Select Publications

Journal articles

Rahaman MM; Millar EKA; Meijering E, 2023, 'Breast cancer histopathology image-based gene expression prediction using spatial transcriptomics data and deep learning', Scientific Reports, 13, pp. 13604, http://dx.doi.org/10.1038/s41598-023-40219-0

Mulholland BS; Hofstee P; Millar EKA; Bliuc D; O'Toole S; Forwood MR; McDonald MM, 2023, 'MCP-1 expression in breast cancer and its association with distant relapse', Cancer Medicine, 12, pp. 16221 - 16230, http://dx.doi.org/10.1002/cam4.6284

Mondol RK; Millar EKA; Graham PH; Browne L; Sowmya A; Meijering E, 2023, 'hist2RNA: An Efficient Deep Learning Architecture to Predict Gene Expression from Breast Cancer Histopathology Images', Cancers, 15, pp. 2569, http://dx.doi.org/10.3390/cancers15092569

Sandarenu P; Millar EKA; Song Y; Browne L; Beretov J; Lynch J; Graham PH; Jonnagaddala J; Hawkins N; Huang J; Meijering E, 2022, 'Survival prediction in triple negative breast cancer using multiple instance learning of histopathological images', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-18647-1

Law AMK; Chen J; Colino-Sanguino Y; Fuente LRDL; Fang G; Grimes SM; Lu H; Huang RJ; Boyle ST; Venhuizen J; Castillo L; Tavakoli J; Skhinas JN; Millar EKA; Beretov J; Rossello FJ; Tipper JL; Ormandy CJ; Samuel MS; Cox TR; Martelotto L; Jin D; Valdes-Mora F; Ji HP; Gallego-Ortega D, 2022, 'ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo', Advanced Science, 9, http://dx.doi.org/10.1002/advs.202103332

Li Y; Zhang F; Zheng H; Kalasabail S; Hicks C; Fung KY; Preaudet A; Putoczki T; Beretov J; Millar EKA; El-Omar E; Jiang XT; Yim HCH, 2022, 'Fecal DNA Virome Is Associated with the Development of Colorectal Neoplasia in a Murine Model of Colorectal Cancer', Pathogens, 11, http://dx.doi.org/10.3390/pathogens11040457

Fox SB; Webster F; Chen CJ; Chua B; Collins L; Foschini MP; Bruce Mann G; Millar E; Pinder SE; Rakha E; Shaaban A; Tan BY; Tse G; Watson P; Tan PH, 2022, 'Dataset for pathology reporting of ductal carcinoma in situ, variants of lobular carcinoma in situ and low-grade lesions: recommendations from the International Collaboration on Cancer Reporting (ICCR)', Histopathology, http://dx.doi.org/10.1111/his.14725

Marra A; Goldfinger M; Millar E; Hanna M; Rothrock B; Lee M; Wang Y; van Eck A; Trlifaj Tydlitatova L; Sue J; Wen H; Stefanelli J; Retamero J; Hamilton P; Fuchs T; Klimstra D; Chandarlapaty S; Reis-Filho JS, 2022, '93P An AI-driven computational biomarker from H&E slides recovers cases with low levels of HER2 from immunohistochemically HER2-negative breast cancers', Annals of Oncology, 33, pp. S581 - S581, http://dx.doi.org/10.1016/j.annonc.2022.07.125

Wu SZ; Roden DL; Al-Eryani G; Bartonicek N; Harvey K; Cazet AS; Chan CL; Junankar S; Hui MN; Millar EA; Beretov J; Horvath L; Joshua AM; Stricker P; Wilmott JS; Quek C; Long GV; Scolyer RA; Yeung BZ; Segara D; Mak C; Warrier S; Powell JE; O’Toole S; Lim E; Swarbrick A, 2021, 'Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis', Genome Medicine, 13, http://dx.doi.org/10.1186/s13073-021-00885-z

Wang J; Browne L; Slapetova I; Shang F; Lee K; Lynch J; Beretov J; Whan R; Graham PH; Millar EKA, 2021, 'Multiplexed immunofluorescence identifies high stromal CD68+PD-L1+ macrophages as a predictor of improved survival in triple negative breast cancer', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-01116-6

