By Conjoint Professor Paul Ekert

Journal articles

Stark Z; Tan TY; Chong B; Brett GR; Yap P; Walsh M; Yeung A; Peters H; Mordaunt D; Cowie S; Amor DJ; Savarirayan R; McGillivray G; Downie L; Ekert PG; Theda C; James PA; Yaplito-Lee J; Ryan MM; Leventer RJ; Creed E; Macciocca I; Bell KM; Oshlack A; Sadedin S; Georgeson P; Anderson C; Thorne N; Gaff C; White SM, 2016, 'A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders', Genetics in Medicine, 18, pp. 1090 - 1096, http://dx.doi.org/10.1038/gim.2016.1

Goodall KJ; Finch-Edmondson ML; Van Vuuren J; Yeoh GC; Gentle IE; Vince JE; Ekert PG; Vaux DL; Callus BA, 2016, 'Cycloheximide can induce bax/bak dependent myeloid cell death independently of multiple BH3-only proteins', Plos One, 11, http://dx.doi.org/10.1371/journal.pone.0164003

Lalaoui N; Hänggi K; Brumatti G; Chau D; Nguyen NYN; Vasilikos L; Spilgies LM; Heckmann DA; Ma C; Ghisi M; Salmon JM; Matthews GM; de Valle E; Moujalled DM; Menon MB; Spall SK; Glaser SP; Richmond J; Lock RB; Condon SM; Gugasyan R; Gaestel M; Guthridge M; Johnstone RW; Munoz L; Wei A; Ekert PG; Vaux DL; Wong WWL; Silke J, 2016, 'Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))', Cancer Cell, 30, pp. 499 - 500, http://dx.doi.org/10.1016/j.ccell.2016.08.009

Brumatti G; Ma C; Lalaoui N; Nguyen NY; Navarro M; Tanzer MC; Richmond J; Ghisi M; Salmon JM; Silke N; Pomilio G; Glaser SP; De Valle E; Gugasyan R; Gurthridge MA; Condon SM; Johnstone RW; Lock R; Salvesen G; Wei A; Vaux DL; Ekert PG; Silke J, 2016, 'The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia', Science Translational Medicine, 8, http://dx.doi.org/10.1126/scitranslmed.aad3099

Lalaoui N; Hänggi K; Brumatti G; Chau D; Nguyen NYN; Vasilikos L; Spilgies LM; Heckmann DA; Ma C; Ghisi M; Salmon JM; Matthews GM; de Valle E; Moujalled DM; Menon MB; Spall SK; Glaser SP; Richmond J; Lock RB; Condon SM; Gugasyan R; Gaestel M; Guthridge M; Johnstone RW; Munoz L; Wei A; Ekert PG; Vaux DL; Wong WWL; Silke J, 2016, 'Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics', Cancer Cell, 29, pp. 145 - 158, http://dx.doi.org/10.1016/j.ccell.2016.01.006

Lalaoui N; Johnstone R; Ekert PG, 2016, 'Autophagy and AML - Food for thought', Cell Death and Differentiation, 23, pp. 5 - 6, http://dx.doi.org/10.1038/cdd.2015.136

Lalaoui N; Lindqvist LM; Sandow JJ; Ekert PG, 2015, 'The molecular relationships between apoptosis, autophagy and necroptosis', Seminars in Cell and Developmental Biology, 39, pp. 63 - 69, http://dx.doi.org/10.1016/j.semcdb.2015.02.003

Gangoda L; Doerflinger M; Srivastava R; Narayan N; Edgington LE; Orian J; Hawkins C; O'Reilly LA; Gu H; Bogyo M; Ekert P; Strasser A; Puthalakath H, 2014, 'Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice', Cell Death and Differentiation, 21, pp. 1815 - 1824, http://dx.doi.org/10.1038/cdd.2014.98

Rickard JA; O'Donnell JA; Evans JM; Lalaoui N; Poh AR; Rogers T; Vince JE; Lawlor KE; Ninnis RL; Anderton H; Hall C; Spall SK; Phesse TJ; Abud HE; Cengia LH; Corbin J; Mifsud S; Di Rago L; Metcalf D; Ernst M; Dewson G; Roberts AW; Alexander WS; Murphy JM; Ekert PG; Masters SL; Vaux DL; Croker BA; Gerlic M; Silke J, 2014, 'RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis', Cell, 157, pp. 1175 - 1188, http://dx.doi.org/10.1016/j.cell.2014.04.019

Sandow JJ; Dorstyn L; O'Reilly LA; Tailler M; Kumar S; Strasser A; Ekert PG, 2014, 'ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis', Cell Death and Differentiation, 21, pp. 475 - 480, http://dx.doi.org/10.1038/cdd.2013.168

