wong EHH; Molchanova N; Jenssen H; Lin JS; Barron AE; Willcox M, 2024, 'The activity of antimicrobial peptoids against multidrug-resistant ocular pathogens', Contact Lens and Anterior Eye, 47, http://dx.doi.org/10.1016/j.clae.2024.102124

Browne K; Kuppusamy R; Walsh WR; Black DSC; Willcox MDP; Kumar N; Chen R, 2023, 'Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms241914966

Urmi UL; Attard S; Vijay AK; Willcox MDP; Kumar N; Islam S; Kuppusamy R, 2023, 'Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus', Antibiotics, 12, pp. 1436, http://dx.doi.org/10.3390/antibiotics12091436

Urmi UL; Vijay AK; Kuppusamy R; Islam S; Willcox MDP, 2023, 'A review of the antiviral activity of cationic antimicrobial peptides', Peptides, 166, http://dx.doi.org/10.1016/j.peptides.2023.171024

Urmi UL; Willcox MDP; Islam S; Kuppusamy R; Vijay AK, 2023, 'Ocular signs and symptoms of monkeypox virus infection, and possible role of the eye in transmission of the virus', Contact Lens and Anterior Eye, 46, http://dx.doi.org/10.1016/j.clae.2022.101808

Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585, http://dx.doi.org/10.3390/antibiotics12030585

Willcox MDP; Bahatheg G; Carnt N; Kalaiselvan P; Kumar N; Kuppusamy R; Rayamajhee B; Sara M; Stapleton F; Vijay AK; Yasir M; Yu TT, 2023, 'Biofilms and contact lenses: problems and solutions', Microbiology Australia, 44, pp. 96 - 99, http://dx.doi.org/10.1071/MA23027

Sabir S; Das T; Kuppusamy R; Yu TT; Willcox MD; Black DSC; Kumar N, 2023, 'Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa', Bioorganic Chemistry, 130, pp. 106226, http://dx.doi.org/10.1016/j.bioorg.2022.106226

Kuppusamy R; Browne K; Suresh D; Do Rosario RM; Chakraborty S; Yang S; Willcox M; Black D; Chen R; Kumar N, 2023, 'Transition Towards Antibiotic Hybrid Vehicles: The Next Generation Antibacterials', Current Medicinal Chemistry, 30, pp. 104 - 125, http://dx.doi.org/10.2174/0929867329666220613105424

Aldilla VR; Chen R; Kuppusamy R; Chakraborty S; Willcox MDP; Black DSC; Thordarson P; Martin AD; Kumar N, 2022, 'Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-26426-1

Peguda HK; Carnt NA; Gu Z; Kumar N; Willcox MDP; Kuppusamy R, 2022, 'The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii', Microorganisms, 10, pp. 2377, http://dx.doi.org/10.3390/microorganisms10122377

Bahatheg G; Kuppusamy R; Yasir M; Black DSC; Willcox M; Kumar N, 2022, 'Short Tryptamine-Based Peptoids as Potential Therapeutics for Microbial Keratitis: Structure-Function Correlation Studies', Antibiotics, 11, pp. 1074, http://dx.doi.org/10.3390/antibiotics11081074

Wu J; Yu TT; Kuppusamy R; Hassan MM; Alghalayini A; Cranfield CG; Willcox MDP; Black DS; Kumar N, 2022, 'Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents', International Journal of Molecular Sciences, 23, pp. 4623, http://dx.doi.org/10.3390/ijms23094623

Kalaiselvan P; Yasir M; Kuppusamy R; Willcox M; Vijay AK, 2022, 'Ability of Essential Oil Vapours to Reduce Numbers of Culturable Aerosolised Coronavirus, Bacteria and Fungi', Antibiotics, 11, pp. 393, http://dx.doi.org/10.3390/antibiotics11030393

Browne K; Kuppusamy R; Chen R; Willcox MDP; Walsh WR; Black DS; Kumar N, 2022, 'Bioinspired Polydopamine Coatings Facilitate Attachment of Antimicrobial Peptidomimetics with Broad-Spectrum Antibacterial Activity', International Journal of Molecular Sciences, 23, pp. 2952, http://dx.doi.org/10.3390/ijms23062952

Kalaiselvan P; Kuppusamy R; Kumar N; Willcox M, 2022, 'Antimicrobial activity of RK-7 peptide mimic against Staphylococcus aureus in solution and when immobilised onto contact lenses', Contact Lens and Anterior Eye, 45, pp. 101607, http://dx.doi.org/10.1016/j.clae.2022.101607

