By Dr Sarah Hancock

Journal articles

Filipe EC; Velayuthar S; Philp A; Nobis M; Latham SL; Parker AL; Murphy KJ; Wyllie K; Major GS; Contreras O; Mok ETY; Enriquez RF; McGowan S; Feher K; Quek LE; Hancock SE; Yam M; Tran E; Setargew YFI; Skhinas JN; Chitty JL; Phimmachanh M; Han JZR; Cadell AL; Papanicolaou M; Mahmodi H; Kiedik B; Junankar S; Ross SE; Lam N; Coulson R; Yang J; Zaratzian A; Da Silva AM; Tayao M; Chin IL; Cazet A; Kansara M; Segara D; Parker A; Hoy AJ; Harvey RP; Bogdanovic O; Timpson P; Croucher DR; Lim E; Swarbrick A; Holst J; Turner N; Choi YS; Kabakova IV; Philp A; Cox TR, 2024, 'Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism', Advanced Science, 11, http://dx.doi.org/10.1002/advs.202307963

Choong LLY; Hancock SE; Nguyen A; Dragutinovic I; Taylor EN; Morris JC; Turner N, 2024, 'Interrogating the anti-obesogenic effect of a novel ceramide synthase inhibitor in high-fat fed mice', Obesity Research & Clinical Practice, 18, pp. S17 - S17, http://dx.doi.org/10.1016/j.orcp.2024.09.040

Banks JL; Choong L; Flaherty J; Kristianto E; Cuny H; Dunwoodie S; Hancock S; Turner N, 2024, 'Metabolic dysfunction ameliorated by reduced nicotinamide mononucleotide in high fat diet fed mice', Obesity Research & Clinical Practice, 18, pp. S6 - S6, http://dx.doi.org/10.1016/j.orcp.2024.09.014

Wu LE; Fiveash CE; Bentley NL; Kang MJ; Govindaraju H; Barbour JA; Wilkins BP; Hancock SE; Madawala R; Das A; Massudi H; Li C; Kim LJ; Wong ASA; Marinova MB; Sultani G; Das A; Youngson NA; Le Couteur DG; Sinclair DA; Turner N, 2023, 'SIRT2 transgenic over-expression does not impact lifespan in mice', Aging Cell, 22, http://dx.doi.org/10.1111/acel.14027

Hancock SE; Ding E; Beves EJ; Mitchell T; Turner N, 2023, 'FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages', Journal of Lipid Research, 64, http://dx.doi.org/10.1016/j.jlr.2023.100341

Hancock SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2022, 'Changes in Phospholipid Composition of the Human Cerebellum and Motor Cortex during Normal Ageing', Nutrients, 14, http://dx.doi.org/10.3390/nu14122495

Phillips GR; Hancock SE; Jenner AM; McLean C; Newell KA; Mitchell TW, 2022, 'Phospholipid Profiles Are Selectively Altered in the Putamen and White Frontal Cortex of Huntington’s Disease', Nutrients, 14, http://dx.doi.org/10.3390/nu14102086

Brandon AE; Small L; Nguyen TV; Suryana E; Gong H; Yassmin C; Hancock SE; Pulpitel T; Stonehouse S; Prescott L; Kebede MA; Yau B; Quek LE; Kowalski GM; Bruce CR; Turner N; Cooney GJ, 2022, 'Insulin sensitivity is preserved in mice made obese by feeding a high starch diet', eLife, 11, http://dx.doi.org/10.7554/eLife.79250

Phillips GR; Saville JT; Hancock SE; Brown SHJ; Jenner AM; Mclean C; Fuller M; Newell KA; Mitchell TW, 2022, 'The long and the short of Huntington's disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases', Brain Communications, 4, http://dx.doi.org/10.1093/braincomms/fcab303

Nguyen GTH; Bennett JL; Liu S; Hancock SE; Winter DL; Glover DJ; Donald WA, 2021, 'Multiplexed Screening of Thousands of Natural Products for Protein–Ligand Binding in Native Mass Spectrometry', Journal of the American Chemical Society, 143, pp. 21379 - 21387, http://dx.doi.org/10.1021/jacs.1c10408

Jayashankar V; Selwan E; Hancock SE; Verlande A; Goodson MO; Eckenstein KH; Milinkeviciute G; Hoover BM; Chen B; Fleischman AG; Cramer KS; Hanessian S; Masri S; Turner N; Edinger AL, 2021, 'Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity', EMBO Molecular Medicine, 13, http://dx.doi.org/10.15252/emmm.202013086

Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202103105

Wang Q; Guan YF; Hancock SE; Wahi K; van Geldermalsen M; Zhang BK; Pang A; Nagarajah R; Mak B; Freidman N; Horvath LG; Turner N; Holst J, 2021, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth', Journal of Pathology, 254, pp. 135 - 146, http://dx.doi.org/10.1002/path.5665

