By Dr Zaklina Kovacevic

Journal articles

Menezes SV; Kovacevic Z; Richardson DR, 2015, 'Abstract A63: Role of the metastasis suppressor, NDRG1, in regulating the EGFR and ErbB family of receptors and its effects on key oncogenic signaling pathways in pancreatic cancer', Molecular Cancer Therapeutics, 14, pp. a63 - a63, http://dx.doi.org/10.1158/1535-7163.targ-15-a63

Jansson PJ; Kalinowski DS; Lane DJR; Kovacevic Z; Seebacher NA; Fouani L; Sahni S; Merlot AM; Richardson DR, 2015, 'The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones', Pharmacological Research, 100, pp. 255 - 260, http://dx.doi.org/10.1016/j.phrs.2015.08.013

Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Lane DJ; Huang MLH; Sahni S; Richardson DR, 2015, 'Making a case for albumin - A highly promising drug-delivery system', Future Medicinal Chemistry, 7, pp. 553 - 556, http://dx.doi.org/10.4155/fmc.15.15

Lui GYL; Kovacevic Z; Richardson V; Merlot AM; Kalinowski DS; Richardson DR, 2015, 'Targeting cancer by binding iron: Dissecting cellular signaling pathways', Oncotarget, 6, pp. 18748 - 18779, http://dx.doi.org/10.18632/oncotarget.v6i22

Moussa RS; Kovacevic Z; Richardson DR, 2015, 'Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types', Oncotarget, 6, pp. 29694 - 29711, http://dx.doi.org/10.18632/oncotarget.5088

Lui GYL; Kovacevic Z; Menezes SV; Kalinowski DS; Merlot AM; Sahni S; Richardson DR, 2015, 'Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (stat3) pathway: Inhibition of constitutive and interleukin 6-induced activation by iron depletion', Molecular Pharmacology, 87, pp. 543 - 560, http://dx.doi.org/10.1124/mol.114.096529

Lui GYL; Kovacevic Z; Richardson V; Merlot AM; Kalinowski DS; Richardson DR, 2015, 'Targeting cancer by binding iron: Dissecting cellular signaling pathways', Oncotarget, 6, pp. 18748 - 18779, http://dx.doi.org/10.18632/oncotarget.4349

Wangpu X; Yang X; Zhao J; Lu J; Guan S; Lu J; Kovacevic Z; Liu W; Mi L; Jin R; Sun J; Yue F; Ma J; Lu A; Richardson DR; Wang L; Zheng M, 2015, 'The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44', Oncotarget, 6, pp. 33893 - 33911, http://dx.doi.org/10.18632/oncotarget.5294

Liu W; Kovacevic Z; Peng Z; Jin R; Wang P; Yue F; Zheng M; Huang MLH; Jansson PJ; Richardson V; Kalinowski DS; Lane DJR; Merlot AM; Sahni S; Richardson DR, 2015, 'The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets', Oncotarget, 6, pp. 35522 - 35541, http://dx.doi.org/10.18632/oncotarget.5849

Liu W; Yue F; Zheng M; Merlot A; Bae DH; Huang M; Lane D; Jansson P; Liu G; Richardson V; Sahni S; Kalinowski D; Kovacevic Z; Richardson DR, 2015, 'The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1', Oncotarget, 6, pp. 8851 - 8874, http://dx.doi.org/10.18632/oncotarget.3316

Sahni S; Bae DH; Lane DJR; Kovacevic Z; Kalinowski DS; Jansson PJ; Richardson DR, 2014, 'The metastasis suppressor, N-myc Downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells', Journal of Biological Chemistry, 289, pp. 9692 - 9709, http://dx.doi.org/10.1074/jbc.M113.529511

Lane DJR; Mills TM; Shafie NH; Merlot AM; Saleh Moussa R; Kalinowski DS; Kovacevic Z; Richardson DR, 2014, 'Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition', Biochimica Et Biophysica Acta Reviews on Cancer, 1845, pp. 166 - 181, http://dx.doi.org/10.1016/j.bbcan.2014.01.005

Lok HC; Sahni S; Richardson V; Kalinowski DS; Kovacevic Z; Lane DJR; Richardson DR, 2014, 'Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells', Free Radical Biology and Medicine, 75, pp. 14 - 29, http://dx.doi.org/10.1016/j.freeradbiomed.2014.07.002

