By Dr Ramon Martinez Marmol

Book Chapters

Small C; Martínez-Mármol R; Amor R; Meunier FA; Joensuu M, 2021, 'Combining Single Molecule Super-Resolution Imaging Techniques to Unravel the Nanoscale Organization of the Presynapse', in Methods in Molecular Biology, pp. 265 - 286, http://dx.doi.org/10.1007/978-1-0716-1044-2_18

Joensuu M; Martínez-Mármol R; Mollazade M; Padmanabhan P; Meunier FA, 2020, 'Single-molecule imaging of recycling synaptic vesicles in live neurons', in Neuromethods, pp. 81 - 114, http://dx.doi.org/10.1007/978-1-0716-0532-5_5

Journal articles

Donato A; Ritchie FK; Lu L; Wadia M; Martinez-Marmol R; Kaulich E; Sankorrakul K; Lu H; Coakley S; Coulson EJ; Hilliard MA, 2025, 'OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-024-55105-0

Longfield SF; Gormal RS; Feller M; Parutto P; Reingruber J; Wallis TP; Joensuu M; Augustine GJ; Martínez-Mármol R; Holcman D; Meunier FA, 2024, 'Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-46256-1

Small C; Harper C; Jiang A; Kontaxi C; Pronot M; Yak N; Malapaka A; Davenport EC; Wallis TP; Gormal RS; Joensuu M; Martínez-Mármol R; Cousin MA; Meunier FA, 2024, 'SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling', Journal of Neurochemistry, 168, pp. 3188 - 3208, http://dx.doi.org/10.1111/jnc.16186

Fath T; Sytnyk V; Martínez-Mármol R, 2024, '‘10th cell architecture in development and disease (CADD)’: Meeting report', Cytoskeleton, 81, pp. 264 - 265, http://dx.doi.org/10.1002/cm.21815

Gormal RS; Martinez-Marmol R; Brooks AJ; Meunier FA, 2024, 'Location, location, location: Protein kinase nanoclustering for optimised signalling output.', Elife, 13, http://dx.doi.org/10.7554/eLife.93902

Longfield SF; Mollazade M; Wallis TP; Gormal RS; Joensuu M; Wark JR; van Waardenberg AJ; Small C; Graham ME; Meunier FA; Martínez-Mármol R, 2023, 'Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-43130-4

Martínez-Mármol R; Giordano-Santini R; Kaulich E; Cho AN; Przybyla M; Riyadh MA; Robinson E; Chew KY; Amor R; Meunier FA; Balistreri G; Short KR; Ke YD; Ittner LM; Hilliard MA, 2023, 'SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.adg2248

Martínez-Mármol R; Chai YJ; Conroy JN; Khan Z; Hong SM; Kim SB; Gormal RS; Lee DH; Lee JK; Coulson EJ; Lee MK; Kim SY; Meunier FA, 2023, 'Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory', Journal of Neurochemistry, 165, pp. 791 - 808, http://dx.doi.org/10.1111/jnc.15767

Martínez-Mármol R; Small C; Jiang A; Palliyaguru T; Wallis TP; Gormal RS; Sibarita JB; Götz J; Meunier FA, 2023, 'Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates', Molecular Psychiatry, 28, pp. 946 - 962, http://dx.doi.org/10.1038/s41380-022-01825-y

Martínez-Mármol R; Muhaisen A; Cotrufo T; Roselló-Busquets C; Ros O; Hernaiz-Llorens M; Pérez-Branguli F; Andrés RM; Parcerisas A; Pascual M; Ulloa F; Soriano E, 2023, 'Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion', Frontiers in Molecular Neuroscience, 16, http://dx.doi.org/10.3389/fnmol.2023.1253954

Hernaiz-Llorens M; Martínez-Mármol R; Roselló-Busquets C; Soriano E, 2021, 'One raft to guide them all, and in axon regeneration inhibit them', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22095009

Hernaiz-Llorens M; Roselló-Busquets C; Durisic N; Filip A; Ulloa F; Martínez-Mármol R; Soriano E, 2021, 'Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors', Cellular and Molecular Life Sciences, 78, pp. 2797 - 2820, http://dx.doi.org/10.1007/s00018-020-03663-z

