By Dr Howard Yim

Book Chapters

Hsin Chew DC; Howard Yim CH; Ali RAR; El-Omar EM, 2024, 'Epidemiology, Microbiome, and Risk Factors Involved in Carcinogenesis of Esophagus, Gastric, and Intestine', in Jankowski JAZ (ed.), Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach, Wiley, pp. 3 - 22, http://dx.doi.org/10.1002/9781119756422.ch1

El‐Omar EM; Yim H, 2022, 'Tumors of the stomach', in , Wiley, pp. 1023 - 1046, http://dx.doi.org/10.1002/9781119600206.ch52

El-Assaad F; Gong L; Gia A; Yim H; El-Omar E, 2019, 'Helicobacter pylori, peptic ulcer disease and gastric cancer', in Eslick G (ed.), Gastrointestinal Diseases and Their Associated Infections, Elsevier, St Louis, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7

Wu N; Yim HCH; Grimm M; El-Omar E, 2019, 'Epithelial Barrier Function', in Encyclopedia of Gastroenterology Second Edition, pp. 300 - 313, http://dx.doi.org/10.1016/B978-0-12-801238-3.65657-X

El-Assaad F; Gong L; Gia A; Yim HCH; El-Omar EM, 2019, 'Chapter 2 Helicobacter pylori, Peptic Ulcer Disease and Gastric Cancer', in Gastrointestinal Diseases and their Associated Infections, Elsevier, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7

Ong HS; Yim HC, 2017, 'Microbial Factors in Inflammatory Diseases and Cancers', in Xu D (ed.), Regulation of Inflammatory Signaling in Health and Disease, pp. 153 - 174, http://dx.doi.org/10.1007/978-981-10-5987-2_7

Journal articles

So SHS; Jiang W; Li Y; Hold GL; Goodrick K; Min A; Bourke MJ; El-Omar EM; Jiang XT; Yim HCH, 2025, 'Mucosal DNA and RNA virome alterations and their interactions with human RNA and microRNA transcriptomes in colorectal polyps', Egastroenterology, 3, http://dx.doi.org/10.1136/egastro-2025-100194

Leung MBW; Chan DYL; Fok EKL; Yim HCH; Jiang X; Li TC, 2025, 'Semen metagenomics and spent culture media in patients undergoing conventional in vitro fertilisation: abridged secondary publication', Hong Kong Medical Journal Xianggang Yi Xue Za Zhi, 31, pp. 45 - 47

Jin J; Yim HCH; Chang HME; Wang Y; Choy KHK; Chan SY; Alqawasmeh OAM; Liao J; Jiang XT; Chan DYL; Fok EKL, 2024, 'DEFB119 stratifies dysbiosis with distorted networks in the seminal microbiome associated with male infertility', Pnas Nexus, 3, http://dx.doi.org/10.1093/pnasnexus/pgae419

Alqawasmeh OAM; Jiang XT; Cong L; Wu W; Leung MBW; Chung JPW; Yim HCH; Fok EKL; Chan DYL, 2024, 'Vertical transmission of microbiomes into embryo culture media and its association with assisted reproductive outcomes', Reproductive Biomedicine Online, 49, http://dx.doi.org/10.1016/j.rbmo.2024.103977

Chesworth R; Yim HCH; Watt G; El-Omar E; Karl T, 2024, 'Cannabidiol (CBD) facilitates cocaine extinction and ameliorates cocaine-induced changes to the gut microbiome in male C57BL/6JArc mice', Progress in Neuro Psychopharmacology and Biological Psychiatry, 133, http://dx.doi.org/10.1016/j.pnpbp.2024.111014

Yim HCH; El-Omar E; Wu JCY; Sung JJY; Lee YY, 2024, 'Recent advances in translating gut microbiota research into clinical practice at 12th Asian Pacific Topic Conference 2023', Journal of Gastroenterology and Hepatology Australia, 39, pp. 979 - 981, http://dx.doi.org/10.1111/jgh.16565