El Bairi K; Haynes HR; Blackley E; Fineberg S; Shear J; Turner S; de Freitas JR; Sur D; Amendola LC; Gharib M; Kallala A; Arun I; Azmoudeh-Ardalan F; Fujimoto L; Sua LF; Liu SW; Lien HC; Kirtani P; Balancin M; El Attar H; Guleria P; Yang W; Shash E; Chen IC; Bautista V; Do Prado Moura JF; Rapoport BL; Castaneda C; Spengler E; Acosta-Haab G; Frahm I; Sanchez J; Castillo M; Bouchmaa N; Md Zin RR; Shui R; Onyuma T; Yang W; Husain Z; Willard-Gallo K; Coosemans A; Perez EA; Provenzano E; Ericsson PG; Richardet E; Mehrotra R; Sarancone S; Ehinger A; Rimm DL; Bartlett JMS; Viale G; Denkert C; Hida AI; Sotiriou C; Loibl S; Hewitt SM; Badve S; Symmans WF; Kim RS; Pruneri G; Goel S; Francis PA; Inurrigarro G; Yamaguchi R; Garcia-Rivello H; Horlings H; Afqir S; Salgado R; Adams S; Kok M; Dieci MV; Michiels S; Demaria S; Loi S; Lien HC, 2021, 'The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group', npj Breast Cancer, 7, http://dx.doi.org/10.1038/s41523-021-00346-1

Wu SZ; Al-Eryani G; Roden DL; Junankar S; Harvey K; Andersson A; Thennavan A; Wang C; Torpy JR; Bartonicek N; Wang T; Larsson L; Kaczorowski D; Weisenfeld NI; Uytingco CR; Chew JG; Bent ZW; Chan CL; Gnanasambandapillai V; Dutertre CA; Gluch L; Hui MN; Beith J; Parker A; Robbins E; Segara D; Cooper C; Mak C; Chan B; Warrier S; Ginhoux F; Millar E; Powell JE; Williams SR; Liu XS; O’Toole S; Lim E; Lundeberg J; Perou CM; Swarbrick A, 2021, 'A single-cell and spatially resolved atlas of human breast cancers', Nature Genetics, 53, pp. 1334 - 1347, http://dx.doi.org/10.1038/s41588-021-00911-1

Pang JMB; Castles B; Byrne DJ; Button P; Hendry S; Lakhani SR; Sivasubramaniam V; Cooper WA; Armes J; Millar EKA; Raymond W; Roberts-Thomson S; Kumar B; Burr M; Selinger C; Harvey K; Chan C; Beith J; Clouston D; O'Toole SA; Fox SB, 2021, 'SP142 PD-L1 Scoring Shows High Interobserver and Intraobserver Agreement in Triple-negative Breast Carcinoma but Overall Low Percentage Agreement with Other PD-L1 Clones SP263 and 22C3', American Journal of Surgical Pathology, 45, pp. 1108 - 1117, http://dx.doi.org/10.1097/PAS.0000000000001701

Millar EKA; Browne LH; Beretov J; Lee K; Lynch J; Swarbrick A; Graham PH, 2020, 'Tumour stroma ratio assessment using digital image analysis predicts survival in triple negative and luminal breast cancer', Cancers, 12, pp. 1 - 14, http://dx.doi.org/10.3390/cancers12123749

Millar E; Browne L; Slapetova I; Shang F; Ren Y; Bradshaw R; Brauer HA; O’toole S; Beretov J; Whan R; Graham PH, 2020, 'Tils immunophenotype in breast cancer predicts local failure and overall survival: Analysis in a large radiotherapy trial with long-term follow-up', Cancers, 12, pp. 1 - 15, http://dx.doi.org/10.3390/cancers12092365

Teo WS; Holliday H; Karthikeyan N; Cazet AS; Roden DL; Harvey K; Konrad CV; Murali R; Varghese BA; Thankamony AP; Chan CL; McFarland A; Junankar S; Ye S; Yang J; Nikolic I; Shah JS; Baker LA; Millar EKA; Naylor MJ; Ormandy CJ; Lakhani SR; Kaplan W; Mellick AS; O'Toole SA; Swarbrick A; Nair R, 2020, 'Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.00552

Wu S; Roden D; Al-Eryani G; Bartonicek N; Harvey K; Cazet A; Chan C-L; Junankar S; Hui M; Millar E; Beretov J; Horvath L; Joshua A; Stricker P; Wilmott J; Quek C; Long G; Scolyer R; Yeung B; Segara D; Mak C; Warrier S; Powell J; O'Toole S; Lim E; Swarbrick A, 2020, 'Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135277

