quality use of medicines; therapeutics; medicinal drug information; adverse drug reactions & interactions; clinical toxicology; treatment of rheumatic conditions & pain.
Field of Research (FoR)
Rheumatic disorders and diabetes are prevalent chronic illnesses that demand high quality pharmacotherapy. We are researching powerful techniques for individualising pharmacotherapy using pharmacokinetic/pharmacodynamic models. Our aim is safe yet effective therapy. Allopurinol used in gout and metformin used in diabetes in patients with kidney, liver or heart failure are currently being studied. We are using therapeutics...view more
Rheumatic disorders and diabetes are prevalent chronic illnesses that demand high quality pharmacotherapy. We are researching powerful techniques for individualising pharmacotherapy using pharmacokinetic/pharmacodynamic models. Our aim is safe yet effective therapy. Allopurinol used in gout and metformin used in diabetes in patients with kidney, liver or heart failure are currently being studied. We are using therapeutics drug monitoring to optimise outcomes in patients treated with antibiotics and antifungal drugs. We are examining genetic factors that predict serious adverse drug reactions and also explain variation in response to medicines, especially transporter molecules and their controlling genes. The effects of electronic medication management and decision support tools in a teaching hospital on the rate of adverse events occurring is a new and exciting research interest.
Broad Research Areas:
Pharmacology, Preventive Medicine, Arthritis / Rheumatology, Diabetes, Anti-infectives, Electronic Medication Management, Decision Support.
AM, MB BS Syd, MD UNSW, FRACP
Society Memberships & Professional Activities:
Fellow Royal Australian College of Physicians, Past Chair Federal PHARM Committee (Pharmaceutical Health and Rational Use of Medicines Committee) , Member of Australian Rheumatology Association and Australasian Society of Clinical & Experimental Pharmacologists and Toxicologists (Past President), Practising Clinical Pharmacologist & Rheumatologist at St Vincent's Hospital Sydney and St Vincent's Medical Centre, Darlinghurst, Director of Clinical Pharmacology & Toxicology, St Vincent's Hospital, President Drug Information Association 2010/11 (http://www.diahome.org/DIAHome/Home.aspx)
Specific Research Keywords:
Rheumatology, Gout, Drug Safety, Clinical Pharmacology, Diabetes and Endocrinology, Anti-infectives, Decision Support, Therapeutic Drug Monitoring.
My Research Supervision
Areas of supervision
- Clinical Pharmacokinetics - Optimisation of drug dosage - e.g. Allopurinol & Febuxostat (gout), Metformin (antidiabetic), Anti-infectives e.g. Gentamicin & Vancomycin (antibiotics) and Ribavirin
- Decision support – Can we help doctors make better prescribing decisions?
- Can outcomes for gout sufferers be improved with eHealth?
- Effect of Paracetamol on myeloperoxidase
- A critical look at drug development
Optimisation of metformin therapy by personalising dosage based on individuals' relevant characteristics
Safety and Pharmacokinetics of Metformin in Heart Failure
Determining the overall cost of healthcare to Australian gout patients
Vancomycin - Implementation of an electronic monitoring program
Development and evaluation of educational resources for vancomycin
A Time and Motion Study of Phlebotomists' work
Therapeutic Drug Monitoring (TDM) of voriconazole
Evaluation of Drug-Drug Interaction Alerts in Electronic Systems
Treat-to-target investigations of febuxostat in gouty and hyperuricaemic patients including those with renal and hepatic impairment as well as in patients intolerant of allopurinol