By Associate Professor Luke Hunter

Journal articles

Patel AR; Lawer A; Bhadbhade M; Hunter L, 2024, 'The influence of backbone fluorination on the helicity of α/γ-hybrid peptides', Organic and Biomolecular Chemistry, 22, pp. 1608 - 1612, http://dx.doi.org/10.1039/d3ob02016a

Miles SA; Nillama JA; Hunter L, 2023, 'Tinker, Tailor, Soldier, Spy: The Diverse Roles That Fluorine Can Play within Amino Acid Side Chains', Molecules, 28, http://dx.doi.org/10.3390/molecules28176192

Lizarme-Salas Y; Yu TT; de Bruin-Dickason C; Kumar N; Hunter L, 2021, 'Fluorinated quorum sensing inhibitors: enhancement of potency through conformational control', Organic and Biomolecular Chemistry, 19, pp. 9629 - 9636, http://dx.doi.org/10.1039/d1ob01649k

Daryl Ariawan A; Mansour F; Richardson N; Bhadbhade M; Ho J; Hunter L; Ariawan AD, 2021, 'The effect of vicinal difluorination on the conformation and potency of histone deacetylase inhibitors', Molecules, 26, pp. 3974, http://dx.doi.org/10.3390/molecules26133974

Surjadinata G; Hunter L; Matesic L; Pascali G, 2021, 'Analytical-scale synthesis of aryl-SF4Cl via flow microfluidic technology', Journal of Flow Chemistry, 11, pp. 107 - 115, http://dx.doi.org/10.1007/s41981-020-00130-5

Richardson NL; O'Malley LJ; Weissberger D; Tumber A; Schofield CJ; Griffith R; Jones NM; Hunter L, 2021, 'Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2', Bioorganic and Medicinal Chemistry, 38, http://dx.doi.org/10.1016/j.bmc.2021.116115

Lawer A; Hunter L, 2021, 'Controlling γ-Peptide Helicity with Stereoselective Fluorination', European Journal of Organic Chemistry, 2021, pp. 1184 - 1190, http://dx.doi.org/10.1002/ejoc.202001619

Constable GEO; Jung J; Read RW; Wakelin LPG; Bhadbhade MM; Hunter L, 2021, 'Synthesis of phenazine-2,8-dicarboxylates', Arkivoc, 2022, http://dx.doi.org/10.24820/ARK.5550190.P011.661

Chen S; Ruan Y; Lu JL; Hunter L; Hu XG, 2020, 'Diastereoselective synthesis and conformational analysis of 4,5-difluoropipecolic acids', Organic and Biomolecular Chemistry, 18, pp. 8192 - 8198, http://dx.doi.org/10.1039/d0ob01811b

Jwad R; Weissberger D; Hunter L, 2020, 'Strategies for Fine-Tuning the Conformations of Cyclic Peptides', Chemical Reviews, 120, pp. 9743 - 9789, http://dx.doi.org/10.1021/acs.chemrev.0c00013

Wu YM; Salas YL; Leung YC; Hunter L; Ho J, 2020, 'Predicting Octanol-Water Partition Coefficients of Fluorinated Drug-Like Molecules: A Combined Experimental and Theoretical Study', Australian Journal of Chemistry, 73, pp. 677 - 685, http://dx.doi.org/10.1071/CH19648

Yeshi K; Ruscher R; Hunter L; Daly NL; Loukas A; Wangchuk P, 2020, 'Revisiting inflammatory bowel disease: Pathology, treatments, challenges and emerging therapeutics including drug leads from natural products', Journal of Clinical Medicine, 9, http://dx.doi.org/10.3390/jcm9051273

Lizarme-Salas Y; Ariawan AD; Ratnayake R; Luesch H; Finch A; Hunter L, 2020, 'Vicinal difluorination as a C=C surrogate: An analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity', Beilstein Journal of Organic Chemistry, 16, pp. 2663 - 2670, http://dx.doi.org/10.3762/BJOC.16.216