Jankovic-Karasoulos T; Bianco-Miotto T; Butler MS; Butler LM; McNeil CM; O’Toole SA; Millar EKA; Sakko AJ; Ruiz AI; Birrell SN; Sutherland RL; Hickey TE; Tilley WD; Ricciardelli C, 2020, 'Elevated levels of tumour apolipoprotein D independently predict poor outcome in breast cancer patients', Histopathology, 76, pp. 976 - 987, http://dx.doi.org/10.1111/his.14081

Smith HW; Hirukawa A; Sanguin-Gendreau V; Nandi I; Dufour CR; Zuo D; Tandoc K; Leibovitch M; Singh S; Rennhack JP; Swiatnicki M; Lavoie C; Papavasiliou V; Temps C; Carragher NO; Unciti-Broceta A; Savage P; Basik M; van Hoef V; Larsson O; Cooper CL; Vargas Calderon AC; Beith J; Millar E; Selinger C; Giguère V; Park M; Harris LN; Varadan V; Andrechek ER; O’Toole SA; Topisirovic I; Muller WJ, 2019, 'An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-10681-4

Parikh R; Millar E; Phan-Thien KC, 2019, 'A case of amoebic colitis following remote historical exposure', ANZ Journal of Surgery, 89, pp. E222 - E223, http://dx.doi.org/10.1111/ans.14278

Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, 37, pp. 4518 - 4533, http://dx.doi.org/10.1038/s41388-018-0295-z

Ricciardelli C; Bianco-Miotto T; Jindal S; Butler LM; Leung S; McNeil CM; O'Toole SA; Ebrahimie E; Millar EKA; Sakko AJ; Ruiz AI; Vowler SL; Huntsman DG; Birrell SN; Sutherland RL; Palmieri C; Hickey TE; Tilley WD, 2018, 'The magnitude of androgen receptor positivity in breast cancer is critical for reliable prediction of disease outcome', Clinical Cancer Research, 24, pp. 2328 - 2341, http://dx.doi.org/10.1158/1078-0432.CCR-17-1199

Pajic M; Froio D; Daly S; Doculara L; Millar E; Graham PH; Drury A; Steinmann A; De Bock CE; Boulghourjian A; Zaratzian A; Carroll S; Toohey J; O'Toole SA; Harris AL; Buffa FM; Gee HE; Hollway GE; Molloy TJ, 2018, 'miR-139-5p modulates radiotherapy resistance in breast cancer by repressing multiple gene networks of DNA repair and ROS defense', Cancer Research, 78, pp. 501 - 515, http://dx.doi.org/10.1158/0008-5472.CAN-16-3105

Law AMK; Yin JXM; Castillo L; Young AIJ; Piggin C; Rogers S; Caldon CE; Burgess A; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2017, 'Andy's Algorithms: New automated digital image analysis pipelines for FIJI', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-15885-6

Pang JMB; Savas P; Fellowes AP; Mir Arnau G; Kader T; Vedururu R; Hewitt C; Takano EA; Byrne DJ; Choong DYH; Millar EKA; Soon Lee C; O'Toole SA; Lakhani SR; Cummings MC; Bruce Mann G; Campbell IG; Dobrovic A; Loi S; Gorringe KL; Fox SB, 2017, 'Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer', Modern Pathology, 30, pp. 952 - 963, http://dx.doi.org/10.1038/modpathol.2017.21

Pang JMB; Molania R; Chand A; Knower K; Takano EA; Byrne DJ; Mikeska T; Millar EKA; Lee CS; O'Toole SA; Clyne C; Gorringe KL; Dobrovic A; Fox SB, 2017, 'LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness', Oncotarget, 8, pp. 83626 - 83636, http://dx.doi.org/10.18632/oncotarget.18886

Young AIJ; Law AMK; Castillo L; Chong S; Cullen HD; Koehler M; Herzog S; Brummer T; Lee EF; Fairlie WD; Lucas MC; Herrmann D; Allam A; Timpson P; Watkins DN; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-016-0781-6

Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330

Gee HE; Buffa FM; Harris AL; Toohey JM; Carroll SL; Cooper CL; Beith J; McNeil C; Carmalt H; Mak C; Warrier S; Holliday A; Selinger C; Beckers R; Kennedy C; Graham P; Swarbrick A; Millar EKA; O'Toole SA; Molloy T, 2015, 'MicroRNA-related DNA repair/cell-cycle genes independently associated with relapse after radiation therapy for early breast cancer', International Journal of Radiation Oncology Biology Physics, 93, pp. 1104 - 1114, http://dx.doi.org/10.1016/j.ijrobp.2015.08.046

Beretov J; Wasinger VC; Millar EKA; Schwartz P; Graham PH; Li Y, 2015, 'Proteomic analysis of urine to identify breast cancer biomarker candidates using a label-free LC-MS/MS approach', PLoS ONE, 10, pp. e0141876, http://dx.doi.org/10.1371/journal.pone.0141876

Huang KT; Mikeska T; Li J; Takano EA; Millar EKA; Graham PH; Boyle SE; Campbell IG; Speed TP; Dobrovic A; Fox SB, 2015, 'Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour', BMC Cancer, 15, http://dx.doi.org/10.1186/s12885-015-1676-0

Stone A; Zotenko E; Locke WJ; Korbie D; Millar EKA; Pidsley R; Stirzaker C; Graham P; Trau M; Musgrove EA; Nicholson RI; Gee JMW; Clark SJ, 2015, 'DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms8758

Junankar S; Baker LA; Roden DL; Nair R; Elsworth B; Gallego-Ortega D; Lacaze P; Cazet A; Nikolic I; Teo WS; Yang J; McFarland A; Harvey K; Naylor MJ; Lakhani SR; Simpson PT; Raghavendra A; Saunus J; Madore J; Kaplan W; Ormandy C; Millar EKA; O'Toole S; Yun K; Swarbrick A, 2015, 'ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype', NATURE COMMUNICATIONS, 6, http://dx.doi.org/10.1038/ncomms7548

Junankar S; Baker LA; Roden DL; Nair R; Elsworth B; Gallego-Ortega D; Lacaze P; Cazet A; Nikolic I; Teo WS; Yang J; McFarland A; Harvey K; Naylor MJ; Lakhani SR; Simpson PT; Raghavendra A; Saunus J; Madore J; Kaplan W; Ormandy C; Millar EKA; O'Toole S; Yun K; Swarbrick A, 2015, 'ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms7548

Giannakopoulos B; Mirarabshahi P; Qi M; Weatherall C; Qi JC; Tanaka K; Millar E; Vonthethoff L; Gatto D; Spielman D; Krilis SA, 2014, 'Deletion of the antiphospholipid syndrome autoantigen β2- glycoprotein i potentiates the lupus autoimmune phenotype in a toll-like receptor 7-mediated murine model', Arthritis and Rheumatology, 66, pp. 2270 - 2280, http://dx.doi.org/10.1002/art.38646

Pang JMB; Deb S; Takano EA; Byrne DJ; Jene N; Boulghourjian A; Holliday A; Millar E; Lee CS; O'Toole SA; Dobrovic A; Fox SB, 2014, 'Methylation profiling of ductal carcinoma in situ and its relationship to histopathological features', Breast cancer research : BCR, 16, pp. 423, http://dx.doi.org/10.1186/s13058-014-0423-9

Gee HE; Froio DA; Doculara LS; Graham PH; Millar EKA; O'Toole SA; Molloy TJ, 2014, 'MicroRNA regulation of radiotherapy sensitivity and resistance in breast cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 34, pp. S12 - S12, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341276000031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Beretov J; Wasinger VC; Graham PH; Millar EK; Kearsley JH; Li Y, 2014, 'Proteomics for breast cancer urine biomarkers', , 63, pp. 123 - 167, http://dx.doi.org/10.1016/B978-0-12-800094-6.00004-2

Pang J-M; Takano E; Byrne D; Deb S; Jene N; Boulghourjian A; Holliday A; Millar E; Lee S; O’Toole S; Dobrovic A; Fox SB, 2014, 'Candidate methylation profiling of ductal carcinoma in situ and its relationship to phenotype', Pathology, 46, pp. S76 - S76, http://dx.doi.org/10.1097/01.pat.0000443597.70603.41

