By Dr Vita Birzniece

Book Chapters

Nelson AE; Ho K; Birzniece V, 2011, 'Growth Hormone in Sports: Is There Evidence of Benefit?', in Ho K (ed.), GROWTH HORMONE RELATED DISEASES AND THERAPY: A MOLECULAR AND PHYSIOLOGICAL PERSPECTIVE FOR THE CLINICIAN, HUMANA PRESS INC, pp. 389 - 404, http://dx.doi.org/10.1007/978-1-60761-317-6_20

Bückström T; Birzniece V; Fernández G; Johansson IM; Kask K; Lindblad C; Lundgren P; Nyberg S; Ragagnin G; Sundström-Poromaa I; Strömberg J; Turkmen S; Wang MD; Van Broekhoven F; Van Wingen G, 2008, 'Neuroactive steroids: Effects on cognitive functions', in Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment, pp. 103 - 121, http://dx.doi.org/10.1007/978-1-4020-6854-6_5

Journal articles

Birzniece V; Lam T; McLean M; Reddy N; Shahidipour H; Hayden A; Gurney H; Stone G; Hjortebjerg R; Frystyk J, 2022, 'Insulin-like growth factor role in determining the anti-cancer effect of metformin: RCT in prostate cancer patients', Endocrine Connections, 11, http://dx.doi.org/10.1530/EC-21-0375

Birzniece V; Ho KKY, 2021, 'Paracrine and endocrine control of the growth hormone axis by estrogen', European Journal of Endocrinology, 184, pp. R269 - R278, http://dx.doi.org/10.1530/EJE-21-0155

Lam T; Cheema B; Hayden A; Lord SR; Gurney H; Gounden S; Reddy N; Shahidipour H; Read S; Stone G; McLean M; Birzniece V, 2020, 'Androgen deprivation in prostate cancer: benefits of home-based resistance training', Sports Medicine - Open, 6, pp. 59, http://dx.doi.org/10.1186/s40798-020-00288-1

Lam T; Birzniece V; McLean M; Gurney H; Hayden A; Cheema BS, 2020, 'The Adverse Effects of Androgen Deprivation Therapy in Prostate Cancer and the Benefits and Potential Anti-oncogenic Mechanisms of Progressive Resistance Training', Sports Medicine - Open, 6, pp. 13, http://dx.doi.org/10.1186/s40798-020-0242-8

Birzniece V, 2019, 'Exercise and the growth hormone–insulin-like growth factor axis', Current Opinion in Endocrine and Metabolic Research, 9, pp. 1 - 7, http://dx.doi.org/10.1016/j.coemr.2019.04.006

Lam T; McLean M; Hayden A; Poljak A; Cheema B; Gurney H; Stone G; Bahl N; Reddy N; Shahidipour H; Birzniece V, 2019, 'A potent liver-mediated mechanism for loss of muscle mass during androgen deprivation therapy', Endocrine Connections, 8, pp. 605 - 615, http://dx.doi.org/10.1530/EC-19-0179

Birzniece V; McLean M; Reddy N; Ho KKY, 2019, 'Disparate Effect of Aromatization on the Central Regulation of GH Secretion by Estrogens in Men and Postmenopausal Women', Journal of Clinical Endocrinology and Metabolism, 104, pp. 2978 - 2984, http://dx.doi.org/10.1210/jc.2019-00265

Birzniece V, 2018, 'Hepatic actions of androgens in the regulation of metabolism', Current Opinion in Endocrinology, Diabetes and Obesity, 25, pp. 201 - 208, http://dx.doi.org/10.1097/MED.0000000000000405

Bahl N; Stone G; McLean M; Ho KKY; Birzniece V, 2018, 'Decorin, a growth hormone-regulated protein in humans', European Journal of Endocrinology, 178, pp. 145 - 152, http://dx.doi.org/10.1530/EJE-17-0844

