By Dr Angelica Marie Merlot

Journal articles

Porter GM; Norris M; Apte M; Merlot A, 2024, 'Abstract C018: Spatial profiling of tumor associated cells expressing endoplasmic reticulum stress proteins predicts poor outcomes in pancreatic cancer patients', Cancer Research, 84, pp. C018 - C018, http://dx.doi.org/10.1158/1538-7445.panca2023-c018

Merlot AM; Porter GM; Sahni S; Lim EG; Peres P; Richardson DR, 2019, 'The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865, pp. 2094 - 2110, http://dx.doi.org/10.1016/j.bbadis.2019.04.007

Seebacher NA; Stacy AE; Porter GM; Merlot AM, 2019, 'Clinical development of targeted and immune based anti-cancer therapies', Journal of Experimental and Clinical Cancer Research, 38, http://dx.doi.org/10.1186/s13046-019-1094-2

Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Sahni S; Huang MLH; Lane DJR; Lok H; Richardson DR, 2019, 'Exploiting cancer metal metabolism using anti-cancer metal- binding agents', Current Medicinal Chemistry, 26, pp. 302 - 322, http://dx.doi.org/10.2174/0929867324666170705120809

Merlot A; Shafie N; Lim E; Chen A; Sahni S; Yu Y; Richardson D, 2018, 'Cellular metal sequestration and redox stress by thiosemicarbazones induces endoplasmic reticulum stress in tumors to suppress cancer progression', FREE RADICAL BIOLOGY AND MEDICINE, 120, pp. S37 - S37, http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.126

Merlot AM; Sahni S; Lane DJR; Richardsons V; Huang MLH; Kalinowski DS; Richardson DR, 2016, 'Letter to the editor: “Analysis of the interaction of Dp44mt with human serum albumin and calf thymus dna using molecular docking and spectroscopic techniques”', International Journal of Molecular Sciences, 17, http://dx.doi.org/10.3390/ijms17111916

Gutierrez EM; Seebacher NA; Arzuman L; Kovacevic Z; Lane DJR; Richardson V; Merlot AM; Lok H; Kalinowski DS; Sahni S; Jansson PJ; Richardson DR, 2016, 'Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 1665 - 1681, http://dx.doi.org/10.1016/j.bbamcr.2016.04.017

Merlot AM; Shafie NH; Yu Y; Richardson V; Jansson PJ; Sahni S; Lane DJR; Kovacevic Z; Kalinowski DS; Richardson DR, 2016, 'Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase', Biochemical Pharmacology, 109, pp. 27 - 47, http://dx.doi.org/10.1016/j.bcp.2016.04.001

Kalinowski DS; Stefani C; Toyokuni S; Ganz T; Anderson GJ; Subramaniam NV; Trinder D; Olynyk JK; Chua A; Jansson PJ; Sahni S; Lane DJR; Merlot AM; Kovacevic Z; Huang MLH; Lee CS; Richardson DR, 2016, 'Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 727 - 748, http://dx.doi.org/10.1016/j.bbamcr.2016.01.026

Paluncic J; Kovacevic Z; Jansson PJ; Kalinowski D; Merlot AM; Huang MLH; Lok HC; Sahni S; Lane DJR; Richardson DR, 2016, 'Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 770 - 784, http://dx.doi.org/10.1016/j.bbamcr.2016.01.025

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, 12, pp. 1 - 222, http://dx.doi.org/10.1080/15548627.2015.1100356

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356', Autophagy, 12, pp. 443, http://dx.doi.org/10.1080/15548627.2016.1147886

Chiang S; Kovacevic Z; Sahni S; Lane DJR; Merlot AM; Kalinowski DS; Huang MLH; Richardson DR, 2016, 'Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia', Clinical Science, 130, pp. 853 - 870, http://dx.doi.org/10.1042/CS20160072

Jansson PJ; Kalinowski DS; Lane DJR; Kovacevic Z; Seebacher NA; Fouani L; Sahni S; Merlot AM; Richardson DR, 2015, 'The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones', Pharmacological Research, 100, pp. 255 - 260, http://dx.doi.org/10.1016/j.phrs.2015.08.013

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Lane DJR; Merlot AM; Huang MLH; Bae DH; Jansson PJ; Sahni S; Kalinowski DS; Richardson DR, 2015, 'Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease', Biochimica et Biophysica Acta - Molecular Cell Research, 1853, pp. 1130 - 1144, http://dx.doi.org/10.1016/j.bbamcr.2015.01.021

Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Lane DJ; Huang MLH; Sahni S; Richardson DR, 2015, 'Making a case for albumin - A highly promising drug-delivery system', Future Medicinal Chemistry, 7, pp. 553 - 556, http://dx.doi.org/10.4155/fmc.15.15

