By Dr Ralf Loeffler

Book Chapters

Krafft AJ; Loeffler RB; Hillenbrand CM, 2024, 'Quantification of Liver Iron Overload with UTE Imaging', in MRI of Short- and Ultrashort-T2 Tissues: Making the Invisible Visible, pp. 535 - 548, http://dx.doi.org/10.1007/978-3-031-35197-6_43

Loeffler RB; Sharma SD; Hillenbrand CM, 2020, 'Iron Mapping Techniques and Applications', in Advances in Magnetic Resonance Technology and Applications, Elsevier, pp. 779 - 803, http://dx.doi.org/10.1016/b978-0-12-817057-1.00031-7

Journal articles

Loeffler RB, 2022, 'Editorial for “Gadolinium Retention in the Brain of Mother and Pup Mouse: Effect of Pregnancy and Repeated Administration of Gadolinium-Based Contrast Agents”', Journal of Magnetic Resonance Imaging, 56, pp. 846 - 847, http://dx.doi.org/10.1002/jmri.28094

Rohani SC; Morin CE; Zhong X; Kannengiesser S; Shrestha U; Goode C; Holtrop J; Khan A; Loeffler RB; Hankins JS; Hillenbrand CM; Tipirneni-Sajja A, 2022, 'Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy-Calibrated R2^* Relaxometry Method', Journal of Magnetic Resonance Imaging, 55, pp. 1407 - 1416, http://dx.doi.org/10.1002/jmri.27921

Tipirneni-Sajja A; Loeffler RB; Hankins JS; Morin C; Hillenbrand CM, 2021, 'Quantitative Susceptibility Mapping Using a Multispectral Autoregressive Moving Average Model to Assess Hepatic Iron Overload', Journal of Magnetic Resonance Imaging, 54, pp. 721 - 727, http://dx.doi.org/10.1002/jmri.27584

Tipirneni-Sajja A; Krafft AJ; Loeffler RB; Song R; Bahrami A; Hankins JS; Hillenbrand CM, 2019, 'Autoregressive moving average modeling for hepatic iron quantification in the presence of fat', Journal of Magnetic Resonance Imaging, 50, pp. 1620 - 1632, http://dx.doi.org/10.1002/jmri.26682

Puri L; Flanagan JM; Kang G; Ding J; Bi W; McCarville BM; Loeffler RB; Tipirneni-Sajja A; Villavicencio M; Crews KR; Hillenbrand CM; Hankins JS, 2019, 'Gstm1 and liver iron content in children with sickle cell anemia and iron overload', Journal of Clinical Medicine, 8, pp. 1878, http://dx.doi.org/10.3390/jcm8111878

Tipirneni-Sajja A; Loeffler RB; Krafft AJ; Sajewski AN; Ogg RJ; Hankins JS; Hillenbrand CM, 2019, 'Ultrashort echo time imaging for quantification of hepatic iron overload: Comparison of acquisition and fitting methods via simulations, phantoms, and in vivo data', Journal of Magnetic Resonance Imaging, 49, pp. 1475 - 1488, http://dx.doi.org/10.1002/jmri.26325

Song R; Loeffler RB; Holtrop JL; McCarville MB; Hankins JS; Hillenbrand CM, 2019, 'Erratum to: Fast quantitative parameter maps without fitting: Integration yields accurate mono-exponential signal decay rates: Fast Parameter Mapping Without Fitting (Magnetic Resonance in Medicine, (2018), 79, 6, (2978-2985), 10.1002/mrm.26964)', Magnetic Resonance in Medicine, 81, pp. 1470, http://dx.doi.org/10.1002/mrm.27405

Tipirneni-Sajja A; Song R; McCarville MB; Loeffler RB; Hankins JS; Hillenbrand CM, 2018, 'Automated vessel exclusion technique for quantitative assessment of hepatic iron overload by R2*-MRI', Journal of Magnetic Resonance Imaging, 47, pp. 1542 - 1551, http://dx.doi.org/10.1002/jmri.25880

Song R; Loeffler RB; Holtrop JL; McCarville MB; Hankins JS; Hillenbrand CM, 2018, 'Fast quantitative parameter maps without fitting: Integration yields accurate mono-exponential signal decay rates', Magnetic Resonance in Medicine, 79, pp. 2978 - 2985, http://dx.doi.org/10.1002/mrm.26964

Krafft AJ; Loeffler RB; Song R; Tipirneni-Sajja A; McCarville MB; Robson MD; Hankins JS; Hillenbrand CM, 2017, 'Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla', Magnetic Resonance in Medicine, 78, pp. 1839 - 1851, http://dx.doi.org/10.1002/mrm.26592