Tan SH; Lee A; Pascovici D; Care N; Birzniece V; Ho K; Molloy MP; Khan A, 2017, 'Plasma biomarker proteins for detection of human growth hormone administration in athletes', Scientific Reports, 7, pp. 10039, http://dx.doi.org/10.1038/s41598-017-09968-7

Birzniece V; Barrett PHR; Ho KKY, 2017, 'Tamoxifen reduces hepatic VLDL production and GH secretion in women: A possible mechanism for steatosis development', European Journal of Endocrinology, 177, pp. 137 - 143, http://dx.doi.org/10.1530/EJE-17-0151

Lam T; Poljak A; McLean M; Bahl N; Ho KKY; Birzniece V, 2017, 'Testosterone prevents protein loss via the hepatic urea cycle in human', European Journal of Endocrinology, 176, pp. 489 - 496, http://dx.doi.org/10.1530/EJE-16-0868

Birzniece V; Ho KKY, 2017, 'Sex steroids and the GH axis: Implications for the management of hypopituitarism', Best Practice and Research: Clinical Endocrinology and Metabolism, 31, pp. 59 - 69, http://dx.doi.org/10.1016/j.beem.2017.03.003

Bahl N; Stone G; Meinhardt U; Nelson AE; McLean M; Ho KKY; Birzniece V, 2017, 'Growth hormone increases serum levels of decorin in healthy recreational athletes', CLINICAL ENDOCRINOLOGY, 86, pp. 19 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000393453600050&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lam T; McLean M; Bahl N; Poljak A; Ho KKY; Birzniece V, 2017, 'Testosterone prevents protein loss via the hepatic urea cycle', CLINICAL ENDOCRINOLOGY, 86, pp. 14 - 14, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000393453600038&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Birzniece V; Ho KKY, 2015, 'Estrogen receptor antagonism uncovers gender-dimorphic suppression of whole body fat oxidation in humans: Differential effects of tamoxifen on the GH and gonadal axes', European Journal of Endocrinology, 173, pp. 479 - 487, http://dx.doi.org/10.1530/EJE-15-0426

Lee P; Birzniece V; Umpleby AM; Poljak A; Ho KKY, 2015, 'Formoterol, a highly β2-selective agonist, induces gender-dimorphic whole body leucine metabolism in humans', Metabolism: Clinical and Experimental, 64, pp. 506 - 512, http://dx.doi.org/10.1016/j.metabol.2014.12.005

Birzniece V, 2015, 'Doping in sport: Effects, harm and misconceptions', Internal Medicine Journal, 45, pp. 239 - 248, http://dx.doi.org/10.1111/imj.12629

Birzniece V; Khaw CH; Nelson AE; Meinhardt U; Ho KKY, 2015, 'A critical evaluation of bioimpedance spectroscopy analysis in estimating body composition during GH treatment: Comparison with bromide dilution and dual X-ray absorptiometry', European Journal of Endocrinology, 172, pp. 21 - 28, http://dx.doi.org/10.1530/EJE-14-0660

Birzniece V; Magnusson NE; Ho KKY; Frystyk J, 2014, 'Effects of raloxifene and estrogen on bioactive IGF1 in GH-deficient women', European Journal of Endocrinology, 170, pp. 375 - 383, http://dx.doi.org/10.1530/EJE-13-0835

Finkelstein JS; Yu EW; Burnett-Bowie S-AM, 2013, 'Gonadal steroids and body composition, strength, and sexual function in men.', N Engl J Med, 369, pp. 2457, http://dx.doi.org/10.1056/NEJMc1313169

Birzniece V; Umpleby MA; Poljak A; Handelsman DJ; Ho KKY, 2013, 'Oral low-dose testosterone administration induces whole-body protein anabolism in postmenopausal women: A novel liver-targeted therapy', European Journal of Endocrinology, 169, pp. 321 - 327, http://dx.doi.org/10.1530/EJE-13-0406

Birzniece V, 2013, 'Gonadal steroids and body composition, strength, and sexual function in men [1]', New England Journal of Medicine, 369, pp. 2455 - 2457, http://dx.doi.org/10.1056/NEJMc1313169

