By Associate Professor Charles Edo de Bock

Conference Papers

de Bock CE; Degryse S; Demeyer S; Sweron B; Gielen O; Mentens N; Geerdens E; Cools J, 2014, 'Synergism Between HOXA9 and Mutant JAK3 (M511I) Leads to Rapid Leukemia Development within an in Vivo Murine Bone Marrow Transplant Model', in BLOOD, AMER SOC HEMATOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242706111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vanden M; de Bock CE; Mentens N; Gielen O; Geerdens E; Demeyer S; Cools J, 2014, 'Use of Crispr/Cas Genome Editing in Ba/F3 Cells to Generate the Fip1l1-Pdgfra and Nup214-Abl1 Fusion Genes', in BLOOD, AMER SOC HEMATOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349242707124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Durinck K; Van Loocke W; Van der Meulen J; Van de Walle I; Rondou P; De Bock CE; Poppe B; Cools J; Soulier J; Taghon T; Speleman F; Van Vlierberghe P, 2014, 'Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.', in CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at AACR Special Conference on Hematologic Malignancies - Translating Discoveries to Novel Therapies, PA, Philadelphia, 20 September 2014 - 23 September 2014, http://dx.doi.org/10.1158/1557-3265.HEMMAL14-B05

Peirs S; Matthijssens F; Goossens S; De Bock C; Cante-Barrett K; Lammens T; Van de Walle I; De Moerloose B; Benoit Y; Poppe B; Taghon T; Cools J; Meijerink J; Soulier J; Speleman F; Van Vlierberghe P, 2014, 'ABT-199 MEDIATED INHIBITION OF BCL2 AS A NOVEL THERAPEUTIC STRATEGY IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, ITALY, Milan, pp. 539 - 540, presented at 19th Congress of the European-Hematology-Association, ITALY, Milan, 12 June 2014 - 15 June 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342830902361&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Durinck K; Rondou P; de Walle IV; De Bock C; Van Roy N; Benoit Y; Poppe B; Taghon T; Soulier J; Cools J; Van Vlierberghe P; Speleman F, 2014, 'PHF6 LOSS DRIVES IL7R ONCOGENE ADDICTION IN T-ALL', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, ITALY, Milan, pp. 1 - 1, presented at 19th Congress of the European-Hematology-Association, ITALY, Milan, 12 June 2014 - 15 June 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342830900003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

de Bock C; Boyd A; Burn G; Cools J; Thorne R, 2013, 'A UNIQUE FAT1 CADHERIN ISOFORM REGULATES THE PROLIFERATION OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL) CELLS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, pp. 4 - 4, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445772400011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Degryse S; Cox L; Gianfelici V; Gielen O; Mentens N; Jacobs K; De Bock C; Cools J, 2013, 'THE ROLE OF JAK3 MUTATIONS IN THE DEVELOPMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: DEVELOPMENT OF IN VITRO AND IN VIVO MODELS', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, pp. 467 - 467, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445782800165&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sadeqzadeh E; Hersey P; Zhang XD; deBock C; Boyd A; Burns G; Thorne R, 2011, 'Aberrant processing of Fat1 Cadherin in human cancer', in CLINICAL BIOCHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, pp. S12 - S12, http://dx.doi.org/10.1016/j.clinbiochem.2011.08.037

Wang Y; Lin Z; Mekkawy AH; De Bock CE, 2008, 'Interaction between urokinase receptor and heat shock protien enhances cell adhesion', in Challenges to Life Sciences: Molecules and cells, Seoul, Korea, pp. 258 - 258, presented at 9th International Congress on Cell Biology, Seoul, Korea, 07 October 2008 - 10 October 2008

Conference Posters

Van Thillo Q; Lauwereins L; Demeyer S; Provost S; Mentens N; de Bock C; Cools J, 'P347: COOPERATION OF TLX3 AND FLT3-ITD IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IS ENHANCED BY TLE4 INACTIVATION', Vol. 6, pp. 247 - 248, http://dx.doi.org/10.1097/01.hs9.0000844276.58126.4d

Conference Abstracts

Lock RB; Toscan CE; McCalmont H; Evans K; Doculara L; Kosasih HJ; Gifford AJ; Ashoorzadeh A; Lin X; Trahair TN; De Bock CE; Patterson AV; Smaill JB, 2023, 'The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia', in BLOOD, ELSEVIER, CA, San Diego, Vol. 142, presented at 65th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 09 December 2023 - 12 December 2023, http://dx.doi.org/10.1182/blood-2023-181298