Browne BC; Hochgräfe F; Wu J; Millar EKA; Barraclough J; Stone A; McCloy RA; Lee CS; Roberts C; Ali NA; Boulghourjian A; Schmich F; Linding R; Farrow L; Gee JMW; Nicholson RI; O'Toole SA; Sutherland RL; Musgrove EA; Butt AJ; Daly RJ, 2013, 'Global characterization of signalling networks associated with tamoxifen resistance in breast cancer', FEBS Journal, 280, pp. 5237 - 5257, http://dx.doi.org/10.1111/febs.12441

Schade B; Lesurf R; Sanguin-Gendreau V; Bui T; Deblois G; O'Toole SA; Millar EKA; Zardawi SJ; Lopez-Knowles E; Sutherland RL; Giguère V; Kahn M; Hallett M; Muller WJ, 2013, 'β-catenin signaling is a critical event in ErbB2-mediated mammary tumor progression', Cancer Research, 73, pp. 4474 - 4487, http://dx.doi.org/10.1158/0008-5472.CAN-12-3925

Hau EK; Browne L; Capp AL; Delaney GP; Fox CH; Kearsley J; Millar E; Nasser E; Papadatos G; Graham PH, 2013, 'The impact of breast cosmetic and functional outcomes on quality of life: long-term results from the St. George and Wollongong randomized breast boost trial', Breast Cancer Research and Treatment, 139, pp. 115 - 123, http://dx.doi.org/10.1007/s10549-013-2508-z

O'Toole S; Beith JM; Millar EKA; West R; McLean A; Cazet A; Swarbrick A; Oakes , 2013, 'Therapeutic targets in triple negative breast cancer', Journal of Clinical Pathology, 66, pp. 530 - 542, http://dx.doi.org/10.1136/jclinpath-2012-201361

Millar EKA; Coates AS; O'Toole S; Selinger C; Musgrove EA; Yan M; Viale G; Regan MM; Price KN; Sun Z; Castiglione MM; Colleoni M; Gelber RD; Goldhirsch A; Sutherland RL, 2012, 'Intrinsic subtype and its clinical significance in early node-negative breast cancer: Results from two randomized trials of adjuvant chemoendocrine therapy.', Journal of Clinical Oncology, 30, pp. 504 - 504, http://dx.doi.org/10.1200/jco.2012.30.15_suppl.504

Millar EKA; Graham PH; O’Toole SA; Browne L; Boulghourjian A; McNeil CM; Kearsley JH; Papadatos G; Delaney G; Fox C; Nasser E; Capp A; Sutherland RL, 2012, '34. Prediction of outcome of early luminal breast cancer is improved using a biomarker panel which includes KI-67 and P53', Pathology, 44, pp. S114 - S114, http://dx.doi.org/10.1016/s0031-3025(16)32926-9

O’Toole S; Machakel D; Millar E; Nair R; Cooper C; Qiu MR; McLeod D; Sutherland R; Watkins N; Swarbrick A, 2012, '35. Hedgehog overexpression is regulated by stromal interactions and predicts for poor outcome in invasive ductal carcinoma', Pathology, 44, pp. S114 - S114, http://dx.doi.org/10.1016/s0031-3025(16)32927-0

Chow HT; Tran K; Millar EKA; Lynch J; Murrell DF, 2012, 'Diverse presentations of carcinoma erysipelatoides from a teaching hospital in australia.', Case Rep Dermatol Med, 2012, pp. 134938, http://dx.doi.org/10.1155/2012/134938

Reynolds R; Marjoniemi V; Millar E, 2012, 'Unusual renal tumours: a report of two interesting cases', Pathology, 44, pp. S91 - S92, http://dx.doi.org/10.1016/s0031-3025(16)32861-6

Afalnia S; Weatherall C; Millar E; Katz I, 2011, 'CASE REPORT: NEUTROPENIC FEVER WITH BK VIRUS NEPHROPATHY AND CYTOMEGALOVIRUS INFECTION IN A RENAL TRANSPLANT PATIENT', NEPHROLOGY, 16, pp. 79 - 79, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000294977600209&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

López-Knowles E; Zardawi SJ; McNeil CM; Millar EKA; Crea P; Musgrove EA; Sutherland RL; O’Toole SA, 2011, '40. Cytoplasmic localisation of β catenin is a marker of poor outcome in breast cancer patients', Pathology, 43, pp. S101 - S101, http://dx.doi.org/10.1016/s0031-3025(16)33328-1


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