By Associate Professor Charles Edo de Bock

Journal articles

Baens M; Stirparo R; Lampi Y; Verbeke D; Vandepoel R; Cools J; Marynen P; de Bock CE; Bornschein S, 2018, 'Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice', European Journal of Immunology, 48, pp. 1728 - 1738, http://dx.doi.org/10.1002/eji.201847597

Vicente C; Stirparo R; Demeyer S; De Bock CE; Gielen O; Atkins M; Yan J; Halder G; Hassan BA; Cools J, 2018, 'The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models', Journal of Hematology and Oncology, 11, pp. 108, http://dx.doi.org/10.1186/s13045-018-0650-0

Vanden Bempt M; Demeyer S; Broux M; De Bie J; Bornschein S; Mentens N; Vandepoel R; Geerdens E; Radaelli E; Bornhauser BC; Kulozik AE; Meijerink JP; Bourquin JP; de Bock CE; Cools J, 2018, 'Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia', Cancer Cell, 34, pp. 271 - 285.e7, http://dx.doi.org/10.1016/j.ccell.2018.07.007

de Bock CE; Cools J, 2018, 'JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia', Molecular and Cellular Oncology, 5, pp. e1458014, http://dx.doi.org/10.1080/23723556.2018.1458014

de Bock CE; Demeyer S; Degryse S; Verbeke D; Sweron B; Gielen O; Vandepoel R; Vicente C; Bempt MV; Dagklis A; Geerdens E; Bornschein S; Gijsbers R; Soulier J; Meijerink JP; Heinäniemi M; Teppo S; Bouvy-Liivrand M; Lohi O; Radaelli E; Cools J, 2018, 'HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development', Cancer Discovery, 8, pp. 616 - 631, http://dx.doi.org/10.1158/2159-8290.CD-17-0583

Bornschein S; Demeyer S; Stirparo R; Gielen O; Vicente C; Geerdens E; Ghesquière B; Aerts S; Cools J; De Bock CE, 2018, 'Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system', Leukemia, 32, pp. 941 - 951, http://dx.doi.org/10.1038/leu.2017.328

Degryse S; De Bock CE; Demeyer S; Govaerts I; Bornschein S; Verbeke D; Jacobs K; Binos S; Skerrett-Byrne DA; Murray HC; Verrills NM; Van Vlierberghe P; Cools J; Dun MD, 2018, 'Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia', Leukemia, 32, pp. 788 - 800, http://dx.doi.org/10.1038/leu.2017.276

Degryse S; Bornschein S; De Bock CE; Leroy E; Bempt MV; Demeyer S; Jacobs K; Geerdens E; Gielen O; Soulier J; Harrison CJ; Constantinescu SN; Cools J, 2018, 'Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL', Blood, 131, pp. 421 - 425, http://dx.doi.org/10.1182/blood-2017-07-797597

Pajic M; Froio D; Daly S; Doculara L; Millar E; Graham PH; Drury A; Steinmann A; De Bock CE; Boulghourjian A; Zaratzian A; Carroll S; Toohey J; O'Toole SA; Harris AL; Buffa FM; Gee HE; Hollway GE; Molloy TJ, 2018, 'miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense', Cancer Research, 78, pp. 501 - 515, http://dx.doi.org/10.1158/0008-5472.CAN-16-3105

de Bock CE; Hughes MR; Snyder K; Alley S; Sadeqzadeh E; Dun MD; McNagny KM; Molloy TJ; Hondermarck H; Thorne RF, 2017, 'Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels', FEBS Letters, 591, pp. 667 - 678, http://dx.doi.org/10.1002/1873-3468.12569

Dagklis A; Demeyer S; DeBie J; Radaelli E; Pauwels D; Degryse S; Gielen O; Vicente C; Vandepoel R; Geerdens E; Uyttebroeck A; Boeckx N; De Bock CE; Cools J, 2016, 'Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors', Blood, 128, pp. 2642 - 2654, http://dx.doi.org/10.1182/blood-2016-03-703454