Duchatel R; Jackson E; Parackal S; Sun C; Daniel P; Mannan A; Findlay I; Staudt D; Germon Z; Laternser S; Kiltschewskij D; Kearney P; Jamaluddin MFB; Douglas A; Beitaki T; Perrson M; Thomas B; Manning E; Murray H; Verrills N; Vilain R; Skerrett-byrne D; Nixon B; Hua S; DeBock C; Valdes-Mora F; Tsoli M; Ziegler D; Cairns M; Raabe E; Vitanza N; Phoenix T; Koschmann C; Alvaro F; Dayas C; Tinkle C; Eisenstat D; Firestein R; Mueller S; Nazarian J; Cain J; Dun M, 2023, 'EXTH-31. EXPLOITING THE GENETIC DEPENDENCY ON PI3K/MTOR SIGNALING FOR THE TREATMENT OF H3-ALTERED DIFFUSE MIDLINE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 25, pp. v230 - v231, http://dx.doi.org/10.1093/neuonc/noad179.0884

Murray H; Enjeti AK; Kahl R; Flanagan H; Skerrett-Byrne D; Al-Mazi J; Smith N; de Bock C; Larsen M; Verrills N; Dun M, 2020, 'Phosphoproteomics Uncovers Synergy between DNA-PK and FLT3 Inhibitors in Acute Myeloid Leukaemia', in BLOOD, ELSEVIER, ELECTR NETWORK, Vol. 136, presented at 62nd Annual Meeting of the American-Society-of-Hematology (ASH), ELECTR NETWORK, 05 December 2020 - 08 December 2020, http://dx.doi.org/10.1182/blood-2020-142435

Loontiens S; Durinck K; Vanhauwaert S; Depestel L; Oliveira ML; Dewyn G; De Bock C; Barata JT; Langenau D; Cools J; Taghon T; Van Vlierberghe P; Speleman F, 2019, 'PHF6loss drives IL7R oncogene addiction in TLX1 driven T-ALL', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-3696

Govaerts I; Gielen O; Habets R; de Bock C; De Keersmaecker K; Segers H; Uyttebroeck A; Maertens J; Boeckx N; De Strooper B; Cools J, 2019, 'PF159 COMBINATION OF SELECTIVE GAMMA‐SECRETASE INHIBITOR MRK‐560 WITH OTHER TARGETED THERAPY IS AN EFFECTIVE AND SAFE TREATMENT FOR T‐ALL', in HemaSphere, Wiley, Vol. 3, pp. 31 - 31, http://dx.doi.org/10.1097/01.hs9.0000558852.50584.54

Verbeke D; de Bock C; Demeyer S; Prieto C; De Bie J; Gielen O; Mentens N; Daelemans D; Uyttebroeck A; Boeckx N; De Keersmaecker K; maertens J; Segers H; Cools J, 2019, 'PF165 THE XPO1 INHIBITOR KPT‐8602 WORKS SYNERGISTIC WITH DEXAMETHASONE TO INHIBIT ACUTE LYMPHOBLASTIC LEUKEMIA CELLS', in HemaSphere, Wiley, Vol. 3, pp. 34 - 35, http://dx.doi.org/10.1097/01.hs9.0000558876.81078.b9

Van Thillo Q; De Bie J; Demeyer S; Tam WL; Sweron B; Geerdens E; Gielen O; Segers H; Boeckx N; Uyttebroeck A; Cools J; de Bock CE, 2019, 'PS916 TCF7-SPI1 AND NRAS (G12D) COOPERATE IN THE DEVELOPMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', in HemaSphere, Wiley, Vol. 3, pp. 413 - 413, http://dx.doi.org/10.1097/01.hs9.0000561944.30888.3a

de Bock C; Habets R; Serneels L; Lodewijckx I; Verbeke D; Nittner D; Narlawar R; Demeyer S; Dooley J; Liston A; Taghon T; de Strooper B; Cools J, 2019, 'PS917 SAFE TARGETING OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA BY SUBUNIT SELECTIVE GAMMA-SECRETASE INHIBITION', in HemaSphere, Wiley, Vol. 3, pp. 413 - 414, http://dx.doi.org/10.1097/01.hs9.0000561948.38512.48

Loontiens S; Durinck K; Vanhauwaert S; Depestel L; Oliveira ML; Dewyn G; de Bock C; Barata JT; Langenau D; Cools J; Taghon T; Van Vlierberghe P; Speleman F, 2019, 'PS920 PHF6 LOSS DRIVES IL7R ONCOGENE ADDICTION IN TLX1 DRIVEN T‐ALL', in HemaSphere, Wiley, Vol. 3, pp. 414 - 415, http://dx.doi.org/10.1097/01.hs9.0000561956.76629.c7

