By Dr Chris Jolly

Journal articles

Truong P; Shen S; Joshi S; Islam MI; Zhong L; Raftery MJ; Afrasiabi A; Alinejad-Rokny H; Nguyen M; Zou X; Bhuyan GS; Sarowar CH; Ghodousi ES; Stonehouse O; Mohamed S; Toscan CE; Connerty P; Kakadia PM; Bohlander SK; Michie KA; Larsson J; Lock RB; Walkley CR; Thoms JAI; Jolly CJ; Pimanda JE, 2024, 'TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells', Nature Communications, 15, pp. 7360, http://dx.doi.org/10.1038/s41467-024-51646-6

Nimmo DG; Jolly CJ; Carthey AJR, 2023, 'Expanding the scope of fire-driven animal evolution', Trends in Ecology and Evolution, 38, pp. 1115 - 1116, http://dx.doi.org/10.1016/j.tree.2023.09.005

Moles E; Howard CB; Huda P; Karsa M; McCalmont H; Kimpton K; Duly A; Chen Y; Huang Y; Tursky ML; Ma D; Bustamante S; Pickford R; Connerty P; Omari S; Jolly CJ; Joshi S; Shen S; Pimanda JE; Dolnikov A; Cheung LC; Kotecha RS; Norris MD; Haber M; de Bock CE; Somers K; Lock RB; Thurecht KJ; Kavallaris M; Moles Meler E, 2023, 'Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia', Science translational medicine, 15, pp. eabm1262 - eabm1262, http://dx.doi.org/10.1126/scitranslmed.abm1262

Schnegg-Kaufmann AS; Thoms JAI; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson Beves EMV; Failes TW; Arndt GM; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Davidson S; Polizzotto MN; Hertzberg M; Papaemmanuil E; Bohlander SK; Faridani OR; Jolly CJ; Zanini F; Pimanda JE, 2023, 'Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy', Blood, 141, pp. 1316 - 1321, http://dx.doi.org/10.1182/blood.2022018602

Thoms JAI; Schnegg-Kaufmann A; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson E; Failes TW; Arndt GM; Koval J; Davidson S; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Hertzberg M; Polizzotto MN; Papaemmanuil E; Bohlander SK; Faridani O; Jolly CJ; Zanini F; Pimanda JE, 2022, 'Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment', Blood, 140, pp. 9751 - 9752, http://dx.doi.org/10.1182/blood-2022-163158

O’Rourke MB; Roediger BR; Jolly CJ; Crossett B; Padula MP; Hansbro PM, 2022, 'Viral Biomarker Detection and Validation Using MALDI Mass Spectrometry Imaging (MSI)', Proteomes, 10, http://dx.doi.org/10.3390/proteomes10030033

Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Henry H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Greg A; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Pappaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, 'P748: SINGLE CELL GENOTYPING OF MATCHED BONE MARROW AND PERIPHERAL BLOOD CELLS IN TREATMENT NAIVE AND AZA-TREATED MDS AND CMML', HemaSphere, 6, pp. 643 - 644, http://dx.doi.org/10.1097/01.hs9.0000845876.01682.15

Michel AO; Donovan TA; Roediger B; Lee Q; Jolly CJ; Monette S, 2022, 'Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats', Veterinary Pathology, 59, pp. 120 - 126, http://dx.doi.org/10.1177/03009858211045439

Jolly CJ; Pimanda JE, 2020, 'Titans awake: HMAs for virus-driven ATL', Blood, 136, pp. 777 - 779, http://dx.doi.org/10.1182/blood.2020006488

Lee Q; Padula MP; Pinello N; Williams SH; O’Rourke MB; Fumagalli MJ; Orkin JD; Song R; Shaban B; Brenner O; Pimanda JE; Weninger W; de Souza WM; Melin AD; Wong JJL; Crim MJ; Monette S; Roediger B; Jolly CJ, 2020, 'Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys', PLoS Pathogens, 16, pp. e1008262, http://dx.doi.org/10.1371/journal.ppat.1008262

Gall MG; Zhang HE; Lee Q; Jolly CJ; McCaughan GW; Cook A; Roediger B; Gorrell MD, 2019, 'Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity', Scientific Reports, 9, pp. 7292, http://dx.doi.org/10.1038/s41598-019-43739-w

