By Professor Kristopher Alan Kilian

Book Chapters

Abdul Halim MS; Nadernezhad A; Kopecky C; Hauser S; Kilian KA; Loessner D, 2026, 'Biomaterial-based Platforms for Modeling the Pre-metastatic Niche', in Reference Module in Materials Science and Materials Engineering, Elsevier, http://dx.doi.org/10.1016/b978-0-443-30151-3.00005-x

LaPointe V; Kilian KA, 2023, 'Cellular signaling', in Tissue Engineering, Elsevier, pp. 109 - 135, http://dx.doi.org/10.1016/B978-0-12-824459-3.00004-4

Romanazzo S; Kilian KA, 2022, 'Geometric Cues for Directing Cell Fate', in Material-based Mechanobiology, The Royal Society of Chemistry, pp. 85 - 109, http://dx.doi.org/10.1039/9781839165375-00085

Romanazzo S; Kilian KA; Roohani I, 2021, 'iPSC bioprinting for musculoskeletal tissue', in Ipscs in Tissue Engineering, pp. 237 - 270, http://dx.doi.org/10.1016/B978-0-12-823809-7.00008-6

Kilian KA, 2015, 'Biomaterials: Incorporating ECM-Derived Molecular Features into Biomaterials', in Mimicking the Extracellular Matrix, The Royal Society of Chemistry, pp. 161 - 194, http://dx.doi.org/10.1039/9781839168956-00161

Journal articles

Liu Y; Pawlush ML; Gleba JJ; Lambert EG; Williams CE; Stenzel MH; Copland JA; Kilian KA, 2026, 'Hydrogel microtumor arrays of patient melanoma recapitulate phenotypes and drug sensitivity', Biomaterials Advances, 188, http://dx.doi.org/10.1016/j.bioadv.2026.215015

Sabahi N; Roohani I; Kilian KA; Wang CH; Li X, 2026, '4D direct ink writing of body temperature-responsive triple-shape memory scaffolds for bone tissue engineering', Biofabrication, 18, http://dx.doi.org/10.1088/1758-5090/ae8a85

Seyedzadeh MH; Tolentino MA; Gil Peres N; Du EY; Bartlett-Tomasetig F; Javier GMN; Kilian KA; Gaus K; Goyette J; Gooding JJ, 2026, 'Stiff matrix impairs cytotoxic T lymphocyte function at multiple levels', Science Advances, 12, pp. eady2299, http://dx.doi.org/10.1126/sciadv.ady2299

Kopecky C; Pandzic E; Porazinski S; Gooding JJ; Kilian KA, 2026, 'Matrix Stiffness Directs Stemness Signatures in Breast Cancer', Advanced Healthcare Materials, 15, http://dx.doi.org/10.1002/adhm.71371

Li L; Ong LJY; Lim KS; Liyanage C; Qu Y; Wen J; Williams C; Molley TG; Barrero RA; Wakale S; Crawford R; Kilian KA; Toh YC; Prasadam I, 2026, 'Light-activated cartilage decellularised extracellular matrix hydrogels for engineering chondrogenic microenvironments with localised oxygen control', Biofabrication, 18, http://dx.doi.org/10.1088/1758-5090/ae61f5

Doshi RB; Yee B; Warburton N; Ruan J; Tilley R; Sidhu K; Kilian KA, 2026, 'Tuning Hydrogel Mechanics and Microstructure to Maximize Extracellular Vesicle Production from Mesenchymal Stem Cells', Cellular and Molecular Bioengineering, 19, pp. 375 - 386, http://dx.doi.org/10.1007/s12195-026-00917-x

Wan S; Esrafilzadeh D; Poole-Warren L; Kilian K; Robles UA, 2026, 'Poly-l-lysine integration in PVA hydrogels enables stable, bioactive matrices for motor neuron differentiation and neural network formation', Journal of Materials Chemistry B, 14, pp. 6298 - 6310, http://dx.doi.org/10.1039/d5tb02475g

Kilian KA, 2026, 'Building mechanochemistry into soft biomaterials', Nature Reviews Bioengineering, 4, pp. 208 - 209, http://dx.doi.org/10.1038/s44222-026-00406-w

