By Dr Anbu Thalamuthu

Journal articles

Zakharov S; Salim A; Thalamuthu A, 2013, 'Comparison of similarity-based tests and pooling strategies for rare variants', BMC Genomics, 14, http://dx.doi.org/10.1186/1471-2164-14-50

Sachdev PS; Lee T; Wen W; Ames D; Batouli AH; Bowden J; Brodaty H; Chong E; Crawford J; Kang K; Mather K; Lammel A; Slavin MJ; Thalamuthu A; Trollor J; Wright MJ, 2013, 'The contribution of twins to the study of cognitive ageing and dementia: The Older Australian Twins Study', International Review of Psychiatry, 25, pp. 738 - 747, http://dx.doi.org/10.3109/09540261.2013.870137

Sandhu KS; Li G; Poh HM; Quek YLK; Sia YY; Peh SQ; Mulawadi FH; Lim J; Sikic M; Menghi F; Thalamuthu A; Sung WK; Ruan X; Fullwood MJ; Liu E; Csermely P; Ruan Y, 2012, 'Large-Scale Functional Organization of Long-Range Chromatin Interaction Networks', Cell Reports, 2, pp. 1207 - 1219, http://dx.doi.org/10.1016/j.celrep.2012.09.022

Ng KP; Hillmer AM; Chuah CTH; Juan WC; Ko TK; Teo ASM; Ariyaratne PN; Takahashi N; Sawada K; Fei Y; Soh S; Lee WH; Huang JWJ; Allen JC; Woo XY; Nagarajan N; Kumar V; Thalamuthu A; Poh WT; Ang AL; Mya HT; How GF; Yang LY; Koh LP; Chowbay B; Chang CT; Nadarajan VS; Chng WJ; Than H; Lim LC; Goh YT; Zhang S; Poh D; Tan P; Seet JE; Ang MK; Chau NM; Ng QS; Tan DSW; Soda M; Isobe K; Nöthen MM; Wong TY; Shahab A; Ruan X; Cacheux-Rataboul V; Sung WK; Tan EH; Yatabe Y; Mano H; Soo RA; Chin TM; Lim WT; Ruan Y; Ong ST, 2012, 'A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer', Nature Medicine, 18, pp. 521 - 528, http://dx.doi.org/10.1038/nm.2713

Gupta A; Nagilla P; Le H-S; Bunney C; Zych C; Thalamuthu A; Bar-Joseph Z; Mathavan S; Ayyavoo V, 2012, 'Retraction: Comparative Expression Profile of miRNA and mRNA in Primary Peripheral Blood Mononuclear Cells Infected with Human Immunodeficiency Virus (HIV-1)', PLOS ONE, 7, pp. 10.1371/annotation/d28d38b2-41a3-42a6-b421-68f9460a676d, http://dx.doi.org/10.1371/annotation/d28d38b2-41a3-42a6-b421-68f9460a676d

Hillmer AM; Ng K-P; Chuah C; Juan WC; Ko T-K; Teo ASM; Ariyaratne PN; Takahashi N; Sawada K; Fei Y; Lee WH; Huang W; Allen JC; Woo XY; Nagarajan N; Kumar V; Thalamuthu A; Poh WT; Ang AL; Mya HT; How GF; Yang LY; Koh LP; Nadarajan VS; Chng W-J; Than H; Lim LC; Goh Y-T; Nöthen MM; Wong TY; Shahab A; Ruan X; Cacheux-Rataboul V; Sung W-K; Ruan Y; Ong ST, 2011, 'A Common Deletion Polymorphism in the BIM Gene Contributes to Intrinsic Imatinib Resistance in Chronic Myelogenous Leukemia', Blood, 118, pp. 1666, http://dx.doi.org/10.1182/blood.v118.21.1666.1666

Png E; Thalamuthu A; Ong RTH; Snippe H; Boland GJ; Seielstad M, 2011, 'A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region', Human Molecular Genetics, 20, pp. 3893 - 3898, http://dx.doi.org/10.1093/hmg/ddr302

Low HQ; Chen CPLH; Kasiman K; Thalamuthu A; Ng SS; Foo JN; Chang HM; Wong MC; Tai ES; Liu J, 2011, 'A comprehensive association analysis of homocysteine metabolic pathway genes in singaporean Chinese with ischemic stroke', Plos One, 6, http://dx.doi.org/10.1371/journal.pone.0024757

Liu T; Thalamuthu A; Liu JJ; Chen C; Wang Z; Wu R, 2011, 'Asymptotic distribution for epistatic tests in case-control studies', Genomics, 98, pp. 145 - 151, http://dx.doi.org/10.1016/j.ygeno.2011.05.001

Thalamuthu A; Khor CC; Venkataraman D; Koh LW; Tan DTH; Aung T; Mehta JS; Vithana EN, 2011, 'Association of TCF4 gene polymorphisms with Fuchs' corneal dystrophy in the Chinese', Investigative Ophthalmology and Visual Science, 52, pp. 5573 - 5578, http://dx.doi.org/10.1167/iovs.11-7568