De Bock CE; Thorne RF, 2016, 'A mitochondrial brake on vascular repair', Nature, 539, pp. 503 - 505, http://dx.doi.org/10.1038/nature20476

Vanden Bempt M; Demeyer S; Mentens N; Geerdens E; De Bock CE; Wlodarska I; Cools J, 2016, 'Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing', Leukemia, 30, pp. 1913 - 1916, http://dx.doi.org/10.1038/leu.2016.62

Durinck K; Van Loocke W; Van Der Meulen J; Van De Walle I; Ongenaert M; Rondou P; Wallaert A; De Bock CE; Van Roy N; Poppe B; Cools J; Soulier J; Taghon T; Speleman F; Van Vlierberghe P, 2015, 'Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia', Leukemia, 29, pp. 2317 - 2327, http://dx.doi.org/10.1038/leu.2015.162

Ahmed AF; De Bock CE; Lincz LF; Pundavela J; Zouikr I; Sontag E; Hondermarck H; Thorne RF, 2015, 'FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation', Cellular and Molecular Life Sciences, 72, pp. 4653 - 4669, http://dx.doi.org/10.1007/s00018-015-1955-6

de Bock CE; Cools J, 2015, 'T-ALL: Home Is where the CXCL12 Is', Cancer Cell, 27, pp. 745 - 746, http://dx.doi.org/10.1016/j.ccell.2015.05.011

Peirs S; Matthijssens F; Goossens S; Van De Walle I; Ruggero K; De Bock CE; Degryse S; Canté-Barrett K; Briot D; Clappier E; Lammens T; De Moerloose B; Benoit Y; Poppe B; Meijerink JP; Cools J; Soulier J; Rabbitts TH; Taghon T; Speleman F; Van Vlierberghe P, 2014, 'ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia', Blood, 124, pp. 3738 - 3747, http://dx.doi.org/10.1182/blood-2014-05-574566

Degryse S; De Bock CE; Cox L; Demeyer S; Gielen O; Mentens N; Jacobs K; Geerdens E; Gianfelici V; Hulselmans G; Fiers M; Aerts S; Meijerink JP; Tousseyn T; Cools J, 2014, 'JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model', Blood, 124, pp. 3092 - 3100, http://dx.doi.org/10.1182/blood-2014-04-566687

Sadeqzadeh E; De Bock CE; O'Donnell MR; Timofeeva A; Burns GF; Thorne RF, 2014, 'FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue', FEBS Letters, 588, pp. 3511 - 3517, http://dx.doi.org/10.1016/j.febslet.2014.08.014

Oliveira CS; de Bock CE; Molloy TJ; Sadeqzadeh E; Geng XY; Hersey P; Zhang XD; Thorne RF, 2014, 'Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma', BMC Cancer, 14, pp. 630, http://dx.doi.org/10.1186/1471-2407-14-630

Sadeqzadeh E; De Bock CE; Wojtalewicz N; Holt JE; Smith ND; Dun MD; Schwarte-Waldhoff I; Thorne RF, 2014, 'Furin processing dictates ectodomain shedding of human FAT1 cadherin', Experimental Cell Research, 323, pp. 41 - 55, http://dx.doi.org/10.1016/j.yexcr.2014.02.012

Wojtalewicz N; Sadeqzadeh E; Weiß JV; Tehrani MM; Klein-Scory S; Hahn S; Schmiegel W; Warnken U; Schnölzer M; De Bock CE; Thorne RF; Schwarte-Waldhoff I, 2014, 'A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding', Plos One, 9, pp. e90461, http://dx.doi.org/10.1371/journal.pone.0090461

Sadeqzadeh E; De Bock CE; Thorne RF, 2014, 'Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease', Medicinal Research Reviews, 34, pp. 190 - 221, http://dx.doi.org/10.1002/med.21286

Sadeqzadeh E; de Bock CE; O'Donnell MR; Timofeeva A; Burns GF; Thorne RF, 2014, 'FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue', FEBS Letters, http://dx.doi.org/10.1016/j.febslet.2014.08.014

