By Associate Professor Izzy Jayasinghe

Journal articles

Ashford F; Kuo CW; Dunning E; Brown E; Calagan S; Jayasinghe I; Henderson C; Fuller W; Wypijewski K, 2024, 'Cysteine post-translational modifications regulate protein interactions of caveolin-3', FASEB Journal, 38, http://dx.doi.org/10.1096/fj.202201497RR

Aghi K; Anderson BM; Castellano BM; Cunningham A; Delano M; Dickinson ES; von Diezmann L; Forslund-Startceva SK; Grijseels DM; Groh SS; Guthman EM; Jayasinghe I; Johnston J; Long S; McLaughlin JF; McLaughlin M; Miyagi M; Rajaraman B; Sancheznieto F; Scheim AI; Sun SD; Titmuss FD; Walsh RJ; Weinberg ZY, 2024, 'Rigorous science demands support of transgender scientists', Cell, 187, pp. 1327 - 1334, http://dx.doi.org/10.1016/j.cell.2024.02.021

Suen KM; Sheard TM; Lin CC; Milonaityte D; Jayasinghe I; Ladbury JE, 2024, 'Erratum: Correction: Expansion microscopy reveals subdomains in C. elegans germ granules (Life science alliance (2023) 6 4 PII: e202302405)', Life science alliance, 7, http://dx.doi.org/10.26508/lsa.202302405

Hurley ME; Shah SS; Sheard TMD; Kirton HM; Steele DS; Gamper N; Jayasinghe I, 2024, 'Super-Resolution Analysis of the Origins of the Elementary Events of ER Calcium Release in Dorsal Root Ganglion Neurons', Cells, 13, http://dx.doi.org/10.3390/cells13010038

Seehra RS; Warrington SJ; Allouis BHK; Sheard TMD; Spencer ME; Shakespeare T; Cadby A; Bose D; Strutt D; Jayasinghe I, 2023, 'Geometry-preserving expansion microscopy microplates enable high-fidelity nanoscale distortion mapping', Cell Reports Physical Science, 4, http://dx.doi.org/10.1016/j.xcrp.2023.101719

Sheard TMD; Shakespeare TB; Seehra RS; Spencer ME; Suen KM; Jayasinghe I, 2023, 'Differential labelling of human sub-cellular compartments with fluorescent dye esters and expansion microscopy', Nanoscale, 15, pp. 18489 - 18499, http://dx.doi.org/10.1039/d3nr01129a

Hurley ME; White E; Sheard TMD; Steele D; Jayasinghe I, 2023, 'Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease', Open Biology, 13, http://dx.doi.org/10.1098/rsob.230045

Suen KM; Sheard TMD; Lin CC; Milonaityte D; Jayasinghe I; Ladbury JE, 2023, 'Expansion microscopy reveals subdomains in C. elegans germ granules', Life Science Alliance, 6, http://dx.doi.org/10.26508/lsa.202201650

Holmes M; Hurley ME; Sheard TMD; Benson AP; Jayasinghe I; Colman MA, 2022, 'Increased SERCA2a sub-cellular heterogeneity in right-ventricular heart failure inhibits excitation-contraction coupling and modulates arrhythmogenic dynamics', Philosophical Transactions of the Royal Society B: Biological Sciences, 377, http://dx.doi.org/10.1098/rstb.2021.0317

Sheard TMD; Hurley ME; Smith AJ; Colyer J; White E; Jayasinghe I, 2022, 'Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads', Philosophical Transactions of the Royal Society B: Biological Sciences, 377, http://dx.doi.org/10.1098/rstb.2021.0316

Jebsen JM; Nicoll Baines K; Oliver RA; Jayasinghe I, 2022, 'Dismantling barriers faced by women in STEM', Nature Chemistry, 14, pp. 1203 - 1206, http://dx.doi.org/10.1038/s41557-022-01072-2

Bristow RG; Engel J; Jayasinghe I; Kampmann M; Sansom OJ; Bryant DM, 2022, 'Conversations with LGBT+ scientists about visibility, leadership and climbing the career ladder', Journal of Cell Science, 135, http://dx.doi.org/10.1242/jcs.259880

Colman MA; Alvarez-Lacalle E; Echebarria B; Sato D; Sutanto H; Heijman J, 2022, 'Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives.', Front Physiol, 13, pp. 836622, http://dx.doi.org/10.3389/fphys.2022.836622