Poyntz HC; Jones A; Jauregui R; Young W; Gestin A; Mooney A; Lamiable O; Altermann E; Schmidt A; Gasser O; Weyrich L; Jolly CJ; Linterman MA; Gros GL; Hawkins ED; Forbes-Blom E, 2019, 'Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice', Immunology and Cell Biology, 97, pp. 39 - 53, http://dx.doi.org/10.1111/imcb.12199

Jolly C; Lee Q; Padula M; Pinello N; Williams S; O’Rourke M; Fumagalli MJ; Orkin J; Shaban B; Brenner O; Weninger W; de Souza WM; Melin A; Wong JJ-L; Crim M; Monette S; Roediger B, 2019, 'MKPV (aka MuCPV) and related chapparvoviruses are nephro-tropic and encode novel accessory proteins p15 and NS2', , http://dx.doi.org/10.1101/732537

Roediger B; Lee Q; Tikoo S; Cobbin JCA; Henderson JM; Jormakka M; O'Rourke MB; Padula MP; Pinello N; Henry M; Wynne M; Santagostino SF; Brayton CF; Rasmussen L; Lisowski L; Tay SS; Harris DC; Bertram JF; Dowling JP; Bertolino P; Lai JH; Wu W; Bachovchin WW; Wong JJL; Gorrell MD; Shaban B; Holmes EC; Jolly CJ; Monette S; Weninger W, 2018, 'An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis', Cell, 175, pp. 530 - 543.e24, http://dx.doi.org/10.1016/j.cell.2018.08.013

Jolly C; Gall M; Gorrell M; Cook A; Roediger B; Zhang HE; McCaughan G, 2018, 'Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity [forthcoming publication]', Forthcoming/preprint available in bioRxiv, http://dx.doi.org/10.1101/431775

Thientosapol ES; Bosnjak D; Durack T; Stevanovski I; Van Geldermalsen M; Holst J; Jahan Z; Shepard C; Weninger W; Kim B; Brink R; Jolly CJ, 2018, 'SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 4921 - 4926, http://dx.doi.org/10.1073/pnas.1719771115

Wang XM; Holz LE; Chowdhury S; Cordoba SP; Evans KA; Gall MG; De Ribeiro AJV; Zheng YZ; Levy MT; Yu DMT; Yao TW; Polak N; Jolly CJ; Bertolino P; McCaughan GW; Gorrell MD, 2017, 'The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury', Immunology and Cell Biology, 95, pp. 443 - 453, http://dx.doi.org/10.1038/icb.2016.116

Thientosapol ES; Sharbeen G; Edwin Lau KK; Bosnjak D; Durack T; Stevanovski I; Weninger W; Jolly CJ, 2017, 'Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2', Nucleic Acids Research, 45, pp. 3146 - 3157, http://dx.doi.org/10.1093/nar/gkw1300

Chang GH; Lay AJ; Ting KK; Zhao Y; Coleman PR; Powter EE; Formaz-Preston A; Jolly CJ; Bower NI; Hogan BM; Rinkwitz S; Becker TS; Vadas MA; Gamble JR, 2014, 'Arhgap18: An endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions', Small GTPases, 5, http://dx.doi.org/10.4161/21541248.2014.975002

Sharbeen G; Yee CWY; Smith AL; Jolly CJ, 2012, 'Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase', Journal of Experimental Medicine, 209, pp. 965 - 974, http://dx.doi.org/10.1084/jem.20112379

Chan TD; Wood K; Hermes JR; Jolly CJ; Basten A; Brink R, 2012, 'Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen', Immunity, 37, pp. 893 - 904, http://dx.doi.org/10.1016/j.immuni.2012.07.017

Sharbeen G; Cook AJL; Lau KKE; Raftery J; Yee CWY; Jolly CJ, 2010, 'Incorporation of dUTP does not mediate mutation of A:T base pairs in Ig genes in vivo', Nucleic Acids Research, 38, pp. 8120 - 8130, http://dx.doi.org/10.1093/nar/gkq682

Jolly CJ; Cook AJL; Manis JP, 2008, 'Fixing DNA breaks during class switch recombination', Journal of Experimental Medicine, 205, pp. 509 - 513, http://dx.doi.org/10.1084/jem.20080356

Jolly C; Cook AJL; Raftery J; Jones ME, 2007, 'Corrigendum to "Measuring bidirectional mutation". [J. Theor. Biol. 246 (2006) 269-277] (DOI:10.1016/j.jtbi.2006.12.034)', Journal of Theoretical Biology, 247, pp. 862, http://dx.doi.org/10.1016/j.jtbi.2007.05.027