Nguyen AK; Islam MS; Doshi RB; Yu M; Romanazzo S; Ruan J; Tilley RD; Kumeria T; Mata J; Kilian KA, 2026, 'Tuning Embryoid Germ Layer Specification in Tryptophan Zipper Hydrogels Through Pendant Matrix-Derived Motifs', Advanced Healthcare Materials, 15, http://dx.doi.org/10.1002/adhm.202503600

Silvani G; Stenzel MH; Kilian KA, 2026, 'Precision Nanomedicine: A Necessary Convergence of Nanodrug Development, Organotypic Models and Microphysiological Systems', ACS Nano Medicine, 1, pp. 54 - 73, http://dx.doi.org/10.1021/acsnanomed.5c00019

Lambert EG; Romanazzo S; Newman PLH; Kilian KA, 2026, 'Engineering tissue patterning in human stem cell-based embryo models', Advanced Drug Delivery Reviews, 229, http://dx.doi.org/10.1016/j.addr.2025.115765

Taheri S; Islam MS; Doshi RB; Mata J; Nguyen AK; Ruan J; Tilley RD; Kilian KA, 2026, 'Hierarchical stabilization of bioactive hydrogels by multi-arm peptide–polymer supramolecular staples', Journal of Materials Chemistry B, http://dx.doi.org/10.1039/d6tb00490c

Silvani G; Kopecky C; Romanazzo S; Rodríguez V; Das A; Pandzic E; Lock JG; Chaffer CL; Poole K; Kilian KA, 2025, 'Capillary constrictions prime cancer cell tumorigenicity through PIEZO1', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-025-63374-6

Milton LA; Kasetsirikul S; Catano JA; Hilmi FS; Zhou Z; Molley TG; Kilian KA; Ong LJY; Chirnside J; Byrom N; Balshaw G; Liang S; Bray LJ; Hutmacher DW; Meinert C; Toh YC, 2025, 'Building multiple microenvironmental niches using a customizable 3D printed well insert', Lab on A Chip, 25, pp. 5875 - 5893, http://dx.doi.org/10.1039/d5lc00753d

Romanazzo S; Tian P; Jalandhra GK; Doshi RB; Gooding JJ; Kilian KA, 2025, 'A biofabricated 3D cancer-stroma tumor microenvironment model', Biofabrication, 17, pp. 045019, http://dx.doi.org/10.1088/1758-5090/ae0a82

Soliman BG; Tian P; Cui J; Kilian KA; Gooding JJ, 2025, 'Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer-Host Interface', Advanced Science, 12, pp. e09361, http://dx.doi.org/10.1002/advs.202509361

Johnson KK; Koshy P; Kopecky C; Devadason M; Holst J; Kilian KA; Sorrell CC, 2025, 'Theranostic performance of EGFR-targeted ceria-based nanoparticles on EGFR-positive cancers', Journal of Biomaterials Applications, 40, pp. 454 - 469, http://dx.doi.org/10.1177/08853282251336556

Tolentino MAK; Du EY; Silvani G; Pandzic E; Kilian KA; Gooding JJ, 2025, 'Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications', Advanced Healthcare Materials, 14, pp. 2500658 - 2500658, http://dx.doi.org/10.1002/adhm.202500658

Huang Y; Li Z; Ranaweera CD; Jayathilaka PB; Islam MS; Ajam A; Silberstein MN; Kilian KA; Kruzic JJ, 2025, 'Stretch activated molecule immobilization in disulfide linked double network hydrogels', Acta Biomaterialia, 198, pp. 174 - 187, http://dx.doi.org/10.1016/j.actbio.2025.04.013

Taief KA; Nemec S; Middleton IA; Kilian KA; Thordarson P, 2025, 'Scrambled RGD Hexameric Peptide Hydrogel Supports Efficient Self-Assembly and Cell Activity', Chemistry A European Journal, 31, http://dx.doi.org/10.1002/chem.202404410

Doshi R; Mohanathas D; Islam MS; Ruan J; Tilley RD; Kilian KA, 2025, 'Biomimetic Hydrogels from Mixed Gellan Gum and Tryptophan Zipper Self-Assembling Peptides', ACS Macro Letters, 14, http://dx.doi.org/10.1021/acsmacrolett.5c00076