Harper CB; Small C; Davenport EC; Low DW; Smillie KJ; Martínez-Mármol R; Meunier FA; Cousin MA, 2020, 'An epilepsy-associated SV2A mutation disrupts synaptotagmin-1 expression and activity-dependent trafficking', Journal of Neuroscience, 40, pp. 4586 - 4595, http://dx.doi.org/10.1523/JNEUROSCI.0210-20.2020

Roselló-Busquets C; Hernaiz-Llorens M; Soriano E; Martínez-Mármol R, 2020, 'Nystatin Regulates Axonal Extension and Regeneration by Modifying the Levels of Nitric Oxide', Frontiers in Molecular Neuroscience, 13, http://dx.doi.org/10.3389/fnmol.2020.00056

Martínez-Mármol R; Mohannak N; Qian L; Wang T; Gormal RS; Ruitenberg MJ; Vanhaesebroeck B; Coulson EJ; Meunier FA, 2019, 'p110δ PI3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation, and prevents cognitive decline in an Alzheimer's disease mouse model', Journal of Neuroscience, 39, pp. 7976 - 7991, http://dx.doi.org/10.1523/JNEUROSCI.0674-19.2019

Padmanabhan P; Martínez-Mármol R; Xia D; Götz J; Meunier FA, 2019, 'Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines.', Elife, 8, http://dx.doi.org/10.7554/eLife.45040

Padmanabhan P; Martínez-Mármol R; Xia D; Götz J; Meunier FA, 2019, 'Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines', Elife, 8, http://dx.doi.org/10.7554/eLife.45040.001

Roselló-Busquets C; de la Oliva N; Martínez-Mármol R; Hernaiz-Llorens M; Pascual M; Muhaisen A; Navarro X; del Valle J; Soriano E, 2019, 'Cholesterol depletion regulates axonal growth and enhances central and peripheral nerve regeneration', Frontiers in Cellular Neuroscience, 13, http://dx.doi.org/10.3389/fncel.2019.00040

Ros O; Barrecheguren PJ; Cotrufo T; Schaettin M; Roselló-Busquets C; Vílchez-Acosta A; Hernaiz-Llorens M; Martínez-Marmol R; Ulloa F; Stoeckli ET; Araújo SJ; Soriano E, 2018, 'A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse', Plos Genetics, 14, http://dx.doi.org/10.1371/journal.pgen.1007432

Polanco JC; Li C; Bodea LG; Martinez-Marmol R; Meunier FA; Götz J, 2018, 'Amyloid-β and tau complexity - Towards improved biomarkers and targeted therapies', Nature Reviews Neurology, 14, pp. 22 - 40, http://dx.doi.org/10.1038/nrneurol.2017.162

Martínez-Mármol R; Styrczewska K; Pérez-Verdaguer M; Vallejo-Gracia A; Comes N; Sorkin A; Felipe A, 2018, 'PKC Activation Induces Ubiquitination-Dependent KV1.3 Endocytosis Mediated by Nedd4-2 Ubiquitin Ligase', Biophysical Journal, 114, pp. 301a - 301a, http://dx.doi.org/10.1016/j.bpj.2017.11.1713

Joensuu M; Martínez-Mármol R; Padmanabhan P; Glass NR; Durisic N; Pelekanos M; Mollazade M; Balistreri G; Amor R; Cooper-White JJ; Goodhill GJ; Meunier FA, 2017, 'Visualizing endocytic recycling and trafficking in live neurons by subdiffractional tracking of internalized molecules', Nature Protocols, 12, pp. 2590 - 2622, http://dx.doi.org/10.1038/nprot.2017.116

Martínez-Mármol R; Styrczewska K; Pérez-Verdaguer M; Vallejo-Gracia A; Comes N; Sorkin A; Felipe A, 2017, 'Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation', Scientific Reports, 7, http://dx.doi.org/10.1038/srep42395

Pérez-Verdaguer M; Capera J; Martínez-Mármol R; Camps M; Comes N; Tamkun MM; Felipe A, 2017, 'Deciphering the Kv1.3/Caveolin Interaction', Biophysical Journal, 112, pp. 252a - 252a, http://dx.doi.org/10.1016/j.bpj.2016.11.1375