Sadras T; Perugini M; Kok CH; Iarossi DG; Heatley SL; Brumatti G; Samuel MS; To LB; Lewis ID; Lopez AF; Ekert PG; Ramshaw HS; D'Andrea RJ, 2014, 'Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia', Journal of Leukocyte Biology, 96, pp. 83 - 91, http://dx.doi.org/10.1189/jlb.2AB1013-559R

Bandopadhayay P; Jabbour AM; Riffkin C; Salmanidis M; Gordon L; Popovski D; Rigby L; Ashley DM; Watkins DN; Thomas DM; Algar E; Ekert PG, 2013, 'The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts', BMC Cancer, 13, http://dx.doi.org/10.1186/1471-2407-13-585

Rahimi A; Lee YY; Abdella H; Doerflinger M; Gangoda L; Srivastava R; Xiao K; Ekert PG; Puthalakath H, 2013, 'Role of p53 in cAMP/PKA pathway mediated apoptosis', Apoptosis, 18, pp. 1492 - 1499, http://dx.doi.org/10.1007/s10495-013-0895-6

Wensveen FM; Geest CR; Libregts SFWM; Derks IAM; Ekert PG; Labi V; Villunger A; Nolte MA; Eldering E, 2013, 'BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis', Apoptosis, 18, pp. 1306 - 1318, http://dx.doi.org/10.1007/s10495-013-0890-y

Brumatti G; Ekert PG, 2013, 'Seeking a MCL-1 inhibitor', Cell Death and Differentiation, 20, pp. 1440 - 1441, http://dx.doi.org/10.1038/cdd.2013.114

Green BD; Jabbour AM; Sandow JJ; Riffkin CD; Masouras D; Daunt CP; Salmanidis M; Brumatti G; Hemmings BA; Guthridge MA; Pearson RB; Ekert PG, 2013, 'Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations', Cell Death and Differentiation, 20, pp. 1341 - 1349, http://dx.doi.org/10.1038/cdd.2013.63

Salmanidis M; Brumatti G; Narayan N; Green BD; Van Den Bergen JA; Sandow JJ; Bert AG; Silke N; Sladic R; Puthalakath H; Rohrbeck L; Okamoto T; Bouillet P; Herold MJ; Goodall GJ; Jabbour AM; Ekert PG, 2013, 'Hoxb8 regulates expression of microRNAs to control cell death and differentiation', Cell Death and Differentiation, 20, pp. 1370 - 1380, http://dx.doi.org/10.1038/cdd.2013.92

Wong NC; Ng J; Hall NE; Lunke S; Salmanidis M; Brumatti G; Ekert PG; Craig JM; Saffery R, 2013, 'Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA', Genomics, 102, pp. 38 - 46, http://dx.doi.org/10.1016/j.ygeno.2013.04.014

Hercus TR; Dhagat U; Kan WLT; Broughton SE; Nero TL; Perugini M; Sandow JJ; D'Andrea RJ; Ekert PG; Hughes T; Parker MW; Lopez AF, 2013, 'Signalling by the βc family of cytokines', Cytokine and Growth Factor Reviews, 24, pp. 189 - 201, http://dx.doi.org/10.1016/j.cytogfr.2013.03.002

Gurzeler U; Rabachini T; Dahinden CA; Salmanidis M; Brumatti G; Ekert PG; Echeverry N; Bachmann D; Simon HU; Kaufmann T, 2013, 'In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8', Allergy European Journal of Allergy and Clinical Immunology, 68, pp. 604 - 613, http://dx.doi.org/10.1111/all.12140

Thomas D; Powell JA; Green BD; Barry EF; Ma Y; Woodcock J; Fitter S; Zannettino ACW; Pitson SM; Hughes TP; Lopez AF; Shepherd PR; Wei AH; Ekert PG; Guthridge MA, 2013, 'Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival', Plos Biology, 11, http://dx.doi.org/10.1371/journal.pbio.1001515

Brumatti G; Salmanidis M; Kok CH; Bilardi RA; Sandow JJ; Silke N; Mason K; Visser J; Jabbour AM; Glaser SP; Okamoto T; Bouillet P; D'Andrea RJ; Ekert PG, 2013, 'HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia', Oncotarget, 4, pp. 1933 - 1947, http://dx.doi.org/10.18632/oncotarget.1306

Lock RB, 2013, 'Targeting acute myeloid leukemia by dual inhibition of P13K signalling and Cdk9-mediated Mcl-1 transcription', Blood, 122, pp. 738 - 748, http://dx.doi.org/10.1182/blood-2012-08-447441