Ardjmand A; de Bock CE; Shahrokhi S; Lincz LF; Boyd AW; Burns GF; Thorne RF, 2013, 'Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia', Hematology, 18, pp. 315 - 322, http://dx.doi.org/10.1179/1607845413Y.0000000080

De Bock CE; Ardjmand A; Molloy TJ; Bone SM; Johnstone D; Campbell DM; Shipman KL; Yeadon TM; Holst J; Spanevello MD; Nelmes G; Catchpoole DR; Lincz LF; Boyd AW; Burns GF; Thorne RF, 2012, 'The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia', Leukemia, 26, pp. 918 - 926, http://dx.doi.org/10.1038/leu.2011.319

Dong L; Jiang CC; Thorne RF; Croft A; Yang F; Liu H; De Bock CE; Hersey P; Zhang XD, 2011, 'Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress', Oncogene, 30, pp. 3716 - 3726, http://dx.doi.org/10.1038/onc.2011.87

Sadeqzadeh E; De Bock CE; Zhang XD; Shipman KL; Scott NM; Song C; Yeadon T; Oliveira CS; Jin B; Hersey P; Boyd AW; Burns GF; Thorne RF, 2011, 'Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products', Journal of Biological Chemistry, 286, pp. 28181 - 28191, http://dx.doi.org/10.1074/jbc.M111.234419

De Bock CE; Garg MB; Scott N; Sakoff JA; Scorgie FE; Ackland SP; Lincz LF, 2011, 'Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo', Pharmacogenomics Journal, 11, pp. 307 - 314, http://dx.doi.org/10.1038/tpj.2010.43

Thorne RF; Ralston KJ; de Bock CE; Mhaidat NM; Zhang XD; Boyd AW; Burns GF, 2010, 'Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum', Biochimica Et Biophysica Acta Molecular Cell Research, 1803, pp. 1298 - 1307, http://dx.doi.org/10.1016/j.bbamcr.2010.07.002

Mekkawy AH; De Bock CE; Lin Z; Morris DL; Wang Y; Pourgholami MH, 2010, 'Novel protein interactors of urokinase-type plasminogen activator receptor', Biochemical and Biophysical Research Communications, 399, pp. 738 - 743, http://dx.doi.org/10.1016/j.bbrc.2010.08.010

De Bock CE; Lin Z; Mekkawy AH; Byrne JA; Wang Y, 2010, 'Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion', International Journal of Oncology, 36, pp. 1155 - 1163, http://dx.doi.org/10.3892/ijo-00000598

De Bock CE; Lin Z; Mekkawy AH; Byrne JA; Wang Y, 2010, 'Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion.', Int J Oncol, 36, pp. 1155 - 1163, http://dx.doi.org/10.3892/ijo_00000598

Jiang CC; Lucas K; Avery-Kiejda KA; Wade M; DeBock CE; Thorne RF; Allen J; Hesey P; Zhang XD, 2008, 'Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress', Cancer Research, 68, pp. 6708 - 6717, http://dx.doi.org/10.1158/0008-5472.CAN-08-0349

Tassabehji M; Zhi MF; Hilton EN; McGaughran J; Zhao Z; De Bock CE; Howard E; Malass M; Donnai D; Diwan A; Manson FDC; Murrell D; Clarke RA, 2008, 'Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome', Human Mutation, 29, pp. 1017 - 1027, http://dx.doi.org/10.1002/humu.20741

Mhaidat NM; Thorne RF; de Bock CE; Zhang XD; Hersey P, 2008, 'Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III β-tubulin levels', FEBS Letters, 582, pp. 267 - 272, http://dx.doi.org/10.1016/j.febslet.2007.12.014

Molloy TJ; de Bock CE; Wang Y; Murrell GAC, 2006, 'Gene expression changes in SNAP-Stimulated and iNOS-Transfected Tenocytes - Expression of extracellular matrix genes and its implications for tendon-healing', Journal of Orthopaedic Research, 24, pp. 1869 - 1882, http://dx.doi.org/10.1002/jor.20237

