By Dr Rui SANG

Journal articles

Hall T; Sang R; Gulati S; Yang M; Zhang C; Goldys EM; Deng F, 2026, 'Circular nucleic acid synthesis: Enzymatic, chemical, and emerging strategies for diagnostic and bioengineering applications', Trac Trends in Analytical Chemistry, 201, pp. 118875, http://dx.doi.org/10.1016/j.trac.2026.118875

Sang R; Yang B; Zahra K; Deng F; Gu Z; Goldys EM; Deng W, 2026, 'Redox responsive nanosystems for medicine: from reactive species mapping to precision treatment', Advanced Drug Delivery Reviews, 235, http://dx.doi.org/10.1016/j.addr.2026.115892

Yang X; Sang R; Hutvagner G; Hewitt AW; Li D; Li Y; Deng W, 2026, 'An optimised lipid nanoparticle platform enables efficient CRISPR/Cas9 genome editing in hard-to-transfect cells', Acta Biomaterialia, 218, pp. 432 - 444, http://dx.doi.org/10.1016/j.actbio.2026.05.044

Xu Z; Haghighat M; Shafiabady N; Wu R; Sang R; Deng W, 2026, 'Nuclear-targeted CRISPR/Cas delivery by using aptamer-modified polymer lipid nanoparticles', Nanomedicine Nanotechnology Biology and Medicine, 74, http://dx.doi.org/10.1016/j.nano.2026.102928

Pan L; Sang R; Xue R; Ma Y; Goldys E; Deng F, 2026, 'AlphaFold3-guided tracrRNA redesign yields small monomeric Cas12f RNPs', Nucleic Acids Research, 54, http://dx.doi.org/10.1093/nar/gkag430

Zong L; Sang R; Zhang X; Lim JL; Zhao S; Deng W; Gunawan C; Amal R; Yun J; Chu D; Tao W; Gu Z, 2026, 'Geobacter sulfurreducens Armed with Biosynthetic Gold Nanoparticles for Tumor-Selective Cascade Catalytic Cancer Therapy', Nano Letters, 26, pp. 322 - 331, http://dx.doi.org/10.1021/acs.nanolett.5c05084

Deng F; Gulati S; Sang R; Li Y; Goldys EM, 2026, 'Autocatalytic Cas13a biosensor enabled by RNA-nanocircles for ultrasensitive RNA detection', npj Biosensing, 3, pp. 5, http://dx.doi.org/10.1038/s44328-025-00067-6

Chen K; Yang B; Sang R; Chen W; Xiang T; Deng F, 2026, 'CRISPR technologies for detecting DNA and RNA methylation: Mechanisms, platforms, and translational opportunities', Bioengineering and Translational Medicine, http://dx.doi.org/10.1002/btm2.70174

Zahra K; Deng F; Deng W; Sang R, 2025, 'Advances in photodynamic therapy and its combination strategies for breast cancer', Acta Biomaterialia, 205, pp. 125 - 140, http://dx.doi.org/10.1016/j.actbio.2025.08.054

Hall T; Gulati S; Sang R; Jia Z; Mckinnirey F; Vesey G; Goldys E; Deng F, 2025, 'CRISPR biosensing with lateral flow assays for point of care Diagnostics: Overcoming commercial development challenges', Trac Trends in Analytical Chemistry, 189, pp. 118275, http://dx.doi.org/10.1016/j.trac.2025.118275

Sang R; Nixdorf S; Hung T; Power C; Deng F; Bui TA; Engel A; Goldys EM; Deng W, 2025, 'Unlocking the in vivo therapeutic potential of radiation-activated photodynamic therapy for locally advanced rectal cancer with lymph node involvement', Ebiomedicine, 116, pp. 105724, http://dx.doi.org/10.1016/j.ebiom.2025.105724

Pan L; Ma Y; Sang R; Lu X; Fan X; Li M; Zuo Q; Wang A; Deng F, 2025, 'Optimization of CRISPR/Cas12f1 guide RNAs using AlphaFold 3 for enhanced nucleic acid detection', Microchemical Journal, 212, pp. 113194, http://dx.doi.org/10.1016/j.microc.2025.113194

