By Dr Chai Ann Ng

Conference Abstracts

O'Neill M; Ma J; Aldridge J; Solus J; Harvey G; Roberson P; Barc J; Bezzina C; Roden D; Walsh R; Vandenberg J; Ng C; Glazer A, 2025, 'Abstract 4364153: Cohort-scale automated patch clamp data improves variant classification and penetrance stratification for SCN5A -Brugada Syndrome', in Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 152, http://dx.doi.org/10.1161/circ.152.suppl_3.4364153

Dyrda A; Tan C-Y; Ng C; Vandenberg J; Van Petegem F; Hool L, 2025, 'Abstract Fri084: Electrophysiological characterization of L1521I-Ca _v 1.2 mutation reported in a cardiology patient provides insight into channel structure', in Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 137, http://dx.doi.org/10.1161/res.137.suppl_1.fri084

Dyrda A; Tan C; Ng C; Vandenberg J; van Petegem F; Hool L, 2025, 'CACNA1C c.4558C>A (p.Leu1520Ile) Variant of Uncertain Significance and Associated With Long QT Syndrome 8 is a Cav1.2 Gain-of-Function Mutation', in Heart, Lung and Circulation, Elsevier BV, Vol. 34, pp. S613 - S613, http://dx.doi.org/10.1016/j.hlc.2025.06.815

Ma J; O’Neill M; Richardson E; Ingles J; Thomson K; Solus J; Harvey G; Robertson P; Bezzina C; Roden D; Walsh R; Vandenberg J; Glazer A; Ng C, 2024, 'A Validated SCN5A Functional Assay to Adjudicate Variants of Uncertain Significance from the International Brugada Syndrome Genetics Consortia', in Heart, Lung and Circulation, Elsevier BV, Vol. 33, pp. S96 - S96, http://dx.doi.org/10.1016/j.hlc.2024.04.170

Tan C; Shen Q; Vandenberg J; Ng C, 2024, 'Establishing a Functional Genomics Assay to Assess Clinical Variants in CACNA1C-Related Disorders', in Heart, Lung and Circulation, Elsevier BV, Vol. 33, pp. S117 - S117, http://dx.doi.org/10.1016/j.hlc.2024.04.210

Shen Q; Tan C; Ng C; Vandenberg J, 2024, 'Establishing an Automated Patch Clamp Assay to Assess Both Activity and Adrenergic Responses of KCNQ1 Variants', in Heart, Lung and Circulation, Elsevier BV, Vol. 33, pp. S115 - S115, http://dx.doi.org/10.1016/j.hlc.2024.04.207

Lau C; Flood E; Hunter M; Corbett K; Ng C; Bouwer J; Stewart A; Perozo E; Allen TW; Vandenberg J, 2023, 'Structural basis of rapid inactivation of HERG potassium channels', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 122, pp. 446A - 446A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000989629702422&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ma G; O’Neill M; Richardson E; Thomson K; Ingles J; Roden D; Vandenberg J; Ng C; Glazer A, 2023, 'Utility of a High-Throughput Electrophysiology Assay to Determine Pathogenicity of SCN5A Variants Associated With Brugada Syndrome', in Heart, Lung and Circulation, Elsevier BV, Vol. 32, pp. S131 - S132, http://dx.doi.org/10.1016/j.hlc.2023.06.763

Ullah R; Ng CA; Vanags L; Mitchell D; Vandenberg J; Kroncke B, 2022, 'Abstract 12815: High Throughput Variant Identification in the S3-S5 Helices of KCNH2 (hERG)', in Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, http://dx.doi.org/10.1161/circ.146.suppl_1.12815

Jiang C; Richardson E; Farr J; Hill A; Ullah R; Kroncke B; Harrison S; Thomson K; Ingles J; Vandenberg J; Ng C, 2022, 'A Calibrated Functional Patch Clamp Assay to Enhance Clinical Variant Interpretation in KCNH2-Related Long QT Syndrome', in Heart Lung and Circulation, Elsevier, Vol. 31, pp. s37 - s37, presented at 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 11 August 2022 - 14 August 2022, http://dx.doi.org/10.1016/j.hlc.2022.06.003

Ullah R; Ng C; Farr J; Hill A; kozek K; Vanags L; Mitchell D; Vandenberg J; Kroncke B, 2021, 'Abstract 11153: Massively Parallel, High-Throughput Approach for Identifying Defective KCNH2 (hERG) Variants', in Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, http://dx.doi.org/10.1161/circ.144.suppl_1.11153

Jiang C; Farr J; Hill A; Kroncke B; Ingles J; Vandenberg J; Ng CA, 2021, 'Abstract 11857: Benchmarking a Functional Assay to Assist Clinical Classification of Variants of Uncertain Significance in KCNH2 (Long QT Syndrome Type 2)', in Circulation, Wolters Kluwer, Vol. 144, pp. a11857 - a11857, http://dx.doi.org/10.1161/circ.144.suppl_1.11857

Li J; Ng CA; Cheng D; Cox CD, 2021, 'Modified N-Linked Glycosylation Status Predicts Trafficking Defective', in BIOPHYSICAL JOURNAL, CELL PRESS, ELECTR NETWORK, Vol. 120, pp. 236A - 237A, presented at 65th Annual Meeting of the Biophysical-Society (BPS), ELECTR NETWORK, 22 February 2021 - 26 February 2021, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000629601401400&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Li J; Ann Ng C; Cheng D; Cox CD, 2021, 'Modified N-Linked Glycosylation Status Predicts Trafficking Defective Piezo1 Channel Mutations', in Biophysical Journal, Elsevier BV, Vol. 120, pp. 236a - 237a, http://dx.doi.org/10.1016/j.bpj.2020.11.1562

Cox CD; Ng CA; Bavi N; Martinac B, 2014, 'Mechanically-Induced Gating in PKD2L1 (Trpp2): Calcium-Induced Activation Masquerading as Force Sensitivity?', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 112, pp. 311A - 311A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.1686

Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800

Ke Y; Hunter M; Ng CA; Vandenberg J, 2012, 'Domain Misfolding and Destabilisation of Domain–Domain Interactions Both Contribute to Defective Trafficking of hERG EAG Domain Mutant Channels', in Heart, Lung and Circulation, Vol. 21, pp. 860 - 861, http://dx.doi.org/10.1016/j.hlc.2012.08.025

Metzger RP; Dang J; Ng CA; Brownlee RTC; Bergdahl M; Separovic F, 2005, 'Virginiamycin M1 conformation in aqueous systems.', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, CA, San Diego, Vol. 229, pp. U188 - U188, presented at 229th National Meeting of the American-Chemical-Society, CA, San Diego, 13 March 2005 - 17 March 2005

Phan K; Ng C; McNitt S; Moss A; Zareba W; Perry M; Vandenberg J, 'The role of in vitro phenotypes for clinical risk stratification of sudden death in Long QT Syndrome Type 2', in Heart, Lung and Circulation, Elsevier, Vol. 24, pp. S232 - S233, presented at Heart, Lung and Circulation, http://dx.doi.org/10.1016/j.hlc.2015.06.289

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