By Dr Howard Yim

Book Chapters

Hsin Chew DC; Howard Yim CH; Ali RAR; El-Omar EM, 2024, 'Epidemiology, Microbiome, and Risk Factors Involved in Carcinogenesis of Esophagus, Gastric, and Intestine', in Jankowski JAZ (ed.), Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach, Wiley, pp. 3 - 22, http://dx.doi.org/10.1002/9781119756422.ch1

El‐Omar EM; Yim H, 2022, 'Tumors of the stomach', in , Wiley, pp. 1023 - 1046, http://dx.doi.org/10.1002/9781119600206.ch52

El-Assaad F; Gong L; Gia A; Yim H; El-Omar E, 2019, 'Helicobacter pylori, peptic ulcer disease and gastric cancer', in Eslick G (ed.), Gastrointestinal Diseases and Their Associated Infections, Elsevier, St Louis, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7

Wu N; Yim HCH; Grimm M; El-Omar E, 2019, 'Epithelial Barrier Function', in Encyclopedia of Gastroenterology, Second Edition, pp. 300 - 313, http://dx.doi.org/10.1016/B978-0-12-801238-3.65657-X

El-Assaad F; Gong L; Gia A; Yim HCH; El-Omar EM, 2019, 'Chapter 2 Helicobacter pylori, Peptic Ulcer Disease and Gastric Cancer', in Gastrointestinal Diseases and their Associated Infections, Elsevier, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7

Ong HS; Yim HC, 2017, 'Microbial Factors in Inflammatory Diseases and Cancers', in Xu D (ed.), Regulation of Inflammatory Signaling in Health and Disease, pp. 153 - 174, http://dx.doi.org/10.1007/978-981-10-5987-2_7

Journal articles

Dai P; Qiao F; Chen Y; Chan DYL; Yim HCH; Fok KL; Chen H; Yim H, 2023, 'SARS-CoV-2 and male infertility: from short- to long-term impacts', Journal of Endocrinological Investigation, 46, pp. 1491 - 1507, http://dx.doi.org/10.1007/s40618-023-02055-x

Alqawasmeh O; Fok E; Yim H; Li T; Chung J; Chan D, 2023, 'The microbiome and male infertility: looking into the past to move forward', Human Fertility, 26, pp. 450 - 462, http://dx.doi.org/10.1080/14647273.2022.2098540

Yim HCH; Chakrabarti A; Kessler S; Morimoto H; Wang D; Sooraj D; Ahmed AU; de la Motte C; Silverman RH; Williams BRG; Sadler AJ; Yim H, 2023, 'The protein kinase R modifies gut physiology to limit colitis', Frontiers in Immunology, 14, pp. 1106737, http://dx.doi.org/10.3389/fimmu.2023.1106737

Pandey D; Szczesniak M; Maclean J; Yim HCH; Zhang F; Graham P; El-Omar EM; Wu P, 2022, 'Dysbiosis in Head and Neck Cancer: Determining Optimal Sampling Site for Oral Microbiome Collection', Pathogens, 11, http://dx.doi.org/10.3390/pathogens11121550

Choy KHK; Chan SY; Lam W; Jin J; Zheng T; Law TYS; Yu SS; Wang W; Li L; Xie G; Yim HCH; Chen H; Fok EKL, 2022, 'The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis', BMC Biology, 20, http://dx.doi.org/10.1186/s12915-022-01268-5

Shi D; Turroni S; Gong L; Wu W; Yim HCH; Yim H, 2022, 'Editorial: Manipulation of gut microbiota as a key target to intervene on the onset and progression of digestive system diseases', Frontiers in Medicine, 9, pp. 999005, http://dx.doi.org/10.3389/fmed.2022.999005

Li Y; Zhang F; Zheng H; Kalasabail S; Hicks C; Fung KY; Preaudet A; Putoczki T; Beretov J; Millar EKA; El-Omar E; Jiang XT; Yim HCH, 2022, 'Fecal DNA Virome Is Associated with the Development of Colorectal Neoplasia in a Murine Model of Colorectal Cancer', Pathogens, 11, http://dx.doi.org/10.3390/pathogens11040457

Kalasabail S; Engelman J; Zhang LY; El‐omar E; Yim HCH, 2021, 'A perspective on the role of microbiome for colorectal cancer treatment', Cancers, 13, http://dx.doi.org/10.3390/cancers13184623

Yim HCH; El-Omar EM, 2021, 'Risk of physical activity and hepatobiliary diseases: East meets west', British Journal of Sports Medicine, 55, pp. 1003 - 1004, http://dx.doi.org/10.1136/bjsports-2020-103348

Yim HCH; Leon TYY; Li JCB, 2020, 'MXD1 regulates the H9N2 and H1N1 influenza A virus–induced chemokine expression and their replications in human macrophage', Journal of Leukocyte Biology, 108, pp. 1631 - 1640, http://dx.doi.org/10.1002/JLB.4MA0620-703RR

