Researcher

Professor Ric Day

Field of Research (FoR)

Biography

Research Interests:
Rheumatic disorders and diabetes are prevalent chronic illnesses that demand high quality pharmacotherapy. We are researching powerful techniques for individualising pharmacotherapy using pharmacokinetic/pharmacodynamic models. Our aim is safe yet effective therapy. Allopurinol used in gout and metformin used in diabetes in patients with kidney, liver or heart failure are currently being studied. We are using therapeutics...view more

Research Interests:
Rheumatic disorders and diabetes are prevalent chronic illnesses that demand high quality pharmacotherapy. We are researching powerful techniques for individualising pharmacotherapy using pharmacokinetic/pharmacodynamic models. Our aim is safe yet effective therapy. Allopurinol used in gout and metformin used in diabetes in patients with kidney, liver or heart failure are currently being studied. We are using therapeutics drug monitoring to optimise outcomes in patients treated with antibiotics and antifungal drugs. We are examining genetic factors that predict serious adverse drug reactions and also explain variation in response to medicines, especially transporter molecules and their controlling genes. The effects of electronic medication management and decision support tools in a teaching hospital on the rate of adverse events occurring is a new and exciting research interest.

Broad Research Areas:
Pharmacology, Preventive Medicine, Arthritis / Rheumatology, Diabetes, Anti-infectives, Electronic Medication Management, Decision Support.

Qualifications:
AM, MB BS Syd, MD UNSW, FRACP

Society Memberships & Professional Activities:
Fellow Royal Australian College of Physicians, Past Chair Federal PHARM Committee (Pharmaceutical Health and Rational Use of Medicines Committee) , Member of Australian Rheumatology Association and Australasian Society of Clinical & Experimental Pharmacologists and Toxicologists (Past President), Practising Clinical Pharmacologist & Rheumatologist at St Vincent's Hospital Sydney and St Vincent's Medical Centre, Darlinghurst, Director of Clinical Pharmacology & Toxicology, St Vincent's Hospital, President Drug Information Association 2010/11 (http://www.diahome.org/DIAHome/Home.aspx)

Specific Research Keywords:
Rheumatology, Gout, Drug Safety, Clinical Pharmacology, Diabetes and Endocrinology, Anti-infectives, Decision Support, Therapeutic Drug Monitoring.


My Research Supervision


Areas of supervision

  • Clinical Pharmacokinetics - Optimisation of drug dosage - e.g. Allopurinol & Febuxostat (gout), Metformin (antidiabetic), Anti-infectives e.g. Gentamicin & Vancomycin (antibiotics) and Ribavirin
  • Decision support – Can we help doctors make better prescribing decisions? 

  • Can outcomes for gout sufferers be improved with eHealth?
  • Effect of Paracetamol on myeloperoxidase 

  • A critical look at drug development 


Currently supervising

  • Optimisation of metformin therapy by personalising dosage based on individuals' relevant characteristics

  • Safety and Pharmacokinetics of Metformin in Heart Failure

  • Determining the overall cost of healthcare to Australian gout patients

  • Vancomycin - Implementation of an electronic monitoring program

  • Development and evaluation of educational resources for vancomycin

  • A Time and Motion Study of Phlebotomists' work

  • Therapeutic Drug Monitoring (TDM) of voriconazole

  • Evaluation of Drug-Drug Interaction Alerts in Electronic Systems

  • Treat-to-target investigations of febuxostat in gouty and hyperuricaemic patients including those with renal and hepatic impairment as well as in patients intolerant of allopurinol


My Expertise

quality use of medicines; therapeutics; medicinal drug information; adverse drug reactions & interactions; clinical toxicology; treatment of rheumatic conditions & pain.

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Location

Department of Clinical Pharmacology & Toxicology
Therapeutics Centre, Level 2 Xavier Building
St Vincent's Hospital Sydney & UNSW
Darlinghurst NSW 2010

Contact

+61 2 8382 2331
+61 2 8382 2724