McAlpine JB; Chen S-N; Kutateladze A; MacMillan JB; Appendino G; Barison A; Beniddir MA; Biavatti MW; Bluml S; Boufridi A; Butler MS; Capon RJ; Choi YH; Coppage D; Crews P; Crimmins MT; Csete M; Dewapriya P; Egan JM; Garson MJ; Genta-Jouve G; Gerwick WH; Gross H; Harper MK; Hermanto P; Hook JM; Hunter L; Jeannerat D; Ji N-Y; Johnson TA; Kingston DGI; Koshino H; Lee H-W; Lewin G; Li J; Linington RG; Liu M; McPhail KL; Molinski TF; Moore BS; Nam J-W; Neupane RP; Niemitz M; Nuzillard J-M; Oberlies NH; Ocampos FMM; Pan G; Quinn RJ; Reddy DS; Renault J-H; Rivera-Chávez J; Robien W; Saunders CM; Schmidt TJ; Seger C; Shen B; Steinbeck C; Stuppner H; Sturm S; Taglialatela-Scafati O; Tantillo DJ; Verpoorte R; Wang B-G; Williams CM; Williams PG; Wist J; Yue J-M; Zhang C; Xu Z; Simmler C; Lankin DC; Bisson J; Pauli GF, 2019, 'Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research (Natural Product Reports (2018) DOI: 10.1039/c7np00064b)', Natural Product Reports, 36, pp. 248 - 249, http://dx.doi.org/10.1039/c8np90041h

Jwad RS; Pang AHC; Hunter L; Read RW, 2019, 'In pursuit of fluorinated sigma receptor ligand candidates related to [ ¹⁸ F]-FPS', Australian Journal of Chemistry, 72, pp. 213 - 225, http://dx.doi.org/10.1071/CH18510

McAlpine JB; Chen SN; Kutateladze A; Macmillan JB; Appendino G; Barison A; Beniddir MA; Biavatti MW; Bluml S; Boufridi A; Butler MS; Capon RJ; Choi YH; Coppage D; Crews P; Crimmins MT; Csete M; Dewapriya P; Egan JM; Garson MJ; Genta-Jouve G; Gerwick WH; Gross H; Harper MK; Hermanto P; Hook JM; Hunter L; Jeannerat D; Ji NY; Johnson TA; Kingston DGI; Koshino H; Lee HW; Lewin G; Li J; Linington RG; Liu M; McPhail KL; Molinski TF; Moore BS; Nam JW; Neupane RP; Niemitz M; Nuzillard JM; Oberlies NH; Ocampos FMM; Pan G; Quinn RJ; Reddy DS; Renault JH; Rivera-Chávez J; Robien W; Saunders CM; Schmidt TJ; Seger C; Shen B; Steinbeck C; Stuppner H; Sturm S; Taglialatela-Scafati O; Tantillo DJ; Verpoorte R; Wang BG; Williams CM; Williams PG; Wist J; Yue JM; Zhang C; Xu Z; Simmler C; Lankin DC; Bisson J; Pauli GF, 2019, 'The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research', Natural Product Reports, 36, pp. 35 - 107, http://dx.doi.org/10.1039/c7np00064b

Au C; Gonzalez C; Leung YC; Mansour F; Trinh J; Wang Z; Hu XG; Griffith R; Pasquier E; Hunter L, 2019, 'Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination', Organic and Biomolecular Chemistry, 17, pp. 664 - 674, http://dx.doi.org/10.1039/c8ob02679c

Lawer A; Nesvaderani J; Marcolin GM; Hunter L; Lawer A, 2018, 'Synthesis and biochemical characterisation of fluorinated analogues of pepstatin A and grassystatin A', Tetrahedron, 74, pp. 1278 - 1287, http://dx.doi.org/10.1016/j.tet.2017.12.033

Hu WL; Hu XG; Hunter L, 2017, 'Recent Developments in the Deoxyfluorination of Alcohols and Phenols: New Reagents, Mechanistic Insights, and Applications', Synthesis (Germany), 49, pp. 4917 - 4930, http://dx.doi.org/10.1055/s-0036-1590881

Cheerlavancha R; Ahmed A; Leung YC; Lawer A; Liu QQ; Cagnes M; Jang HC; Hu XG; Hunter L; Lawer A, 2017, 'Homologated amino acids with three vicinal fluorines positioned along the backbone: Development of a stereoselective synthesis', Beilstein Journal of Organic Chemistry, 13, pp. 2316 - 2325, http://dx.doi.org/10.3762/bjoc.13.228

Konstandaras N; Matto L; Bhadbhade M; Hunter L; Harper JB, 2017, 'Synthesis and Determination of the pKa Values of a Series of Bis(anilino)furazano[3, 4-b]pyrazines', ChemistrySelect, 2, pp. 7018 - 7023, http://dx.doi.org/10.1002/slct.201701674

