By Dr David Samuel Khoury

Journal articles

Davenport MP; Khoury DS; Cromer D; Lewin SR; Kelleher AD; Kent SJ, 2019, 'Functional cure of HIV: the scale of the challenge', Nature Reviews Immunology, 19, pp. 45 - 54, http://dx.doi.org/10.1038/s41577-018-0085-4

Betts M; Kuri Cervantes L; Pampena MB; Samer S; Khoury D; Frank I; Paiardini M; Davenport M; Bar K; Veazey R, 2019, 'Peripheral blood SIV/HIV originates from infected cells in tissues', Journal of Virus Eradication, 5, pp. 27 - 27, http://dx.doi.org/10.1016/s2055-6640(20)30142-4

Zaloumis SG; Cao P; Dini S; Davenport MP; Cromer D; Khoury DS; Fowkes FJI; McCaw JM; Simpson JA, 2018, 'In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance', Antimicrobial Agents and Chemotherapy, 62, pp. 10.1128/aac.01292 - 10.1128/aac.01218, http://dx.doi.org/10.1128/AAC.01292-18

Aogo RA; Khoury DS; Cromer D; Elliott T; Akter J; Fogg LG; Nair AS; Liligeto UN; Soon MSF; Thomas BS; Pernold CPS; Romanczuk AS; Laohamonthonkul P; Haque A; Davenport MP, 2018, 'Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice', International Journal for Parasitology, 48, pp. 903 - 913, http://dx.doi.org/10.1016/j.ijpara.2018.05.010

Khoury DS; Aogo R; Randriafanomezantsoa-Radohery G; McCaw JM; Simpson JA; McCarthy JS; Haque A; Cromer D; Davenport MP, 2018, 'Within-host modeling of blood-stage malaria', Immunological Reviews, 285, pp. 168 - 193, http://dx.doi.org/10.1111/imr.12697

Khoury DS; Cromer D; Elliott T; Soon MSF; Thomas BS; James KR; Best SE; Aogo RA; Engel JA; Gartlan KH; Akter J; Sebina I; Haque A; Davenport MP, 2017, 'Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo', International Journal for Parasitology, 47, pp. 913 - 922, http://dx.doi.org/10.1016/j.ijpara.2017.05.009

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, 'A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection', Journal of Theoretical Biology, 430, pp. 117 - 127, http://dx.doi.org/10.1016/j.jtbi.2017.07.017

Khoury DS; Cromer D; Akter J; Sebina I; Elliott T; Thomas BS; Soon MSF; James KR; Best SE; Haque A; Davenport MP, 2017, 'Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection', Proceedings of the National Academy of Sciences of the United States of America, 114, pp. 7701 - 7706, http://dx.doi.org/10.1073/pnas.1618939114

Griffin P; Pasay C; Elliott S; Sekuloski S; Sikulu M; Hugo L; Khoury D; Cromer D; Davenport M; Sattabongkot J; Ivinson K; Ockenhouse C; McCarthy J, 2016, 'Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission', PLoS Neglected Tropical Diseases, 10, pp. e0005139, http://dx.doi.org/10.1371/journal.pntd.0005139

Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2016, 'Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration', Journal of Infectious Diseases, 214, pp. 753 - 761, http://dx.doi.org/10.1093/infdis/jiw234

Khoury DS; Cromer D; Best SE; James KR; Sebina I; Haque A; Davenport MP, 2015, 'Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria', Scientific Reports, 5, pp. 9412, http://dx.doi.org/10.1038/srep09412

Khoury DS; Cromer D; Best SE; James KR; Kim PS; Engwerda CR; Haque A; Davenport MP, 2013, 'Effect of mature, blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria.', Infection and Immunity, 82, pp. 212 - 220, http://dx.doi.org/10.1128/IAI.00705-13

Delaney GW; Khoury D, 2013, 'Onset of rigidity in 3D stretched string networks', European Physical Journal B, 86, http://dx.doi.org/10.1140/epjb/e2012-30445-y

Khoury DS; Barron AB; Myerscough MR, 2013, 'Modelling Food and Population Dynamics in Honey Bee Colonies', PLoS ONE, 8, pp. Article numbere59084, http://dx.doi.org/10.1371/journal.pone.0059084

Khoury DS; Myerscough MR; Barron AB, 2011, 'A quantitative model of honey bee colony population dynamics', PLoS ONE, 6, http://dx.doi.org/10.1371/journal.pone.0018491