Sandow JJ; Jabbour AM; Condina MR; Daunt CP; Stomski FC; Green BD; Riffkin CD; Hoffmann P; Guthridge MA; Silke J; Lopez AF; Ekert PG, 2012, 'Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death', Cell Death and Differentiation, 19, pp. 633 - 641, http://dx.doi.org/10.1038/cdd.2011.131

Hercus TR; Broughton SE; Ekert PG; Ramshaw HS; Perugini M; Grimbaldeston M; Woodcock JM; Thomas D; Pitson S; Hughes T; D'Andrea RJ; Parker MW; Lopez AF, 2012, 'The GM-CSF receptor family: Mechanism of activation and implications for disease', Growth Factors, 30, pp. 63 - 75, http://dx.doi.org/10.3109/08977194.2011.649919

Jabbour AM; Gordon L; Daunt CP; Green BD; Kok CH; D'Andrea R; Ekert PG, 2012, 'p53-dependent transcriptional responses to interleukin-3 signaling', Plos One, 7, http://dx.doi.org/10.1371/journal.pone.0031428

Hahn CN; Chong CE; Carmichael CL; Wilkins EJ; Brautigan PJ; Li XC; Babic M; Lin M; Carmagnac A; Lee YK; Kok CH; Gagliardi L; Friend KL; Ekert PG; Butcher CM; Brown AL; Lewis ID; To LB; Timms AE; Storek J; Moore S; Altree M; Escher R; Bardy PG; Suthers GK; D'Andrea RJ; Horwitz MS; Scott HS, 2011, 'Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia', Nature Genetics, 43, pp. 1012 - 1019, http://dx.doi.org/10.1038/ng.913

Ekert PG; Jabbour AM, 2011, 'Critical Evaluation of Antiepileptic Drugs in Epileptic Pregnant Women - Hungarian Experiences', The Open Cell Signaling Journal, 3, pp. 20 - 26, http://dx.doi.org/10.2174/1876390101103010020

Scott HS; Hahn CN; Carmichael CL; Wilkins EJ; Chong C-E; Brautigan PJ; Li X-C; Stankovic M; Lin M; Carmagnac A; Butcher CM; Friend KL; Ekert PG; Kok CH; Brown AL; Lewis ID; To LB; Timms AE; Storek J; Moore S; Altree M; Escher R; Bardy PG; Suthers GK; D'Andrea RJ; Horwitz MS, 2010, 'GATA2 is a New Predisposition Gene for Familial Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)', Blood, 116, pp. lba - 3, http://dx.doi.org/10.1182/blood.v116.21.lba-3.lba-3

Geest CR; Wensveen FM; Libregts SFWM; de Bruin AM; Derks IAM; Ekert PG; Labi V; Villunger A; Nolte MA; Eldering E, 2010, 'Role for BH3-Only Protein NOXA In Growth-Factor Deprivation and Early Erythropoiesis', Blood, 116, pp. 4235 - 4235, http://dx.doi.org/10.1182/blood.v116.21.4235.4235

Oberle C; Huai J; Reinheckel T; Tacke M; Rassner M; Ekert PG; Buellesbach J; Borner C, 2010, 'Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes', Cell Death and Differentiation, 17, pp. 1167 - 1178, http://dx.doi.org/10.1038/cdd.2009.214

Brumatti G; Salmanidis M; Ekert PG, 2010, 'Crossing paths: Interactions between the cell death machinery and growth factor survival signals', Cellular and Molecular Life Sciences, 67, pp. 1619 - 1630, http://dx.doi.org/10.1007/s00018-010-0288-8

Jabbour AM; Daunt CP; Green BD; Vogel S; Gordon L; Lee RS; Silke N; Pearson RB; Vandenberg CJ; Kelly PN; Nutt SL; Strasser A; Borner C; Ekert PG, 2010, 'Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation', Blood, 115, pp. 344 - 352, http://dx.doi.org/10.1182/blood-2009-07-230730

Kok CH; Brown AL; Ekert PG; D'Andrea RJ, 2010, 'Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML', Leukemia, 24, pp. 1239 - 1243, http://dx.doi.org/10.1038/leu.2010.85

Lopez AF; Hercus TR; Ekert P; Littler DR; Guthridge M; Thomas D; Ramshaw HS; Stomski F; Perugini M; D'Andrea R; Grimbaldeston M; Parker MW, 2010, 'Molecular basis of cytokine receptor activation', IUBMB Life, 62, pp. 509 - 518, http://dx.doi.org/10.1002/iub.350

Algar EM; Muscat A; Dagar V; Rickert C; Chow CW; Biegel JA; Ekert PG; Saffery R; Craig J; Johnstone RW; Ashley DM, 2009, 'Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors', Plos One, 4, http://dx.doi.org/10.1371/journal.pone.0004482

