Dr Frances Louise Byrne

Professional Awards and Experience

Cancer Institute NSW Career Development Fellow (UNSW) 2022-2024

Associate Fellow (AFHEA) Advance Higher Education 2021

Bridge Industry Fellowship 2021

Cancer Institute NSW Early Career Fellow (UNSW) 2018-2021

Hope Funds for Cancer Research Postdoctoral Fellow (University of Virginia/UNSW) 2014-2017

Postdoctoral Research Associate, University of Virginia (USA) 2012-2014

Anthony Rothe Memorial Trust PhD Scholar, Children’s Cancer Institute (UNSW) 2008-2012

Research Assistant, Children’s Cancer Institute (UNSW) 2005-2008

Methods Development Scientist, GroPep Bioreagents (Adelaide) 2003-2005

Bachelor of Biotechnology (Hons), Flinders University of South Australia 1999-2002

Research 

Dr Byrne received her PhD in 2012 for her research on the childhood cancer neuroblastoma (Byrne et al. 2014, Oncogene). Dr Byrne trained as a postdoc at the University of Virginia (USA) from 2012-2014 where she investigated the relationship between obesity and cancer, particularly liver and endometrial cancers (Byrne et al. 2014, Cancer Research). She returned to Australia in 2014 to the School of Biotechnology & Biomolecular Sciences (UNSW) and now leads an independent lab focused on developing novel drugs and dietary interventions for cancer.

Research Focus 1: Developing new drugs that target cancer cell metabolism

Dr Byrne is working with Professor Kyle Hoehn (School of BABS, UNSW) to investigate the therapeutic potential of new mitochondrial uncouplers in liver cancer. She is also working in collaboration with medicinal chemist, Professor Naresh Kumar (Chemistry, UNSW) to develop novel small molecules that alter cancer metabolism and selectively kill cancer cells.

Research Focus 2: Unravelling the links between diet, obesity, and cancer

Cancers of the liver and uterus (endometrium) are strongly linked to diet and obesity.  Dr Byrne's lab is investigating how dietary factors (fructose) and dietary interventions (e.g., calorie restriction, low fat and ketogenic diets) impact liver tumour progression. She is also working with collaborators to identify 'cancer specific' alterations in uterine microbiota (Kaakoush et al. 2022, Cancers), the transcriptome (Tanaka et al. 2022, Int J Mol Sci), circular RNAs (Tanaka et al. 2023, Gene) and the lipidome associated with endometrial cancer.

Contribution to Profession

Dr Byrne reviews fellowship applications (Hope Funds for Cancer Research), NHMRC grants, HDR student theses, and manuscripts for Cancer Research, Cellular & Molecular Life Sciences, Cancers, AJP Endocrinology & Metabolism, etc. She also serves on the Honours Committee for BABS and helps organise and chair sessions at national conferences. Dr Byrne is also the UNSW representative on the steering committee for the Bridge Program.

Teaching

Dr Byrne is an Associate Fellow of Advance Higher Education (AFHEA). She lectures in BABS3151 (topic: Cancer Genetics), BIOC3271/3671 (topic: Molecular Approaches to Cancer Cell Biology, Human Cytoskeleton and Disease), BIOC3261 (topic: Cancer Metabolism), and co-convenes BABS2011 (Current Trends in Biotechnology). She also lectures and leads practicals in the School of Medicine (MFAC1525: Ageing and Endings), supervises PhD, honours, and undergraduate students in the Schools of BABS and Chemistry. She also supervises Independent Learning Project (ILP), honours, and PhD students in the School of Medicine. Dr Byrne has research projects suited to honours and PhD students.  

Social Engagement & Equity

Co-chair, Executive Committee for the Women in Research Network (WiRN). The WiRN aims to support, inform, and advocate for women at UNSW. 

Co-chair, Schools of BABS and BEES Equity, Diversity and Inclusion (EDI) Committee (UNSW) and member of the Faculty of Science EDI working group (SEDIWG).

Engagement with community. Dr Byrne recognizes the importance of communicating her research with research advocates, including Mr Jeff Cuff who sadly lost his wife colon cancer in 2013. Jeff has been an active member of Dr Byrne’s laboratory which led to co-authorship on Dr Byrne’s publication (Byrne et al, 2020 Redox Biology) and he continues to play an important role in guiding her research and helping her establish new collaborations with cancer researchers. Dr Byrne was recently interviewed by Leah Hazard, an NHS midwife and best-selling author, for her new book ‘Womb: The Inside Story of Where We All Began’. In this book Dr Byrne highlights her research on the link between disruption of uterine microbiota and uterine (endometrial) cancer.