Conference Papers

Myerscough MR; Khoury DS; Ronzani S; Barron AB, 2015, 'Why Do Hives Die? Using Mathematics to Solve the Problem of Honey Bee Colony Collapse', in Anderssen B; Broadbridge P; Fukumoto Y; Kamiyama N; Mizoguchi Y; Polthier K; Saeki O (eds.), ROLE AND IMPORTANCE OF MATHEMATICS IN INNOVATION, SPRINGER-VERLAG SINGAPORE PTE LTD, JAPAN, Kyushu Univ, Ito Campus, Inst Math Ind, Fukuoka, pp. 35 - 50, presented at Forum on Math-for-Industry - Role and Importance of Mathematics in Innovation, JAPAN, Kyushu Univ, Ito Campus, Inst Math Ind, Fukuoka, 26 October 2015 - 30 October 2015, http://dx.doi.org/10.1007/978-981-10-0962-4_4

Conference Abstracts

Lansink LIM; Engel JA; Lee HJ; Soon MSF; Williams CG; Aogo RA; Cromer D; Davenport MP; Khoury DS; Haque A, 2021, 'Exposure to host inflammation in vivo induces rapid transcriptomic change and impaired maturation in malaria parasites', in JOURNAL OF IMMUNOLOGY, AMER ASSOC IMMUNOLOGISTS, Vol. 206, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000713665801305&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Working Papers

Goel RR; Painter MM; Lundgreen KA; Apostolidis SA; Baxter AE; Giles JR; Mathew D; Pattekar A; Reynaldi A; Khoury DS; Gouma S; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; Kc W; Oldridge DA; Erickson RI; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Dougherty J; Long S; D'Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; Drapeau EM; Davenport MP; Hensley SE; Bates P; Greenplate AR; Wherry EJ, 2022, Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine., http://dx.doi.org10.1101/2022.02.20.481163, https://www.ncbi.nlm.nih.gov/pubmed/35233575

Cele S; Jackson L; Khoury DS; Khan K; Moyo-Gwete T; Tegally H; San JE; Cromer D; Scheepers C; Amoako D; Karim F; Bernstein M; Lustig G; Archary D; Smith M; Ganga Y; Jule Z; Reedoy K; Hwa S-H; Giandhari J; Blackburn JM; Gosnell BI; Abdool Karim SS; Hanekom W; NGS-SA ; COMMIT-KZN Team ; von Gottberg A; Bhiman J; Lessells RJ; Moosa M-YS; Davenport MP; de Oliveira T; Moore PL; Sigal A, 2021, SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection., http://dx.doi.org10.1101/2021.12.08.21267417, https://www.ncbi.nlm.nih.gov/pubmed/34909788

Preprints

Berry MT; MacIntyre CR; Cromer D; Hacker A; Davenport MP; Khoury DS, 2024, Optimal deployment of limited vaccine supplies to combat mpox, http://dx.doi.org/10.1101/2024.11.03.24316551

Ashley CL; Bloul M; Alca S; Smith L; Jin W; Khoury D; Counoupas C; Davenport M; Triccas JA; Steain M, 2024, Optimisation of a multiplexed, high throughput assay to measure neutralising antibodies against SARS-CoV-2 variants, http://dx.doi.org/10.1101/2024.09.01.610733

Cromer D; Reynaldi A; Hie A; Schlub T; Juno J; Wheatley A; Kent S; Khoury D; Davenport M, 2024, Predicting COVID-19 booster immunogenicity against future SARS-CoV-2 variants and the benefits of vaccine updates, http://dx.doi.org/10.1101/2024.02.08.24302032

Williams CG; Moreira ML; Asatsuma T; Skinner OP; Lee HJ; Li S; Barrera I; Murray E; Soon MSF; Engel JA; Khoury DS; Asad S; Steiner TM; Joseph R; Alexandre Y; Mueller SN; Chen F; Haque A, 2023, Spatial transcriptomics maps molecular and cellular requirements for CD4⁺T cell-dependent immunity to malaria, http://dx.doi.org/10.1101/2023.02.23.529309