Fang HF; Lee TY; Hui KC; Ho Yim HC; Chi MJ; Chung MH, 2019, 'Association between sedative-hypnotics and subsequent cancer in patients with and without insomnia: A 14-year follow-up study in Taiwan', Journal of Cancer, 10, pp. 2288 - 2298, http://dx.doi.org/10.7150/jca.30680

Dou Y; Yim HCH; Kirkwood CD; Williams BRG; Sadler AJ, 2017, 'The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation', EMBO Journal, 36, pp. 2742 - 2757, http://dx.doi.org/10.15252/embj.201696273

Ahmed AU; Yim HH; Alorro M; Ernst M; Williams BRG, 2017, 'Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis', Journal of Immunology, http://dx.doi.org/10.4049/jimmunol.1700125

Yim HCH; Wang D; Yu L; White CL; Faber PW; Williams BRG; Sadler AJ, 2016, 'The kinase activity of PKR represses inflammasome activity', Cell Research, 26, pp. 367 - 379, http://dx.doi.org/10.1038/cr.2016.11

Sadler AJ; Rossello FJ; Yu L; Deane JA; Yuan X; Wang D; Irving AT; Kaparakis-Liaskos M; Gantier MP; Ying H; Yim HCH; Hartland EL; Notini AJ; De Boer S; White SJ; Mansell A; Liu JP; Watkins DN; Gerondakis S; Williams BRG; Xu D, 2015, 'BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs', Proceedings of the National Academy of Sciences of the United States of America, 112, pp. 1535 - 1540, http://dx.doi.org/10.1073/pnas.1409728112

Liu MS; Wang D; Morimoto H; Yim HCH; Irving AT; Williams BRG; Sadler AJ, 2014, 'Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation', Journal of Molecular Cell Biology, 6, pp. 473 - 485, http://dx.doi.org/10.1093/jmcb/mju044

Yim HCH; Williams BRG, 2014, 'Protein kinase R and the inflammasome', Journal of Interferon and Cytokine Research, 34, pp. 447 - 454, http://dx.doi.org/10.1089/jir.2014.0008

Li JCB; Chan LLY; Yim HCH; Cheung BKW; Lee DCW; Lau ASY, 2013, 'Suppression of cellular antibacterial effects by HIV', Hong Kong Medical Journal, 19, pp. S19 - S23

Pong J; Li J; Yim H; Lau A, 2013, 'The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection (P4235)', The Journal of Immunology, 190, pp. 130.17 - 130.17, http://dx.doi.org/10.4049/jimmunol.190.supp.130.17

Yim HCH; Chakrabarti A; Silverman R; Williams B; Sadler A, 2012, 'A role for Protein Kinase R in regulating NLRP3 inflammasome signaling pathway', CYTOKINE, 59, pp. 533 - 533, http://dx.doi.org/10.1016/j.cyto.2012.06.129

Yim HCH; Li JCB; Pong JCH; Lau ASY, 2011, 'A role for c-Myc in regulating anti-mycobacterial responses', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 17749 - 17754, http://dx.doi.org/10.1073/pnas.1104892108

Ling WWL; Wang L; Yim HCH; Lau ASY; Li JCB, 2011, 'A role for interleukin 17 in mycobacterial infection', CYTOKINE, 56, pp. 26 - 27, http://dx.doi.org/10.1016/j.cyto.2011.07.058

Li JCB; Au KY; Fang JW; Yim HC; Chow KH; Ho PL; Lau ASY, 2011, 'HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction', AIDS, 25, pp. 15 - 25, http://dx.doi.org/10.1097/QAD.0b013e328340fd61

Fang JW; Li JCB; Au KY; Yim HCH; Lau ASY, 2011, 'Interleukin-17A differentially modulates BCG induction of cytokine production in human blood macrophages', Journal of Leukocyte Biology, 90, pp. 333 - 341, http://dx.doi.org/10.1189/jlb.0510311

Li JCB; Yim HCH; Lau AS, 2010, 'Role of HIV-1 Tat in AIDS pathogenesis: Its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection', AIDS, 24, pp. 1609 - 1623, http://dx.doi.org/10.1097/QAD.0b013e32833ac6a0

Cheung BKW; Yim HCH; Lee NCM; Lau ASY, 2009, 'A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1', BMC Immunology, 10, http://dx.doi.org/10.1186/1471-2172-10-64

Cheung BKW; Chan MMP; Yim HCH; Chan LL; Li JCB; Lee DCW; Lau ASY, 2009, 'Immunotherapy of mycobacterial infections: A cell and molecular model', Hong Kong Medical Journal, 15, pp. 32 - 36

Au KY; Li JCB; Yim HCH; Fang JW; Lau ASY, 2009, 'HIV Tat modulation of IFN-gamma-induced expression of autophagy-associated genes in primary human blood macrophages', CYTOKINE, 48, pp. 67 - 67, http://dx.doi.org/10.1016/j.cyto.2009.07.218