Hurley ME; Sheard TMD; Norman R; Kirton HM; Shah SS; Pervolaraki E; Yang Z; Gamper N; White E; Steele D; Jayasinghe I, 2021, 'A correlative super-resolution protocol to visualise structural underpinnings of fast second-messenger signalling in primary cell types', Methods, 193, pp. 27 - 37, http://dx.doi.org/10.1016/j.ymeth.2020.10.005

Armada-Moreira A; Cizauskas C; Fleury G; Forslund SK; Guthman EM; Hanafiah A; Hope JM; Jayasinghe I; McSweeney D; Young ID, 2021, 'STEM Pride: Perspectives from transgender, nonbinary, and genderqueer scientists', Cell, 184, pp. 3352 - 3355, http://dx.doi.org/10.1016/j.cell.2021.05.043

Colman MA; Holmes M; Whittaker DG; Jayasinghe I; Benson AP, 2021, 'Multi-scale approaches for the simulation of cardiac electrophysiology: I – Sub-cellular and stochastic calcium dynamics from cell to organ', Methods, 185, pp. 49 - 59, http://dx.doi.org/10.1016/j.ymeth.2020.02.011

Jebsen JM; Abbott C; Oliver R; Ochu E; Jayasinghe I; Gauchotte-Lindsay C, 2020, 'Review of barriers women face in research funding processes in the UK', Psychology of Women and Equalities Section Review, 3, pp. 3 - 14, http://dx.doi.org/10.53841/bpspowe.2020.3.1-2.3

Sheard TMD; Hurley ME; Colyer J; White E; Norman R; Pervolaraki E; Narayanasamy KK; Hou Y; Kirton HM; Yang Z; Hunter L; Shim JU; Clowsley AH; Smith AJ; Baddeley D; Soeller C; Colman MA; Jayasinghe I, 2019, 'Three-dimensional and chemical mapping of intracellular signaling nanodomains in health and disease with enhanced expansion microscopy', ACS Nano, 13, pp. 2143 - 2157, http://dx.doi.org/10.1021/acsnano.8b08742

Miteva KT; Pedicini L; Wilson LA; Jayasinghe I; Slip RG; Marszalek K; Gaunt HJ; Bartoli F; Deivasigamani S; Sobradillo D; Beech DJ; McKeown L, 2019, 'Rab46 integrates Ca²⁺ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies', Journal of Cell Biology, 218, pp. 2232 - 2246, http://dx.doi.org/10.1083/jcb.201810118

Cully TR; Murphy RM; Jayasinghe I; Rodney GG; Launikonis BS, 2019, 'Assessing Membrane Micro-domain Physiology from the Inside-Out Using Confocal Microscopy', Microscopy and Microanalysis, 25, pp. 1082 - 1083, http://dx.doi.org/10.1017/s1431927619006147

Jayasinghe I; Clowsley AH; De Langen O; Sali SS; Crossman DJ; Soeller C, 2018, 'Shining new light on the structural determinants of cardiac couplon function: Insights from ten years of nanoscale microscopy', Frontiers in Physiology, 9, http://dx.doi.org/10.3389/fphys.2018.01472

Jayasinghe I; Clowsley AH; Soeller C, 2018, 'Advances in the Visualization of Molecular Assemblies Within Cellular Signaling Nanodomains: Insights From a Decade of Mapping of Ryanodine Receptor Clusters', Advances in Biomembranes and Lipid Self-Assembly, 28, pp. 167 - 197, http://dx.doi.org/10.1016/bs.abl.2018.04.001

Jayasinghe I; Clowsley AH; Lin R; Lutz T; Harrison C; Green E; Baddeley D; Di Michele L; Soeller C, 2018, 'True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors', Cell Reports, 22, pp. 557 - 567, http://dx.doi.org/10.1016/j.celrep.2017.12.045

Crossman DJ; Jayasinghe ID; Soeller C, 2017, 'Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?', Biophysical Reviews, 9, pp. 919 - 929, http://dx.doi.org/10.1007/s12551-017-0273-7

Lin R; Clowsley AH; Jayasinghe ID; Baddeley D; Soeller C, 2017, 'Algorithmic corrections for localization microscopy with sCMOS cameras - Characterisation of a computationally efficient localization approach', Optics Express, 25, pp. 11701 - 11716, http://dx.doi.org/10.1364/OE.25.011701

Cully TR; Murphy RM; Roberts L; Raastad T; Fassett RG; Coombes JS; Jayasinghe ID; Launikonis BS, 2017, 'Human skeletal muscle plasmalemma alters its structure to change its Ca²⁺-handling following heavy-load resistance exercise', Nature Communications, 8, http://dx.doi.org/10.1038/ncomms14266

