By Dr Charles Cox

Conference Abstracts

Cox CD; Bavi N; Martinac B, 2018, 'Cytoskeleton-Associated Proteins Modulate the Tension Sensitivity of Piezo1', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 114, pp. 111A - 111A, presented at 62nd Annual Meeting of the Biophysical-Society, CA, San Francisco, 17 February 2018 - 21 February 2018, http://dx.doi.org/10.1016/j.bpj.2017.11.641

Bavi N; Cox CD; Bavi O; Martinac B, 2017, 'The role of surface tension in ion channel mechanosensitivity', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, SCOTLAND, British Biophys Soc, Edinburgh, Vol. 46, pp. S243 - S243, presented at 19th IUPAB Congress / 11th EBSA Congress, SCOTLAND, British Biophys Soc, Edinburgh, 16 July 2017 - 20 July 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000416406201384&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ridone P; Cox C; Vassalli M; Pandzic E; Gottlieb P; Martinac B, 2017, 'Human Piezo1 Membrane Localization and Gating Kinetics are Modulated by Cholesetrol Levels', in Biophysical Journal, Elsevier, Vol. 112, pp. 533a, http://dx.doi.org/10.1016/j.bpj.2016.11.2883

Bavi N; Cox CD; Rohde PR; Hill AP; Corry B; Martinac B, 2016, 'The N-Terminal Helix Acts as a Dynamic Membrane Coupler in the Gating Cycle of the Mechanosensitive Channel MscL', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, Los Angeles, Vol. 110, pp. 116A - 116A, presented at 60th Annual Meeting of the Biophysical-Society, CA, Los Angeles, 27 February 2016 - 02 March 2016, http://dx.doi.org/10.1016/j.bpj.2015.11.677

Cox CD; Martinac B, 2016, 'Bending Piezo1: The Effect of Amphipaths on the Gating of a Mechanosensitive Channel', in Biophysical Journal, Elsevier, Vol. 110, pp. 349a, http://dx.doi.org/10.1016/j.bpj.2015.11.1880

Nikolaev YA; Rohde PR; Cox CD; Laver DR; Martinac B, 2015, 'Mechanosensitivity of TRPC6 Ion Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 108, pp. 564A - 564A, presented at 59th Annual Meeting of the Biophysical-Society, MD, Baltimore, 07 February 2015 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.3088

Cox CD; Martinac B, 2015, 'Probing the Mechanosensitivity of Piezo1 Channels', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 108, pp. 562A - 562A, presented at 59th Annual Meeting of the Biophysical-Society, MD, Baltimore, 07 February 2015 - 11 February 2015, http://dx.doi.org/10.1016/j.bpj.2014.11.3079

Cox CD; Ng CA; Bavi N; Martinac B, 2014, 'Mechanically-Induced Gating in PKD2L1 (Trpp2): Calcium-Induced Activation Masquerading as Force Sensitivity?', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 112, pp. 311A - 311A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.1686

Preprints

Yu Z-Y; Guo Y; Kesteven S; Cheng D; Lei H; Wu J; Nadar E; Macdonald P; Xaymardan M; Cox C; Feneley M; Martinac B, 2025, Deletion of PIEZO1 in adult cardiomyocytes accelerates cardiac aging and causes premature death, http://dx.doi.org/10.1101/2025.01.20.633994

Kuchel PW; Cox CD; Daners D; Shishmarev D; Galvosas P, 2021, Surface model of the human red blood cell simulating changes in membrane curvature under strain, http://dx.doi.org/10.21203/rs.3.rs-467222/v1

Xue F; Cox CD; Bavi N; Rohde PR; Nakayama Y; Martinac B, 2019, Membrane stiffness is a key determinant of E coli MscS channel mechanosensitivity, http://dx.doi.org/10.1101/790501

Zhang Y; Jiang F; Zhao YC; Cho A-N; Fang G; Cox CD; Zreiqat H; Lu ZF; Lu H; Ju LA, 3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay, http://dx.doi.org/10.1101/2022.11.19.517181

Romanov V; Silvani G; Zhu H; Cox CD; Martinac B, An acoustic platform for single-cell, high-throughput measurements of the viscoelastic properties of cells, http://dx.doi.org/10.1101/2020.09.07.286898

