By Professor Hongyuan (Robert) Yang

Journal articles

Coates HW; Nguyen TB; Du X; Olzomer EM; Farrell R; Byrne FL; Yang H; Brown AJ, 2024, 'The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues', Journal of Biological Chemistry, 300, http://dx.doi.org/10.1016/j.jbc.2024.107232

Liu Y; Yang H, 2024, 'WIPI4 loss linked to ferroptosis', Nature Cell Biology, 26, pp. 506 - 507, http://dx.doi.org/10.1038/s41556-024-01359-1

Peng K; Chen X; Pei K; Wang X; Ma X; Liang C; Dong Q; Liu Z; Han M; Liu G; Yang H; Zheng M; Liu G; Gao M, 2024, 'Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr^−/− mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870, http://dx.doi.org/10.1016/j.bbadis.2023.166850

Li YE; Norris DM; Xiao FN; Pandzic E; Whan RM; Fok S; Zhou M; Du G; Liu Y; Du X; Yang H, 2024, 'Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains', Journal of Cell Biology, 223, http://dx.doi.org/10.1083/jcb.202307041

Lin Y; Ran L; Du X; Yang H; Wu Y, 2023, 'Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1868, http://dx.doi.org/10.1016/j.bbalip.2023.159365

Zadoorian A; Du X; Yang H, 2023, 'Lipid droplet biogenesis and functions in health and disease', Nature Reviews Endocrinology, 19, pp. 443 - 459, http://dx.doi.org/10.1038/s41574-023-00845-0

Tao B; Yang H; Fan R, 2023, 'Seeing the Action of Lipid Droplets in Aging and Longevity', GEN Biotechnology, 2, pp. 287 - 289, http://dx.doi.org/10.1089/genbio.2023.29106.bta

Norris D; Aw Y; Yang H, 2023, 'Nonvesicular trafficking of cholesterol by Aster proteins', Life Metabolism, 2, http://dx.doi.org/10.1093/lifemeta/load003

Coates HW; Capell-Hattam IM; Olzomer EM; Du X; Farrell R; Yang H; Byrne FL; Brown AJ, 2023, 'Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase', eLife, 12, http://dx.doi.org/10.7554/eLife.82843

Lukmantara I; Chen F; Mak HY; Zadoorian A; Du X; Xiao FN; MacMurray Norris D; Pandzic E; Whan R; Zhong Q; Yang H, 2022, 'PI(3)P and DFCP1 regulate the biogenesis of lipid droplets', Molecular Biology of the Cell, 33, http://dx.doi.org/10.1091/mbc.E22-07-0279

Tang G; Ma C; Li L; Zhang S; Li F; Wu J; Yin Y; Zhu Q; Liang Y; Wang R; Huang H; Zhao TJ; Yang H; Li P; Chen FJ, 2022, 'PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure', Science China Life Sciences, 65, pp. 2287 - 2300, http://dx.doi.org/10.1007/s11427-022-2157-y

Keable R; Hu S; Pfundstein G; Kozlova I; Su F; Du X; Yang H; Gunnersen J; Schachner M; Leshchyns’ka I; Sytnyk V, 2022, 'The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes', Cellular and Molecular Life Sciences, 79, http://dx.doi.org/10.1007/s00018-022-04575-w

Ye JY; Huang AJ; Fu ZZ; Gong YY; Yang HY; Zhou HW, 2022, 'A study of congenital generalized lipodystrophy (CGL) caused by BSCL2 gene mutation', Yi chuan = Hereditas, 44, pp. 926 - 936, http://dx.doi.org/10.16288/j.yczz.22-222

Xu J; Chen S; Wang W; Man Lam S; Xu Y; Zhang S; Pan H; Liang J; Huang X; Wang Y; Li T; Jiang Y; Wang Y; Ding M; Shui G; Yang H; Huang X, 2022, 'Hepatic CDP-diacylglycerol synthase 2 deficiency causes mitochondrial dysfunction and promotes rapid progression of NASH and fibrosis', Science Bulletin, 67, pp. 299 - 314, http://dx.doi.org/10.1016/j.scib.2021.10.014

Liang C; Wang X; Peng K; Lai P; Liu Z; Ma J; Chen X; Liu G; Zheng M; Wang Y; Yang H; Liu G; Xian X; Gao M, 2022, 'Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia', Oxidative Medicine and Cellular Longevity, 2022, http://dx.doi.org/10.1155/2022/1889632

Mak HY; Ouyang Q; Tumanov S; Xu J; Rong P; Dong F; Lam SM; Wang X; Lukmantara I; Du X; Gao M; Brown AJ; Gong X; Shui G; Stocker R; Huang X; Chen S; Yang H, 2021, 'AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-27279-4

