By Dr Zhihong Xu

Book Chapters

Pang T; Xu Z; Perera C; Apte MV, 2023, 'Tumor Microenvironment', in , Wiley, pp. 942 - 950, http://dx.doi.org/10.1002/9781119876007.ch123

Pang T; Xu Z; Perera C; Apte MV, 2023, 'Tumor Microenvironment: Immune Cells and Immunosuppressive Functions of Carcinoma-associated Fibroblasts and Macrophages', in The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition, pp. 942 - 950

Apte MV; Xu Z; Pirola R; Wilson JS, 2017, 'Pancreatic Stellate Cells: What do they tell us about chronic pancreatitis?', in Pancreatitis Medical and Surgical Management, John Wiley & Sons, pp. 143 - 151

Journal articles

Perera CJ; Hosen SZ; Khan T; Fang H; Mekapogu AR; Xu Z; Falasca M; Chari ST; Wilson JS; Pirola R; Greening DW; Apte MV, 2024, 'Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer', Proteomics, http://dx.doi.org/10.1002/pmic.202300067

Sarkar R; Xu Z; Perera CJ; Apte MV, 2023, 'Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer', Seminars in Cancer Biology, 93, pp. 114 - 122, http://dx.doi.org/10.1016/j.semcancer.2023.05.007

Mekapogu AR; Xu Z; Pothula S; Perera C; Pang T; Hosen SMZ; Damalanka V; Janetka J; Goldstein D; Pirola R; Wilson J; Apte M, 2023, 'HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis', Cancer Letters, 568, http://dx.doi.org/10.1016/j.canlet.2023.216286

Waldron RT; Mishra C; Choudhary N; Xu Z; Trivedi R; Gukovskaya A; Apte MV; Pandol SJ; Lugea A, 2023, 'Tu1421 CIGARETTE SMOKING MODULATES CYCLOOXYGENASE-2 SIGNALING AND PGE2 PRODUCTION IN PANCREATIC ACINAR CELLS', Gastroenterology, 164, pp. S - 1050, http://dx.doi.org/10.1016/s0016-5085(23)03439-x

Hosen SMZ; Uddin MN; Xu Z; Buckley BJ; Perera C; Pang TCY; Mekapogu AR; Moni MA; Notta F; Gallinger S; Pirola R; Wilson J; Ranson M; Goldstein D; Apte M, 2022, 'Metastatic phenotype and immunosuppressive tumour microenvironment in pancreatic ductal adenocarcinoma: Key role of the urokinase plasminogen activator (PLAU)', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.1060957

Channon LM; Tyma VM; Xu Z; Greening DW; Wilson JS; Perera CJ; Apte MV, 2022, 'Small extracellular vesicles (exosomes) and their cargo in pancreatic cancer: Key roles in the hallmarks of cancer', Biochimica et Biophysica Acta - Reviews on Cancer, 1877, pp. 188728, http://dx.doi.org/10.1016/j.bbcan.2022.188728

Perera CJ; Falasca M; Chari ST; Greenfield JR; Xu Z; Pirola RC; Wilson JS; Apte MV, 2021, 'Role of pancreatic stellate cell-derived exosomes in pancreatic cancer-related diabetes: A novel hypothesis', Cancers, 13, pp. 5224, http://dx.doi.org/10.3390/cancers13205224

Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker T; Corley S; Wilkins MR; Goldstein D; Pirola R; Wilson J; Apte M, 2021, 'Hgf/c-met inhibition as adjuvant therapy improves outcomes in an orthotopic mouse model of pancreatic cancer', Cancers, 13, pp. 2763, http://dx.doi.org/10.3390/cancers13112763

Geleta B; Park KC; Jansson PJ; Sahni S; Maleki S; Xu Z; Murakami T; Pajic M; Apte MV; Richardson DR; Kovacevic Z, 2021, 'Breaking the cycle: Targeting of NDRG1 to inhibit bi-directional oncogenic cross-talk between pancreatic cancer and stroma', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202002279R