Lee WS; Tan H-X; Reynaldi A; Esterbauer R; Koutsakos M; Nguyen J; Amarasena T; Kent H; Aggarwal A; Turville S; Taiaroa G; Kinsella P; Liew KC; Tran T; Williamson D; Cromer D; Davenport M; Kent S; Juno J; Khoury D; Wheatley A, 2023, Durable reprogramming of neutralising antibody responses following breakthrough Omicron infection, http://dx.doi.org/10.1101/2023.02.19.23286159

Hogan A; Doohan P; Wu S; Mesa DO; Toor J; Watson O; Winskill P; Charles G; Barnsley G; Riley E; Khoury D; Ferguson N; Ghani A, 2023, Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach, http://dx.doi.org/10.1101/2023.01.03.23284131

Hogan A; Wu S; Toor J; Mesa DO; Doohan P; Watson O; Winskill P; Charles G; Barnsley G; Riley E; Khoury D; Ferguson N; Ghani A, 2023, Long term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: a modelling study, http://dx.doi.org/10.1101/2023.02.09.23285743

Berry M; Khan S; Schlub T; Notaras A; Kunasekaran M; Grulich A; MacIntyre R; Davenport M; Khoury D, 2023, Predicting vaccine effectiveness in Mpox, http://dx.doi.org/10.1101/2023.11.23.23298850

Elias K; Khan S; Stadler E; Schlub T; Cromer D; Polizzotto M; Kent S; Turner T; Davenport M; Khoury D, 2023, Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: A systematic review and meta-analysis, http://dx.doi.org/10.1101/2023.06.18.23291566

Koutsakos M; Reynaldi A; Lee WS; Nguyen J; Amarasena T; Taiaroa G; Kinsella P; Liew KC; Tran T; Kent HE; Tan H-X; Rowntree LC; Nguyen THO; Thomas PG; Kedzierska K; Petersen J; Rossjohn J; Williamson DA; Khoury D; Davenport MP; Kent SJ; Wheatley AK; Juno JA, 2022, Rapid recall andde novoT cell responses during SARS-CoV-2 breakthrough infection, http://dx.doi.org/10.1101/2022.12.19.521129

Hogan AB; Wu SL; Doohan P; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, 2022, The value of vaccine booster doses to mitigate the global impact of the Omicron SARS-CoV-2 variant, http://dx.doi.org/10.1101/2022.01.17.22269222

Stadler E; Cromer D; Ogunlade S; Ongoiba A; Doumbo S; Kayentao K; Traore B; Crompton P; Portugal S; Davenport M; Khoury D, 2022, A role for super-spreaders in carrying malaria parasites across the months-long dry season, http://dx.doi.org/10.1101/2022.04.28.22274398

Khoury D; Schlub T; Cromer D; Steain M; Fong Y; Gilbert P; Subbarao K; Triccas J; Kent S; Davenport M, 2022, Correlates of protection, thresholds of protection, and immunobridging in SARS-CoV-2 infection, http://dx.doi.org/10.1101/2022.06.05.22275943

Stadler E; Chai KL; Schlub T; Cromer D; Polizzotto M; Kent S; Beecher C; White H; White H; Turner T; Skoetz N; Skoetz N; Estcourt L; McQuilten Z; Wood E; Khoury D; Davenport M, 2022, Determinants of passive antibody efficacy in SARS-CoV-2 infection, http://dx.doi.org/10.1101/2022.03.21.22272672

Stadler E; Burgess M; Schlub T; Chai KL; McQuilten Z; Wood E; Polizzotto M; Kent S; Cromer D; Davenport M; Khoury D, 2022, Monoclonal antibody levels and protection from COVID-19, http://dx.doi.org/10.1101/2022.11.22.22282199

Cromer D; Steain M; Reynaldi A; Schlub T; Sasson S; Kent S; Khoury D; Davenport MP, 2022, Neutralising antibodies predict protection from severe COVID-19, http://dx.doi.org/10.1101/2022.06.09.22275942

Khoury D; Docken S; Subbarao K; Kent S; Davenport M; Cromer D, 2022, Predicting the efficacy of variant-modified COVID-19 vaccine boosters, http://dx.doi.org/10.1101/2022.08.25.22279237

Stadler E; Cromer D; Mehra S; Adekunle A; Flegg J; Anstey N; Watson J; Chu C; Mueller I; Robinson L; Schlub T; Davenport M; Khoury D, 2022, Risk of Plasmodium vivax recurrences follows a 30-70 rule and indicates relapse heterogeneity in the population, http://dx.doi.org/10.1101/2022.05.18.22275180