Birzniece V; Meinhardt UJ; Gibney J; Johannsson G; Armstrong N; Baxter RC; Ho KK, 2012, 'Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women', Journal of Clinical Endocrinology and Metabolism, 97, pp. 1005 - 1012, http://dx.doi.org/10.1210/jc.2011-2837

Birzniece V; Sutanto S; Ho KK, 2012, 'Gender difference in the neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulators', Journal of Clinical Endocrinology and Metabolism, 97, pp. E521 - E527, http://dx.doi.org/10.1210/jc.2011-3347

Birzniece V; Ho KK, 2012, 'Growth and development: Patching up a better pill for GH-deficient women', Nature Reviews. Endocrinology, 8, pp. 197 - 198, http://www.ncbi.nlm.nih.gov/pubmed/22290355

Birzniece V; Gibney J; Ho K; Frystyk J, 2012, 'OR10-2 Effects of raloxifene and estrogen on bioactive IGF-I in healthy and GH-deficient women', Growth Hormone & IGF Research, 22, pp. S26 - S26, http://dx.doi.org/10.1016/s1096-6374(12)60069-0

Birzniece V; Nelson AE; Ho KK, 2011, 'Growth hormone and physical performance', Trends in Endocrinology and Metabolism, 22, pp. 171 - 178, http://dx.doi.org/10.1016/j.tem.2011.02.005

Zhao JT; Cowley MJ; Lee P; Birzniece V; Kaplan W; Ho KK, 2011, 'Identification of novel GH-regulated pathway of lipid metabolism in adipose tissue: A gene expression study in hypopituitary men', Journal of Clinical Endocrinology and Metabolism, 96, pp. E1188 - E1196, http://dx.doi.org/10.1210/jc.2010-2679

Birzniece V; Meinhardt U; Umpleby M; Handelsman D; Ho KK, 2011, 'Interaction between testosterone and growth hormone on whole-body protein anabolism occurs in the liver', Journal of Clinical Endocrinology and Metabolism, 96, pp. 1060 - 1067, http://www.ncbi.nlm.nih.gov/pubmed/21239519

Birzniece V; Meinhardt U; Gibney J; Johannsson G; Baxter RC; Seibel MJ; Ho KKY, 2010, 'Modulatory Effect of Raloxifene and Estrogen on the Metabolic Action of Growth Hormone in Hypopituitary Women', Endocrine Reviews, 31, pp. 257 - 258, http://dx.doi.org/10.1210/edrv.31.2.9985

Birzniece V; Nelson AE; Ho KK, 2010, 'Growth hormone administration: is it safe and effective for athletic performance', Endocrinology and Metabolism Clinics of North America, 39, pp. 11 - 23

Birzniece V; Meinhardt U; Gibney J; Johannsson G; Baxter R; Seibel MJ; Ho KK, 2010, 'Modulatory effect of raloxifene and estrogen on the metabolic action of growth hormone in hypopituitary women', Journal of Clinical Endocrinology and Metabolism, 95, pp. 2099 - 2106

Birzniece V; Meinhardt U; Gibney J; Johannsson G; Baxter RC; Seibel MJ; Ho KKY, 2010, 'Modulatory Effect of Raloxifene and Estrogen on the Metabolic Action of Growth Hormone in Hypopituitary Women', Molecular Endocrinology, 24, pp. 873 - 874, http://dx.doi.org/10.1210/mend.24.4.9996

Birzniece V; Sata A; Sutanto S; Ho KK, 2010, 'Neuroendocrine regulation of growth hormone and androgen axes by selective estrogen receptor modulators in healthy men', Journal of Clinical Endocrinology and Metabolism, 95, pp. 5443 - 5448, http://dx.doi.org/10.1210/jc.2010-1477

