By Professor Thomas Robert Cox

Preprints

Liot S; Schmitter C; Mercier-Gouy P; Kholti NE; Balas J; Prigent L; Aubert A; Lethias C; Chitty JL; Koch M; Fenouil T; Cox TR; Hennino A; Hervieu V; Ricard-Blum S; Valcourt U; Lambert E, 2025, Dynamic dysregulation of Tenascin-X/Tenascin-C balance controlled by Transforming Growth Factor-β leads to tumor cell proliferation during pancreatic carcinogenesis, http://dx.doi.org/10.1101/2025.02.07.635757

Es HA; Aref AR; Kulasinghe A; Cox TR; Thiery JP; Ebrahimi Warkiani M, 2021, Epithelial-Mesenchymal Transition Inversely Associates With Immune Activity in Breast Cancer Tumour Immune Microenvironment, http://dx.doi.org/10.2139/ssrn.3811836

Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer, http://dx.doi.org/10.1101/2020.06.04.135327

Valdes-Mora F; Salomon R; Gloss B; Law AM; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; de la Fuente LR; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JR; Oakes SR; Sikta N; O'Donoghue SI; Cox TR; Timpson P; Ormandy CJ; Ortega DG, 2020, Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype, http://dx.doi.org/10.2139/ssrn.3634808

Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, Recent advances in understanding the complexities of metastasis., http://dx.doi.org/10.12688/f1000research.15064.2

Latham SL; O’Donnell YE; Girgis-Cook O; Clearwater MS; Bryce NS; Mok ET; Lynn SA; Ni J; Alfred S; Leong H; Quek L-E; Murphy KJ; Pantarelli C; Dragutinovic I; Naeini MM; Thiel C; Cadell A; Phimmachanh M; Sharma R; Millar E; Han JZ; Hastings JF; Köhler M; Brummer T; Young A; O’Toole S; Oakes SR; Hardeman E; Lock J; Kolch W; Taft MH; Nobis M; Goldstein L; Timpson P; Parker BL; Holst J; Gunning PW; Cox TR; Morris JC; Croucher DR, A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade, http://dx.doi.org/10.1101/2025.04.16.649243

Wullkopf L; Jensen LE; Horton ER; Mayorca Guiliani AE; Madsen CD; Cox TR; Reuten R; Erler JT, Breast Cancer-Secreted Laminin γ2 Promotes Metastatic Progression Through Attraction of Blood Vessels, http://dx.doi.org/10.2139/ssrn.3631394

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey S; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill A; Gonzales-Aloy E; Kokkinos J; Gebski V; Turner N; Apte M; Davis TP; Morton JP; Haghighi K; Initiative APCG; Phillips PA, Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition, http://dx.doi.org/10.1101/2020.07.12.199638

Vaidyanathan S; Yuwono NL; Mok ET; Chitty JL; Rudd-Schmidt JA; Goldsworthy RA; Sathiqu RM; Cox AG; Cox TR; Brown KK, Cholesterol remodels the endoplasmic reticulum to control myofibroblastic CAF function, http://dx.doi.org/10.64898/2026.02.16.706237

Perryman L; Høye AM; Cox TR; Baker A-M; Strøbech J; Leonte L; Singh LB; Popov S; Lorentzen LG; Reuten R; Poulsen HS; Davies MJ; Jones C; Erler JT, Cleavage of the vascular matrix attracts glioblastoma cells to infiltrate the brain parenchyma, http://dx.doi.org/10.1101/2024.08.02.606279

Rad MA; Mahmodi H; Filipe EC; Cox TR; Kabakova I; Tipper JL, Micromechanical Characterisation of 3D Bioprinted neural cell models using Brillouin Microscopy, http://dx.doi.org/10.1101/2021.08.17.456575

Murphy KJ; Chambers CR; Reed DA; Channon LM; Mills NE; McKay SE; Lee V; Howell AE; Tran AM; Nobis M; Magenau A; Stoehr J; Pereira BA; Kuepper N; Ritchie S; Gordon K; Trpceski M; Tyma VM; Hafiz S; Johri V; Ang A; Barkauskas DS; Vennin C; Wang XQ; Naeini MM; Meyer B; Parker AL; Gummadi S; Chitti SV; Fajardo DC; Zaratzian A; Tayao M; Da Silva A; Initiative APG; Atlas APM; Cesare AJ; Mathivanan S; Stirzaker C; Latham SL; Croucher DR; Sharbeen G; Phillips PA; Goldstein LD; Lyons RJ; Nagrial A; Pavlakis N; Gill AJ; Biankin AV; Samra J; Caldon CE; Evans TRJ; Chantrill L; Horvath LG; Sansom OJ; Morton JP; Phan TG; Wang Y; Cock T-A; Kinkel SA; Bishop A; Devlin M; Lambert J; Cox TR; Pajic M; Burns CJ; Herrmann D; Timpson P, Pulsed priming with the FAK inhibitor narmafotinib enhances both gemcitabine/Abraxane and FOLFIRINOX chemotherapy response in pancreatic cancer, http://dx.doi.org/10.64898/2026.07.23.740234

Reed DA; Howell AE; Kuepper N; Tran AMH; Magenau A; Barkauskas DS; Nobis M; Chambers CR; Lee V; Channon LM; Zhu J; Ritchie S; Stoehr J; Wylie K; Chen J; Attwater D; Harvey K; Wu SZ; Saw K; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Gallego-Ortega D; Gill AJ; Cox TR; Pereira BA; Murphy KJ; Morton JP; Lim E; Swarbrick A; O’Toole S; Samuel MS; Caldon CE; Zanin-Zhorov A; Timpson P; Herrmann D, ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion, http://dx.doi.org/10.1101/2025.07.21.666015

Widodo SS; Dinevska M; Cuzcano L; Papanicolaou M; Cox TR; Stylli SS; Mantamadiotis T, Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment, http://dx.doi.org/10.1101/2022.08.30.505945

Mantamadiotis T; Widodo SS; Dinevska M; Cuzcano L; Papanicolaou M; Cox TR; Stylli SS, Spatial Analysis of the Metastatic Brain Tumor Immune and Extracellular Matrix Microenvironment, http://dx.doi.org/10.2139/ssrn.4214030

Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan C-L; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N-T; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel M; Martín M; Swarbrick A, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer, http://dx.doi.org/10.1101/215954

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