By Dr Holly Holliday

Journal articles

Upton DH; Liu J; George SM; Valvi S; Ung C; Rayner BS; Gopalakrishnan A; Pandher R; Khan A; Venkat P; Mayoh C; Holliday H; Yeung N; Nguyen H; Franshaw L; Ehteda A; Shen H; Farruggia G; Orienti I; Reynolds CP; Tsoli M; Ziegler DS, 2025, 'High-throughput in vitro drug screening and in vivo studies identify fenretinide as a brain-penetrant DMG therapeutic.', Neuro Oncol, http://dx.doi.org/10.1093/neuonc/noaf035

Pereira BA; Ritchie S; Chambers CR; Gordon KA; Magenau A; Murphy KJ; Nobis M; Tyma VM; Liew YF; Lucas MC; Naeini MM; Barkauskas DS; Chacon-Fajardo D; Howell AE; Parker AL; Warren SC; Reed DA; Lee V; Metcalf XL; Lee YK; O'Regan LP; Zhu J; Trpceski M; Fontaine ARM; Stoehr J; Rouet R; Lin X; Chitty JL; Porazinski S; Wu SZ; Filipe EC; Cadell AL; Holliday H; Yang J; Papanicolaou M; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Vennin C; Yin J; Dew AB; McMillan PJ; Goldstein LD; Deveson IW; Croucher DR; Samuel MS; Sim HW; Batten M; Chantrill L; Grimmond SM; Gill AJ; Samra J; Jeffry Evans TR; Sasaki T; Phan TG; Swarbrick A; Sansom OJ; Morton JP; Pajic M; Parker BL; Herrmann D; Cox TR; Timpson P, 2024, 'Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response', Science Advances, 10, http://dx.doi.org/10.1126/sciadv.adl1197

Holliday H; Yang J; Dodson E; Nikolic I; Kamili A; Wheatley M; Deng N; Alexandrou S; Davis TP; Kavallaris M; Caldon CE; McCarroll J; De Preter K; Mestdagh P; Marshall GM; Simpson KJ; Fletcher J; Swarbrick A, 2024, 'Erratum: miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma (Molecular Therapy (2022) 30(3) (1119–1134), (S1525001622000041), (10.1016/j.ymthe.2022.01.004))', Molecular Therapy, 32, pp. 2031 - 2033, http://dx.doi.org/10.1016/j.ymthe.2024.05.008

Ross SE; Holliday H; Tsoli M; Ziegler DS; Dinger ME, 2024, 'Abstract B015: RNA N6-methyladenosine (m6A) as a therapeutic target in Diffuse Midline Glioma (DMG)', Cancer Research, 84, pp. B015 - B015, http://dx.doi.org/10.1158/1538-7445.brain23-b015

Glover HJ; Holliday H; Shparberg RA; Winkler D; Day M; Morris MB, 2023, 'Signalling pathway crosstalk stimulated by L-proline drives mouse embryonic stem cells to primitive-ectoderm-like cells', Development (Cambridge), 150, http://dx.doi.org/10.1242/dev.201704

Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477

Holliday H; Yang J; Dodson E; Nikolic I; Kamili A; Wheatley M; Deng N; Alexandrou S; Davis TP; Kavallaris M; Caldon CE; McCarroll J; De Preter K; Mestdagh P; Marshall GM; Simpson KJ; Fletcher J; Swarbrick A, 2022, 'miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma', Molecular Therapy, 30, pp. 1119 - 1134, http://dx.doi.org/10.1016/j.ymthe.2022.01.004

Hayden E; Holliday H; Lehmann R; Khan A; Tsoli M; Rayner BS; Ziegler DS, 2021, 'Therapeutic targets in diffuse midline gliomas—an emerging landscape', Cancers, 13, http://dx.doi.org/10.3390/cancers13246251

Holliday H; Khoury A; Swarbrick A, 2021, 'Chromatin immunoprecipitation of transcription factors and histone modifications in Comma-Dβ mammary epithelial cells', STAR Protocols, 2, http://dx.doi.org/10.1016/j.xpro.2021.100514