Loeffler RB; McCarville MB; Wagstaff AW; Smeltzer MP; Krafft AJ; Song R; Hankins JS; Hillenbrand CM, 2017, 'Can multi-slice or navigator-gated R2* MRI replace single-slice breath-hold acquisition for hepatic iron quantification?', Pediatric Radiology, 47, pp. 46 - 54, http://dx.doi.org/10.1007/s00247-016-3700-1

Winchell AM; Song R; Loeffler RB; Wang WC; Hankins JS; Helton KJ; Hillenbrand CM, 2017, 'Removal of Arterial Vessel Contributions in Susceptibility-Weighted Images for Quantification of Normalized Visible Venous Volume in Children with Sickle Cell Disease', Journal of Healthcare Engineering, 2017, http://dx.doi.org/10.1155/2017/5369385

Winchell AM; Song R; Loeffler RB; Wang WC; Hankins JS; Helton KJ; Hillenbrand CM, 2017, 'Removal of Arterial Vessel Contributions in Susceptibility-Weighted Images for Quantification of Normalized Visible Venous Volume in Children with Sickle Cell Disease.', J Healthc Eng, 2017, pp. 5369385, http://dx.doi.org/10.1155/2017/5369385

Krafft AJ; Loeffler RB; Song R; Bian X; McCarville MB; Hankins JS; Hillenbrand CM, 2016, 'Does fat suppression via chemically selective saturation affect R2*-MRI for transfusional iron overload assessment? A clinical evaluation at 1.5T and 3T', Magnetic Resonance in Medicine, 76, pp. 591 - 601, http://dx.doi.org/10.1002/mrm.25868

Mitrea BG; Krafft AJ; Song R; Loeffler RB; Hillenbrand CM, 2016, 'Paired self-compensated spin-lock preparation for improved T1ρ quantification', Journal of Magnetic Resonance, 268, pp. 49 - 57, http://dx.doi.org/10.1016/j.jmr.2016.04.017

Tipirneni-Sajja A; Loeffler RB; Oesingmann N; Bissler J; Song R; Mccarville B; Jones DP; Hudson M; Spunt SL; Hillenbrand CM, 2016, 'Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model', Physiological Reports, 4, pp. 1 - 12, http://dx.doi.org/10.14814/phy2.12755

Goll D; Loeffler R; Herbst J; Frey C; Goeb S; Grubesa T; Hohs D; Kopp A; Pflanz U; Stein R; Schneider G, 2015, 'Magnetic properties of hard magnetic (Fe,Cr)3Sn2 intermetallic compound', Physica Status Solidi - Rapid Research Letters, 9, pp. 603 - 606, http://dx.doi.org/10.1002/pssr.201510243

Winchell AM; Taylor BA; Song R; Loeffler RB; Grundlehner P; Hankins JS; Wang WC; Ogg RJ; Hillenbrand CM; Helton KJ, 2014, 'Evaluation of SWI in children with sickle cell disease', American Journal of Neuroradiology, 39, pp. 1016 - 1021, http://dx.doi.org/10.3174/ajnr.A3794

Taylor BA; Loeffler RB; Song R; McCarville ME; Hankins JS; Hillenbrand CM, 2013, 'Automated T2* measurements using supplementary field mapping to assess cardiac iron content', Journal of Magnetic Resonance Imaging, 38, pp. 441 - 447, http://dx.doi.org/10.1002/jmri.23990

Sedlacik J; Winchell A; Kocak M; Loeffler RB; Broniscer A; Hillenbrand CM, 2013, 'MR imaging assessment of tumor perfusion and 3D segmented volume at baseline, during treatment, and at tumor progression in children with newly diagnosed diffuse intrinsic pontine glioma', American Journal of Neuroradiology, 34, pp. 1450 - 1455, http://dx.doi.org/10.3174/ajnr.A3421

Taylor BA; Loeffler RB; Song R; McCarville MB; Hankins JS; Hillenbrand CM, 2013, 'Erratum: Simultaneous field and R2* mapping to quantify liver iron content using autoregressive moving average modeling (Journal of Magnetic Resonance Imaging (2012) 35 (1125-1132))', Journal of Magnetic Resonance Imaging, 37, pp. 1254 - 1255, http://dx.doi.org/10.1002/jmri.24135

Sedlacik J; Myers A; Loeffler RB; Williams RF; Davidoff AM; Hillenbrand CM, 2013, 'A dedicated automated injection system for dynamic contrast-enhanced MRI experiments in mice', Journal of Magnetic Resonance Imaging, 37, pp. 746 - 751, http://dx.doi.org/10.1002/jmri.23810

Panandiker ASP; Winchell A; Loeffler R; Song R; Rolen M; Hillenbrand C, 2013, '4DMRI Provides More Accurate Renal Motion Estimation in IMRT in Young Children.', Pract Radiat Oncol, 3, pp. S1, http://dx.doi.org/10.1016/j.prro.2013.01.008