Li JCB; Cheng SM; Yim HCH; Lee DCW; Lau ASY, 2009, 'Mechanisms underlying HIV-1 suppression of IFN gamma signaling pathways: A role for transactivator Tat in the induction of SOCS-2 in primary human blood monocytes', CYTOKINE, 48, pp. 63 - 63, http://dx.doi.org/10.1016/j.cyto.2009.07.201

Cheung BKW; Yim HCH; Lau ASY, 2009, 'Positive role of mitogen-activated protein kinase phosphatase-1 in regulating the anti-mycobacterial immune responses', CYTOKINE, 48, pp. 61 - 62, http://dx.doi.org/10.1016/j.cyto.2009.07.194

Yim HCH; Li JCB; Lau JSH; Lau ASY, 2009, 'HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: Microbial interactions in HIV infection', AIDS, 23, pp. 1473 - 1484, http://dx.doi.org/10.1097/QAD.0b013e32832d7abe

Mak WWS; Cheung F; Woo J; Lee D; Li P; Chan KS; Tam CM, 2009, 'A comparative study of the stigma associated with infectious diseases (SARS, AIDS, TB)', HONG KONG MEDICAL JOURNAL, 15, pp. 34 - 37, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000216394800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Yim HCH; Li JCB; Lee DCW; Lau AS, 2008, 'Microbial interactions in AIDS pathogenesis: HIV-TAT suppression of endotoxin-TLR4 induced interferon induction and cytokine dysregulation', CYTOKINE, 43, pp. 320 - 320, http://dx.doi.org/10.1016/j.cyto.2008.07.407

Law AHY; Lee DCW; Cheung BKW; Yim HCH; Lau ASY, 2007, 'Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation', Journal of Virology, 81, pp. 416 - 422, http://dx.doi.org/10.1128/JVI.02336-05

Conference Papers

Li JC; Yim HC; Rieder MJ; Lau AS, 2008, 'Immunomodulatory Effects of Drug Metabolites: An Unexpected Role of Sulfamethoxazole in the Regulation of Inflammation', in Hiscott J (ed.), PROCEEDINGS OF THE 7TH JOINT MEETING OF THE INTERNATIONAL MEETING OF THE INTERNATIONAL CYTOKINE SOCIETY AND THE INTERNATIONAL SOCIETY FOR INTERFERON AND CYTOKINE RESEARCH, MEDIMOND S R L, CANADA, Montreal, pp. 55 - 58, presented at 7th Joint Conference of the International-Cytokines-Society/International-Society-for-Interferon-and-Cytoklin-Research, CANADA, Montreal, 12 October 2008 - 16 October 2008, http://dx.doi.org/10.1145/1370788.1370803

Yim HCH; Li JCB; Lau AS, 2006, 'Effects of HIV-1 tat on lipopolysaccharide induced cytokine response', in Schwarzmeier JD (ed.), Proceedings of the 6th International Cytokine Conference, MEDIMOND S R L, AUSTRIA, Vienna, pp. 163 - 166, presented at 6th International Cytokine Conference, AUSTRIA, Vienna, 27 August 2006 - 31 August 2006, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243535100030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Yim HH; Yu L; Wang D; Chakrabarti A; Silverman R; Williams BRW; Sadler AJ, 2014, 'A role for protein kinase R in regulating NLRP3 inflammasome assembly', in SI: 2014 ICIS Abstract Issue, Melbourne, Australia, presented at ICIS Conference, Melbourne, Australia, 26 October 2014 - 29 October 2014, http://dx.doi.org/10.1016/j.cyto.2014.07.212

Yim HH; Pindel A, 2013, 'The protein kinase R as a repressor of inflammasome activity', in 2013 ICS Abstract Issue, presented at ICIS Conference, http://dx.doi.org/10.1016/j.cyto.2013.06.293

Pong JC; Li JC; Yim HH; Lau AS, 2012, 'The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection', in 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, Geneva, Switzerland, Vol. 59, pp. 522 - 522, presented at 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, Geneva, Switzerland, 11 September 2012 - 14 September 2012, http://dx.doi.org/10.1016/j.cyto.2012.06.096

Li JC; Yim HC; Rieder MJ; Lee DC; Lau AS, 2008, 'Immunomodulatory effects of drug metaboites: An unexpected role of sulfamethoxazole in the regulation of inflammation', in CYTOKINES IN CANCER, INFLAMMATION AND INFECTIOUS DISEASES: TRANSLATING SCIENCE INTO HEALTH, Cytokine, Elsevier, Montreal, Quebec, Canada, Vol. 43, pp. 250 - 250, presented at 7thJoint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Montreal, Quebec, Canada, 12 October 2008 - 16 August 2017, http://dx.doi.org/10.1016/j.cyto.2008.07.101

Preprints

Choy KHK; Chan SY; Lam W; Jin J; Zheng T; Yu SS; Wang W; Li L; Xie G; Yim HCH; Chen H; Fok EKL, 2021, The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication required for spermatogenesis, http://dx.doi.org/10.1101/2021.01.08.426002

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