Holliday H; Roden D; Junankar S; Wu SZ; Baker LA; Krisp C; Chan CL; McFarland A; Skhinas JN; Cox TR; Pal B; Huntington ND; Ormandy CJ; Carroll JS; Visvader J; Molloy MP; Swarbrick A, 2021, 'Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB', iScience, 24, http://dx.doi.org/10.1016/j.isci.2021.102072

McEvoy CR; Holliday H; Thio N; Mitchell C; Choong DY; Yellapu B; Leong HS; Xu H; Lade S; Browning J; Takano EA; Byrne DJ; Gill AJ; Duong CP; Li J; Fellowes AP; Fox SB; Swarbrick A; Prall OWJ, 2021, 'A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors', Laboratory Investigation, 101, pp. 26 - 37, http://dx.doi.org/10.1038/s41374-020-00484-3

McEvoy CR; Holliday H; Thio N; Mitchell C; Choong DY; Yellapu B; Leong HS; Xu H; Lade S; Browning J; Takano EA; Byrne DJ; Gill AJ; Duong CP; Li J; Fellowes AP; Fox SB; Swarbrick A; Prall OWJ, 2021, 'A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors.', Lab Invest, 101, pp. 26 - 37, http://dx.doi.org/10.1038/s41374-020-00484-3

Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, 39, pp. embj2019104063, http://dx.doi.org/10.15252/embj.2019104063

Thankamony AP; Murali R; Karthikeyan N; Varghese BA; Teo WS; McFarland A; Roden DL; Holliday H; Konrad CV; Cazet A; Dodson E; Yang J; Baker LA; George JT; Levine H; Jolly MK; Swarbrick A; Nair R, 2020, 'Targeting the id1-kif11 axis in triple-negative breast cancer using combination therapy', Biomolecules, 10, pp. 1 - 15, http://dx.doi.org/10.3390/biom10091295

Teo WS; Holliday H; Karthikeyan N; Cazet AS; Roden DL; Harvey K; Konrad CV; Murali R; Varghese BA; Thankamony AP; Chan CL; McFarland A; Junankar S; Ye S; Yang J; Nikolic I; Shah JS; Baker LA; Millar EKA; Naylor MJ; Ormandy CJ; Lakhani SR; Kaplan W; Mellick AS; O'Toole SA; Swarbrick A; Nair R, 2020, 'Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1', Frontiers in Cell and Developmental Biology, 8, http://dx.doi.org/10.3389/fcell.2020.00552

Baker LA; Holliday H; Roden D; Krisp C; Wu SZ; Junankar S; Junankar S; Serandour AA; Mohammed H; Nair R; Sankaranarayanan G; Law AMK; McFarland A; Simpson PT; Lakhani S; Dodson E; Selinger C; Anderson L; Samimi G; Hacker NF; Lim E; Ormandy CJ; Naylor MJ; Simpson K; Nikolic I; O'Toole S; Kaplan W; Cowley MJ; Carroll JS; Molloy M; Swarbrick A, 2020, 'Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer', Breast Cancer Research, 22, http://dx.doi.org/10.1186/s13058-020-01306-6

Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv, http://dx.doi.org/10.1101/2020.06.04.135327

Holliday H; Roden D; Junankar S; Wu S; Baker L; Krisp C; Chan C-L; McFarland A; Skhinas J; Cox T; Pal B; Huntington N; Ormandy C; Carroll J; Visvader J; Molloy M; Swarbrick A, 2020, 'Inhibitor of Differentiation 4 (ID4) represses myoepithelial differentiation of mammary stem cells through its interaction with HEB', , http://dx.doi.org/10.1101/2020.04.06.026963

Holliday H; Baker LA; Junankar SR; Clark SJ; Swarbrick A, 2018, 'Epigenomics of mammary gland development', Breast Cancer Research, 20, http://dx.doi.org/10.1186/s13058-018-1031-x