Fang BA; Kovačević Z; Park KC; Kalinowski DS; Jansson PJ; Lane DJR; Sahni S; Richardson DR, 2014, 'Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy', Biochimica Et Biophysica Acta Reviews on Cancer, 1845, pp. 1 - 19, http://dx.doi.org/10.1016/j.bbcan.2013.11.002

Jin R; Liu W; Menezes S; Yue F; Zheng M; Kovacevic Z; Richardson DR, 2014, 'The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of ß-catenin through mechanisms involving FRAT1 and PAK4', Journal of Cell Science, 127, pp. 3116 - 3130, http://dx.doi.org/10.1242/jcs.147835

Lui GYL; Kovacevic Z; Richardson DR, 2013, 'Abstract A232: Novel thiosemicarbazones with potent antitumor and antimetastatic activity inhibit the signal transducer and activator of transcription (STAT) pathway.', Molecular Cancer Therapeutics, 12, pp. a232 - a232, http://dx.doi.org/10.1158/1535-7163.targ-13-a232

Bae DH; Jansson PJ; Huang ML; Kovacevic Z; Kalinowski D; Lee CS; Sahni S; Richardson DR, 2013, 'The role of NDRG1 in the pathology and potential treatment of human cancers', Journal of Clinical Pathology, 66, pp. 911 - 917, http://dx.doi.org/10.1136/jclinpath-2013-201692

Sun J; Zhang D; Bae DH; Sahni S; Jansson P; Zheng Y; Zhao Q; Yue F; Zheng M; Kovacevic Z; Richardson DR, 2013, 'Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors', Carcinogenesis, 34, pp. 1943 - 1954, http://dx.doi.org/10.1093/carcin/bgt163

Richardson A; Kovacevic Z; Richardson DR, 2013, 'Iron chelation: Inhibition of key signaling pathways in the induction of the epithelial mesenchymal transition in pancreatic cancer and other tumors', Critical Reviews in Oncogenesis, 18, pp. 409 - 434, http://dx.doi.org/10.1615/CritRevOncog.2013007921

Kovacevic Z; Chikhani S; Lui GYL; Sivagurunathan S; Richardson DR, 2013, 'The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and ras signaling pathways', Antioxidants and Redox Signaling, 18, pp. 874 - 887, http://dx.doi.org/10.1089/ars.2011.4273

Kalinowski DS; Jansson PJ; Kovacevic Z; Richardson DR, 2013, 'The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism', Redox Report, 18, pp. 48 - 50, http://dx.doi.org/10.1179/1351000213Y.0000000041

Lane DJR; Saletta F; Rahmanto YS; Kovacevic Z; Richardson DR, 2013, 'N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion', Plos One, 8, http://dx.doi.org/10.1371/journal.pone.0057273

Dixon KM; Lui GYL; Kovacevic Z; Zhang D; Yao M; Chen Z; Dong Q; Assinder SJ; Richardson DR, 2013, 'Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells', British Journal of Cancer, 108, pp. 409 - 419, http://dx.doi.org/10.1038/bjc.2012.582

Sun J; Zhang D; Zheng Y; Zhao Q; Zheng M; Kovacevic Z; Richardson DR, 2013, 'Targeting the metastasis suppressor, NDRG1, using novel iro chelators: Regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway', Molecular Pharmacology, 83, pp. 454 - 469, http://dx.doi.org/10.1124/mol.112.083097

Lui GYL; Obeidy P; Ford SJ; Tselepis C; Sharp DM; Jansson PJ; Kalinowski DS; Kovacevic Z; Lovejoy DB; Richardson DR, 2013, 'The iron chelator, deferasirox, as a novel strategy for cancer treatment: Oral activity against human lung tumor xenografts and molecular mechanism of actions', Molecular Pharmacology, 83, pp. 179 - 190, http://dx.doi.org/10.1124/mol.112.081893

Serda M; Kalinowski DS; Mrozek-Wilczkiewicz A; Musiol R; Szurko A; Ratuszna A; Pantarat N; Kovacevic Z; Merlot AM; Richardson DR; Polanski J, 2012, 'Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy', Bioorganic and Medicinal Chemistry Letters, 22, pp. 5527 - 5531, http://dx.doi.org/10.1016/j.bmcl.2012.07.030