Broux M; Prieto C; Demeyer S; Vanden Bempt M; Alberti‐Servera L; Vandepoel R; Mentens N; Gielen O; Jacobs K; Geerdens E; Vicente C; de Bock CE; Cools J, 2019, 'S858 SUZ12 INACTIVATION COOPERATES WITH JAK3 MUTANT SIGNALING TO DRIVE T‐ALL DEVELOPMENT', in HemaSphere, Wiley, Vol. 3, pp. 383 - 384, http://dx.doi.org/10.1097/01.hs9.0000561712.29231.fb

Ardjmand A; Bock CED; Molloy TJ; Bone SM; Johnstone D; Campbell DM; Shipman KL; Yeadon TM; Holst J; Spanevello MD; Catchpoole DR; Lincz LF; Boyd AW; Burns GF; Thorne RF, 2011, 'Altered expression of Fat1 cadherin, a novel tumor marker for acute lymphoblastic leukemia', in Clinical Biochemistry, Elsevier BV, Vol. 44, pp. S71 - S71, http://dx.doi.org/10.1016/j.clinbiochem.2011.08.154

Preprints

Bond DR; Burnard SM; Uddipto K; Hunt KV; Harvey BM; Steffens Reinhardt L; Lawlor-O’Neill C; Roper EA; Humphries S; Murray HC; Mannan A; Dun MD; de Bock CE; Bowden NA; Enjeti AK; Verrills NM; Riveros C; Lê Cao K-A; Lee HJ, 2024, Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for AML cell self-renewal, http://dx.doi.org/10.1101/2024.01.30.577864

Jing D; Beck D; Cao H; Tian F; Huang Y; Zhao H; Tai X; XU WENQIAN; Kosasih H; Kealy D; Bridge K; Zhao W; Holding A; Dowle A; Taylor S; Song G; Fajardo D; Walia Y; Wang M; Zhang C; Wang J; Mi J-Q; Lock R; de Bock C, 2024, PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.21203/rs.3.rs-3872306/v1

Zhang Q; Li MK; Hu XY; Wang YY; Zhao PP; Cheng LN; Yu RH; Zhang XD; Chen S; Zhu ZM; de Bock C; Thorne R, 2023, The tumour suppressor Fat1 is dispensable for normal murine hematopoiesis, http://dx.doi.org/10.1101/2023.12.20.572284

Germon Z; Sillar J; Mannan A; Duchatel R; Staudt D; Murray H; Findlay I; Jackson E; McEwen H; Douglas A; McLachlan T; Schjenken J; Skerrett-Bryne D; Huang H; Melo-Braga M; Plank M; Alvaro F; Chamberlain J; Iuliis GD; Aitken J; Nixon B; Wei A; Enjeti A; Lock R; Larsen M; Lee H; de Bock C; Verrills N; Dun M, 2022, Blockade of redox second messengers inhibits JAK/STAT and MEK/ERK signaling sensitizing FLT3-mutant acute myeloid leukemia to targeted therapies, http://dx.doi.org/10.1101/2022.03.09.483687

Other

Dong L; Jiang CC; Thorne RF; Croft A; Yang F; Liu H; de Bock CE; Hersey P; Zhang XD, 2025, Editorial Expression of Concern: Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress(Oncogene, 10.1038/onc.2011.87), http://dx.doi.org/10.1038/s41388-025-03436-7

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Data from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.c.6529397

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Data from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.c.6529397.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplement from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476449

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplement from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476449.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 1 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476443

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 1 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476443.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 2 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476440.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 2 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476440

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 3 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476437

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 3 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476437.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 4 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476434.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Figure 4 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476434

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Table 4 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476431

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Table 4 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476431.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Table 5 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476428.v1

Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J, 2023, Supplementary Table 5 from The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia, http://dx.doi.org/10.1158/1078-0432.22476428

Barz CS; Benford ME; Mishra MK; Chia TS; Cooper E; Newton K; Bonel N; de Bock C; Farenhem K; Zupanc J; Elsanadidy E; Gopinath SD; Winter M; Kemp KC; Nieuwenhuis R; Hoyer JS; Li R; Lindsay G; Li D; O'Mullane A; Schuenemann KC; Ramirez D; Yu SS; Pun M; Li CY, 2016, Measures of success, AMER ASSOC ADVANCEMENT SCIENCE, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000373039600017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

de Bock C, 2016, Measures of success Reply, AMER ASSOC ADVANCEMENT SCIENCE, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000373039600052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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