Taylor BA; Loeffler RB; Song R; McCarville MB; Hankins JS; Hillenbrand CM, 2012, 'Simultaneous field and R 2*mapping to quantify liver iron content using autoregressive moving average modeling', Journal of Magnetic Resonance Imaging, 35, pp. 1125 - 1132, http://dx.doi.org/10.1002/jmri.23545

Song R; Loeffler RB; Hillenbrand CM, 2012, 'QUIPSS II with window-sliding saturation sequence (Q2WISE)', Magnetic Resonance in Medicine, 67, pp. 1127 - 1132, http://dx.doi.org/10.1002/mrm.23093

Song R; Tipirneni A; Johnson P; Loeffler RB; Hillenbrand CM, 2011, 'Evaluation of respiratory liver and kidney movements for MRI navigator gating', Journal of Magnetic Resonance Imaging, 33, pp. 143 - 148, http://dx.doi.org/10.1002/jmri.22418

Hankins JS; McCarville MB; Hillenbrand CM; Loeffler RB; Ware RE; Song R; Smeltzer MP; Joshi V, 2010, 'Ventricular diastolic dysfunction in sickle cell anemia is common but not associated with myocardial iron deposition', Pediatric Blood and Cancer, 55, pp. 495 - 500, http://dx.doi.org/10.1002/pbc.22587

McCarville MB; Hillenbrand CM; Loeffler RB; Smeltzer MP; Song R; Li CS; Hankins JS, 2010, 'Comparison of whole liver and small region-of-interest measurements of MRI liver R2* in children with iron overload', Pediatric Radiology, 40, pp. 1360 - 1367, http://dx.doi.org/10.1007/s00247-010-1596-8

Sedlacik J; Löbel U; Kocak M; Loeffler RB; Reichenbach JR; Broniscer A; Patay Z; Hillenbrand CM, 2010, 'Attenuation of cerebral venous contrast in susceptibility-weighted imaging of spontaneously breathing pediatric patients sedated with propofol', American Journal of Neuroradiology, 31, pp. 901 - 906, http://dx.doi.org/10.3174/ajnr.A1960

Song R; Loeffler RB; Hillenbrand CM, 2010, 'Improved renal perfusion measurement with a dual navigator-gated Q2TIPS fair technique', Magnetic Resonance in Medicine, 64, pp. 1352 - 1359, http://dx.doi.org/10.1002/mrm.22532

Choli M; Jakob PM; Loeffler RB; Hillenbrand CM, 2010, 'Mixed-bandwidth acquisitions: signal-to-noise ratio and signal-to-noise efficiency.', Journal of magnetic resonance imaging : JMRI, 32, pp. 997 - 1002, http://dx.doi.org/10.1002/jmri.22327

Hankins JS; McCarville MB; Loeffler RB; Smeltzer MP; Onciu M; Hoffer FA; Li CS; Wang WC; Ware RE; Hillenbrand CM, 2009, 'R2* magnetic resonance imaging of the liver in patients with iron overload', Blood, 113, pp. 4853 - 4855, http://dx.doi.org/10.1182/blood-2008-12-191643

Hankins J; Hillenbrand C; Joshi V; Loeffler R; Song R; Ware R; Hansbury E; Rieman M; Mortier N; Smeltzer M; Li C-S; McCarville MB, 2007, 'Cardiac T2* Magnetic Resonance Imaging (MRI) in Iron Overload and Ventricular Diastolic Function.', Blood, 110, pp. 2676 - 2676, http://dx.doi.org/10.1182/blood.v110.11.2676.2676

Setser RM; Kim JK; Chung YC; Chen K; Stillman AE; Loeffler R; Simonetti OP; Weaver JA; Lieber ML; White RD, 2006, 'Cine delayed-enhancement MR imaging of the heart: Initial experience', Radiology, 239, pp. 856 - 862, http://dx.doi.org/10.1148/radiol.2393050228

Peller M; Kurze V; Loeffler R; Pahernik S; Dellian M; Goetz AE; Issels R; Reiser M, 2003, 'Hyperthermia induces T1 relaxation and blood flow changes in tumors. A MRI thermometry study in vivo', Magnetic Resonance Imaging, 21, pp. 545 - 551, http://dx.doi.org/10.1016/S0730-725X(03)00070-5

Müller CJ; Schwaiblmair M; Scheidler J; Deimling M; Weber J; Löffler RB; Reiser MF, 2002, 'Pulmonary diffusing capacity: Assessment with oxygen-enhanced lung MR imaging - Preliminary findings', Radiology, 222, pp. 499 - 506, http://dx.doi.org/10.1148/radiol.2222000869