Daryl Ariawan A; Webb JEA; Howe ENW; Gale PA; Thordarson P; Hunter L, 2017, 'Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate', Organic and Biomolecular Chemistry, 15, pp. 2962 - 2967, http://dx.doi.org/10.1039/C7OB00316A

Patel AR; Hu XG; Lawer A; Ahmed MI; Au C; Jwad R; Trinh J; Gonzalez C; Hannah E; Bhadbhade MM; Hunter L, 2016, 'Scalable, stereoselective syntheses of α,β-difluoro-γ-amino acids', Tetrahedron, 72, pp. 3305 - 3317, http://dx.doi.org/10.1016/j.tet.2016.04.070

Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'Concise Synthesis of Dictyoquinazol A via a Dimerisation-Cyclocondensation Sequence', Synlett, 27, pp. 1237 - 1240, http://dx.doi.org/10.1055/s-0035-1561569

Lizarme Y; Wangsahardja J; Marcolin GM; Morris JC; Jones NM; Hunter L, 2016, 'Synthesis and neuroprotective activity of dictyoquinazol A and analogues', Bioorganic and Medicinal Chemistry, 24, pp. 1480 - 1487, http://dx.doi.org/10.1016/j.bmc.2016.02.016

Hu XG; Lawer A; Peterson MB; Iranmanesh H; Ball GE; Hunter L, 2016, 'Diastereoselective Synthesis and Conformational Analysis of (2R)- and (2S)-Fluorostatines: An Approach Based on Organocatalytic Fluorination of a Chiral Aldehyde', Organic Letters, 18, pp. 662 - 665, http://dx.doi.org/10.1021/acs.orglett.5b03592

Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'ChemInform Abstract: Concise Synthesis of Dictyoquinazol A via a Dimerisation—Cyclocondensation Sequence.', ChemInform, 47, http://dx.doi.org/10.1002/chin.201640213

Yap DQJ; Cheerlavancha R; Lowe R; Wang S; Hunter L, 2015, 'Investigation of cis- and trans-4-Fluoroprolines as Enantioselective Catalysts in a Variety of Organic Transformations', Australian Journal of Chemistry, 68, pp. 44 - 49, http://dx.doi.org/10.1071/CH14129

Absalom N; Yamamoto I; O'Hagan D; Hunter L; Chebib M, 2015, 'Probing the Mode of Neurotransmitter Binding to GABA Receptors Using Selectively Fluorinated GABA Analogues', Australian Journal of Chemistry, 68, pp. 23 - 30, http://dx.doi.org/10.1071/CH14456

Hu X; Daryl Ariawan A; Hunter L, 2015, 'ChemInform Abstract: A D‐Ribose‐Derived α‐Amino Nitrile as a Versatile Intermediate for the Collective Synthesis of Piperidine‐Type Iminosugar C‐Glycosides.', ChemInform, 46, http://dx.doi.org/10.1002/chin.201517263

Hu XG; Daryl Ariawan A; Hunter L, 2014, 'A d-ribose-derived α-amino nitrile as a versatile intermediate for the collective synthesis of piperidine-type iminosugar C-glycosides', Tetrahedron Letters, 55, pp. 7222 - 7225, http://dx.doi.org/10.1016/j.tetlet.2014.11.024

Hu X; Hunter L, 2014, 'ChemInform Abstract: Stereoselectively Fluorinated N‐Heterocycles: A Brief Survey', ChemInform, 45, http://dx.doi.org/10.1002/chin.201440259

Ahmed MI; Harper JB; Hunter L, 2014, 'Incrementally increasing the length of a peptide backbone: Effect on macrocyclisation efficiency', Organic and Biomolecular Chemistry, 12, pp. 4598 - 4601, http://dx.doi.org/10.1039/c4ob00492b

Lawer A; Tai J; Jolliffe KA; Fletcher S; Avery VM; Hunter L, 2014, 'Total synthesis and antiplasmodial activity of pohlianin C and analogues', Bioorganic and Medicinal Chemistry Letters, 24, pp. 2645 - 2647, http://dx.doi.org/10.1016/j.bmcl.2014.04.071