Molenaar MR; Yadav KK; Toulmay A; Wassenaar TA; Mari MC; Caillon L; Chorlay A; Lukmantara IE; Haaker MW; Wubbolts RW; Houweling M; Vaandrager AB; Prieur X; Reggiori F; Choudhary V; Yang H; Schneiter R; Thiam AR; Prinz WA; Helms JB, 2021, 'Retinyl esters form lipid droplets independently of triacylglycerol and seipin', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202011071

Li YE; Wang Y; Du X; Zhang T; Mak H; Hancock SE; McEwen H; Pandzic E; Whan RM; Aw YC; Lukmantara IE; Yuan Y; Dong X; Don A; Turner N; Qi S; Yang H, 2021, 'TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/jcb.202103105

Xiang J; Zhang S; Xu R; Chu H; Biswas S; Yu S; Miao D; Li W; Li S; Brown AJ; Yang H; Xu Y; Li B; Liu H, 2021, 'Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression', FASEB Journal, 35, http://dx.doi.org/10.1096/fj.202001945R

Zoni V; Khaddaj R; Lukmantara I; Shinoda W; Yang H; Schneiter R; Vanni S, 2021, 'Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure', Proceedings of the National Academy of Sciences of the United States of America, 118, http://dx.doi.org/10.1073/pnas.2017205118

Yan R; Cao P; Song W; Qian H; Du X; Coates HW; Zhao X; Li Y; Gao S; Gong X; Liu X; Sui J; Lei J; Yang H; Brown AJ; Zhou Q; Yan C; Yan N, 2021, 'A structure of human scap bound to insig-2 suggests how their interaction is regulated by sterols', Science, 371, pp. 1012 - +, http://dx.doi.org/10.1126/science.abb2224

Chu BB; Liao YC; Qi W; Xie C; Du X; Wang J; Yang H; Miao HH; Li BL; Song BL, 2021, 'Erratum: Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts (2015) 161(2) (291–306), (S0092867415001853), (10.1016/j.cell.2015.02.019))', Cell, 184, pp. 289, http://dx.doi.org/10.1016/j.cell.2020.12.023

Du X; Yang H, 2021, 'Seipin regulates the formation of nuclear lipid droplets from a distance', Journal of Cell Biology, 220, http://dx.doi.org/10.1083/JCB.202011166

Zhang T; Li YE; Yuan Y; Du X; Wang Y; Dong X; Yang H; Qi S, 2021, 'TMEM41B and VMP1 are phospholipid scramblases', Autophagy, 17, pp. 2048 - 2050, http://dx.doi.org/10.1080/15548627.2021.1937898

Gao M; Yang C; Wang X; Guo M; Yang L; Gao S; Zhang X; Ruan G; Li X; Tian W; Lu G; Dong X; Ma S; Li W; Wang Y; Zhu H; He J; Yang H; Liu G; Xian X, 2020, 'ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death', Metabolism: Clinical and Experimental, 109, http://dx.doi.org/10.1016/j.metabol.2020.154296

Zhao M; Zhao L; Xiong X; He Y; Huang W; Liu Z; Ji L; Pan B; Guo X; Wang L; Cheng S; Xu M; Yang H; Yin Y; Garcia-Barrio MT; Chen YE; Meng X; Zheng L, 2020, 'TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice', Gastroenterology, 158, pp. 2266 - 2281.e27, http://dx.doi.org/10.1053/j.gastro.2020.02.033

Luo J; Yang H; Song BL, 2020, 'Mechanisms and regulation of cholesterol homeostasis', Nature Reviews Molecular Cell Biology, 21, pp. 225 - 245, http://dx.doi.org/10.1038/s41580-019-0190-7

Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Gao M; Liao J, 2020, 'Erratum: Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR^-/- mice fed on high-fat diet (Scientific reports (2019) 9 1 (17848))', Scientific reports, 10, pp. 2181, http://dx.doi.org/10.1038/s41598-020-58201-5

Gao M; Liu L; Wang X; Mak HY; Liu G; Yang H, 2020, 'GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy', Human Molecular Genetics, 29, pp. 432 - 443, http://dx.doi.org/10.1093/hmg/ddz300

Du X; Zhou L; Aw YC; Mak HY; Xu Y; Rae J; Wang W; Zadoorian A; Hancock SE; Osborne B; Chen X; Wu JW; Turner N; Parton RG; Li P; Yang H, 2020, 'ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201905162

