By Conjoint Professor Steven krilis

Journal articles

Bester C; Shi T; Iverson GM; Cockerill KA; Linnik MD; Konecny P; Krilis S, 2004, 'B-2-glycoprotein I binds factor XI by its C-terminal domain and inhibits its activation by thrombin and factor XIIA. Plasmin cleavage of B-2-glycoprotein I abolishes its inhibition of factor XIIA activation of factor XI', Thrombosis Research, 114, pp. 608 - 609

Shi T; Iverson M; Qi JC; Cockerill KA; Linnik MD; Konecny P; Krilis S, 2004, 'B2Glycoprotein I binds Factor XI and inhibits its activation by thrombin and Factor XIIa. Loss of Inhibition by Clipped B2Glycoprotein I.', Proceedings of the National Academy of Sciences of the United States of America, 101, pp. 3939 - 3944

Miyakis S; Giannakopoulos B; Krilis S, 2004, 'Beta 2-Glycoprotein I-function in health and disease', Thrombosis Research, 114, pp. 335 - 346

Miyakis S; Robertson SA; Krilis S, 2004, 'Beta-2 glycoprotein I and its role in antiphospholipid syndrome-lessons from knockout mice', Clinical Immunology, 112, pp. 136 - 143

Robertson SA; Roberts CT; Beijering E; Pensa K; Sheng YH; Shi T; Krilis S, 2004, 'Effect of B2Glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in mice', Molecular Human Reproduction, pp. 1 - 8

Shi T; Robertson SA; Roberts CT; Beijering D; Pensa K; Sheng YH; Krilis S, 2004, 'Effect of beta(2)-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in mice', Thrombosis Research, 114, pp. 608 - 608

Robertson SA; Roberts CT; van Beijering E; Pensa K; Sheng YH; Shi T; Krilis S, 2004, 'Effect of beta(2)-glycoprotein I null mutation on reproductive outcomea and antiphospholipid antibody-mediated pregnancy pathology in mice', Molecular Human Reproduction, 10, pp. 409 - 416

Ho LH; Ruffin RE; Murgia C; Li L; Krilis S; Zalewski P, 2004, 'Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation', Journal of Immunology, 172, pp. 7750 - 7760

Passam F; Krilis S, 2004, 'Laboratory tests for the antiphospholipid syndrome', Pathology, 36, pp. 129 - 138

Renaudineau Y; Dugue C; Arvieux J; Perraut R; Krilis S; Youinou P, 2004, 'No correlations between anti-endothelial cell and anti phospholipid antibodies in a cohort of 176 leprosy patients', Thrombosis Research, 114, pp. 611 - 611

Yasuda S; Wong GW; Rossi A; Madhusudhan MS; Morokawa N; Sali A; Krilis S; Stevens RL, 2004, 'Urokinase-type plasminogen activator is a preferred substrate of thehuman epithelium serine protease tryptase epsilon/PRSS22', Federation of American Societies for Experimantal Biology Journal, 18, pp. A793 - A793

Reddel SW; Wang YX; Krilis SA, 2003, 'Anti-β2-glycoprotein I autoantibodies require an antigen density threshold, consistent with divalent binding', Lupus, 12, pp. 37 - 45, http://dx.doi.org/10.1191/0961203303lu280oa

Li Z; Krilis SA, 2003, 'Anti-β2-glycoprotein I antibodies and the antiphospholipid syndrome', Autoimmunity Reviews, 2, pp. 229 - 234, http://dx.doi.org/10.1016/S1568-9972(03)00015-6

Qi JC; Krilis SA, 2003, 'MCs/basophils in human blood - What are they and how did they get there?', Allergy and Clinical Immunology International, 15, pp. 11 - 17

Krilis S, 2003, 'Anti-.2-glycoprotein I antibodies and the antiphospholipid syndrome', Autoimmunity Reviews, 2, pp. 229 - 234

Krilis S; Reddel SW; Wang YX, 2003, 'Anti-B2-glycoprotein I autoantibodiese require an antigen density threshold, consistent with divalent binding', Lupus, 12, pp. 37 - 45

Krilis S; Lockshin M; Tenedios F; Petri M; McCarty G; Forastiero R; Tincani A; Erkan D; Khamashta MA; Shoenfeld Y, 2003, 'Cardiac disease in the antiphospholipid syndrome: recommendations for treatment. Committee consensus report', Lupus, 12, pp. 518 - 523

Wang J; Qi JC; Konecny P; Krilis SA, 2003, 'Hemopoietic cells with features of the mast cell and basophil lineages and their potential role in allergy.', Curr Drug Targets Inflamm Allergy, 2, pp. 293 - 302, http://dx.doi.org/10.2174/1568010033484034

Qi JC; Krilis S, 2003, 'MCs/Basophils in Human Blood', ACI International, 15, pp. 11 - 16

Wong GW; Foster PS; Yasuda S; Qi JC; Mahalingam S; Mellor EA; Katsoulotos G; Li LX; Boyce JA; Krilis SA; Stevens RL, 2002, 'Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase γ', JOURNAL OF BIOLOGICAL CHEMISTRY, 277, pp. 41906 - 41915, http://dx.doi.org/10.1074/jbc.M205868200

