Select Publications
Book Chapters
2014, 'Lipidomics in Breast Cancer', in Barh D (ed.), Omics Approaches in Breast Cancer: Towards Next-Generation Diagnosis, Prognosis and Therapy, Springer, India
,Journal articles
2024, 'Abstract B007: High-risk pediatric cancer models in zebrafish, mouse and short-term culture predict individual patient responses to therapy', Cancer Research, 84, pp. B007 - B007, http://dx.doi.org/10.1158/1538-7445.pediatric24-b007
,2024, 'Erratum: miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma (Molecular Therapy (2022) 30(3) (1119–1134), (S1525001622000041), (10.1016/j.ymthe.2022.01.004))', Molecular Therapy, 32, pp. 2031 - 2033, http://dx.doi.org/10.1016/j.ymthe.2024.05.008
,2024, 'Preclinical assessment of combined BCL-2 and MCL-1 inhibition in high-risk neuroblastoma', EJC Paediatric Oncology, 3, http://dx.doi.org/10.1016/j.ejcped.2024.100168
,2024, 'Abstract 5475: Development of high-throughput 3D bioprinted pediatric models for precision medicine', Cancer Research, 84, pp. 5475 - 5475, http://dx.doi.org/10.1158/1538-7445.am2024-5475
,2024, 'Generation of Orthotopic and Subcutaneous Patient-Derived Xenograft Models from Diverse Clinical Tissue Samples of Pediatric Extracranial Solid Tumors', , 2806, pp. 55 - 74, http://dx.doi.org/10.1007/978-1-0716-3858-3_6
,2023, 'High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer', Cancer Research, 83, pp. 2716 - 2732, http://dx.doi.org/10.1158/0008-5472.CAN-22-3702
,2023, 'Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma', Science Advances, 9, http://dx.doi.org/10.1126/sciadv.abp8314
,2022, 'In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer', EMBO Molecular Medicine, 14, pp. emmm202114608, http://dx.doi.org/10.15252/emmm.202114608
,2022, 'Suppression of the ABCA1 Cholesterol Transporter Impairs the Growth and Migration of Epithelial Ovarian Cancer', Cancers, 14, pp. 1878, http://dx.doi.org/10.3390/cancers14081878
,2022, 'miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma', Molecular Therapy, 30, pp. 1119 - 1134, http://dx.doi.org/10.1016/j.ymthe.2022.01.004
,2021, 'Dual targeting of chromatin stability by the curaxin CBL0137 and histone deacetylase inhibitor panobinostat shows significant preclinical efficacy in neuroblastoma', Clinical Cancer Research, 27, pp. 4338 - 4352, http://dx.doi.org/10.1158/1078-0432.CCR-20-2357
,2021, 'Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors', Cell Death and Disease, 12, pp. 268, http://dx.doi.org/10.1038/s41419-020-03269-0
,2021, 'Targeted therapy of TERT-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy', Clinical Cancer Research, 27, pp. 1438 - 1451, http://dx.doi.org/10.1158/1078-0432.CCR-20-3044
,2021, 'The important role of routine cytopathology in pediatric precision oncology', Cancer Cytopathology, 129, pp. 805 - 818, http://dx.doi.org/10.1002/cncy.22448
,2021, 'Whole-genome sequencing facilitates patient-specific quantitative PCR-based minimal residual disease monitoring in acute lymphoblastic leukaemia, neuroblastoma and Ewing sarcoma', British Journal of Cancer, 126, pp. 482 - 491, http://dx.doi.org/10.1038/s41416-021-01538-z
,2020, 'Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN-amplified neuroblastoma', International Journal of Cancer, 147, pp. 1928 - 1938, http://dx.doi.org/10.1002/ijc.32936
,2020, 'Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression', Cancer Research, 80, pp. 3706 - 3718, http://dx.doi.org/10.1158/0008-5472.CAN-19-3914
,2020, 'Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivation', Theranostics, 10, pp. 6411 - 6429, http://dx.doi.org/10.7150/thno.42602
,2020, 'CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth', Biochemical Pharmacology, 172, pp. 113770, http://dx.doi.org/10.1016/j.bcp.2019.113770
,2020, 'Mouse models of high-risk neuroblastoma', Cancer and Metastasis Reviews, http://dx.doi.org/10.1007/s10555-020-09855-0
,2020, 'Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy', British Journal of Cancer, 122, pp. 680 - 691, http://dx.doi.org/10.1038/s41416-019-0682-4
,2019, 'Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma', Science Translational Medicine, 11, http://dx.doi.org/10.1126/scitranslmed.aau1099
,2015, 'TPD52 expression increases neutral lipid storage within cultured cells', Journal of Cell Science, 128, pp. 3223 - 3238, http://dx.doi.org/10.1242/jcs.167692
,2013, 'Tumor protein D52 represents a negative regulator of ATM protein levels', Cell Cycle, 12, pp. 3083 - 3097, http://dx.doi.org/10.4161/cc.26146
,2013, 'Dietary Sphingomyelin Lowers Hepatic Lipid Levels and Inhibits Intestinal Cholesterol Absorption in High-Fat-Fed Mice', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0055949
,2012, 'Abstract 439: Dietary Sphingomyelin Lowers Hepatic Lipids by Inhibiting Intestinal Cholesterol Absorption in High-Fat-Fed Mice', Arteriosclerosis, Thrombosis, and Vascular Biology, 32, http://dx.doi.org/10.1161/atvb.32.suppl_1.a439
,2010, 'Hepatic accumulation of intestinal cholesterol is decreased and fecal cholesterol excretion is increased in mice fed a high-fat diet supplemented with milk phospholipids', Nutrition and Metabolism, 7, http://dx.doi.org/10.1186/1743-7075-7-90
,2010, 'Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet', Atherosclerosis, 213, pp. 142 - 147, http://dx.doi.org/10.1016/j.atherosclerosis.2010.07.050