Jolly C; Cook AJL; Raferty J; Jones ME, 2007, 'Measuring bidirectional mutation', Journal of Theoretical Biology, 246, pp. 269 - 277, http://dx.doi.org/10.1016/j.jtbi.2006.12.034

Cook AJL; Raftery JM; Lau KKE; Jessup A; Harris RS; Takeda S; Jolly CJ, 2007, 'DNA-dependent protein kinase inhibits AID-induced antibody gene conversion', PLoS Biology, 5, pp. 792 - 799, http://dx.doi.org/10.1371/journal.pbio.0050080

Cook AJL; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ, 2003, 'Reduced Switching in SCID B Cells Is Associated with Altered Somatic Mutation of Recombined S Regions', Journal of Immunology, 171, pp. 6556 - 6564, http://dx.doi.org/10.4049/jimmunol.171.12.6556

Jolly CJ; Neuberger MS, 2001, 'Somatic hypermutation of immunoglobulin κ transgenes: Association of mutability with demethylation', Immunology and Cell Biology, 79, pp. 18 - 22, http://dx.doi.org/10.1046/j.1440-1711.2001.00968.x

Neuberger MS; Sale JE; Cumbers SJ; Jolly CJ; Bemark MP; Ehrenstein MR; Lanoue A; Brüggemann M; Batista FD; Davies SL; Williams GT, 2000, 'Diversification and selection mechanisms for the production of protein repertoires: Lessons from the immune system', Applied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology, 83, pp. 53 - 62, http://dx.doi.org/10.1385/ABAB:83:1-3:53

Williams GT; Jolly CJ; Köhler J; Neuberger MS, 2000, 'The contribution of somatic hypermutation to the diversity of serum immunoglobulin: Dramatic increase with age', Immunity, 13, pp. 409 - 417, http://dx.doi.org/10.1016/S1074-7613(00)00040-6

Neuberger MS; Ehrenstein MR; Klix N; Jolly CJ; Yélamos J; Rada C; Milstein C, 1998, 'Monitoring and interpreting the intrinsic features of somatic hypermutation', Immunological Reviews, 162, pp. 107 - 116, http://dx.doi.org/10.1111/j.1600-065X.1998.tb01434.x

Klix N; Jolly CJ; Davies SL; Brüggemann M; Williams GT; Neuberger MS, 1998, 'Multiple sequences from downstream of the J(κ) cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain', European Journal of Immunology, 28, pp. 317 - 326, http://dx.doi.org/10.1002/(SICI)1521-4141(199801)28:01<317::AID-IMMU317>3.0.CO;2-S

Jolly CJ; Klix N; Neuberger MS, 1997, 'Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene targeted mice', Nucleic Acids Research, 25, pp. 1913 - 1919, http://dx.doi.org/10.1093/nar/25.10.1913

Jolly CJ; O'Neill HC, 1997, 'Specific transcription of the unrearranged TCR Vβ8.2 gene in lymphoid tissues occurs independently of V(D)J rearrangement', Immunology and Cell Biology, 75, pp. 13 - 20, http://dx.doi.org/10.1038/icb.1997.3

Jolly CJ; Glenn GM; Rahman S, 1996, 'GSP-1 genes are linked to the grain hardness locus (Ha) on wheat chromosome 5D', Proceedings of the National Academy of Sciences of the United States of America, 93, pp. 2408 - 2413, http://dx.doi.org/10.1073/pnas.93.6.2408

Jolly CJ; Wagner SD; Rada C; Klix N; Milstein C; Neuberger MS, 1996, 'The targeting of somatic hypermutation', Seminars in Immunology, 8, pp. 159 - 168, http://dx.doi.org/10.1006/smim.1996.0020

Jolly CJ; O'neill HC, 1995, 'Expression of a TCR Vβ8.2 polypeptide from the unrearranged gene in a murine lymphoid precursor cell line', International Immunology, 7, pp. 1147 - 1156, http://dx.doi.org/10.1093/intimm/7.7.1147

O'Neill HC; Jolly CJ, 1995, 'Germline transcription and expression of Tcrb-V8 genes in peripheral mouse lymphoid tissues', Immunogenetics, 42, pp. 309 - 314, http://dx.doi.org/10.1007/BF00179391

Ho ESP; Jolly CJ; O'Neill HC, 1994, 'Analysis of oncogenic progression in a radiation leukemia virus model', Leukemia, 8, pp. 1202 - 1213