Friedrich MG; Skora A; Hancock SE; Mitchell TW; Else PL; Truscott RJW, 2021, 'Tau is truncated in five regions of the normal adult human brain', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22073521

Phillips GR; Hancock SE; Brown SHJ; Jenner AM; Kreilaus F; Newell KA; Mitchell TW, 2020, 'Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-76973-8

Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162

Wang Q; Guan Y; Hancock S; Wahi K; van Geldermalsen M; Zhang B; Pang A; Nagarajah R; Mak B; Horvath L; Turner N; Holst J, 2020, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growthin vitroandin vivo', , http://dx.doi.org/10.1101/2020.09.07.286997

Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, 9, pp. 15665, http://dx.doi.org/10.1038/s41598-019-52169-7

Hancock SE; Maccarone AT; Poad BLJ; Trevitt AJ; Mitchell TW; Blanksby SJ, 2019, 'Reaction of ionised steryl esters with ozone in the gas phase', Chemistry and Physics of Lipids, 221, pp. 198 - 206, http://dx.doi.org/10.1016/j.chemphyslip.2018.12.013

Liu M; Hancock SE; Sultani G; Wilkins BP; Ding E; Osborne B; Quek LE; Turner N, 2019, 'Snail-overexpression induces epithelialmesenchymal transition and metabolic reprogramming in human pancreatic ductal adenocarcinoma and non-tumorigenic ductal cells', Journal of Clinical Medicine, 8, http://dx.doi.org/10.3390/jcm8060822

Hancock SE; Poad BLJ; Willcox MDP; Blanksby SJ; Mitchell TW, 2019, 'Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry', Journal of Lipid Research, 60, pp. 1968 - 1978, http://dx.doi.org/10.1194/jlr.D094854

Hancock SE; Ailuri R; Marshall DL; Brown SHJ; Saville JT; Narreddula VR; Boase NR; Poad BLJ; Trevitt AJ; Willcox MDP; Kelso MJ; Mitchell TW; Blanksby SJ, 2018, 'Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids', Journal of Lipid Research, 59, pp. 1510 - 1518, http://dx.doi.org/10.1194/jlr.M086702

Hancock SE; Poad BLJ; Batarseh A; Abbott SK; Mitchell TW, 2017, 'Advances and unresolved challenges in the structural characterization of isomeric lipids', Analytical Biochemistry, 524, pp. 45 - 55, http://dx.doi.org/10.1016/j.ab.2016.09.014

Hancock SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2017, 'The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging', GeroScience, 39, pp. 73 - 82, http://dx.doi.org/10.1007/s11357-017-9961-2

Cornely R; Pollock AH; Rentero C; Norris SE; Alvarez-Guaita A; Grewal T; Mitchell T; Enrich C; Moss SE; Parton RG; Rossy J; Gaus K, 2016, 'Annexin A6 regulates interleukin-2-mediated T-cell proliferation', Immunology and Cell Biology, 94, pp. 543 - 553, http://dx.doi.org/10.1038/icb.2016.15

Pollock AH; Tedla N; Hancock SE; Cornely R; Mitchell TW; Yang Z; Kockx M; Parton RG; Rossy J; Gaus K, 2016, 'Prolonged intake of dietary lipids alters membrane structure and T cell responses in LDLr^-/- mice', Journal of Immunology, 196, pp. 3993 - 4002, http://dx.doi.org/10.4049/jimmunol.1501261

Friedrich MG; Hancock SE; Raftery MJ; Truscott RJW, 2016, 'Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: Could this represent a trigger for disease onset?', Acta Neuropathologica Communications, 4, http://dx.doi.org/10.1186/s40478-016-0348-x

Cortie CH; Hulbert AJ; Hancock SE; Mitchell TW; McAndrew D; Else PL, 2015, 'Of mice, pigs and humans: An analysis of mitochondrial phospholipids from mammals with very different maximal lifespans', Experimental Gerontology, 70, pp. 135 - 143, http://dx.doi.org/10.1016/j.exger.2015.08.011

Hancock SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2015, 'Decreases in Phospholipids Containing Adrenic and Arachidonic Acids Occur in the Human Hippocampus over the Adult Lifespan', Lipids, 50, pp. 861 - 872, http://dx.doi.org/10.1007/s11745-015-4030-z

Norris SE; Friedrich MG; Mitchell TW; Truscott RJW; Else PL, 2015, 'Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease', Neurobiology of Aging, 36, pp. 1659 - 1669, http://dx.doi.org/10.1016/j.neurobiolaging.2015.01.002

Norris SE; Mitchell TW; Else PL, 2012, 'Phospholipid peroxidation: Lack of effect of fatty acid pairing', Lipids, 47, pp. 451 - 460, http://dx.doi.org/10.1007/s11745-012-3654-5

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