Jabbour AM; Heraud JE; Daunt CP; Kaufmann T; Sandow J; O'Reilly LA; Callus BA; Lopez A; Strasser A; Vaux DL; Ekert PG, 2009, 'Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim', Cell Death and Differentiation, 16, pp. 555 - 563, http://dx.doi.org/10.1038/cdd.2008.179

Hercus TR; Thomas D; Guthridge MA; Ekert PG; King-Scott J; Parker MW; Lopez AF, 2009, 'The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease', Blood, 114, pp. 1289 - 1298, http://dx.doi.org/10.1182/blood-2008-12-164004

Salmanidis M; Brumatti G; Jabbour AM; Green BD; Silke J; Bouillet P; Ekert PG, 2008, 'Regulated Hox Gene Expression Reveals a Novel Role for Hox Genes in Myeloid Cell Proliferation and Survival', Blood, 112, pp. 5323 - 5323, http://dx.doi.org/10.1182/blood.v112.11.5323.5323

Callus BA; Ekert PG; Heraud JE; Jabbour AM; Kotevski A; Vince JE; Silke J; Vaux DL, 2008, 'Cytoplasmic p53 is not required for PUMA-induced apoptosis [1]', Cell Death and Differentiation, 15, pp. 213 - 215, http://dx.doi.org/10.1038/sj.cdd.4402245

Callus BA; Moujallad DM; Silke J; Gerl R; Jabbour AM; Ekert PG; Vaux DL, 2008, 'Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins', Journal of Molecular Biology, 384, pp. 313 - 323, http://dx.doi.org/10.1016/j.jmb.2008.09.041

Kaufmann T; Tai L; Ekert PG; Huang DCS; Norris F; Lindemann RK; Johnstone RW; Dixit VM; Arnoult D; Strasser A, 2007, 'Response: Does Bid Play a Role in the DNA Damage Response?', Cell, 130, pp. 10 - 11, http://dx.doi.org/10.1016/j.cell.2007.06.037

Kaufmann T; Tai L; Ekert PG; Huang DCS; Norris F; Lindemann RK; Johnstone RW; Dixit VM; Strasser A, 2007, 'The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest', Cell, 129, pp. 423 - 433, http://dx.doi.org/10.1016/j.cell.2007.03.017

Mason KD; Carpinelli MR; Fletcher JI; Collinge JE; Hilton AA; Ellis S; Kelly PN; Ekert PG; Metcalf D; Roberts AW; Huang DCS; Kile BT, 2007, 'Programmed Anuclear Cell Death Delimits Platelet Life Span', Cell, 128, pp. 1173 - 1186, http://dx.doi.org/10.1016/j.cell.2007.01.037

Verhagen AM; Kratina TK; Hawkins CJ; Silke J; Ekert PG; Vaux DL, 2007, 'Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs', Cell Death and Differentiation, 14, pp. 348 - 357, http://dx.doi.org/10.1038/sj.cdd.4402001

Ekert PG; Jabbour AM; Manoharan A; Heraud JE; Yu J; Pakusch M; Michalak EM; Kelly PN; Callus B; Kiefer T; Verhagen A; Silke J; Strasser A; Borner C; Vaux DL, 2006, 'Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma', Blood, 108, pp. 1461 - 1468, http://dx.doi.org/10.1182/blood-2006-03-014209

Tan TY; Jameson JL; Campbell PE; Ekert PG; Zacharin M; Savarirayan R, 2006, 'Two sisters with IMAGe syndrome: Cytomegalic adrenal histopathology, support for autosomal recessive inheritance and literature review', American Journal of Medical Genetics Part A, 140, pp. 1778 - 1784, http://dx.doi.org/10.1002/ajmg.a.31365

Pardo J; Urban C; Galvez EM; Ekert PG; Müller U; Kwon-Chung J; Lobigs M; Müllbacher A; Wallich R; Borner C; Simon MM, 2006, 'The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice', Journal of Cell Biology, 174, pp. 509 - 519, http://dx.doi.org/10.1083/jcb.200604044

Jabbour AM; Puryer MA; Yu JY; Lithgow T; Riffkin CD; Ashley DM; Vaux DL; Ekert PG; Hawkins CJ, 2006, 'Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1', Journal of Cell Science, 119, pp. 2572 - 2582, http://dx.doi.org/10.1242/jcs.02985

Filan PM; Mills JF; Clarnette TD; Ekert H; Ekert P, 2005, 'Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: A potential role for recombinant factor VIIa', Journal of Pediatrics, 147, pp. 857 - 859, http://dx.doi.org/10.1016/j.jpeds.2005.07.034

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