Styrczewska K; Martínez-Mármol R; Comes N; Estadella I; Pérez-Verdaguer M; Pujadas L; Soriano E; Sorkin A; Felipe A, 2017, 'ERK1/2 Mediates EGF-Dependent Kv1.3 Endocytosis', Biophysical Journal, 112, pp. 251a - 252a, http://dx.doi.org/10.1016/j.bpj.2016.11.1374

Roig SR; Solé L; Vallejo-Gracia A; Sastre D; Serrano-Albarrás A; Serrano-Novillo C; Martínez-Mármol R; Tamkun MM; Felipe A, 2017, 'The C-Terminal Domain of Kv1.3 Interacts with KCNE4 to form Oligomeric Channels', Biophysical Journal, 112, pp. 545a - 545a, http://dx.doi.org/10.1016/j.bpj.2016.11.2944

Wang T; Martin S; Nguyen TH; Harper CB; Gormal RS; Martinez-Marmol R; Karunanithi S; Coulson EJ; Glass NR; Cooper-White JJ; van Swinderen B; Meunier FA, 2016, 'Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB (vol 7, 12976, 2016)', NATURE COMMUNICATIONS, 7, http://dx.doi.org/10.1038/ncomms13768

Martínez-Mármol R; Barneda-Zahonero B; Soto D; Andrés RM; Coccia E; Gasull X; Planells-Ferrer L; Moubarak RS; Soriano E; Comella JX, 2016, 'FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration', Scientific Reports, 6, http://dx.doi.org/10.1038/srep35775

Wang T; Martin S; Nguyen TH; Harper CB; Gormal RS; Martínez-Mármol R; Karunanithi S; Coulson EJ; Glass NR; Cooper-White JJ; Van Swinderen B; Meunier FA, 2016, 'Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms12976

Martínez-Mármol R; Comes N; Styrczewska K; Pérez-Verdaguer M; Vicente R; Pujadas L; Soriano E; Sorkin A; Felipe A, 2016, 'Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis', Cellular and Molecular Life Sciences, 73, pp. 1515 - 1528, http://dx.doi.org/10.1007/s00018-015-2082-0

Pérez-Verdaguer M; Capera J; Martínez-Mármol R; Camps M; Comes N; Tamkun MM; Felipe A, 2016, 'Caveolin interaction governs Kv1.3 lipid raft targeting', Scientific Reports, 6, http://dx.doi.org/10.1038/srep22453

Solé L; Roig SR; Vallejo-Gracia A; Serrano-Albarrás A; Martínez-Mármol R; Tamkun MM; Felipe A, 2016, 'The C-terminal domain of Kv1.3 regulates functional interactions with the KCNE4 subunit', Journal of Cell Science, 129, pp. 4265 - 4277, http://dx.doi.org/10.1242/jcs.191650

Ros O; Cotrufo T; Martínez-Mármol R; Soriano E, 2015, 'Regulation of patterned dynamics of local exocytosis in growth cones by Netrin-1', Journal of Neuroscience, 35, pp. 5156 - 5170, http://dx.doi.org/10.1523/JNEUROSCI.0124-14.2015

Ulloa F; Gonzàlez-Juncà A; Meffre D; Barrecheguren PJ; Martínez-Mármol R; Pazos I; Olivé N; Cotrufo T; Seoane J; Soriano E, 2015, 'Blockade of the SNARE protein syntaxin 1 inhibits glioblastoma tumor growth', Plos One, 10, http://dx.doi.org/10.1371/journal.pone.0119707

Martínez-Mármol R; Pérez-Verdaguer M; Roig SR; Vallejo-Gracia A; Gotsi P; Serrano-Albarrás A; Bahamonde MI; Ferrer-Montiel A; Fernández-Ballester G; Comes N; Felipe A, 2014, 'A Non-Canonical Di-Acidic Signal at the C-Terminal of KV1.3 Determines Anterograde Trafficking and Surface Expression', Biophysical Journal, 106, pp. 739a - 739a, http://dx.doi.org/10.1016/j.bpj.2013.11.4072

Marti'nez-Mármol R; Pérez-Verdaguer M; Roig SR; Vallejo-Gracia A; Gotsi P; Serrano-Albarrás A; Bahamonde MI; Ferrer-Montiel A; Fernández-Ballester G; Comes N; Felipe A, 2013, 'A non-canonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression', Journal of Cell Science, 126, pp. 5681 - 5691, http://dx.doi.org/10.1242/jcs.134825