Baker L; Krisp C; Roden D; Holliday H; Wu S; Junankar S; Serandour A; Mohammed H; Nair R; Chan C-L; Yang J; Foreman N; Fitzpatrick B; Sankaranarayanan G; Law AMK; Ormandy C; Naylor M; McFarland A; Simpson P; Lakhani S; O'Toole S; Selinger C; Anderson L; Samimi G; Hacker N; Kaplan W; Carroll J; Molloy M; Swarbrick A, 2018, 'A novel role for the HLH protein Inhibitor of Differentiation 4 (ID4) in the DNA damage response in basal-like breast cancer.', BIORXIV, http://dx.doi.org/10.1101/281196

Baker LA; Holliday H; Swarbrick A, 2016, 'ID4 controls luminal lineage commitment in normal mammary epithelium and inhibits BRCA1 function in basal-like breast cancer', Endocrine-Related Cancer, 23, pp. R381 - R392, http://dx.doi.org/10.1530/ERC-16-0196

Conference Abstracts

Holliday H; Khan A; Jayatilleke N; Mayoh C; Ross SE; Guo X; Sanguino YC; Gopalakrishnan A; Ehteda A; Tsoli M; Ziegler DS, 2024, 'COMBINED EPIGENETIC THERAPY WITH FACT AND BET INHIBITORS REMODELS CHROMATIN AND DISRUPTS ONCOGENIC TRANSCRIPTION IN DIFFUSE MIDLINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.077

Rayner BS; Samadder A; Holliday H; Chen Y; Nguyen H; Lee A; Liu J; Hayden E; Ogunmodede OS; Rye K-A; Tsoli M; Bertoldo JB; Ziegler DS, 2024, 'THE BIG AND SMALL OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS: TARGETING SUMOYLATION AND CITRULLINATION IN DIFFUSE MIDLINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, PA, Philadelphia, Vol. 26, presented at International Symposium on Pediatric Neuro-Oncology (ISPNO), PA, Philadelphia, 29 June 2024 - 02 July 2024, http://dx.doi.org/10.1093/neuonc/noae064.069

Holliday H; Khan A; Jayatilleke N; Mayoh C; Ross SE; Sanguino YC; Gopalakrishnan A; Ehteda A; Rayner B; Tsoli M; Ziegler DS, 2023, 'Targeting the epigenome through combined Facilitates Chromatin Transcription (FACT) and Bromodomain and Extra-Terminal Domain (BET) inhibition in Diffuse Midline Glioma (DMG)', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, MN, Minneapolis, Vol. 84, presented at AACR Special Conference on Brain Cancer, MN, Minneapolis, 19 October 2023 - 22 October 2023, http://dx.doi.org/10.1158/1538-7445.BRAIN23-B016

Sanguino YC; de la Fuente LR; Kisswani D; Kearney P; Jackson E; Duchatel R; Holliday H; Jabado N; Tsoli M; Ziegler D; Dun M; Mora FV, 2022, 'EXPLORING THE ROLE OF THE EPIGENETIC FACTOR H2A.Z ACETYLATION IN DIPG', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, GERMANY, Hamburg, Vol. 24, pp. 26 - 27, presented at 20th International Symposium on Pediatric Neuro-Oncology (ISPNO) / Annual Meeting of the Brain-Tumor-Group-of-SIOP-Europe (SIOPE-BTG), GERMANY, Hamburg, 11 June 2022 - 15 June 2022, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400096&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Holliday H; Ehteda A; Khan A; Krug B; Rouaen JRC; Jayatilleke N; Mayoh C; Vittorio O; Jabado N; Tsoli M; Ziegler DS, 2022, 'DIPG-06. Uncovering the FACTs in Diffuse Midline Glioma (DMG)', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i18 - i18, http://dx.doi.org/10.1093/neuonc/noac079.063