Silvani G; Romanov V; Cox CD; Martinac B, Biomechanical characterization of endothelial cells exposed to shear stress using acoustic force spectroscopy, http://dx.doi.org/10.1101/2020.09.29.319772

Pineda S; Nikolova-Krstevski V; Leimena C; Atkinson AJ; Altekoester A-K; Cox CD; Jacoby A; Huttner IG; Ju Y-K; Soka M; Ohanian M; Trivedi G; Kalvakuri S; Johnson R; Molenaar P; Kuchar D; Allen DG; van Helden DF; Harvey RP; Hill AP; Bodmer R; Vogler G; Dobrzynski H; Ocorr K; Fatkin D, Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk, http://dx.doi.org/10.1101/2020.06.28.176495

Cox CD; Zhang Y; Zhou Z; Walz T; Martinac B, Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels, http://dx.doi.org/10.1101/2021.03.08.434340

Ridone P; Pandzic E; Vassalli M; Cox CD; Macmillan A; Gottlieb PA; Martinac B, Disruption of membrane cholesterol organization impairs the concerted activity of PIEZO1 channel clusters, http://dx.doi.org/10.1101/604488

Kuchel P; Romanenko K; Shishmarev D; Galvosas P; Cox C, Enhanced Ca2+ Influx in Mechanically Distorted Erythrocytes: Measurements with 19F Nuclear Magnetic Resonance Spectroscopy, http://dx.doi.org/10.21203/rs.3.rs-107038/v1

Yao M; Tijore A; Cheng D; Li JV; Hariharan A; Martinac B; Van Nhieu GT; Cox CD; Sheetz M, Force-dependent recruitment of Piezo1 drives adhesion maturation and calcium entry in normal but not tumor cells, http://dx.doi.org/10.1101/2020.03.09.972307

Zhou Z; Dai F; Cheng D; Ma X; Omidkhoda SF; Clarke J; Zhang H; Laden M; Guo Y; Li JV; Liu R; Wong ES; Zhang Y; Cox CD, MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit, http://dx.doi.org/10.1101/2025.10.26.684595

Yang S; Miao X; Arnold S; Li B; Ly AT; Wang H; Wang M; Guo X; Pathak MM; Zhao W; Cox CD; Shi Z, Membrane curvature governs the distribution of Piezo1 in live cells, http://dx.doi.org/10.1101/2022.06.22.497259

Ju L; Wang H; Vatankhah P; Wang Y; Russel B; Su Q; Zhou Z; Cox C; Jin J, Microscale geometrical modulation of PIEZO1 mediated cell mechanosensing via cytoskeletal redistribution buckle, http://dx.doi.org/10.21203/rs.3.rs-3218836/v1

Li JV; Ng C-A; Cheng D; Yao M; Guo Y; Yu Z-Y; Ramaswamy Y; Ju LA; Kuchel PW; Feneley MP; Fatkin D; Cox CD, Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations, http://dx.doi.org/10.1101/2020.11.30.404962

Buyan A; Cox CD; Rae J; Barnoud J; Li J; Cvetovska J; Bastiani M; Chan HSM; Hodson MP; Martinac B; Parton RG; Marrink SJ; Corry B, Piezo1 Induces Local Curvature in a Mammalian Membrane and Forms Specific Protein-Lipid Interactions, http://dx.doi.org/10.1101/787531

Yu Z-Y; Gong H; Kesteven S; Guo Y; Wu J; Li J; Iismaa S; Kaidonis X; Graham R; Cox C; Feneley M; Martinac B, Piezo1 is the cardiac mechanosensor that initiates the hypertrophic response to pressure overload, http://dx.doi.org/10.21203/rs.3.rs-895561/v1

Guo Y; Yu Z-Y; Wu J; Gong H; Kesteven S; Iismaa SE; Chan AY; Holman S; Pinto S; Pironet A; Cox CD; Graham RM; Vennekens R; Feneley MP; Martinac B, The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy, http://dx.doi.org/10.1101/2020.12.21.423727

Lin Y; Zhou Z; Han Y; Cheng D; Wang H; Ju AL; Zhang Y; Cox CD; Corry B, TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience, http://dx.doi.org/10.1101/2025.07.26.664997

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