Correnti C; Richardson V; Sia AK; Bandaranayake AD; Ruiz M; Rahmanto YS; Kovačević Z; Clifton MC; Holmes MA; Kaiser BK; Barasch J; Raymond KN; Richardson DR; Strong RK, 2012, 'Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines', Plos One, 7, http://dx.doi.org/10.1371/journal.pone.0043696

Chen Z; Zhang D; Yue F; Zheng M; Kovacevic Z; Richardson DR, 2012, 'The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1)', Journal of Biological Chemistry, 287, pp. 17016 - 17028, http://dx.doi.org/10.1074/jbc.M112.350470

Saletta F; Kovacevic Z; Richardson DR, 2012, 'Erratum: Iron chelation: Deciphering novel molecular targets for cancer therapy. The tip of the iceberg of a web of iron-regulated molecules (Future Medicinal Chemistry (2011) 3:16 (1983-1986))', Future Medicinal Chemistry, 4, pp. 124, http://dx.doi.org/10.4155/fmc.11.178

Yu Y; Gutierrez E; Kovacevic Z; Saletta F; Obeidy P; Rahmanto YS; Richardson DR, 2012, 'Iron chelators for the treatment of cancer', Current Medicinal Chemistry, 19, pp. 2689 - 2702, http://dx.doi.org/10.2174/092986712800609706

Kovacevic Z, 2012, 'Targeting Iron in Cancer Cells: A New Strategy to Inhibit Metastatic Progression', Vitamins & Trace Elements, 01, http://dx.doi.org/10.4172/2167-0390.1000e114

Richardson DR; Chikhani S; Lui G; Sivagurunathan S; Kovacevic Z, 2012, 'Targeting the Metastasis Suppressor NDRG1: A New Strategy for the Treatment of Pancreatic Cancer', The FASEB Journal, 26, pp. 761.28 - 761.28, http://dx.doi.org/10.1096/fasebj.26.1_supplement.761.28

Saletta F; Kovacevic Z; Richardson DR, 2011, 'Research Spotlight: Iron chelation: Deciphering novel molecular targets for cancer therapy. the tip of the iceberg of a web of iron-regulated molecules', Future Medicinal Chemistry, 3, pp. 1983 - 1986, http://dx.doi.org/10.4155/fmc.11.154

Moussa RS; Kovacevic Z; Zhang D; Siafakas AR; Richardson DR, 2011, 'Abstract A67: Mechanisms involved in regulating the expression of the cyclin-dependent kinase (cdk) inhibitor, p21, by intracellular iron levels.', Molecular Cancer Therapeutics, 10, pp. a67 - a67, http://dx.doi.org/10.1158/1535-7163.targ-11-a67

Kovacevic Z; Chikhani S; Lovejoy DB; Richardson DR, 2011, 'Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: A new strategy for the treatment of pancreatic cancer', Molecular Pharmacology, 80, pp. 598 - 609, http://dx.doi.org/10.1124/mol.111.073627

Kovacevic Z; Sivagurunathan S; Mangs H; Chikhani S; Zhang D; Richardson DR, 2011, 'The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms', Carcinogenesis, 32, pp. 732 - 740, http://dx.doi.org/10.1093/carcin/bgr046

Kovacevic Z; Kalinowski DS; Lovejoy DB; Yu Y; Rahmanto YS; Sharpe PC; Bernhardt PV; Richardson DR, 2011, 'The medicinal chemistry of novel iron Chelators for the treatment of cancer', Current Topics in Medicinal Chemistry, 11, pp. 483 - 499, http://dx.doi.org/10.2174/156802611794785190

Kovacevic Z; Yu Y; Richardson DR, 2011, 'Chelators to the rescue: Different horses for different courses!', Chemical Research in Toxicology, 24, pp. 279 - 282, http://dx.doi.org/10.1021/tx100435c