Wong GW; Foster PS; Yasuda S; Qi JC; Mahalingam S; Mellor EA; Katsoulotos G; Li X; Boyce JA; Krilis SA; Stevens RL, 2002, 'Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase γ: TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor α/signal transducer and activator of transcription (STAT) 6-dependent pathway', Journal of Biological Chemistry, 277, pp. 41906 - 41915, http://dx.doi.org/10.1074/jbc.M205868200

Qi JC; Stevens RL; Wadley R; Collins A; Cooley M; Naif HM; Nasr N; Cunningham A; Katsoulotos G; Wanigasek Y; Roufogalis B; Krilis SA, 2002, 'IL-16 regulation of human mast cells/basophils and their susceptibility to HIV-1.', J Immunol, 168, pp. 4127 - 4134, http://dx.doi.org/10.4049/jimmunol.168.8.4127

Guerin J; Sheng Y; Reddel S; Michael Iverson G; Chapman MG; Krilis SA, 2002, 'Heparin inhibits the binding of β2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome', Journal of Biological Chemistry, 277, pp. 2644 - 2649, http://dx.doi.org/10.1074/jbc.M110176200

Arvieux J; Renaudineau Y; Mane I; Perraul R; Krilis S; Youinou P, 2002, 'Distinguishing Features of Anti-2-glycoprotein 1 Antibodies between Patients with Leprasy and the Antiphospholipid Syndrome', Thrombosis and Haemostasis, 87, pp. 599 - 605

Guerin J; Sheng YH; Reddel SW; Iverson GM; Chapman MG; Krilis S, 2002, 'Heparin Inhabits the Binding of .2-glycoprotein 1 to Phospholipids and Promotes the Plasmin-mediated Inactivation of this Blood Protein', The Journal of Biological Chemistry, 277, pp. 2644 - 2649

Yang Y; Li L; Wong GW; Krilis S; Madhusudhan MS; Sali A; Stevens RL, 2002, 'RasGRP4, a New Mast Cell - Restricted Ras Guanine Nucleotide-releasing Protein with Calcium- and Diacylglycerol-binding Motifs', The Journal of Biological Chemistry, 277, pp. 25756 - 25774

Iverson GM; Reddel SW; Victoria EJ; Cockerill KA; Wang YX; Marti-Renom MA; Sali A; Marquis DM; Krilis S; Linnik MD, 2002, 'Use of Single Point Mutations in Domain I of B2-Glycoprotein I to Determine Fine Antigenic Specifity of Antiphospholipid Autoantibodies', Journal of Immunology, pp. 7097 - 7103

Sheng Y; Hanly JG; Reddel SW; Kouts S; Guerin J; Koike T; Ichikawa K; Sturgess A; Krilis SA, 2001, 'Detection of 'antiphospholipid' antibodies: A single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants, anticardiolipin antibodies, plus antibodies binding β 2-glycoprotein I and prothrombin', Clinical and Experimental Immunology, 124, pp. 502 - 508, http://dx.doi.org/10.1046/j.1365-2249.2001.01555.x

Li Y; Li L; Wadley R; Reddel SW; Qi JC; Archis C; Collins A; Clark E; Cooley M; Kouts S; Naif HM; Alali M; Cunningham A; Wong GW; Stevens RL; Krilis SA, 2001, 'Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4.', Blood, 97, pp. 3484 - 3490, http://dx.doi.org/10.1182/blood.v97.11.3484

Sheng Y; Reddel SW; Herzog H; Wang YX; Brighton T; France MP; Krilis SA, 2001, 'Impaired In vitro thrombin generation in beta 2-glycoprotein I null mice', ARTHRITIS RESEARCH & THERAPY, 3, http://dx.doi.org/10.1186/ar248

Qi JC; Li L; Krilis S, 2001, 'Cells with features of mast cells and basophils', Allergy and Clinical Immunology International, 13, pp. 197 - 202

Wong GW; Yasuda S; Madhusudhan MS; Yang Y; Krilis S; Li L; Sali A; Stevens RL, 2001, 'Human Tryptas essilon (PRSS26), a new member of the Chromosome 16p13.3 family of human serine proteases expressed in airway epithelian cells', The Journal of Biological Chemistry, pp. 49169 - 49182

Sheng YH; Reddel SW; Herzog H; Brighton TA; France MP; Robertson SL; Krilis S; Wang YX, 2001, 'Impaired thrombin generation in Beta 2-gylcoprotein I null mice', The Journal of Biological Chemistry, pp. 13817 - 13821

Wong GW; Li L; Madhusudhan MS; Krilis S; Gurish MF; Rothenberg ME; Sali A; Stevens RL, 2001, 'Tryptase 4, a new member of the chromosome 17 family of mouse serine proteases', The Journal of Biological Chemistry, pp. 20648 - 20658

