Select Publications

Journal articles

Merlot AM; Porter GM; Sahni S; Lim EG; Peres P; Richardson DR, 2019, 'The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response', Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1865, pp. 2094 - 2110, http://dx.doi.org/10.1016/j.bbadis.2019.04.007

Seebacher NA; Stacy AE; Porter GM; Merlot AM, 2019, 'Clinical development of targeted and immune based anti-cancer therapies', Journal of Experimental and Clinical Cancer Research, vol. 38, http://dx.doi.org/10.1186/s13046-019-1094-2

Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Sahni S; Huang MLH; Lane DJR; Lok H; Richardson DR, 2019, 'Exploiting cancer metal metabolism using anti-cancer metal- binding agents', Current Medicinal Chemistry, vol. 26, pp. 302 - 322, http://dx.doi.org/10.2174/0929867324666170705120809

Merlot AM; Sahni S; Lane DJR; Richardsons V; Huang MLH; Kalinowski DS; Richardson DR, 2016, 'Letter to the editor: “Analysis of the interaction of Dp44mt with human serum albumin and calf thymus dna using molecular docking and spectroscopic techniques”', International Journal of Molecular Sciences, vol. 17, http://dx.doi.org/10.3390/ijms17111916

Gutierrez EM; Seebacher NA; Arzuman L; Kovacevic Z; Lane DJR; Richardson V; Merlot AM; Lok H; Kalinowski DS; Sahni S; Jansson PJ; Richardson DR, 2016, 'Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1863, pp. 1665 - 1681, http://dx.doi.org/10.1016/j.bbamcr.2016.04.017

Merlot AM; Shafie NH; Yu Y; Richardson V; Jansson PJ; Sahni S; Lane DJR; Kovacevic Z; Kalinowski DS; Richardson DR, 2016, 'Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase', Biochemical Pharmacology, vol. 109, pp. 27 - 47, http://dx.doi.org/10.1016/j.bcp.2016.04.001

Kalinowski DS; Stefani C; Toyokuni S; Ganz T; Anderson GJ; Subramaniam NV; Trinder D; Olynyk JK; Chua A; Jansson PJ; Sahni S; Lane DJR; Merlot AM; Kovacevic Z; Huang MLH; Lee CS; Richardson DR, 2016, 'Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1863, pp. 727 - 748, http://dx.doi.org/10.1016/j.bbamcr.2016.01.026

Paluncic J; Kovacevic Z; Jansson PJ; Kalinowski D; Merlot AM; Huang MLH; Lok HC; Sahni S; Lane DJR; Richardson DR, 2016, 'Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1863, pp. 770 - 784, http://dx.doi.org/10.1016/j.bbamcr.2016.01.025

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, vol. 12, pp. 1 - 222, http://dx.doi.org/10.1080/15548627.2015.1100356

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356', Autophagy, vol. 12, pp. 443, http://dx.doi.org/10.1080/15548627.2016.1147886

Chiang S; Kovacevic Z; Sahni S; Lane DJR; Merlot AM; Kalinowski DS; Huang MLH; Richardson DR, 2016, 'Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia', Clinical Science, vol. 130, pp. 853 - 870, http://dx.doi.org/10.1042/CS20160072

Jansson PJ; Kalinowski DS; Lane DJR; Kovacevic Z; Seebacher NA; Fouani L; Sahni S; Merlot AM; Richardson DR, 2015, 'The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones', Pharmacological Research, vol. 100, pp. 255 - 260, http://dx.doi.org/10.1016/j.phrs.2015.08.013

Lane DJR; Merlot AM; Huang MLH; Bae DH; Jansson PJ; Sahni S; Kalinowski DS; Richardson DR, 2015, 'Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1853, pp. 1130 - 1144, http://dx.doi.org/10.1016/j.bbamcr.2015.01.021

Lane DJR; Bae DH; Merlot AM; Sahni S; Richardson DR, 2015, 'Duodenal cytochrome b (DCYTB) in Iron metabolism: An update on function and regulation', Nutrients, vol. 7, pp. 2274 - 2296, http://dx.doi.org/10.3390/nu7042274

Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Lane DJ; Huang MLH; Sahni S; Richardson DR, 2015, 'Making a case for albumin - A highly promising drug-delivery system', Future Medicinal Chemistry, vol. 7, pp. 553 - 556, http://dx.doi.org/10.4155/fmc.15.15

Lui GYL; Kovacevic Z; Menezes SV; Kalinowski DS; Merlot AM; Sahni S; Richardson DR, 2015, 'Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (stat3) pathway: Inhibition of constitutive and interleukin 6-induced activation by iron depletion', Molecular Pharmacology, vol. 87, pp. 543 - 560, http://dx.doi.org/10.1124/mol.114.096529

Merlot AM; Sahni S; Lane DJR; Fordham AM; Pantarat N; Hibbs DE; Richardson V; Doddareddy MR; Ong JA; Huang MLH; Richardson DR; Kalinowski DS, 2015, 'Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: Two saturable mechanisms of Dp44mT uptake by cells', Oncotarget, vol. 6, pp. 10374 - 10398, http://dx.doi.org/10.18632/oncotarget.3606

Lui GYL; Kovacevic Z; Richardson V; Merlot AM; Kalinowski DS; Richardson DR, 2015, 'Targeting cancer by binding iron: Dissecting cellular signaling pathways', Oncotarget, vol. 6, pp. 18748 - 18779, http://dx.doi.org/10.18632/oncotarget.4349