Aw YC; Brown AJ; Wu JW; Yang H, 2020, 'ORP1L, ORP1S, and ORP2: Lipid Sensors and Transporters', Contact, 3, http://dx.doi.org/10.1177/2515256420956818

Dou YQ; Kong P; Li CL; Sun HX; Li WW; Yu Y; Nie L; Zhao LL; Miao SB; Li XK; Dong C; Zhang JW; Liu Y; Huo XX; Chi K; Gao X; Zhang N; Weng L; Yang H; Zhang F; Han M, 2020, 'Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia', Theranostics, 10, pp. 1197 - 1212, http://dx.doi.org/10.7150/thno.39320

Du X; Yang H, 2020, 'Triacylglycerol Measurement in HeLa Cells', Bio-protocol, 10, http://dx.doi.org/10.21769/BioProtoc.3852

Qian H; Zhao X; Yan R; Yao X; Gao S; Sun X; Du X; Yang H; Wong CCL; Yan N, 2020, 'Structural basis for catalysis and substrate specificity of human ACAT1', Nature, 581, pp. 333 - 338

Qian H; Wu X; Du X; Yao X; Zhao X; Lee J; Yang H; Yan N, 2020, 'Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2', Cell

Xu Y; Du X; Turner N; Brown AJ; Yang H, 2019, 'Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function', Journal of Biological Chemistry, 294, pp. 19306 - 19321, http://dx.doi.org/10.1074/jbc.RA119.011160

Dong J; Du X; Wang H; Wang J; Lu C; Chen X; Zhu Z; Luo Z; Yu L; Brown AJ; Yang H; Wu JW, 2019, 'Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P 2 /PI(3,4)P 2', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-08791-0

Gao G; Sheng Y; Yang H; Chua BT; Xu L, 2019, 'DFCP1 associates with lipid droplets', Cell Biology International, 43, pp. 1492 - 1504, http://dx.doi.org/10.1002/cbin.11199

Liu L; Liang C; Wang X; Ding X; Lu Y; Dong J; Han M; Yang H; Liao J; Gao M, 2019, 'Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR^−/− mice fed on high-fat diet', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-54392-8

Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, 294, pp. 16740 - 16755, http://dx.doi.org/10.1074/jbc.RA119.009992

Yang H, 2019, 'Extended synaptotagmins, peroxisome-endoplasmic reticulum contact and cholesterol transport', Science China Life Sciences, 62, pp. 1266 - 1269, http://dx.doi.org/10.1007/s11427-019-9573-9

Gao M; Huang X; Song BL; Yang H, 2019, 'The biogenesis of lipid droplets: Lipids take center stage', Progress in Lipid Research, 75, http://dx.doi.org/10.1016/j.plipres.2019.100989

Luo J; Jiang LY; Yang H; Song BL, 2019, 'Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites', Trends in Biochemical Sciences, 44, pp. 273 - 292, http://dx.doi.org/10.1016/j.tibs.2018.10.001

Wang H; Ma Q; Qi Y; Dong J; Du X; Rae J; Wang J; Wu WF; Brown AJ; Parton RG; Wu JW; Yang H, 2019, 'ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P 2 )', Molecular Cell, 73, pp. 458 - 473.e7, http://dx.doi.org/10.1016/j.molcel.2018.11.014

Lv X; Liu J; Qin Y; Liu Y; Jin M; Dai J; Chua BT; Yang H; Li P, 2019, 'Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864, pp. 113 - 127, http://dx.doi.org/10.1016/j.bbalip.2018.11.001

Gao M; Yang H, 2018, 'VPs13: A lipid transfer protein making contacts at multiple cellular locations', Journal of Cell Biology, 217, pp. 3322 - 3324, http://dx.doi.org/10.1083/JCB.201808151

Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, 81, pp. 149 - 153, http://dx.doi.org/10.1016/j.semcdb.2017.07.017

Du X; Zadoorian A; Lukmantara IE; Qi Y; Brown AJ; Yang H, 2018, 'Oxysterol-binding protein–related protein 5 (ORP5) promotes cell proliferation by activation of MTORC1 signaling', Journal of Biological Chemistry, 293, pp. 3806 - 3818, http://dx.doi.org/10.1074/jbc.RA117.001558

Xu D; Li Y; Wu L; Li Y; Zhao D; Yu J; Huang T; Ferguson C; Parton RG; Yang H; Li P, 2018, 'Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions', Journal of Cell Biology, 217, pp. 975 - 995, http://dx.doi.org/10.1083/jcb.201704184

Reid DW; Xu D; Chen P; Yang H; Sun L, 2017, 'Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs', Scientific Reports, 7, pp. 5681, http://dx.doi.org/10.1038/s41598-017-06077-3

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