Otevrel J; Mandelova Z; Pesko M; Guo J; Kralova K; Sersen F; Vejsova M; Kalinowski DS; Kovacevic Z; Coffey A; Csollei J; Richardson DR; Jampilek J, 2010, 'Investigating the spectrum of biological activity of ring- substituted salicylanilides and carbamoylphenylcarbamates', Molecules, 15, pp. 8122 - 8142, http://dx.doi.org/10.3390/molecules15118122

Kovacevic Z; Kalinowski DS; Lovejoy DB; Quach P; Wong J; Richardson DR, 2010, 'Iron chelators: Development of novel compounds with high and selective anti-tumour activity', Current Drug Delivery, 7, pp. 194 - 207, http://dx.doi.org/10.2174/156720110791560991

Mrozek-Wilczkiewicz A; Kalinowski DS; Musiol R; Finster J; Szurko A; Serafin K; Knas M; Kamalapuram SK; Kovacevic Z; Jampilek J; Ratuszna A; Rzeszowska-Wolny J; Richardson DR; Polanski J, 2010, 'Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones', Bioorganic and Medicinal Chemistry, 18, pp. 2664 - 2671, http://dx.doi.org/10.1016/j.bmc.2010.02.025

Yu Y; Kalinowski DS; Kovacevic Z; Siafakas AR; Jansson PJ; Stefani C; Lovejoy DB; Sharpe PC; Bernhardt PV; Richardson DR, 2009, 'ChemInform Abstract: Thiosemicarbazones from the Old to New: Iron Chelators that Are More than Just Ribonucleotide Reductase Inhibitors', ChemInform, 40, pp. no - no, http://dx.doi.org/10.1002/chin.200950248

Kovacevic Z; Sivagurunathan S; Mangs H; Chikhani S; Richardson DR, 2009, 'Abstract B172: The metastasis suppressor NDRG1 up-regulates p21 in a p53-independent manner in cancer cells: A novel insight into its antitumor function', Molecular Cancer Therapeutics, 8, pp. b172 - b172, http://dx.doi.org/10.1158/1535-7163.targ-09-b172

Yu Y; Kalinowski DS; Kovacevic Z; Siafakas AR; Jansson PJ; Stefani C; Lovejoy DB; Sharpe PC; Bernhardt PV; Richardson DR, 2009, 'Thiosemicarbazones from the old to new: Iron chelators that are more than just ribonucleotide reductase inhibitors', Journal of Medicinal Chemistry, 52, pp. 5271 - 5294, http://dx.doi.org/10.1021/jm900552r

Assinder SJ; Dong Q; Kovacevic Z; Richardson DR, 2009, 'The TGF-β, PI3K/Akt and PTEN pathways: Established and proposed biochemical integration in prostate cancer', Biochemical Journal, 417, pp. 411 - 421, http://dx.doi.org/10.1042/BJ20081610

Kovacevic Z; Fu D; Richardson DR, 2008, 'The iron-regulated metastasis suppressor, Ndrg-1: Identification of novel molecular targets', Biochimica Et Biophysica Acta Molecular Cell Research, 1783, pp. 1981 - 1992, http://dx.doi.org/10.1016/j.bbamcr.2008.05.016

Yu Y; Kovacevic Z; Richardson DR, 2007, 'Tuning cell cycle regulation with an iron key', Cell Cycle, 6, pp. 1982 - 1994, http://dx.doi.org/10.4161/cc.6.16.4603

Kovacevic Z; Richardson DR, 2006, 'The metastasis suppressor, Ndrg-1: A new ally in the fight against cancer', Carcinogenesis, 27, pp. 2355 - 2366, http://dx.doi.org/10.1093/carcin/bgl146

Conference Papers

Geleta B; Park KC; Jansson PJ; Apte M; Richardson DR; Kovacevic Z, 2019, 'Abstract A16: A novel therapeutic approach to inhibit the bidirectional oncogenic crosstalk between pancreatic cancer cells and the surrounding stroma', in Cancer Research, American Association for Cancer Research (AACR), pp. a16 - a16, http://dx.doi.org/10.1158/1538-7445.panca19-a16

Paluncic J; Lane DJR; Saletta F; Rahmanto YS; Kovacevic Z; Richardson DR, 2018, 'Abstract B212: N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. b212 - b212, http://dx.doi.org/10.1158/1535-7163.targ-17-b212

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