Li Y; Li L; Wadley R; Reddel S; Qi J; Archis C; Collins A; Clark E; Cooley M; Kouts S; Hassan N; Mohammed A; Cunningham A; Wong G; Stevens R; Krilis S, 2000, 'Identification of a novel population of mast cells/basophils in human periphal blood of allergic patients which is HIV-1 susceptible due to its surface expression of CD4, CCR5, and CXCR4', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 105, pp. S86 - S87, http://dx.doi.org/10.1016/S0091-6749(00)90690-0

Wong G; Krilis S; Stevens R, 2000, 'Identification, cloning, and expression of a new human and mouse tryptase', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 105, pp. S89 - S89, http://dx.doi.org/10.1016/S0091-6749(00)90697-3

Reddel SW; Wang Y; Sheng YH; Krilis S, 2000, 'Epitope studies with anti-beta 2-glycoprotein I antibodies from autoantibody and immunized sources', Journal of Autoimmunity, 15, pp. 91 - 96

Li L; Li Y; Krilis SA, 1999, 'Monoclonal antibodies recognizing antigens expressed in human mast cells and their progenitors', FASEB JOURNAL, 13, pp. A337 - A337, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000082033301949&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li L; Li Y; Reddel SW; Cherrian M; Friend DS; Stevens RL; Krilis SA, 1999, 'Cells that have features of both mast cells and basophils in the peripheral blood of allergy, asthma, and drug reactive', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 103, pp. S43 - S43, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000078509000169&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li L; Krilis SA, 1999, 'Mast-cell growth and differentiation', Allergy European Journal of Allergy and Clinical Immunology, 54, pp. 306 - 313, http://dx.doi.org/10.1034/j.1398-9995.1999.00086.x

Li L; Li Y; Krilis SA, 1999, 'Monoclonal antibodies recognizing antigens expressed in human mast cells and their progenitors.', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 103, pp. S43 - S43, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000078509000170&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Reddel SW; Krilis SA, 1999, 'Testing for and clinical significance of anticardiolipin antibodies', Clinical and Diagnostic Laboratory Immunology, 6, pp. 775 - 782, http://dx.doi.org/10.1128/cdli.6.6.775-782.1999

Huang C; Li L; Krilis SA; Chanasyk K; Tang Y; Li Z; Hunt JE; Stevens RL, 1999, 'Human Tryptases α and β/II Are Functionally Distinct Due, in Part, to a Single Amino Acid Difference in One of the Surface Loops That Forms the Substrate-binding Cleft', Journal of Biological Chemistry, 274, pp. 19670 - 19676, http://dx.doi.org/10.1074/jbc.274.28.19670

Wong GW; Tang Y; E F; Sali A; Li L; Li YW; Huang C; Friend DS; Krilis S; Stevens RL, 1999, 'Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension', The Journal of Biological Chemistry, pp. 30784 - 30793

Sheng Y; Kandiah DA; Krilis SA, 1998, 'Anti-β2-glycoprotein I autoantibodies from patients with the 'antiphospholipid' syndrome bind to β2-glycoprotein I with low affinity: Dimerization of β2-glycoprotein I induces a significant increase in anti- β2-glycoprotein I antibody affinity', Journal of Immunology, 161, pp. 2038 - 2043, http://dx.doi.org/10.4049/jimmunol.161.4.2038

Kandiah DA; Krilis SA, 1998, 'Anti-β2-glycoprotein I and anti-prothrombin antibodies in patients with the 'antiphospholipid' syndrome: Immunological specificity and clotting profiles', Lupus, 7, pp. 323 - 332, http://dx.doi.org/10.1191/096120398678920253

Tsutsumi A; Ichikawa K; Atsumi T; Matsuura E; Koike T; Krilis SA, 1998, 'Use of various methods for anticardiolipin detection in the updated American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus: Comment on the letter by Hochberg [1]', Arthritis and Rheumatism, 41, pp. 1326 - 1327, http://dx.doi.org/10.1002/1529-0131(199807)41:7<1326::AID-ART29>3.0.CO;2-4

Del Papa N; Sheng YH; Raschi E; Kandiah DA; Tincani A; Khamashta MA; Atsumi T; Hughes GRV; Ichikawa K; Koike T; Balestrieri G; Krilis SA; Meroni PL, 1998, 'Human β2-glycoprotein I binds to endothelial cells through a cluster of lysine residues that are critical for anionic phospholipid binding and offers epitopes for anti-β2-glycoprotein I antibodies', Journal of Immunology, 160, pp. 5572 - 5578, http://dx.doi.org/10.4049/jimmunol.160.11.5572

Vlachoyiannopoulos PG; Petrovas C; Tektonidou M; Krilis S; Moutsopoulos HM, 1998, 'Antibodies to β2-glycoprotein-I: Urea resistance, binding specificity, and association with thrombosis', Journal of Clinical Immunology, 18, pp. 380 - 391, http://dx.doi.org/10.1023/A:1023274505128

Sheng Y; Kandiah DA; Krilis SA, 1998, 'β2-Glycoprotein I : Target antigen for 'antiphospholipid' antibodies. Immunological and molecular aspects', Lupus, 7, pp. S5 - S9, http://dx.doi.org/10.1177/096120339800700202

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