Sanguino YC; de la Fuente LR; Kisswani D; Kearney P; Jackson E; Duchatel R; Holliday H; Jabado N; Tsoli M; Ziegler D; Dun M; Mora FV, 2022, 'DIPG-37. Exploring the role of the epigenetic factor H2A.Z acetylation in DIPG', in Neuro-Oncology, Oxford University Press (OUP), Vol. 24, pp. i26 - i27, http://dx.doi.org/10.1093/neuonc/noac079.094

Holliday H; Ehteda A; Khan A; Krug B; Rouaen JRC; Jayatilleke N; Mayoh C; Vittorio O; Jabado N; Tsoli M; Ziegler DS, 2022, 'UNCOVERING THE FACTS IN DIFFUSE MIDLINE GLIOMA (DMG)', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 24, pp. 18 - 18, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000840122400065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints

Apostolov E; Roden DL; Holliday H; Cazet A; Harvey K; Zhang H; Wu SZ; van der Leij S; Selth LA; Bartonicek N; Al-Eryani G; He M; Lundeberg J; Reeves J; Kench JG; Potter AJ; Stricker P; Joshua AM; Horvath L; Swarbrick A, 2024, Profiling of epithelial functional states and fibroblast phenotypes in hormone therapy-naïve localised prostate cancer, http://dx.doi.org/10.1101/2024.10.23.619925

Holliday H; Khan A; Ehteda A; Ross S; Jayatilleke N; Gopalakrishnan A; Guo X; Liu J; Nguyen H; Lee A; Sanguino YC; Dinger M; Mayoh C; Rayner B; Tsoli M; Ziegler D, 2024, Chromatin remodeling with combined FACT and BET inhibition disrupts oncogenic transcription in Diffuse Midline Glioma, http://dx.doi.org/10.1101/2024.06.06.597703

Glover H; Holliday H; Shparberg R; Winkler D; Day M; Morris M, 2023, Signalling pathway crosstalk stimulated by L-proline drives differentiation of mouse embryonic stem cells to primitive-ectoderm-like cells, http://dx.doi.org/10.1101/2023.02.14.528585

Baker LA; Holliday H; Roden D; Krisp C; Wu SZ; Junankar S; Serandour AA; Mohammed H; Nair R; Sankaranarayanan G; Law AMK; McFarland A; Simpson PT; Lakhani S; Dodson E; Selinger C; Anderson L; Samimi G; Hacker NF; Lim E; Ormandy CJ; Naylor MJ; Simpson K; Nikolic I; O’Toole S; Kaplan W; Cowley MJ; Carroll JS; Molloy M; Swarbrick A, 2020, Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer, http://dx.doi.org/10.21203/rs.3.rs-16182/v2

Baker LA; Holliday H; Roden D; Krisp C; Wu SZ; Junankar S; Serandour AA; Mohammed H; Nair R; Sankaranarayanan G; Law AMK; McFarland A; Simpson PT; Lakhani S; Dodson E; Selinger C; Anderson L; Samimi G; Hacker NF; Lim E; Ormandy CJ; Naylor MJ; Simpson K; Nikolic I; O’Toole S; Kaplan W; Cowley MJ; Carroll JS; Molloy M; Swarbrick A, 2020, Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer, http://dx.doi.org/10.21203/rs.3.rs-16182/v1

Murali R; Varghese BA; Karthikeyan N; Archana PT; Teo WS; McFarland A; Roden DL; Holliday H; Konrad C; Cazet A; Dodson E; George JT; Levine H; Jolly MK; Swarbrick A; Nair R, 2019, Targeting the Id1-Kif11-Aurka axis in triple negative breast cancer using combination therapy, http://dx.doi.org/10.1101/760686

Teo WS; Holliday H; Karthikeyan N; Cazet AS; Roden DL; Harvey K; Konrad CV; Murali R; Varghese BA; P. T. A; Chan C-L; McFarland A; Junankar S; Ye S; Yang J; Nikolic I; Shah JS; Baker LA; Millar EKA; Naylor MJ; Ormandy CJ; Lakhani SR; Kaplan W; Mellick AS; O’Toole SA; Swarbrick A; Nair R, 2018, Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1, http://dx.doi.org/10.1101/497313

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