Teo SM; Pawitan Y; Kumar V; Thalamuthu A; Seielstad M; Chia KS; Salim A, 2011, 'Multi-platform segmentation for joint detection of copy number variants', Bioinformatics, 27, pp. 1555 - 1561, http://dx.doi.org/10.1093/bioinformatics/btr162

Li J; Humphreys K; Heikkinen T; Aittomäki K; Blomqvist C; Pharoah PDP; Dunning AM; Ahmed S; Hooning MJ; Martens JWM; Van Den Ouweland AMW; Alfredsson L; Palotie A; Peltonen-Palotie L; Irwanto A; Low HQ; Teoh GHK; Thalamuthu A; Easton DF; Nevanlinna H; Liu J; Czene K; Hall P, 2011, 'A combined analysis of genome-wide association studies in breast cancer', Breast Cancer Research and Treatment, 126, pp. 717 - 727, http://dx.doi.org/10.1007/s10549-010-1172-9

Sng CCA; Cackett PD; Yeo IY; Thalamuthu A; Venkatraman A; Venkataraman D; Koh AH; Tai ES; Wong TY; Aung T; Vithana EN, 2011, 'Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects', Ophthalmic Research, 45, pp. 191 - 196, http://dx.doi.org/10.1159/000321387

Amerasinghe N; Zhang J; Thalamuthu A; He M; Vithana EN; Viswanathan A; Wong TY; Foster PJ; Aung T, 2011, 'The heritability and sibling risk of angle closure in Asians', Ophthalmology, 118, pp. 480 - 485, http://dx.doi.org/10.1016/j.ophtha.2010.06.043

Zhao J; Gupta S; Seielstad M; Liu J; Thalamuthu A, 2011, 'Pathway-based analysis using reduced gene subsets in genome-wide association studies', BMC Bioinformatics, 12, http://dx.doi.org/10.1186/1471-2105-12-17

Gupta A; Nagilla P; Le HS; Bunney C; Zych C; Thalamuthu A; Bar-Joseph Z; Mathavan S; Ayyavoo V, 2011, 'Comparative expression profile of miRNA and mRNA In primary peripheral blood mononuclear cells infected with human immunodeficiency virus (HIV-1)', Plos One, 6, http://dx.doi.org/10.1371/journal.pone.0022730

Chan SL; Thalamuthu A; Goh BC; Chia KS; Chuah B; Wong A; Lee SC, 2011, 'Exon sequencing and association analysis of EPHX1 genetic variants with maintenance warfarin dose in a multiethnic Asian population', Pharmacogenetics and Genomics, 21, pp. 35 - 41, http://dx.doi.org/10.1097/FPC.0b013e328341b68f

Thalamuthu A; Zhao J; Keong GTH; Kondragunta V; Mukhopadhyay I, 2011, 'Association tests for rare and common variants based on genotypic and phenotypic measures of similarity between individuals', BMC Proceedings, 5, pp. s89, http://dx.doi.org/10.1186/1753-6561-5-s9-s89

Zhao J; Thalamuthu A, 2011, 'Gene-based multiple trait analysis for exome sequencing data', BMC Proceedings, 5, pp. s75, http://dx.doi.org/10.1186/1753-6561-5-s9-s75

Png E; Thalamuthu A; Ong RTH; Snippe H; Sudoyo H; Muljono DH; Marzuki S; Boland GJ; Seielstad M, 2011, 'Genetic determinants of hepatitis B vaccine response', BMC Proceedings, 5, http://dx.doi.org/10.1186/1753-6561-5-s1-o3

Liu T; Thalamuthu A, 2011, 'Identity by descent and association analysis of dichotomous traits based on large pedigrees', BMC Proceedings, 5, pp. s31, http://dx.doi.org/10.1186/1753-6561-5-s9-s31

Li J; Humphreys K; Darabi H; Rosin G; Hannelius U; Heikkinen T; Aittomäki K; Blomqvist C; Pharoah PDP; Dunning AM; Ahmed S; Hooning MJ; Hollestelle A; Oldenburg RA; Alfredsson L; Palotie A; Peltonen-Palotie L; Irwanto A; Low HQ; Teoh GHK; Thalamuthu A; Kere J; D'Amato M; Easton DF; Nevanlinna H; Liu J; Czene K; Hall P, 2010, 'A genome-wide association scan on estrogen receptor-negative breast cancer', Breast Cancer Research, 12, http://dx.doi.org/10.1186/bcr2772

Low YL; Li Y; Humphreys K; Thalamuthu A; Li Y; Darabi H; Wedrén S; Bonnard C; Czene K; Iles MM; Heikkinen T; Aittomäki K; Blomqvist C; Nevanlinna H; Hall P; Liu ET; Liu J, 2010, 'Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility.', PLoS genetics, 6, http://dx.doi.org/10.1371/journal.pgen.1001012