,2010, 'Reduction in intestinal cholesterol absorption by various food components: Mechanisms and implications', Atherosclerosis Supplements, 11, pp. 45 - 48, http://dx.doi.org/10.1016/j.atherosclerosissup.2010.04.004
,2010, 'Dietary krill oil significantly reduces hepatic steatosis, glycaemia and hypercholesterolaemia in high-fat-fed mice', PROCEEDINGS OF THE NUTRITION SOCIETY, 69, pp. E48 - E48, http://dx.doi.org/10.1017/S0029665109992369
,2010, 'Dietary phospholipids and intestinal cholesterol absorption', Nutrients, 2, pp. 116 - 127, http://dx.doi.org/10.3390/nu2020116
,2010, 'P264 DIETARY MILK PHOSPHOLIPID IMPROVES DIET-INDUCED HEPATIC STEATOSIS IN MICE BY REDUCING INTESTINAL CHOLESTEROL ABSORPTION', Atherosclerosis Supplements, 11, pp. 72 - 72, http://dx.doi.org/10.1016/s1567-5688(10)70331-7
,2009, 'Dietary Krill Oil Supplementation Reduces Hepatic Steatosis, Glycemia, and Hypercholesterolemia in High-Fat-Fed Mice', JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 57, pp. 9339 - 9345, http://dx.doi.org/10.1021/jf9016042
,2009, 'Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high-fat diet', Atherosclerosis, 205, pp. 144 - 150, http://dx.doi.org/10.1016/j.atherosclerosis.2008.12.004
,2009, 'Abstract: 1031 DIETARY KRILL OIL SUPPLEMENTATION SIGNIFICANTLY REDUCES HEPATOMEGALY, HEPATIC STEATOSIS AND HYPERCHOLESTEROLEMIA IN HIGH-FAT FED MICE', Atherosclerosis Supplements, 10, pp. e395 - e395, http://dx.doi.org/10.1016/s1567-5688(09)70387-3
,2009, 'Abstract: 601 DIETARY MILK PHOSPHOLIPID AS A CARDIOVASCULAR NUTRACEUTICAL', Atherosclerosis Supplements, 10, pp. e354 - e354, http://dx.doi.org/10.1016/s1567-5688(09)70350-2
,2008, 'Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease', Current Opinion in Lipidology, 19, pp. 257 - 262, http://dx.doi.org/10.1097/MOL.0b013e3282ffaf96
,2007, 'Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation', The Journal of Biological Chemistry, 282, pp. 2851 - 2861
,Conference Papers
2021, 'Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR', in Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR, American Association for Cancer Research (AACR), pp. 639 - 639, presented at AACR 2021, http://dx.doi.org/10.1158/1538-7445.AM2021-639
,2014, 'The target and the targeted-Tumor protein D52 (TPD52) and cancer', in INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBL LTD, pp. S39 - S39, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341276000139&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2010, 'DIETARY MILK PHOSPHOLIPID IMPROVES DIET-INDUCED HEPATIC STEATOSIS IN MICE BY REDUCING INTESTINAL CHOLESTEROL ABSORPTION', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, GERMANY, Hamburg, pp. 72 - 72, presented at 78th Congress of the European-Atherosclerosis-Society, GERMANY, Hamburg, 20 June 2010 - 23 June 2010, http://dx.doi.org/10.1016/j.atherosclerosissup.2010.04.022
,2010, 'Dietary Milk Phospholipid Improves Diet-Induced Hepatic Steatosis In Mice By Reducing Intestinal Cholesterol Absorption', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, NETHERLANDS, Rotterdam, pp. 72 - 73, presented at 2nd International Symposium of Chylomicrons in Disease, NETHERLANDS, Rotterdam, 02 June 2010 - 05 June 2010, http://dx.doi.org/10.1016/j.atherosclerosissup.2010.04.022
,2010, 'Dietary Milk Phospholipid Improves Diet-Induced Hepatic Steatosis in Mice by Reducing Intestinal Cholesterol Absorption', in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, CA, San Francisco, pp. E241 - E241, presented at Scientific Sessions on Arteriosclerosis, Thrombosis and Vascular Biology, CA, San Francisco, 08 April 2010 - 10 April 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283234800267&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2009, 'DIETARY KRILL OIL SUPPLEMENTATION SIGNIFICANTLY REDUCES HEPATOMEGALY, HEPATIC STEATOSIS AND HYPERCHOLESTEROLEMIA IN HIGH-FAT FED MICE', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957101042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2009, 'DIETARY MILK PHOSPHOLIPID AS A CARDIOVASCULAR NUTRACEUTICAL', in ATHEROSCLEROSIS SUPPLEMENTS, ELSEVIER IRELAND LTD, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207957101001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,Conference Abstracts
2023, 'Abstract 4670: True bench-to-bedside science: An international pilot study modeling hard-to-cure pediatric cancers to prioritize therapeutic intervention', in Cancer Research, American Association for Cancer Research (AACR), Vol. 83, pp. 4670 - 4670, http://dx.doi.org/10.1158/1538-7445.am2023-4670
,2020, 'Abstract A35: P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), Vol. 80, pp. A35 - A35, http://dx.doi.org/10.1158/1538-7445.pedca19-a35
,2019, 'Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 23 - 24, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2019, 'P-Glycoprotein is a resistance mechanism for conventional induction chemotherapy but not ALK inhibitors in high-risk neuroblastoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CANADA, Montreal, Vol. 80, pp. 61 - 61, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, CANADA, Montreal, 17 September 2019 - 20 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
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