Pothula SP; Xu Z; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Targeting hgf/c-met axis in pancreatic cancer', International Journal of Molecular Sciences, 21, pp. 1 - 18, http://dx.doi.org/10.3390/ijms21239170

Xu Z; Pothula S; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Reply letter to comments on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis', British Journal of Cancer, 123, pp. 1466, http://dx.doi.org/10.1038/s41416-020-1004-6

Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'An Orthotopic Resectional Mouse Model of Pancreatic Cancer', Journal of Visualized Experiments, http://dx.doi.org/10.3791/61726-v

Pang TCY; Xu Z; Mekapogu AR; Pothula S; Becker TM; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'An orthotopic resectional mouse model of pancreatic cancer', Journal of Visualized Experiments, 2020, pp. 1 - 13, http://dx.doi.org/10.3791/61726

Xu Z; Pang TCY; Liu AC; Pothula SP; Mekapogu AR; Perera CJ; Murakami T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2020, 'Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis', British Journal of Cancer, 122, pp. 1486 - 1495, http://dx.doi.org/10.1038/s41416-020-0782-1

Perera C; Xu Z; Mekapogu AR; Hosen SMZ; Pothula S; Greenfield J; Chari S; Goldstein D; Pirola R; Wilson J; Apte MV, 2020, '1133 PANCREATIC STELLATE CELL AND CANCER CELL DERIVED EXOSOMES IMPAIR BETA CELL FUNCTION: IMPLICATIONS FOR PANCREATIC CANCER RELATED DIABETES.', Gastroenterology, 158, pp. S - 221, http://dx.doi.org/10.1016/s0016-5085(20)31245-2

Zhu L; Dillon DL; Xu Z; Wightman CJ; Pirola R; Wilson J; Gukovskaya A; Apte MV; Mareninova OA, 2020, 'Mo1371 INFLAMMATORY RESPONSE IN EXPERIMENTAL PANCREATITIS INDUCED BY ALCOHOL AND CIGARETTE SMOKE IS MEDIATED THROUGH ROS-STAT3-P62 SIGNALING PATHWAY', Gastroenterology, 158, pp. S - 867, http://dx.doi.org/10.1016/s0016-5085(20)32848-1

Pang T; Xu Z; Pothula S; Yang MH; Becker T; Goldstein D; Heeschen C; Pirola R; Wilson J; Apte MV, 2018, '517 - World-First Identification of Circulating Pancreatic Stellate Cells in Metastatic Pancreatic Cancer', Gastroenterology, 154, pp. S - 114, http://dx.doi.org/10.1016/s0016-5085(18)30816-3

Lugea A; Gerloff A; Su HY; Xu Z; Go A; Hu C; French SW; Wilson JS; Apte MV; Waldron RT; Pandol SJ, 2017, 'The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells', Gastroenterology, 153, pp. 1674 - 1686, http://dx.doi.org/10.1053/j.gastro.2017.08.036

Pang TCY; Xu Z; Pothula S; Becker T; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2017, 'Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research', Carcinogenesis, 38, pp. 588 - 591, http://dx.doi.org/10.1093/carcin/bgx030

Pothula SP; Xu Z; Goldstein D; Merrett N; Pirola RC; Wilson JS; Apte MV, 2017, 'Targeting the HGF/c-MET pathway: Stromal remodelling in pancreatic cancer', Oncotarget, 8, pp. 76722 - 76739, http://dx.doi.org/10.18632/oncotarget.20822

Pothula SP; Xu Z; Goldstein D; Biankin AV; Pirola RC; Wilson JS; Apte MV, 2016, 'Hepatocyte growth factor inhibition: A novel therapeutic approach in pancreatic cancer', British Journal of Cancer, 114, pp. 269 - 280, http://dx.doi.org/10.1038/bjc.2015.478

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, 12, pp. 1 - 222, http://dx.doi.org/10.1080/15548627.2015.1100356

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356', Autophagy, 12, pp. 443, http://dx.doi.org/10.1080/15548627.2016.1147886

Pothula SP; Xu Z; Goldstein D; Pirola RC; Wilson JS; Apte MV, 2016, 'Key role of pancreatic stellate cells in pancreatic cancer', Cancer Letters, http://dx.doi.org/10.1016/j.canlet.2015.10.035