Low YL; Li Y; Humphreys K; Thalamuthu A; Li Y; Darabi H; Wedrén S; Bonnard C; Czene K; Iles MM; Heikkinen T; Aittomäki K; Blomqvist C; Nevanlinna H; Hall P; Liu ET; Liu J, 2010, 'Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility', Plos Genetics, 6, pp. 1 - 8, http://dx.doi.org/10.1371/journal.pgen.1001012

Mukhopadhyay I; Feingold E; Weeks DE; Thalamuthu A, 2010, 'Association tests using kernel-based measures of multi-locus genotype similarity between individuals', Genetic Epidemiology, 34, pp. 213 - 221, http://dx.doi.org/10.1002/gepi.20451

Lee KYC; Ho SL; Thalamuthu A; Venkatraman A; Venkataraman D; Pek DCK; Aung T; Vithana EN, 2009, 'Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese', Molecular Vision, 15, pp. 1120 - 1126

Burgner D; Davila S; Breunis WB; Ng SB; Li Y; Bonnard C; Ling L; Wright VJ; Thalamuthu A; Odam M; Shimizu C; Burns JC; Levin M; Kuijpers TW; Hibberd ML; Christiansen F; Witt C; Goldwater P; Curtis N; Palasanthiran P; Ziegler J; Nissan M; Nourse C; Kuipers IM; Ottenkamp JJ; Geissler J; Biezeveld M; Filippini L; Brogan P; Klein N; Shah V; Dillon M; Booy R; Shingadia D; Bose A; Mukasa T; Tulloh R; Michie C; Shike H; Nievergelt CM; Schork NJ; Newburger JW; Baker AL; Sundel RP; Rowley AH; Shulman ST, 2009, 'A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease', Plos Genetics, 5, http://dx.doi.org/10.1371/journal.pgen.1000319

Ozaki M; Lee KYC; Vithana EN; Yong VH; Thalamuthu A; Mizoguchi T; Venkatraman A; Aung T, 2008, 'Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese', Investigative Ophthalmology and Visual Science, 49, pp. 3976 - 3980, http://dx.doi.org/10.1167/iovs.08-1805

Aung T; Lim MCC; Wong TTL; Thalamuthu A; Yong VHK; Venkataraman D; Venkatraman A; Chew PTK; Vithana EN, 2008, 'Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes', Molecular Vision, 14, pp. 1313 - 1318

Hill SY; Hoffman EK; Zezza N; Thalamuthu A; Weeks DE; Matthews AG; Mukhopadhyay I, 2008, 'Dopaminergic mutations: Within-family association and linkage in multiplex alcohol dependence families', American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 147, pp. 517 - 526, http://dx.doi.org/10.1002/ajmg.b.30630

Lee KY; Vithana EN; Mathur R; Yong VH; Yeo IY; Thalamuthu A; Lee MW; Koh AH; Lim MC; How AC; Wong DW; Aung T, 2008, 'Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy', Investigative Ophthalmology and Visual Science, 49, pp. 2613 - 2619, http://dx.doi.org/10.1167/iovs.07-0860

Plenge RM; Seielstad M; Padyukov L; Lee AT; Remmers EF; Ding B; Liew A; Khalili H; Chandrasekaran A; Davies LRL; Li W; Tan AKS; Bonnard C; Ong RTH; Thalamuthu A; Pettersson S; Liu C; Tian C; Chen WV; Carulli JP; Beckman EM; Altshuler D; Alfredsson L; Criswell LA; Amos CI; Seldin MF; Kastner DL; Klareskog L; Gregersen PK, 2007, 'TRAF1-C5 as a risk locus for rheumatoid arthritis - A genomewide study', New England Journal of Medicine, 357, pp. 1199 - 1209, http://dx.doi.org/10.1056/NEJMoa073491

Thalamuthu A; Mukhopadhyay I; Zheng X; Tseng GC, 2006, 'Evaluation and comparison of gene clustering methods in microarray analysis', Bioinformatics, 22, pp. 2405 - 2412, http://dx.doi.org/10.1093/bioinformatics/btl406

Thalamuthu A; Mukhopadhyay I; Ray A; Weeks DE, 2005, 'A comparison between microsatellite and single-nucleotide polymorphism markers with respect to two measures of information content', BMC Genetics, 6, http://dx.doi.org/10.1186/1471-2156-6-S1-S27

Conley YP; Thalamuthu A; Jakobsdottir J; Weeks DE; Mah T; Ferrell RE; Gorin MB, 2005, 'Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy', Human Molecular Genetics, 14, pp. 1991 - 2002, http://dx.doi.org/10.1093/hmg/ddi204

Vengadesan K; Anbupalam T; Gautham N, 2004, 'An application of experimental design using mutually orthogonal Latin squares in conformational studies of peptides', Biochemical and Biophysical Research Communications, 316, pp. 731 - 737, http://dx.doi.org/10.1016/j.bbrc.2004.02.114

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