Deng F; Sang R; Li Y; Yang B; Zhai X; Xue R; Zhang C; Deng W; Goldys EM, 2025, 'Hairpin-locker mediated CRISPR/Cas tandem system for ultrasensitive detection of DNA without pre-amplification', Microchemical Journal, 210, pp. 113025, http://dx.doi.org/10.1016/j.microc.2025.113025

Pan L; Wang A; Sang R; Lu X; Chen W; Ma Y; Deng F, 2025, 'AlphaFold 3 sheds insights into chemical enhancer-induced structural changes in Cas12a RNPs', Health Nanotechnology, 1, pp. 1, http://dx.doi.org/10.1186/s44301-024-00003-z

Deng F; Li Y; Yang B; Sang R; Deng W; Kansara M; Lin F; Thavaneswaran S; Thomas DM; Goldys EM, 2024, 'Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing', Nature Communications, 15, pp. 1818, http://dx.doi.org/10.1038/s41467-024-46001-8

Deng F; Sang R; Li Y; Yang D; Mckinnirey F; Deng W; Goldys EM, 2024, 'Towards understanding Trans-cleavage of natural and synthetic nucleic acids by Cas12a for sensitive CRISPR biosensing', Microchemical Journal, 207, pp. 111850, http://dx.doi.org/10.1016/j.microc.2024.111850

Bui TA; Mei H; Sang R; Ortega DG; Deng W, 2024, 'Advancements and challenges in developing in vivo CAR T cell therapies for cancer treatment', Ebiomedicine, 106, http://dx.doi.org/10.1016/j.ebiom.2024.105266

Chandrasekara CMN; Gemikonakli G; Mach J; Sang R; Anwer AG; Agha A; Goldys EM; Hilmer SN; Campbell JM, 2024, 'Ageing and Polypharmacy in Mesenchymal Stromal Cells: Metabolic Impact Assessed by Hyperspectral Imaging of Autofluorescence', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms25115830

Yang B; Sang R; Li Y; Goldys EM; Deng W, 2024, 'Improved effectiveness of X-PDT against human triple-negative breast cancer cells through the use of liposomes co-loaded with protoporphyrin IX and perfluorooctyl bromide', Journal of Materials Chemistry B, 12, pp. 3764 - 3773, http://dx.doi.org/10.1039/d4tb00011k

Yang B; Sang R; Li Y; Goldys E; Deng W, 2024, 'Abstract 5743: Liposome platform enables X-ray induced photodynamic therapy treatment against human triple negative breast cancer cells', Cancer Research, 84, pp. 5743 - 5743, http://dx.doi.org/10.1158/1538-7445.am2024-5743

Sang R; Deng F; Engel A; Goldys E; Deng W; Engel A, 2022, 'Lipid-polymer nanocarrier platform enables X-ray induced photodynamic therapy against human colorectal cancer cells', Biomedicine and Pharmacotherapy, 155, pp. 113837, http://dx.doi.org/10.1016/j.biopha.2022.113837

Sang R; Stratton B; Engel A; Deng W; Engel A, 2021, 'Liposome technologies towards colorectal cancer therapeutics', Acta Biomaterialia, 127, pp. 24 - 40, http://dx.doi.org/10.1016/j.actbio.2021.03.055

Sang R; Zheng Y; Zhang H; Wu X; Wang Q; Hai L; Wu Y, 2018, 'Palladium-catalyzed direct C-H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant', Organic Chemistry Frontiers, 5, pp. 648 - 652, http://dx.doi.org/10.1039/c7qo00945c

Zhang H; Jing L; Zheng Y; Sang R; Zhao Y; Wang Q; Wu Y, 2018, 'Rhodium-Catalyzed ortho-Cyanation of 2-Aryl-1,2,3-triazole: An Alternative Approach to Suvorexant', European Journal of Organic Chemistry, 2018, pp. 723 - 729, http://dx.doi.org/10.1002/ejoc.201701476

Ma X; Lv G; Cheng X; Li W; Sang R; Zhang Y; Wang Q; Hai L; Wu Y, 2017, 'Novel cyclodextrin-modified h-BN@Pd(II) nanomaterial: An efficient and recoverable catalyst for ligand-free C-C cross-coupling reactions in water', Applied Organometallic Chemistry, 31, http://dx.doi.org/10.1002/aoc.3854