Tran HA; Maraldo A; Ho TTP; Thai MT; van Hilst Q; Joukhdar H; Kordanovski M; Sahoo JK; Hartsuk O; Santos M; Wise SG; Kaplan DL; Do TN; Kilian KA; Lim KS; Rnjak-Kovacina J, 2025, 'Probing the Interplay of Protein Self-Assembly and Covalent Bond Formation in Photo-Crosslinked Silk Fibroin Hydrogels', Small, 21, http://dx.doi.org/10.1002/smll.202407923

Hu C; Dief EM; Soliman BG; Romanazzo S; Rana S; Kilian KA; Tilley RD; Gooding JJ, 2025, 'Direct detection of microRNA in liquid biopsies from single cancer spheroids', Chemical Science, 16, pp. 8970 - 8978, http://dx.doi.org/10.1039/d5sc01036e

Islam MS; Molley TG; Jalandhra GK; Fang J; Kruzic JJ; Kilian KA, 2025, 'Magnetoactive Nanotopography on Hydrogels for Stimulated Cell Adhesion and Differentiation', Small Science, 5, http://dx.doi.org/10.1002/smsc.202400468

Putra VDL; Kilian KA; Knothe Tate ML, 2025, 'Stem cell mechanoadaptation. I. Effect of microtubule stabilization and volume changing stresses on cytoskeletal remodeling', APL Bioengineering, 9, http://dx.doi.org/10.1063/5.0231273

Putra VDL; Kilian KA; Knothe Tate ML, 2025, 'Stem cell mechanoadaptation. II. Microtubule stabilization and substrate compliance effects on cytoskeletal remodeling', APL Bioengineering, 9, http://dx.doi.org/10.1063/5.0231287

Li Z; Ranaweera CD; Lin K; Huang Y; Molley TG; Qin L; Kruzic JJ; Kilian KA, 2025, 'Multi-step functionalization of hydrogels through mechano- and photo-responsive linkages', Materials Horizons, 12, pp. 3084 - 3090, http://dx.doi.org/10.1039/d4mh00761a

Tran HA; Maraldo A; Ho TT; Thai MT; van Hilst Q; Joukhdar H; Kordanovski M; Sahoo JK; Hartsuk O; Santos M; Wise SG; Kaplan DL; Do TN; Kilian KA; Lim KS; Rnjak‐Kovacina J, 2025, 'Probing the Interplay of Protein Self‐Assembly and Covalent Bond Formation in Photo‐Crosslinked Silk Fibroin Hydrogels (Small 16/2025)', Small, 21, http://dx.doi.org/10.1002/smll.202570127

Liu Y; Islam MS; Bakker A; Li Z; Ajam A; Kruzic JJ; Kilian KA, 2024, 'Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network', Journal of Materials Chemistry B, 13, pp. 1286 - 1295, http://dx.doi.org/10.1039/d4tb02002b

Ireland J; Kilian KA, 2024, 'The importance of matrix in cardiomyogenesis: Defined substrates for maturation and chamber specificity', Matrix Biology Plus, 24, http://dx.doi.org/10.1016/j.mbplus.2024.100160

Soliman BG; Nguyen AK; Gooding JJ; Kilian KA, 2024, 'Advancing Synthetic Hydrogels through Nature-Inspired Materials Chemistry', Advanced Materials, 36, pp. e2404235 - e2404235, http://dx.doi.org/10.1002/adma.202404235

Jalandhra GK; Hung TT; Kilian KA, 2024, 'Laponite Nanoclay-Loaded Microgel Suspensions as Supportive Matrices for Osteogenesis', Advanced Nanobiomed Research, 4, http://dx.doi.org/10.1002/anbr.202400024

Jalandhra GK; Kilian KA, 2024, 'Biofabrication approaches to fabricating gradients and interfaces in osteochondral tissue engineering', Current Opinion in Biomedical Engineering, 31, http://dx.doi.org/10.1016/j.cobme.2024.100544

Ajam A; Huang Y; Islam MS; Kilian KA; Kruzic JJ, 2024, 'Mechanical and biological behavior of double network hydrogels reinforced with alginate versus gellan gum', Journal of the Mechanical Behavior of Biomedical Materials, 157, http://dx.doi.org/10.1016/j.jmbbm.2024.106642