Müller CJ; Löffler R; Deimling M; Peller M; Reiser M, 2001, 'MR lung imaging at 0.2 T with T1-weighted true FISP: Native and oxygen-enhanced', Journal of Magnetic Resonance Imaging, 14, pp. 164 - 168, http://dx.doi.org/10.1002/jmri.1167

Löffler R; Müller CJ; Peller M; Penzkofer H; Deimling M; Schwaiblmair M; Scheidler J; Reiser M, 2000, 'Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging', Magnetic Resonance in Medicine, 43, pp. 860 - 866, http://dx.doi.org/10.1002/1522-2594(200006)43:6<860::AID-MRM12>3.3.CO;2-3

Pahernik SA; Peller M; Dellian M; Loeffler R; Issels R; Reiser M; Messmer K; Goetz AE, 1999, 'Validation of MR thermometry technology: A small animal model for hyperthermic treatment of tumours', Research in Experimental Medicine, 199, pp. 59 - 71, http://dx.doi.org/10.1007/s004330050133

Peller M; Löffler R; Baur A; Turner P; Abdel-Rahman S; Futschik G; Santl M; Hiddemann W; Reiser M; Issels R, 1999, 'MRI-controlled regional hyperthermia', Radiologe, 39, pp. 756 - 763, http://dx.doi.org/10.1007/s001170050572

Scholz VH; Löffler R; Bruening R; Jaeger L; Weber J; Reiser M, 1998, 'EPI sequences in use of fMRI: Comparing susceptibility effects of different gradient rise-times and shapes', NeuroImage, 7, http://dx.doi.org/10.1016/s1053-8119(18)31369-7

Bertsch F; Mattner J; Stehling MK; Müller-Lisse U; Peller M; Loeffler R; Weber J; Meßmer K; Wilmanns W; Issels R; Reiser M, 1998, 'Non-invasive temperature mapping using MRI: Comparison of two methods based on chemical shift and T1-relaxation', Magnetic Resonance Imaging, 16, pp. 393 - 403, http://dx.doi.org/10.1016/S0730-725X(97)00311-1

Conference Papers

Shrestha U; Morin C; Loeffler R; Abramson ZR; Hankins J; Hillenbrand C; Tipirneni-Sajja A, 2023, 'Automatic Extraction of Liver Parenchyma and R2* Estimation using Deep Learning for UTE Imaging for Assessment of Hepatic Iron Overload', in ISMRM Annual Meeting, ISMRM, presented at 2023 ISMRM & ISMRT Annual Meeting, 03 June 2023 - 08 June 2023, http://dx.doi.org/10.58530/2023/1841

Tipirneni-Sajja A; Krafft AJ; McCarville MB; Loeffler RB; Song R; Hankins JS; Hillenbrand CM, 2017, 'Radial ultrashort TE imaging removes the need for breath-holding in hepatic iron overload quantification by R2∗ MRI', in American Journal of Roentgenology, pp. 187 - 194, http://dx.doi.org/10.2214/AJR.16.17183

Puri L; Hankins J; Hillenbrand C; Flanagan J; Kang G; Bi W; Tipirneni-Sajja A; Villavicencio M; Loeffler R, 2017, 'Genetic Modifiers of Iron Overload in Sickle Cell Disease', in PEDIATRIC BLOOD & CANCER, WILEY, pp. S24 - S25, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000398571100104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Panandiker ASP; Winchell A; Rolen M; Loeffler R; Song R; Hua C; Hillenbrand C, 2013, '4DMRI Provides More Accurate Renal Motion Estimation for IMRT in Young Children', in INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, ELSEVIER SCIENCE INC, GA, Atlanta, pp. S599 - S599, presented at 55th Annual Meeting of the American-Society-for-Radiation-Oncology (ASTRO), GA, Atlanta, 22 September 2013 - 25 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324503602237&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hankins J; Hillenbrand C; Joshi V; Loeffler R; Song R; Ware R; Hansbury E; Rieman M; Mortier N; Smeltzer M; Li C-S; McCarville MB, 2007, 'Cardiac T2*magnetic resonance imaging (MRI) in iron overload and ventricular diastolic function', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 786A - 787A, presented at 49th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 08 December 2007 - 11 December 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000251100803458&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hankins JS; McCarville MB; Loeffler R; Song R; Ware RE; Hansbury E; Rieman M; Mortier N; Smeltzer M; Li C-S; Hoffer F; Hillenbrand C, 2007, 'R* magnetic resonance imaging (MRI) of the liver for patients with iron overload', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, pp. 785A - 785A, presented at 49th Annual Meeting of the American-Society-of-Hematology, GA, Atlanta, 08 December 2007 - 11 December 2007, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000251100803452&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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