Chakraborty S; Kuppusamy R; Roohani I; Walsh WR; Willcox MDP; Kumar N; Chen R, 2021, 'Antibacterial peptidomimetic and characterization of its efficacy as an antibacterial and biocompatible coating for bioceramic-based bone substitutes', Materials Advances, 2, pp. 6369 - 6379, http://dx.doi.org/10.1039/d1ma00648g

Yu TT; Kuppusamy R; Yasir M; Hassan MM; Sara M; Ho J; Willcox MDP; Black DS; Kumar N, 2021, 'Polyphenylglyoxamide‐based amphiphilic small molecular peptidomimetics as antibacterial agents with anti‐biofilm activity', International Journal of Molecular Sciences, 22, pp. 7344, http://dx.doi.org/10.3390/ijms22147344

Tummanapalli SS; Kuppusamy R; Yeo JH; Kumar N; New EJ; Willcox MDP, 2021, 'The role of nitric oxide in ocular surface physiology and pathophysiology', Ocular Surface, 21, pp. 37 - 51, http://dx.doi.org/10.1016/j.jtos.2021.04.007

Sabir S; Yu TT; Kuppusamy R; Almohaywi B; Iskander G; Das T; Willcox MDP; Black DS; Kumar N, 2021, 'Novel seleno-and thio-urea-containing dihydropyrrol-2-one analogues as antibacterial agents', Antibiotics, 10, pp. 321, http://dx.doi.org/10.3390/antibiotics10030321

Yu TT; Bhadbhade M; Kuppusamy R; Black DSC; Kumar N, 2020, 'A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics', Tetrahedron Letters, 61, http://dx.doi.org/10.1016/j.tetlet.2020.152560

Yu TT; Kuppusamy R; Yasir M; Hassan MM; Alghalayini A; Gadde S; Deplazes E; Cranfield C; Willcox MDP; Black DS; Kumar N, 2020, 'Design, synthesis and biological evaluation of biphenylglyoxamide-based small molecular antimicrobial peptide mimics as antibacterial agents', International Journal of Molecular Sciences, 21, pp. 1 - 38, http://dx.doi.org/10.3390/ijms21186789

Yasir M; Dutta D; Hossain KR; Chen R; Ho KKK; Kuppusamy R; Clarke RJ; Kumar N; Willcox MDP, 2020, 'Mechanism of Action of Surface Immobilized Antimicrobial Peptides Against Pseudomonas aeruginosa', Frontiers in Microbiology, 10, pp. 3053, http://dx.doi.org/10.3389/fmicb.2019.03053

Appadurai T; Subramaniyam CM; Kuppusamy R; Karazhanov S; Subramanian B, 2019, 'Electrochemical performance of nitrogen-doped TiO2 nanotubes as electrode material for supercapacitor and Li-ion battery', Molecules, 24, http://dx.doi.org/10.3390/molecules24162952

Kuppusamy R; Willcox M; Black DSC; Kumar N, 2019, 'Short cationic peptidomimetic antimicrobials', Antibiotics, 8, pp. 44, http://dx.doi.org/10.3390/antibiotics8020044

Kuppusamy R; Yasir M; Berry T; Cranfield CG; Nizalapur S; Yee E; Kimyon O; Taunk A; Ho KKK; Cornell B; Manefield M; Willcox M; Black DSC; Kumar N, 2018, 'Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents', European Journal of Medicinal Chemistry, 143, pp. 1702 - 1722, http://dx.doi.org/10.1016/j.ejmech.2017.10.066

Kuppusamy R; Yasir M; Yee E; Willcox M; Black DSC; Kumar N, 2018, 'Guanidine functionalized anthranilamides as effective antibacterials with biofilm disruption activity', Organic and Biomolecular Chemistry, 16, pp. 5871 - 5888, http://dx.doi.org/10.1039/c8ob01699b

Chittimalla SK; Koodalingam M; Bandi C; Putturu S; Kuppusamy R, 2016, 'Expedient Baylis-Hillman reaction protocol to functionalize cyclohexa-2,4-dienones', Rsc Advances, 6, pp. 1460 - 1465, http://dx.doi.org/10.1039/c5ra21842j

Devasthale P; Wang W; Mignone J; Renduchintala K; Radhakrishnan S; Dhanapal J; Selvaraj J; Kuppusamy R; Pelleymounter MA; Longhi D; Huang N; Flynn N; Azzara AV; Rohrbach K; Devenny J; Rooney S; Thomas M; Glick S; Godonis H; Harvey S; Cullen MJ; Zhang H; Caporuscio C; Stetsko P; Grubb M; Huang C; Zhang L; Freeden C; Murphy BJ; Robl JA; Washburn WN, 2015, 'Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies', Bioorganic and Medicinal Chemistry Letters, 25, pp. 4412 - 4418, http://dx.doi.org/10.1016/j.bmcl.2015.09.018

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