Goel RR; Painter MM; Apostolidis SA; Mathew D; Meng W; Rosenfeld AM; Lundgreen KA; Reynaldi A; Khoury DS; Pattekar A; Gouma S; Kuri-Cervantes L; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; Baxter AE; Oldridge DA; Giles JR; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Drapeau EM; Dougherty J; Long S; D'Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; UPenn COVID Processing Unit ; Frank I; Betts MR; Vella LA; Grifoni A; Weiskopf D; Sette A; Hensley SE; Davenport MP; Bates P; Luning Prak ET; Greenplate AR; Wherry EJ, 2021, mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern., http://dx.doi.org/10.1101/2021.08.23.457229

Lansink LIM; Engel JA; Lee HJ; Soon MSF; Williams CG; SheelaNair A; Pernold CPS; Laohamonthonkul P; Akter J; Stoll T; Hill MM; Talman AM; Russell A; Lawniczak M; Davenport MP; Khoury DS; Haque A, 2021, Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites, http://dx.doi.org/10.1101/2021.08.18.456784

Mehra S; Stadler E; Khoury D; McCaw JM; Flegg JA, 2021, Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure, http://dx.doi.org/10.48550/arxiv.2107.00779

Khoury D; Steain M; Triccas J; Sigal A; Davenport M; Cromer D, 2021, A meta-analysis of Early Results to predict Vaccine efficacy against Omicron, http://dx.doi.org/10.1101/2021.12.13.21267748

Koutsakos M; Lee WS; Reynaldi A; Tan H-X; Gare G; Kinsella P; Liew KC; Williamson D; Kent H; Stadler E; Cromer D; Khoury D; Wheatley A; Juno J; Davenport M; Kent S, 2021, Dynamics of immune recall following SARS-CoV-2 vaccination or breakthrough infection, http://dx.doi.org/10.1101/2021.12.23.21268285

Aggarwal A; Stella AO; Walker G; Akerman A; Milogiannakis V; Brilot F; Amatayakul-Chantler S; Roth N; Coppola G; Schofield P; Jackson J; Henry J; Mazigi O; Langley D; Lu Y; Forster C; McAllery S; Mathivanan V; Fichter C; Hoppe AC; Munier ML; Jack H-M; Cromer D; Darley D; Matthews G; Christ D; Khoury D; Davenport M; Rawlinson W; Kelleher A; Turville S, 2021, SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern, http://dx.doi.org/10.1101/2021.12.14.21267772

Wheatley A; Juno J; Wang J; Selva K; Reynaldi A; Tan H-X; Shi Lee W; Wragg K; Kelly H; Esterbauer R; Davis S; Kent H; Mordant F; Schlub T; Gordon D; Khoury D; Subbarao K; Cromer D; Gordon T; Chung A; Davenport M; Kent S, 2020, Evolution of immunity to SARS-CoV-2, http://dx.doi.org/10.1101/2020.09.09.20191205

Soon M; Lee HJ; Engel J; Straube J; Thomas B; Clarke L; Laohamonthonkul P; Pernold C; Haldar R; Williams C; Lansink L; Koufariotis R; Lakis V; Wood S; Chen X; James K; Lönnberg T; Lane S; Davenport M; Khoury D; Svensson V; Teichmann S; Haque A, 2019, Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4⁺T cells, http://dx.doi.org/10.1101/675967

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection, http://dx.doi.org/10.48550/arxiv.1701.05302

Hogan AB; Wu SL; Toor J; Doohan P; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, Long Term Vaccination Strategies to Mitigate the Global Impact of SARS-CoV-2 Transmission: A Modelling Study, http://dx.doi.org/10.2139/ssrn.4135323

Koutsakos M; Reynaldi A; Lee WS; Nguyen J; Amarasena T; Taiaroa G; Kinsella P; Liew KC; Tran T; Kent H; Tan H-X; Rowntree LC; Nguyen THO; Thomas P; Kedzierska K; Petersen J; Rossjohn J; Williamson D; Khoury D; Davenport M; Kent SJ; Wheatley AK; Juno JA, Rapid Recall and <i>de novo</i> T Cell Responses During SARS-CoV-2 Breakthrough Infection, http://dx.doi.org/10.2139/ssrn.4311124

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