Birzniece V; Sata A; Sutanto S; Ho KKY, 2010, 'OR2,7 Gender difference in neuroendocrine regulation of growth hormone axis by selective estrogen receptor modulators', Growth Hormone & IGF Research, 20, pp. S4 - S4, http://dx.doi.org/10.1016/s1096-6374(10)70013-7

Birzniece V; Meinhardt UJ; Handelsman DJ; Ho KKY, 2010, 'OR7,37 Interaction between testosterone and growth hormone on whole body protein anabolism is mediated through the liver', Growth Hormone & IGF Research, 20, pp. S17 - S17, http://dx.doi.org/10.1016/s1096-6374(10)70049-6

Birzniece V; Sata A; Sutanto S; Ho KK, 2010, 'Paracrine regulation of growth hormone secretion by estrogen in women', Journal of Clinical Endocrinology and Metabolism, 95, pp. 3771 - 3776, http://dx.doi.org/10.1210/jc.2010-0476

Meinhardt U; Nelson AE; Hansen J; Birzniece V; Clifford D; Leung K; Graham K; Ho KK, 2010, 'The effects of growth hormone on body composition and physical performance in recreational athletes: a randomized trial', Annals of Internal Medicine, 152, pp. 568 - 577

Birzniece V; Sata A; Ho K, 2009, 'Growth hormone receptor modulators', Reviews in Endocrine and Metabolic Disorders, 10, pp. 145 - 156, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18622706

Birzniece V; Meinhardt U; Handelsman D; Ho K, 2009, 'Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox): Comparison of oral and transdermal testosterone administration in hypopituitary men', Clinical Endocrinology, 71, pp. 715 - 721, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19170715

Birzniece V; Gibney J; Meinhardt U; Ho KKY, 2008, 'OR7,1 Comparison of the effects of raloxifene and estrogen on growth hormone action in hypopituitary women', Growth Hormone & IGF Research, 18, pp. S14 - S14, http://dx.doi.org/10.1016/s1096-6374(08)70045-5

Birzniece V; Bäckström T; Johansson IM; Lindblad C; Lundgren P; Löfgren M; Olsson T; Ragagnin G; Taube M; Turkmen S; Wahlström G; Wang MD; Wihlbäck AC; Zhu D, 2006, 'Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems', Brain Research Reviews, 51, pp. 212 - 239, http://dx.doi.org/10.1016/j.brainresrev.2005.11.001

Türkmen S; Löfgren M; Birzniece V; Bäckström T; Johansson IM, 2006, 'Tolerance development to Morris water maze test impairments induced by acute allopregnanolone', Neuroscience, 139, pp. 651 - 659, http://dx.doi.org/10.1016/j.neuroscience.2005.12.031

Birzniece V; Türkmen S; Lindblad C; Zhu D; Johansson IM; Bäckström T; Wahlström G, 2006, 'GABAA receptor changes in acute allopregnanolone tolerance', European Journal of Pharmacology, 535, pp. 125 - 134, http://dx.doi.org/10.1016/j.ejphar.2006.01.059

Turkmen S; Lundgren P; Birzniece V; Zingmark E; Backstrom T; Johansson IM, 2004, '3β-20β-dihydroxy-5α-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone', European Journal of Neuroscience, 20, pp. 1604 - 1612, http://dx.doi.org/10.1111/j.1460-9568.2004.03610.x

Zhu D; Birzniece V; Bäckström T; Wahlström G, 2004, 'Dynamic aspects of acute tolerance to allopregnanolone evaluated using anaesthesia threshold in male rats', British Journal of Anaesthesia, 93, pp. 560 - 567, http://dx.doi.org/10.1093/bja/aeh233

Bäckström T; Andreen L; Birzniece V; Björn I; Johansson IM; Nordenstam-Haghjo M; Nyberg S; Sundström-Poromaa I; Wahlström G; Wang M; Zhu D, 2003, 'The role of hormones and hormonal treatments in premenstrual syndrome', CNS Drugs, 17, pp. 325 - 342, http://dx.doi.org/10.2165/00023210-200317050-00003

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