Sang R; Cheng X; Li W; Luo P; Zhang Y; Nie R; Hai L; Wu Y, 2017, 'Heterogeneous h-BN@Cyclodextrin@Pd(II) nanomaterial: Fabrication, characterization and application as a highly efficient and recyclable catalyst for C—C coupling reactions', Chemical Research in Chinese Universities, 33, pp. 811 - 815, http://dx.doi.org/10.1007/s40242-017-6455-9

Cheng X; Li W; Nie R; Ma X; Sang R; Guo L; Wu Y, 2017, 'Ligand-Free C–C Coupling Reactions Promoted by Hexagonal Boron Nitride-Supported Palladium(II) Catalyst in Water', Advanced Synthesis and Catalysis, 359, pp. 454 - 466, http://dx.doi.org/10.1002/adsc.201600815

Wang Y; Sang R; Zheng Y; Guo L; Guan M; Wu Y, 2017, 'Graphene oxide: An efficient recyclable solid acid for the synthesis of bis(indolyl)methanes from aldehydes and indoles in water', Catalysis Communications, 89, pp. 138 - 142, http://dx.doi.org/10.1016/j.catcom.2016.09.027

Nie R; Sang R; Ma X; Zheng Y; Cheng X; Li W; Guo L; Jin H; Wu Y, 2016, 'Copper-γ-cyclodextrin complexes immobilized on hexagonal boron nitride as an efficient catalyst in the multicomponent synthesis of 1,2,3-triazoles', Journal of Catalysis, 344, pp. 286 - 292, http://dx.doi.org/10.1016/j.jcat.2016.09.022

Li W; Lv G; Cheng X; Sang R; Ma X; Zhang Y; Nie R; Li J; Guan M; Wu Y, 2016, 'Palladium(II)-Schiff base complex immobilized covalently on h-BN: An efficient and recyclable catalyst for aqueous organic transformations', Tetrahedron, 72, pp. 8557 - 8564, http://dx.doi.org/10.1016/j.tet.2016.11.027

Conference Papers

Qiao L; Guo T; Xue R; Sang R; Yang D; Deng F, 2024, 'Flexible chip-based wearable sensors enhanced by gold nanoparticles for IFN-γ detection', in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS, Institute of Electrical and Electronics Engineers (IEEE), United States, pp. 1 - 4, presented at 2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), United States, 15 July 2024 - 19 July 2024, http://dx.doi.org/10.1109/EMBC53108.2024.10782776

Deng F; Goldys E; Li Y; SANG R; Hall T; Zhang C, 2023, 'RNA reporter based CRISPR/Cas12a biosensing platform for sensitive detection of circulating tumor DNA', in 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Institute of Electrical and Electronics Engineers (IEEE), Sydney, pp. 1 - 4, presented at 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Sydney, 24 July 2023 - 27 July 2023, http://dx.doi.org/10.1109/EMBC40787.2023.10340759

Preprints

Xu Z; Shafiabady N; Shafiabady N; Wu RMX; Sang R; Deng W, 2026, Nuclear-targeted CRISPR/Cas delivery by using aptamer-modified polymer lipid nanoparticles, http://dx.doi.org/10.2139/ssrn.6192467

Deng F; Sang R; Li Y; Deng W; Goldys E, 2023, Bifunctional circular DNA amplifier transforms a classic CRISPR/Cas sensor into an ultrasensitive autocatalytic sensor, http://dx.doi.org/10.21203/rs.3.rs-2626952/v1

Deng F; Sang R; Li Y; Yang B; Zhai X; Xue R; Zhang C; Deng W; Goldys EM, Hairpin-locker mediated CRISPR/Cas tandem system for ultrasensitive detection of DNA without pre-amplification, http://dx.doi.org/10.1101/2024.03.05.583466

Deng F; Gulati S; Sang R; Li Y; Goldys EM, Modulating Cas13a trans-cleavage by double strand RNA: Application to the development of an autocatalytic sensor, http://dx.doi.org/10.1101/2024.03.05.583472

Deng F; Sang R; Li Y; Yang D; Deng W; Goldys E, Towards Understanding Trans-Cleavage of Natural and Synthetic Nucleic Acids by Cas12a for Sensitive CRISPR Biosensing, http://dx.doi.org/10.26434/chemrxiv-2024-rw2rr

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