Lee ATK; Xu Z; Pothula SP; Patel MB; Pirola RC; Wilson JS; Apte MV, 2015, 'Alcohol and Cigarette Smoke Components Activate Human Pancreatic Stellate Cells: Implications for the Progression of Chronic Pancreatitis', Alcoholism: Clinical and Experimental Research, 39, pp. 2123 - 2133, http://dx.doi.org/10.1111/acer.12882

Apte MV; Xu Z; Pothula S; Goldstein D; Pirola RC; Wilson JS, 2015, 'Pancreatic cancer: The microenvironment needs attention too!', Pancreatology, 15, pp. S32 - S38, http://dx.doi.org/10.1016/j.pan.2015.02.013

Ali S; Suresh R; Banerjee S; Bao B; Xu Z; Wilson J; Philip PA; Apte M; Sarkar FH, 2015, 'Contribution of microRNAs in understanding the pancreatic tumor microenvironment involving cancer associated stellate and fibroblast cells.', American Journal of Cancer Research, 5, pp. 1251 - 1264

Xu Z; Pothula SP; Wilson JS; Apte MV, 2014, 'Pancreatic cancer and its stroma: A conspiracy theory', World Journal of Gastroenterology, 20, pp. 11216 - 11229, http://dx.doi.org/10.3748/wjg.v20.i32.11216

Patel MB; Pothula SP; Xu Z; Lee AK; Goldstein D; Pirola RC; Apte MV; Wilson JS, 2014, 'The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: Anti-angiogenic implications in pancreatic cancer', Carcinogenesis, 35, http://dx.doi.org/10.1093/carcin/bgu122

Xu Z; Shah S; Pirola RC; Wilson J; Apte MV, 2013, 'Su1788 Pancreatic Fibrosis in Alcohol-Fed LPS Challenged Mice Is Regulated by the TLR4 Receptor', Gastroenterology, 144, pp. S - 477, http://dx.doi.org/10.1016/s0016-5085(13)61765-5

Apte M; Xu Z; Wilson J, 2012, 'Battle-scarred pancreas: Role of pancreatic stellate cells', Pancreatology, 12, pp. e4 - e4, http://dx.doi.org/10.1016/j.pan.2012.07.008

Arun SJ; Xu Z; Fiala-Beer E; Phillips P; Goldstein D; Biankin A; Pirola R; Wilson JS; Apte MV, 2011, 'Hepatocyte growth factor: a potential therapeutic target in pancreatic cancer', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-LB-395

Vonlaufen A; Phillips PA; Xu ; Zhang X; Yang L; Pirola R; Wilson JS; Apte MV, 2011, 'Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats', Gut, 60, pp. 238 - 246, http://dx.doi.org/10.1136/gut.2010.211250

Yang L; Phillips PA; Xu Z; Youkhana J; Vonlaufen A; Pirola R; Wilson J; Apte MV, 2010, 'Collagen-I Increases the Expression of Transgelin and Lumican (Regulators of Cell Migration) by Activated Pancreatic Stellate Cells', PANCREAS, 39, pp. 1358 - 1359, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000282946600262&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yang L; Phillips PA; Xu Z; Youkhana J; Vonlaufen A; Pirola R; Wilson J; Apte MV, 2010, 'Collagen-I increases the expression of transgelin and lumican (regulators of cell migration) by activated pancreatic stellate cells', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 25, pp. A14 - A15, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283321200036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Seth D; D'Souza el-Guindy NB; Apte MV; Mari M; Dooley S; Neumann M; Haber P; Kundu S; Darwanto A; De villiers WJ; Vonlaufen A; Xu Z; Phillips P; Yang S; Goldstein D; Pirola RM; Wilson JS; Moles A; Fernandez A; Colell A; Garcia-ruiz C; Fernandez-checa JC; Meyer C; Meindl-beinker N, 2010, 'Alcohol, signaling, and ECM turnover', Alcoholism : Clinical and Experimental Research, 34, pp. 4 - 18, http://dx.doi.org/10.1111/j.1530-0277.2009.01060.x