Law HKW; Yim HCH, 2024, 'Early diagnosis of cancer using circulating microbial DNA', Cell Reports Medicine, 5, http://dx.doi.org/10.1016/j.xcrm.2024.101502

Dai P; Qiao F; Chen Y; Chan DYL; Yim HCH; Fok KL; Chen H; Yim H, 2023, 'SARS-CoV-2 and male infertility: from short- to long-term impacts', Journal of Endocrinological Investigation, 46, pp. 1491 - 1507, http://dx.doi.org/10.1007/s40618-023-02055-x

Alqawasmeh O; Fok E; Yim H; Li T; Chung J; Chan D, 2023, 'The microbiome and male infertility: looking into the past to move forward', Human Fertility, 26, pp. 450 - 462, http://dx.doi.org/10.1080/14647273.2022.2098540

Yim HCH; Chakrabarti A; Kessler S; Morimoto H; Wang D; Sooraj D; Ahmed AU; de la Motte C; Silverman RH; Williams BRG; Sadler AJ; Yim H, 2023, 'The protein kinase R modifies gut physiology to limit colitis', Frontiers in Immunology, 14, pp. 1106737, http://dx.doi.org/10.3389/fimmu.2023.1106737

Pandey D; Szczesniak M; Maclean J; Yim HCH; Zhang F; Graham P; El-Omar EM; Wu P, 2022, 'Dysbiosis in Head and Neck Cancer: Determining Optimal Sampling Site for Oral Microbiome Collection', Pathogens, 11, http://dx.doi.org/10.3390/pathogens11121550

Choy KHK; Chan SY; Lam W; Jin J; Zheng T; Law TYS; Yu SS; Wang W; Li L; Xie G; Yim HCH; Chen H; Fok EKL, 2022, 'The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis', BMC Biology, 20, http://dx.doi.org/10.1186/s12915-022-01268-5

Shi D; Turroni S; Gong L; Wu W; Yim HCH; Yim H, 2022, 'Editorial: Manipulation of gut microbiota as a key target to intervene on the onset and progression of digestive system diseases', Frontiers in Medicine, 9, pp. 999005, http://dx.doi.org/10.3389/fmed.2022.999005

Chang HM; Jin J; Yim H; Chan DYL; Fok E, 2022, 'P-041 Elevated beta-defensin 119 level is associated with seminal microbiome dysbiosis in male infertility', Human Reproduction, 37, http://dx.doi.org/10.1093/humrep/deac107.038

Li Y; Zhang F; Zheng H; Kalasabail S; Hicks C; Fung KY; Preaudet A; Putoczki T; Beretov J; Millar EKA; El-Omar E; Jiang XT; Yim HCH, 2022, 'Fecal DNA Virome Is Associated with the Development of Colorectal Neoplasia in a Murine Model of Colorectal Cancer', Pathogens, 11, http://dx.doi.org/10.3390/pathogens11040457

Kalasabail S; Engelman J; Zhang LY; El‐omar E; Yim HCH, 2021, 'A perspective on the role of microbiome for colorectal cancer treatment', Cancers, 13, http://dx.doi.org/10.3390/cancers13184623

Yim HCH; El-Omar EM, 2021, 'Risk of physical activity and hepatobiliary diseases: East meets west', British Journal of Sports Medicine, 55, pp. 1003 - 1004, http://dx.doi.org/10.1136/bjsports-2020-103348

Yim HCH; Leon TYY; Li JCB, 2020, 'MXD1 regulates the H9N2 and H1N1 influenza A virus–induced chemokine expression and their replications in human macrophage', Journal of Leukocyte Biology, 108, pp. 1631 - 1640, http://dx.doi.org/10.1002/JLB.4MA0620-703RR

Fang HF; Lee TY; Hui KC; Ho Yim HC; Chi MJ; Chung MH, 2019, 'Association between sedative-hypnotics and subsequent cancer in patients with and without insomnia: A 14-year follow-up study in Taiwan', Journal of Cancer, 10, pp. 2288 - 2298, http://dx.doi.org/10.7150/jca.30680