Lane DJR; Bae DH; Merlot AM; Sahni S; Richardson DR, 2015, 'Duodenal cytochrome b (DCYTB) in Iron metabolism: An update on function and regulation', Nutrients, 7, pp. 2274 - 2296, http://dx.doi.org/10.3390/nu7042274

Lui GYL; Kovacevic Z; Menezes SV; Kalinowski DS; Merlot AM; Sahni S; Richardson DR, 2015, 'Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (stat3) pathway: Inhibition of constitutive and interleukin 6-induced activation by iron depletion', Molecular Pharmacology, 87, pp. 543 - 560, http://dx.doi.org/10.1124/mol.114.096529

Merlot AM; Sahni S; Lane DJR; Fordham AM; Pantarat N; Hibbs DE; Richardson V; Doddareddy MR; Ong JA; Huang MLH; Richardson DR; Kalinowski DS, 2015, 'Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: Two saturable mechanisms of Dp44mT uptake by cells', Oncotarget, 6, pp. 10374 - 10398, http://dx.doi.org/10.18632/oncotarget.3606

Lui GYL; Kovacevic Z; Richardson V; Merlot AM; Kalinowski DS; Richardson DR, 2015, 'Targeting cancer by binding iron: Dissecting cellular signaling pathways', Oncotarget, 6, pp. 18748 - 18779, http://dx.doi.org/10.18632/oncotarget.4349

Liu W; Kovacevic Z; Peng Z; Jin R; Wang P; Yue F; Zheng M; Huang MLH; Jansson PJ; Richardson V; Kalinowski DS; Lane DJR; Merlot AM; Sahni S; Richardson DR, 2015, 'The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets', Oncotarget, 6, pp. 35522 - 35541, http://dx.doi.org/10.18632/oncotarget.5849

Liu W; Yue F; Zheng M; Merlot A; Bae DH; Huang M; Lane D; Jansson P; Liu G; Richardson V; Sahni S; Kalinowski D; Kovacevic Z; Richardson DR, 2015, 'The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1', Oncotarget, 6, pp. 8851 - 8874, http://dx.doi.org/10.18632/oncotarget.3316

Lane DJR; Mills TM; Shafie NH; Merlot AM; Saleh Moussa R; Kalinowski DS; Kovacevic Z; Richardson DR, 2014, 'Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition', Biochimica et Biophysica Acta - Reviews on Cancer, 1845, pp. 166 - 181, http://dx.doi.org/10.1016/j.bbcan.2014.01.005

Lane DJR; Merlot AM; Richardson DR, 2014, 'The lure of a LYR: The logistics of iron sulfur cluster delivery', Cell Metabolism, 19, pp. 348 - 350, http://dx.doi.org/10.1016/j.cmet.2014.02.011

Sahni S; Merlot AM; Krishan S; Jansson PJ; Richardson DR, 2014, 'Gene of the month: BECN1', Journal of Clinical Pathology, 67, pp. 656 - 660, http://dx.doi.org/10.1136/jclinpath-2014-202356

Merlot AM; Kalinowski DS; Richardson DR, 2014, 'Unraveling the mysteries of serum albumin-more than just a serum protein', Frontiers in Physiology, 5 AUG, http://dx.doi.org/10.3389/fphys.2014.00299

Merlot AM; Pantarat N; Menezes SV; Sahni S; Richardson DR; Kalinowski DS, 2013, 'Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanisms', Molecular Pharmacology, 84, pp. 911 - 924, http://dx.doi.org/10.1124/mol.113.088393

Merlot AM; Kalinowski DS; Richardson DR, 2013, 'Novel chelators for cancer treatment: Where are we now?', Antioxidants and Redox Signaling, 18, pp. 973 - 1006, http://dx.doi.org/10.1089/ars.2012.4540

Serda M; Kalinowski DS; Mrozek-Wilczkiewicz A; Musiol R; Szurko A; Ratuszna A; Pantarat N; Kovacevic Z; Merlot AM; Richardson DR; Polanski J, 2012, 'Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy', Bioorganic and Medicinal Chemistry Letters, 22, pp. 5527 - 5531, http://dx.doi.org/10.1016/j.bmcl.2012.07.030

Merlot AM; Pantarat N; Lovejoy DB; Kalinowski DS; Richardson DR, 2010, 'Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer', Molecular Pharmacology, 78, pp. 675 - 684, http://dx.doi.org/10.1124/mol.110.066126

Bachelet M; Bader C; Merlot A; Laborde K; Snarska J; Ulmann A, 1983, 'Cellular utilization of cytosolic NADPH in kidney and liver cells from rats fed a normal or a vitamin D‐deficient diet', Cell Biochemistry and Function, 1, pp. 25 - 29, http://dx.doi.org/10.1002/cbf.290010105

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