De Bock CE; Lin Z; Itoh T; Morris D; Murrell G; Wang Y, 2005, 'Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells', FEBS Journal, 272, pp. 3572 - 3582, http://dx.doi.org/10.1111/j.1742-4658.2005.04778.x

de Bock CE; Wang Y, 2004, 'Clinical Significance of Urokinase‐Type Plasminogen Activator Receptor (uPAR) Expression in Cancer', ChemInform, 35, http://dx.doi.org/10.1002/chin.200414278

De Bock CE; Wang Y, 2004, 'Clinical significance of urokinase-type plasminogen activator receptor (uPAR) expression in cancer', Medicinal Research Reviews, 24, pp. 13 - 39

Xia W; de Bock C; Murrell GAC; Wang Y, 2003, 'Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing', Journal of Orthopaedic Research, 21, pp. 819 - 825, http://dx.doi.org/10.1016/S0736-0266(03)00058-5

Gieseg MA; De Bock C; Turner P; Ferguson LR; Denny WA, 2002, 'The effect of DNA-alkylating agents on gene expression from two integrated reporter genes in a mouse mammary tumor line', Anti Cancer Drugs, 13, pp. 271 - 280, http://dx.doi.org/10.1097/00001813-200203000-00009

Gieseg MA; De Bock C; Ferguson LR; Denny WA, 2001, 'Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033', Anti Cancer Drugs, 12, pp. 683 - 690, http://dx.doi.org/10.1097/00001813-200109000-00007

Conference Papers

Connerty P; Moles E; deBock C; Jayatilleke N; Smith JL; Meshinchi S; Mayoh C; Kavallaris M; Lock RB, 2021, 'Abstract P143: Development of siRNA-loaded lipid nanoparticles targeting long non-coding RNA LINC01257 as a novel and safe therapeutic approach for paediatric acute myeloid leukaemia', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. p143 - p143, http://dx.doi.org/10.1158/1535-7163.targ-21-p143

Loontiens S; Durinck K; Vanhauwaert S; Depestel L; Oliveira ML; Dewyn G; Bock CD; Barata JT; Langenau D; Cools J; Taghon T; Vlierberghe PV; Speleman F, 2019, 'Abstract 3696: PHF6 loss drives IL7R oncogene addiction in TLX1 driven T-ALL', American Association for Cancer Research (AACR), pp. 3696 - 3696, presented at Tumor Biology, http://dx.doi.org/10.1158/1538-7445.sabcs18-3696

Sillar J; Murray H; Al Mazi J; Skerrett-Byrne D; Kahl R; Flanagan H; Smith N; Huang H; Hondermarck H; Wei A; de Bock C; Cools J; Enjeti A; Larsen M; Verrills N; Dun M, 2016, 'QUANTITATIVE, HIGH-RESOLUTION PROTEOMICS FOR A SYSTEMS BIOLOGICAL ANALYSIS OF ACUTE MYELOID LEUKEMIA', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 9 - 9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387772400008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

De Bock C; Demeyer S; Degryse S; Vicente C; Sweron B; Gielen O; Vandepoel R; Geerdens E; Radaelli E; Cools J, 2016, 'ACTIVATED JAK-STAT SIGNALING COOPERATES WITH HOXA9 AND DRIVES LEUKEMIA DEVELOPMENT', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 322 - 323, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484601163&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Degryse S; Bempt MV; Demeyer S; Jacobs K; Geerdens E; Cools J; de Bock CE, 2016, 'CHARACTERISATION OF JAK3 KINASE DOMAIN MUTANTS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 344 - 344, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484601210&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bornschein S; de Bock C; Degryse S; Gielen O; Cools J, 2016, 'CHARACTERIZATION OF AN EX VIVO T-CELL CULTURE MODEL FOR THE STUDY OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 28 - 28, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

De Bie J; Dagklis A; Demeyer S; Radaelli E; Pauwels D; Degryse S; Gielen O; Vicente C; Geerdens E; Uyttebroeck A; Boeckx N; De Bock CE; Cools J, 2016, 'HEDGEHOG PATHWAY ACTIVATION IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA PREDICTS RESPONSE TO SMO AND GLI1 INHIBITORS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, pp. 26 - 26, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379484600054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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