Hu XG; Thomas DS; Griffith R; Hunter L, 2014, 'Stereoselective fluorination alters the geometry of a cyclic peptide: Exploration of backbone-fluorinated analogues of unguisin a', Angewandte Chemie - International Edition, 53, pp. 6176 - 6179, http://dx.doi.org/10.1002/anie.201403071

Hu X; Thomas DS; Griffith R; Hunter L, 2014, 'Stereoselective Fluorination Alters the Geometry of a Cyclic Peptide: Exploration of Backbone‐Fluorinated Analogues of Unguisin A', Angewandte Chemie, 126, pp. 6290 - 6293, http://dx.doi.org/10.1002/ange.201403071

Wang Z; Chang T; Hunter L; Gregory AM; Tanudji M; Jones S; Stenzel MH, 2014, 'Radio-opaque micelles for X-ray imaging', Australian Journal of Chemistry, 67, pp. 78 - 84, http://dx.doi.org/10.1071/CH13391

Patel AR; Hunter L; Bhadbhade MM; Liu F, 2014, 'Conformational regulation of substituted azepanes through mono-, di-, and trifluorination', European Journal of Organic Chemistry, 2014, pp. 2584 - 2593, http://dx.doi.org/10.1002/ejoc.201301811

Cheerlavancha R; Lawer A; Cagnes M; Bhadbhade M; Hunter L, 2014, 'ChemInform Abstract: Sequential Deoxyfluorination Approach for the Synthesis of Protected α,β,γ‐Trifluoro‐δ‐amino Acids.', ChemInform, 45, http://dx.doi.org/10.1002/chin.201413220

Hu XG; Hunter L, 2013, 'Stereoselectively fluorinated N-heterocycles: A brief survey', Beilstein Journal of Organic Chemistry, 9, pp. 2696 - 2708, http://dx.doi.org/10.3762/bjoc.9.306

Cheerlavancha R; Lawer A; Cagnes M; Bhadbhade M; Hunter L, 2013, 'Sequential deoxyfluorination approach for the synthesis of protected α,β,γ-trifluoro-δ-amino acids', Organic Letters, 15, pp. 5562 - 5565, http://dx.doi.org/10.1021/ol402756e

Patel AR; Ball G; Hunter L; Liu F, 2013, 'Conformational regulation of substituted azepanes through selective monofluorination.', Org. Biomol. Chem., 11, pp. 3781 - 3785, http://dx.doi.org/10.1039/c3ob40391b

Hunter L, 2012, 'ChemInform Abstract: α,β‐Difluoro‐γ‐amino Acids — Synthesis and Applications', ChemInform, 43, http://dx.doi.org/10.1002/chin.201243251

Hunter L, 2012, 'alpha,beta-Difluoro-gamma- amino acids Synthesis and applications', CHIMICA OGGI-CHEMISTRY TODAY, 30, pp. 20 - 22, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305146800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hunter L, 2012, 'α,β-difluoro-γ-amino acids synthesis and applications', Chimica Oggi/Chemistry Today, 30, pp. 20 - 22

Hunter L, 2012, 'α,β-Difluoro-γ-amino acids: synthesis and applications', Chimica Oggi-Chemistry Today, 30, pp. 20 - 22

Hunter L; Butler SL; Ludbrook SB, 2012, 'Solid phase synthesis of peptides containing backbone-fluorinated amino acids', Organic and Biomolecular Chemistry, 10, pp. 8911 - 8918, http://dx.doi.org/10.1039/c2ob26596f

Harty D; Farahani RMZ; Simonian MR; Hunter L; Hunter N, 2012, 'Streptococcus gordonii FSS2 Challisin affects fibrin clot formation by digestion of the áC region and cleavage of the N-terminal region of the Bâ chains of fibrinogen', Thrombosis and Haemostasis, 108, pp. 236 - 246, http://dx.doi.org/10.1160/TH12-01-0032

Wang Z; Hunter L, 2012, 'Synthesis of difluorinated β- and γ-amino acids: Investigation of a challenging deoxyfluorination reaction', Journal of Fluorine Chemistry, 143, pp. 143 - 147, http://dx.doi.org/10.1016/j.jfluchem.2012.06.016

Yamamoto I; Jordan MA; Gavande N; Doddareddy M; Chebib M; Hunter L, 2012, 'The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABAC receptor', Chemical Communications, 48, pp. 829 - 831, http://dx.doi.org/10.1039/C1CC15816C

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