Liu W; Kovacevic Z; Peng Z; Jin R; Wang P; Yue F; Zheng M; Huang MLH; Jansson PJ; Richardson V; Kalinowski DS; Lane DJR; Merlot AM; Sahni S; Richardson DR, 2015, 'The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets', Oncotarget, vol. 6, pp. 35522 - 35541, http://dx.doi.org/10.18632/oncotarget.5849

Lane DJR; Mills TM; Shafie NH; Merlot AM; Saleh Moussa R; Kalinowski DS; Kovacevic Z; Richardson DR, 2014, 'Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition', Biochimica et Biophysica Acta - Reviews on Cancer, vol. 1845, pp. 166 - 181, http://dx.doi.org/10.1016/j.bbcan.2014.01.005

Lane DJR; Merlot AM; Richardson DR, 2014, 'The lure of a LYR: The logistics of iron sulfur cluster delivery', Cell Metabolism, vol. 19, pp. 348 - 350, http://dx.doi.org/10.1016/j.cmet.2014.02.011

Sahni S; Merlot AM; Krishan S; Jansson PJ; Richardson DR, 2014, 'Gene of the month: BECN1', Journal of Clinical Pathology, vol. 67, pp. 656 - 660, http://dx.doi.org/10.1136/jclinpath-2014-202356

Merlot AM; Kalinowski DS; Richardson DR, 2014, 'Unraveling the mysteries of serum albumin-more than just a serum protein', Frontiers in Physiology, vol. 5 AUG, http://dx.doi.org/10.3389/fphys.2014.00299

Merlot AM; Pantarat N; Menezes SV; Sahni S; Richardson DR; Kalinowski DS, 2013, 'Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanisms', Molecular Pharmacology, vol. 84, pp. 911 - 924, http://dx.doi.org/10.1124/mol.113.088393

Merlot AM; Kalinowski DS; Richardson DR, 2013, 'Novel chelators for cancer treatment: Where are we now?', Antioxidants and Redox Signaling, vol. 18, pp. 973 - 1006, http://dx.doi.org/10.1089/ars.2012.4540

Serda M; Kalinowski DS; Mrozek-Wilczkiewicz A; Musiol R; Szurko A; Ratuszna A; Pantarat N; Kovacevic Z; Merlot AM; Richardson DR; Polanski J, 2012, 'Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy', Bioorganic and Medicinal Chemistry Letters, vol. 22, pp. 5527 - 5531, http://dx.doi.org/10.1016/j.bmcl.2012.07.030

Merlot AM; Pantarat N; Lovejoy DB; Kalinowski DS; Richardson DR, 2010, 'Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer', Molecular Pharmacology, vol. 78, pp. 675 - 684, http://dx.doi.org/10.1124/mol.110.066126

Bachelet M; Bader C; Merlot A; Laborde K; Snarska J; Ulmann A, 1983, 'Cellular utilization of cytosolic NADPH in kidney and liver cells from rats fed a normal or a vitamin D‐deficient diet', Cell Biochemistry and Function, vol. 1, pp. 25 - 29, http://dx.doi.org/10.1002/cbf.290010105

Conference Papers

Merlot AM; Peres P; Sahni S; Richardson DR, 2016, 'Dissecting the Role of the Iron-Regulated Metastasis Suppressor NDRG1 in Regulating Endoplasmic Reticulum Stress and Cancer Cell Survival', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S126 - S126, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.329

Merlot AM; Shafie N; Yu Y; Kalinowski DS; Richardson DR, 2016, 'The Redox Active Anti-Cancer Drug, Dp44mT, Induces Endoplasmic Reticulum Stress Activating Pro-Apoptotic Pathways of the Unfolded Protein Response in Cancer Cells', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S126 - S126, http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.328

Merlot AM; Fordham AM; Sahni S; Pantarat N; Kalinowski DS; Richardson DR, 2014, 'EXPLOITING HSA TO STIMULATE THE DELIVERY AND ANTI-TUMOUR ACTIVITY OF THE ANTI-CANCER THIOSEMICARBAZONE, DP44MT, TO CANCER CELLS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 19 - 19, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Merlot AM; Kalinowski DS; Pantarat N; Menezes S; Doddareddy M; Hibbs D; Richardson DR, 2012, 'Transport of the Anticancer Agent, Dp44mT, via a Receptor-mediated Process', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, European Org Res & Treatment Canc (EORTC), Dublin, IRELAND, pp. 36 - 36, presented at 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, European Org Res & Treatment Canc (EORTC), Dublin, IRELAND, 06 November 2012 - 09 November 2012, http://dx.doi.org/10.1016/S0959-8049(12)71914-7

Conference Abstracts

Merlot AM; Porter G; Sahni S; Lim E; Peres P; Richardson DR, 2019, 'The interactions between the metastasis suppressor, NDRG1, and the endoplasmic reticulum response in cancer cells', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Ferrara, ITALY, Vol. 139, pp. S37 - S37, presented at Annual Meeting of the Society-for-Free-Radical-Research- Europe (SFRRE) on Redox Homeostasis - From Signaling to Damage, Ferrara, ITALY, 19 June 2019 - 21 June 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000471646000141&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Merlot AM; Shafie NH; Porter G; Lim E; Sahni S; Yu Y; Richardson DR, 2019, 'Thiosemicarbazone-induced redox stress stimulates endoplasmic reticulum stress to inhibit cancer proliferation and migration', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, Ferrara, ITALY, Vol. 139, pp. S37 - S38, presented at Annual Meeting of the Society-for-Free-Radical-Research- Europe (SFRRE) on Redox Homeostasis - From Signaling to Damage, Ferrara, ITALY, 19 June 2019 - 21 June 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000471646000142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1


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