Doshi RB; Vakil D; Molley TG; Islam MS; Kilian KA; Cunningham C; Sidhu KS, 2024, 'Mesenchymal stem cell-secretome laden photopolymerizable hydrogels for wound healing', Journal of Biomedical Materials Research Part A, 112, pp. 1484 - 1493, http://dx.doi.org/10.1002/jbm.a.37697

Karimi F; Farbehi N; Ziaee F; Lau K; Monfared M; Kordanovski M; Joukhdar H; Molly TG; Nordon R; Kilian KA; Stenzel MH; Lim KS; Rnjak-Kovacina J, 2024, 'Photocrosslinked Silk Fibroin Microgel Scaffolds for Biomedical Applications', Advanced Functional Materials, 34, http://dx.doi.org/10.1002/adfm.202313354

Johnson KK; Koshy P; Kopecky C; Devadason M; Biazik J; Zheng X; Jiang Y; Wang X; Liu Y; Holst J; Yang JL; Kilian KA; Sorrell CC, 2024, 'ROS-mediated anticancer effects of EGFR-targeted nanoceria', Journal of Biomedical Materials Research Part A, 112, pp. 754 - 769, http://dx.doi.org/10.1002/jbm.a.37656

Karimi F; Farbehi N; Ziaee F; Lau K; Monfared M; Kordanovski M; Joukhdar H; Molly TG; Nordon R; Kilian KA; Stenzel MH; Lim KS; Rnjak‐Kovacina J, 2024, 'Photocrosslinked Silk Fibroin Microgel Scaffolds for Biomedical Applications (Adv. Funct. Mater. 29/2024)', Advanced Functional Materials, 34, http://dx.doi.org/10.1002/adfm.202470158

Putra VDL; Kilian KA; Knothe Tate ML, 2023, 'Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment', Communications Biology, 6, http://dx.doi.org/10.1038/s42003-022-04320-w

Nguyen AK; Molley TG; Kardia E; Ganda S; Chakraborty S; Wong SL; Ruan J; Yee BE; Mata J; Vijayan A; Kumar N; Tilley RD; Waters SA; Kilian KA, 2023, 'Hierarchical assembly of tryptophan zipper peptides into stress-relaxing bioactive hydrogels', Nature Communications, 14, http://dx.doi.org/10.1038/s41467-023-41907-1

Islam MS; Molley TG; Hung TT; Sathish CI; Putra VDL; Jalandhra GK; Ireland J; Li Y; Yi J; Kruzic JJ; Kilian KA, 2023, 'Magnetic Nanofibrous Hydrogels for Dynamic Control of Stem Cell Differentiation', ACS Applied Materials and Interfaces, 15, pp. 50663 - 50678, http://dx.doi.org/10.1021/acsami.3c07021

Moore MJ; Lam YT; Santos M; Tan RP; Yang N; Hung J; Li Z; Kilian KA; Rnjak-Kovacina J; Pitts JB; Menzel H; Wise SG, 2023, 'Evaluation of the Immune Response to Chitosan-graft-poly(caprolactone) Biopolymer Scaffolds', ACS Biomaterials Science and Engineering, 9, pp. 3320 - 3334, http://dx.doi.org/10.1021/acsbiomaterials.3c00553

Kilian K; Fischbach C; Fong ELS, 2023, 'Engineered Biomaterials for Developing the Next Generation of In Vitro Tumor Models', Advanced Healthcare Materials, 12, http://dx.doi.org/10.1002/adhm.202300411

Liu Y; Nemec S; Kopecky C; Stenzel MH; Kilian KA, 2023, 'Hydrogel Microtumor Arrays to Evaluate Nanotherapeutics', Advanced Healthcare Materials, 12, http://dx.doi.org/10.1002/adhm.202201696

Molley TG; Jiang S; Ong L; Kopecky C; Ranaweera CD; Jalandhra GK; Milton L; Kardia E; Zhou Z; Rnjak-Kovacina J; Waters SA; Toh YC; Kilian KA, 2023, 'Gas-modulating microcapsules for spatiotemporal control of hypoxia', Proceedings of the National Academy of Sciences of the United States of America, 120, pp. e2217557120, http://dx.doi.org/10.1073/pnas.2217557120

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