Dou Y; Yim HCH; Kirkwood CD; Williams BRG; Sadler AJ, 2017, 'The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation', EMBO Journal, 36, pp. 2742 - 2757, http://dx.doi.org/10.15252/embj.201696273

Ahmed AU; Yim HH; Alorro M; Ernst M; Williams BRG, 2017, 'Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis', Journal of Immunology, http://dx.doi.org/10.4049/jimmunol.1700125

Yim HCH; Wang D; Yu L; White CL; Faber PW; Williams BRG; Sadler AJ, 2016, 'The kinase activity of PKR represses inflammasome activity', Cell Research, 26, pp. 367 - 379, http://dx.doi.org/10.1038/cr.2016.11

Sadler AJ; Rossello FJ; Yu L; Deane JA; Yuan X; Wang D; Irving AT; Kaparakis-Liaskos M; Gantier MP; Ying H; Yim HCH; Hartland EL; Notini AJ; De Boer S; White SJ; Mansell A; Liu JP; Watkins DN; Gerondakis S; Williams BRG; Xu D, 2015, 'BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs', Proceedings of the National Academy of Sciences of the United States of America, 112, pp. 1535 - 1540, http://dx.doi.org/10.1073/pnas.1409728112

Liu MS; Wang D; Morimoto H; Yim HCH; Irving AT; Williams BRG; Sadler AJ, 2014, 'Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation', Journal of Molecular Cell Biology, 6, pp. 473 - 485, http://dx.doi.org/10.1093/jmcb/mju044

Yim HCH; Williams BRG, 2014, 'Protein kinase R and the inflammasome', Journal of Interferon and Cytokine Research, 34, pp. 447 - 454, http://dx.doi.org/10.1089/jir.2014.0008

Li JCB; Chan LLY; Yim HCH; Cheung BKW; Lee DCW; Lau ASY, 2013, 'Suppression of cellular antibacterial effects by HIV', Hong Kong Medical Journal, 19, pp. S19 - S23

Pong J; Li J; Yim H; Lau A, 2013, 'The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection (P4235)', The Journal of Immunology, 190, pp. 130.17 - 130.17, http://dx.doi.org/10.4049/jimmunol.190.supp.130.17

Yim HCH; Chakrabarti A; Silverman R; Williams B; Sadler A, 2012, 'A role for Protein Kinase R in regulating NLRP3 inflammasome signaling pathway', CYTOKINE, 59, pp. 533 - 533, http://dx.doi.org/10.1016/j.cyto.2012.06.129

Yim HCH; Li JCB; Pong JCH; Lau ASY, 2011, 'A role for c-Myc in regulating anti-mycobacterial responses', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 17749 - 17754, http://dx.doi.org/10.1073/pnas.1104892108

Ling WWL; Wang L; Yim HCH; Lau ASY; Li JCB, 2011, 'A role for interleukin 17 in mycobacterial infection', CYTOKINE, 56, pp. 26 - 27, http://dx.doi.org/10.1016/j.cyto.2011.07.058

Li JCB; Au KY; Fang JW; Yim HC; Chow KH; Ho PL; Lau ASY, 2011, 'HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction', AIDS, 25, pp. 15 - 25, http://dx.doi.org/10.1097/QAD.0b013e328340fd61

Fang JW; Li JCB; Au KY; Yim HCH; Lau ASY, 2011, 'Interleukin-17A differentially modulates BCG induction of cytokine production in human blood macrophages', Journal of Leukocyte Biology, 90, pp. 333 - 341, http://dx.doi.org/10.1189/jlb.0510311

Li JCB; Yim HCH; Lau AS, 2010, 'Role of HIV-1 Tat in AIDS pathogenesis: Its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection', AIDS, 24, pp. 1609 - 1623, http://dx.doi.org/10.1097/QAD.0b013e32833ac6a0

Cheung BKW; Yim HCH; Lee NCM; Lau ASY, 2009, 'A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1', BMC Immunology, 10, http://dx.doi.org/10.1186/1471-2172-10-64