Cotrufo T; Andrés RM; Ros O; Pérez‐Brangulí F; Muhaisen A; Fuschini G; Martínez R; Pascual M; Comella JX; Soriano E, 2013, 'Syntaxin 1 is required for DCC / N etrin‐1‐dependent chemoattraction of migrating neurons from the lower rhombic lip', European Journal of Neuroscience, 38, pp. 2338 - 2338, http://dx.doi.org/10.1111/ejn.12312

Cotrufo T; Andrés RM; Ros O; Pérez-Brangulí F; Muhaisen A; Fuschini G; Martínez R; Pascual M; Comella JX; Soriano E, 2012, 'Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip', European Journal of Neuroscience, 36, pp. 3152 - 3164, http://dx.doi.org/10.1111/j.1460-9568.2012.08259.x

David M; Macías A; Moreno C; Prieto A; Martínez-Mármol R; Vicente R; González T; Felipe A; Tamkun MM; Valenzuela C, 2012, 'Protein kinase C (PKC) activity regulates functional effects of K vβ1.3 subunit on K V1.5 channels: Identification of a cardiac K v1.5 channelosome', Journal of Biological Chemistry, 287, pp. 21416 - 21428, http://dx.doi.org/10.1074/jbc.M111.328278

David M; Martinez-Marmol R; Gonzalez T; Felipe A; Valenzuela C, 2009, 'Differential Regulation Of Navß Subunits During Myogenesis', Biophysical Journal, 96, pp. 250a - 251a, http://dx.doi.org/10.1016/j.bpj.2008.12.1233

Villalonga N; Martínez-Mármol R; Solè L; Vicente R; Soler C; Tamkun MM; Felipe A, 2009, 'Partnership interactions target Kv1.5 to distinct membrane surface microdomains', Biophysical Journal, 96, pp. 176a - 176a, http://dx.doi.org/10.1016/j.bpj.2008.12.820

Martínez-Mármol R; Villalonga N; Solé L; Vicente R; Tamkun MM; Soler C; Felipe A, 2008, 'Multiple Kv1.5 targeting to membrane surface microdomains', Journal of Cellular Physiology, 217, pp. 667 - 673, http://dx.doi.org/10.1002/jcp.21538

Martínez-Mármol R; Roura-Ferrer M; Felipe A, 2008, 'Targeting potassium channels: New advances in cardiovascular therapy', Recent Patents on Cardiovascular Drug Discovery, 3, pp. 105 - 118, http://dx.doi.org/10.2174/157489008784705386

Roura-Ferrer M; Solé L; Martínez-Mármol R; Villalonga N; Felipe A, 2008, 'Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation', Biochemical and Biophysical Research Communications, 369, pp. 1094 - 1097, http://dx.doi.org/10.1016/j.bbrc.2008.02.152

Villalonga N; Martínez-Mármol R; Roura-Ferrer M; David M; Valenzuela C; Soler C; Felipe A, 2008, 'Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation', Biochimica Et Biophysica Acta Molecular Cell Research, 1783, pp. 728 - 736, http://dx.doi.org/10.1016/j.bbamcr.2008.01.001

David M; Martínez-Mármol R; Gonzalez T; Felipe A; Valenzuela C, 2008, 'Differential regulation of Navβ subunits during myogenesis', Biochemical and Biophysical Research Communications, 368, pp. 761 - 766, http://dx.doi.org/10.1016/j.bbrc.2008.01.138

Martínez-Mármol R; David M; Sanches R; Roura-Ferrer M; Villalonga N; Sorianello E; Webb SM; Zorzano A; Gumà A; Valenzuela C; Felipe A, 2007, 'Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair', Cardiovascular Research, 76, pp. 430 - 441, http://dx.doi.org/10.1016/j.cardiores.2007.08.009

Felipe A; Vicente R; Villalonga N; Roura-Ferrer M; Martínez-Mármol R; Solé L; Ferreres JC; Condom E, 2006, 'Potassium channels: New targets in cancer therapy', Cancer Detection and Prevention, 30, pp. 375 - 385, http://dx.doi.org/10.1016/j.cdp.2006.06.002

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