Vonlaufen A; Phillips PA; Yang L; Xu Z; Fiala-Beer E; Zhang X; Pirola R; Wilson JS; Apte MV, 2010, 'Isolation of Quiescent Human Pancreatic Stellate Cells: A Promising in vitro Tool for Studies of Human Pancreatic Stellate Cell Biology', Pancreatology, 10, pp. 434 - 443, http://dx.doi.org/10.1159/000260900

Xu Z; Li Y; Rizos C; Xu X, 2010, 'Novel hybrid of LS-SVM and Kalman filter for GPS/INS integration', Journal of Navigation, 63, pp. 289 - 299, http://dx.doi.org/10.1017/S0373463309990361

Phillips PA; Yang L; Shulkes A; Vonlaufen A; Poljak A; Bustamante S; Warren A; Xu ; Guilhaus M; Pirola R; Apte MV; Wilson JS, 2010, 'Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 17397 - 17402, http://dx.doi.org/10.1073/pnas.1000359107

Xu Z; Phillips PA; Vonlaufen A; Fiala-Beer E; Yang L; Biankin A; Goldstein D; Pirola R; Wilson J; Apte M, 2009, 'Normal Pancreatic Stellate Cells Facilitate Pancreatic Cancer Progression, Exhibit Transendothelial Migration and Accompany Cancer Cells to Distant Metastatic Sites', PANCREAS, 38, pp. 1062 - 1062, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271225300403&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Phillips PA; Yang L; Poljak A; Bustamante S; Shulkes A; Vonlaufen A; Xu Z; Guilhaus M; Pirola R; Apte M; Wilson J, 2009, 'Pancreatic Stellate Cells Stimulate Acinar Enzyme Secretion Via the Production of Acetylcholine', PANCREAS, 38, pp. 1038 - 1039, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271225300294&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Phillips PA; Yang L; Poljak A; Bustamante S; Shulkes A; Vonlaufen A; Xu Z; Pirola R; Apte M; Wilson J, 2009, 'Pancreatic stellate cells synthesise and secrete acetylcholine: a potential role in enzyme secretion', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 24, pp. A335 - A335, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000270551200307&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Phillips P; Chow MW; Vonlaufen A; Xu Z; Yang L; Biankin A; Goldstein D; Pirola R; Wilson J; Apte M, 2009, 'Gene expression profiling of human pancreatic stellate cells and their roles in pancreatic cancer progression.', CANCER RESEARCH, 69, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702804198&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Phillips P; Yang L; Vonlaufen A; Xu Z; Biankin A; Goldstein D; Pirola R; Wilson J; Apte M, 2009, 'Heat shock proteins are induced during pancreatic stellate cell activation in pancreatic cancer', CANCER RESEARCH, 69, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209702804197&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Phillips P; Yang L; Vonlaufen A; Xu Z; Biankin AV; Goldstein D; Pirola R; Wilson JS; Apte MV, 2009, 'S1820 Heat Shock Proteins Are Induced During Pancreatic Stellate Cell Activation in Pancreatic Cancer', Gastroenterology, 136, pp. A - 277, http://dx.doi.org/10.1016/s0016-5085(09)61262-2

Vonlaufen A; Phillips P; Xu Z; Zhang X; Yang L; Pirola R; Wilson JS; Apte MV, 2009, 'T1835 Alcohol Withdrawal Promotes Regression of Pancreatic Fibrosis via Induction of Pancreatic Stellate Cell (PSC) Apoptosis', Gastroenterology, 136, http://dx.doi.org/10.1016/s0016-5085(09)62716-5

Vonlaufen A; Xu Z; Yang L; Phillips P; Zhang X; Pirola R; Wilson JS; Apte MV, 2008, 'T1894 Abstinence Promotes Regression While Continued Alcohol Intake Promotes Persistence of LPS-Induced Pancreatic Injury in Alcohol-Fed Rats', Gastroenterology, 134, pp. A - 585, http://dx.doi.org/10.1016/s0016-5085(08)62736-5

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