Cheung BKW; Chan MMP; Yim HCH; Chan LL; Li JCB; Lee DCW; Lau ASY, 2009, 'Immunotherapy of mycobacterial infections: A cell and molecular model', Hong Kong Medical Journal, 15, pp. 32 - 36

Au KY; Li JCB; Yim HCH; Fang JW; Lau ASY, 2009, 'HIV Tat modulation of IFN-gamma-induced expression of autophagy-associated genes in primary human blood macrophages', CYTOKINE, 48, pp. 67 - 67, http://dx.doi.org/10.1016/j.cyto.2009.07.218

Li JCB; Cheng SM; Yim HCH; Lee DCW; Lau ASY, 2009, 'Mechanisms underlying HIV-1 suppression of IFN gamma signaling pathways: A role for transactivator Tat in the induction of SOCS-2 in primary human blood monocytes', CYTOKINE, 48, pp. 63 - 63, http://dx.doi.org/10.1016/j.cyto.2009.07.201

Cheung BKW; Yim HCH; Lau ASY, 2009, 'Positive role of mitogen-activated protein kinase phosphatase-1 in regulating the anti-mycobacterial immune responses', CYTOKINE, 48, pp. 61 - 62, http://dx.doi.org/10.1016/j.cyto.2009.07.194

Yim HCH; Li JCB; Lau JSH; Lau ASY, 2009, 'HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: Microbial interactions in HIV infection', AIDS, 23, pp. 1473 - 1484, http://dx.doi.org/10.1097/QAD.0b013e32832d7abe

Mak WWS; Cheung F; Woo J; Lee D; Li P; Chan KS; Tam CM, 2009, 'A comparative study of the stigma associated with infectious diseases (SARS, AIDS, TB)', HONG KONG MEDICAL JOURNAL, 15, pp. 34 - 37

Yim HCH; Li JCB; Lee DCW; Lau AS, 2008, 'Microbial interactions in AIDS pathogenesis: HIV-TAT suppression of endotoxin-TLR4 induced interferon induction and cytokine dysregulation', CYTOKINE, 43, pp. 320 - 320, http://dx.doi.org/10.1016/j.cyto.2008.07.407

Law AHY; Lee DCW; Cheung BKW; Yim HCH; Lau ASY, 2007, 'Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation', Journal of Virology, 81, pp. 416 - 422, http://dx.doi.org/10.1128/JVI.02336-05

Conference Papers

Pandey D; Szcczesniak M; Maclean J; Zhang F; Yim H; El-Omar E; Graham P; Wu P, 2023, 'IMPLICATIONS OF ORO-PHARYNGEAL DYSBIOSIS IN HEAD AND NECK CANCER: ORAL MICROBIOME AND CHEMORADIATION-RELATED COMPLICATIONS', in GUT, BMJ PUBLISHING GROUP, PEOPLES R CHINA, Hong Kong, pp. A114 - A116, presented at International Digestive Disease Forum (IDDF), PEOPLES R CHINA, Hong Kong, 10 June 2023 - 11 June 2023, http://dx.doi.org/10.1136/gutjnl-2023-IDDF.101

Li JC; Yim HC; Rieder MJ; Lau AS, 2008, 'Immunomodulatory Effects of Drug Metabolites: An Unexpected Role of Sulfamethoxazole in the Regulation of Inflammation', in Hiscott J (ed.), PROCEEDINGS OF THE 7TH JOINT MEETING OF THE INTERNATIONAL MEETING OF THE INTERNATIONAL CYTOKINE SOCIETY AND THE INTERNATIONAL SOCIETY FOR INTERFERON AND CYTOKINE RESEARCH, MEDIMOND S R L, CANADA, Montreal, pp. 55 - 58, presented at 7th Joint Conference of the International-Cytokines-Society/International-Society-for-Interferon-and-Cytoklin-Research, CANADA, Montreal, 12 October 2008 - 16 October 2008, http://dx.doi.org/10.1145/1370788.1370803

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