Munro ML; Jayasinghe ID; Wang Q; Quick A; Wang W; Baddeley D; Wehrens XHT; Soeller C, 2016, 'Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes', Journal of Cell Science, 129, pp. 4388 - 4398, http://dx.doi.org/10.1242/jcs.196873

Crossman DJ; Hou Y; Jayasinghe I; Baddeley D; Soeller C, 2015, 'Combining confocal and single molecule localisation microscopy: A correlative approach to multi-scale tissue imaging', Methods, 88, pp. 98 - 108, http://dx.doi.org/10.1016/j.ymeth.2015.03.011

Hou Y; Jayasinghe I; Crossman DJ; Baddeley D; Soeller C, 2015, 'Nanoscale analysis of ryanodine receptor clusters in dyadic couplings of rat cardiac myocytes', Journal of Molecular and Cellular Cardiology, 80, pp. 45 - 55, http://dx.doi.org/10.1016/j.yjmcc.2014.12.013

Jayasinghe ID; Clowsley AH; Munro M; Hou Y; Crossman DJ; Soeller C, 2015, 'Revealing T-Tubules in Striated Muscle with New Optical Super-Resolution Microscopy Techniquess.', Eur J Transl Myol, 25, pp. 4747, http://dx.doi.org/10.4081/ejtm.2015.4747

Jayasinghe ID; Munro M; Baddeley D; Launikonis BS; Soeller C, 2014, 'Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging', Journal of the Royal Society Interface, 11, http://dx.doi.org/10.1098/rsif.2014.0570

Hou Y; Crossman DJ; Rajagopal V; Baddeley D; Jayasinghe I; Soeller C, 2014, 'Super-resolution fluorescence imaging to study cardiac biophysics: α-actinin distribution and Z-disk topologies in optically thick cardiac tissue slices', Progress in Biophysics and Molecular Biology, 115, pp. 328 - 339, http://dx.doi.org/10.1016/j.pbiomolbio.2014.07.003

Jayasinghe ID; Launikonis BS, 2013, 'Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle', Journal of Cell Science, 126, pp. 4048 - 4058, http://dx.doi.org/10.1242/jcs.131565

Jayasinghe I; Lo HP; Morgan GP; Baddeley D; Parton RG; Soeller C; Launikonis BS, 2013, 'Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers', Biophysical Journal, 104, http://dx.doi.org/10.1016/j.bpj.2013.04.029

Jayasinghe ID; Crossman DJ; Soeller C; Cannell MB, 2012, 'Comparison of the organization of t-tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium', Clinical and Experimental Pharmacology and Physiology, 39, pp. 469 - 476, http://dx.doi.org/10.1111/j.1440-1681.2011.05578.x

Jayasinghe I; Baddeley D; Kong CHT; Wehrens XHT; Cannell MB; Soeller C, 2012, 'Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes', Biophysical Journal, 102, http://dx.doi.org/10.1016/j.bpj.2012.01.034

Baddeley D; Crossman D; Rossberger S; Cheyne JE; Montgomery JM; Jayasinghe ID; Cremer C; Cannell MB; Soeller C, 2011, '4D super-resolution microscopy with conventional fluorophores and single wavelength excitation in optically thick cells and tissues', PLoS ONE, 6, http://dx.doi.org/10.1371/journal.pone.0020645

Jayasinghe ID; Crossman DJ; Soeller C; Cannell MB, 2010, 'A new twist in cardiac muscle: Dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes', Journal of Molecular and Cellular Cardiology, 48, pp. 964 - 971, http://dx.doi.org/10.1016/j.yjmcc.2009.12.012

Baddeley D; Jayasinghe ID; Lam L; Rossberger S; Cannell MB; Soeller C, 2009, 'Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 22275 - 22280, http://dx.doi.org/10.1073/pnas.0908971106

Jayasinghe I; Cannell MB; Soeller C, 2009, 'Organization of ryanodine receptors, transverse tubules, and sodium-calcium exchanger in rat myocytes', Biophysical Journal, 97, pp. 2664 - 2673, http://dx.doi.org/10.1016/j.bpj.2009.08.036

Baddeley D; Jayasinghe I; Cremer C; Cannell MB; Soeller C, 2009, 'Light-induced dark states of organic fluochromes enable 30 nm resolution imaging in standard media', Biophysical Journal, 96, http://dx.doi.org/10.1016/j.bpj.2008.11.002

Soeller C; Jayasinghe ID; Li P; Holden AV; Cannell MB, 2009, 'Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca²⁺ signalling in rat ventricular myocytes', Experimental Physiology, 94, pp. 496 - 508, http://dx.doi.org/10.1113/expphysiol.2008.043976

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