RAHMAN S; JOLLY CJ; SKERRITT JH; WALLOSHECK A, 1994, 'Cloning of a wheat 15‐kDa grain softness protein (GSP): GSP is a mixture of puroindoline‐like polypeptides', European Journal of Biochemistry, 223, pp. 917 - 925, http://dx.doi.org/10.1111/j.1432-1033.1994.tb19069.x

Jolly CJ; Rahman S; Kortt AA; Higgins TJV, 1993, 'Characterisation of the wheat Mr 15000 "grain-softness protein" and analysis of the relationship between its accumulation in the whole seed and grain softness', Theoretical and Applied Genetics, 86, pp. 589 - 597, http://dx.doi.org/10.1007/BF00838714

O'Neill HC; Jolly C, 1992, 'Retroviral superantigens', Immunology Today, 13, pp. 462 - 463, http://dx.doi.org/10.1016/0167-5699(92)90078-L

Jolly CJ; Reid JB; Ross JJ, 1987, 'Internode length in Pisum. Action of gene lw', Physiologia Plantarum, 69, pp. 489 - 498, http://dx.doi.org/10.1111/j.1399-3054.1987.tb09230.x

Conference Papers

Jolly C; Sharbeen G; Yee C; Smith A, 2012, 'Processing of AID-induced uracils in distinct cell cycle phases', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, MA, Boston, presented at 99th Annual Meeting of the American-Association-of-Immunologists, MA, Boston, 04 May 2012 - 08 May 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000304659700662&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sale JE; Bemark M; Williams GT; Jolly CJ; Ehrenstein MR; Rada C; Milstein C; Neuberger MS, 2001, 'In vivo and in vitro studies of immunoglobulin gene somatic hypermutation', in Philosophical Transactions of the Royal Society B: Biological Sciences, pp. 21 - 28

Jolly C; Kohonen-Corish M; Hodgkin P; Deenick E, 2000, 'MSH2-deficiency reduces the rate of switching to all mouse isotypes without altering the regulation of switching by cell division number', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, pp. A1046 - A1046, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086643100792&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Truong P; Shen S; Joshi S; Afrasiabi A; Zhong L; Raftery MJ; Larsson J; Lock RB; Walkley CR; Rokny HA; Thoms JAI; Jolly CJ; Pimanda JE, 2022, 'Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and Sumoylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, LA, New Orleans, Vol. 140, presented at 64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), LA, New Orleans, 10 December 2022 - 13 December 2022, http://dx.doi.org/10.1182/blood-2022-165713

Preprints

Thoms JAI; Yan F; Hampton HR; Davidson S; Joshi S; Saw J; Sarowar CH; Lim XY; Nunez AC; Kakadia PM; Bhuyan GS; Zou X; Nguyen M; Ghodousi ES; Koch FC; Vafaee F; Pickford R; Raftery MJ; Hough S; Buckland G; Bailey M; Ghodke Y; Absar N; Vaughan L; Pasalic L; Fong CY; Kenealy M; Hiwase DK; Stoddart RI; Mohammed S; Lee L; Passam FH; Larsen SR; Spring KJ; Skarratt KK; Rebeiro P; Presgrave P; Stevenson WS; Ling S; Tiley C; Fuller SJ; Roncolato F; Enjeti AK; Hoenemann D; Lemech C; Jolly CJ; Bohlander SK; Curtis DJ; Wong JWH; Unnikrishnan A; Hertzberg M; Olivier J; Polizzotto MN; Pimanda JE, 2024, Clinical Response to Azacitidine in Myelodysplastic Neoplasms is Associated with Distinct DNA Methylation Changes in Haematopoietic Stem and Progenitor cellsin vivo, http://dx.doi.org/10.1101/2024.07.19.24310679

Truong P; Shen S; Joshi S; Islam MI; Zhong L; Raftery M; Afrasiabi A; Alinejad-Rokny H; Nguyen M; Zou X; Bhuyan GS; Sarowar C; Ghodousi E; Stonehouse O; Mohamed S; Toscan C; Connerty P; Kakadia P; Bohlander S; Michie K; Larsson J; Lock R; Walkley C; Thoms J; Jolly C; Pimanda J, 2024, Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML, http://dx.doi.org/10.1101/2024.04.17.589858

Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Hampton H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Arndt G; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Papaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML, http://dx.doi.org/10.1101/2022.01.20.476890

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