By Dr Jason Ciril Kovacic

Journal articles

Kovacic JC, 2017, 'Unraveling the Complex Genetics of Coronary Artery Disease', Journal of the American College of Cardiology, 69, pp. 837 - 840, http://dx.doi.org/10.1016/j.jacc.2016.12.007

Evrard SM; Lecce L; Michelis KC; Nomura-Kitabayashi A; Pandey G; Purushothaman KR; d'Escamard V; Li JR; Hadri L; Fujitani K; Moreno PR; Benard L; Rimmele P; Cohain A; Mecham B; Randolph GJ; Nabel EG; Hajjar R; Fuster V; Boehm M; Kovacic JC, 2017, 'Corrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability', Nature communications, 8, pp. 14710, http://dx.doi.org/10.1038/ncomms14710

Kini AS; Vengrenyuk Y; Shameer K; Maehara A; Purushothaman M; Yoshimura T; Matsumura M; Aquino M; Haider N; Johnson KW; Readhead B; Kidd BA; Feig JE; Krishnan P; Sweeny J; Milind M; Moreno P; Mehran R; Kovacic JC; Baber U; Dudley JT; Narula J; Sharma S, 2017, 'Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes After Intensive Statin Treatment: The YELLOW II Study', Journal of the American College of Cardiology, 69, pp. 628 - 640, http://dx.doi.org/10.1016/j.jacc.2016.10.029

Kini AS; Vengrenyuk Y; Pena J; Yoshimura T; Panwar SR; Motoyama S; Kezbor S; Hasan CM; Palkhiwala S; Kovacic JC; Moreno P; Baber U; Mehran R; Narula J; Sharma SK, 2017, 'Plaque morphology predictors of side branch occlusion after provisional stenting in coronary bifurcation lesion: Results of optical coherence tomography bifurcation study (ORBID)', Catheterization and Cardiovascular Interventions, 89, pp. 259 - 268, http://dx.doi.org/10.1002/ccd.26524

Theodoropoulos K; Mennuni MG; Dangas GD; Meelu OA; Bansilal S; Baber U; Sartori S; Kovacic JC; Moreno PR; Sharma SK; Mehran R; Kini AS, 2016, 'Resistant in-stent restenosis in the drug eluting stent era', Catheterization and Cardiovascular Interventions, 88, pp. 777 - 785, http://dx.doi.org/10.1002/ccd.26559

Kiando SR; Tucker NR; Castro-Vega LJ; Katz A; D’Escamard V; Tréard C; Fraher D; Albuisson J; Kadian-Dodov D; Ye Z; Austin E; Yang ML; Hunker K; Barlassina C; Cusi D; Galan P; Empana JP; Jouven X; Gimenez-Roqueplo AP; Bruneval P; Hyun Kim ES; Olin JW; Gornik HL; Azizi M; Plouin PF; Ellinor PT; Kullo IJ; Milan DJ; Ganesh SK; Boutouyrie P; Kovacic JC; Jeunemaitre X; Bouatia-Naji N, 2016, 'PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance', PLoS Genetics, 12, http://dx.doi.org/10.1371/journal.pgen.1006367

Franzén O; Ermel R; Cohain A; Akers NK; Di Narzo A; Talukdar HA; Foroughi-Asl H; Giambartolomei C; Fullard JF; Sukhavasi K; Köks S; Gan LM; Giannarelli C; Kovacic JC; Betsholtz C; Losic B; Michoel T; Hao K; Roussos P; Skogsberg J; Ruusalepp A; Schadt EE; Björkegren JLM, 2016, 'Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases', Science, 353, pp. 827 - 830, http://dx.doi.org/10.1126/science.aad6970

Evrard SM; Lecce L; Michelis KC; Nomura-Kitabayashi A; Pandey G; Purushothaman KR; D'Escamard V; Li JR; Hadri L; Fujitani K; Moreno PR; Benard L; Rimmele P; Cohain A; Mecham B; Randolph GJ; Nabel EG; Hajjar R; Fuster V; Boehm M; Kovacic JC, 2016, 'Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms11853

Jeong D; Lee M-A; Li Y; Yang DK; Kho C; Oh JG; Hong G; Lee A; Song MH; LaRocca TJ; Chen J; Liang L; Mitsuyama S; D'Escamard V; Kovacic JC; Kwak TH; Hajjar RJ; Park WJ, 2016, 'Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis (vol 67, pg 1556, 2016)', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67, pp. 2809 - 2809, http://dx.doi.org/10.1016/j.jacc.2016.04.014

Mosley GE; Beckerman W; Kovacic JC; Kini AS; Sharma SK; Tadros RO, 2016, 'Management of complete iliofemoral artery avulsion with a hybrid technique', Journal of Vascular Surgery Cases and Innovative Techniques, 2, pp. 37 - 39, http://dx.doi.org/10.1016/j.jvsc.2016.03.002

Santini MP; Forte E; Harvey RP; Kovacic JC, 2016, 'Developmental origin and lineage plasticity of endogenous cardiac stem cells', Development (Cambridge), 143, pp. 1242 - 1258, http://dx.doi.org/10.1242/dev.111591

Vedanthan R; Bansilal S; Soto AV; Kovacic JC; Latina J; Jaslow R; Santana M; Gorga E; Kasarskis A; Hajjar R; Schadt EE; Björkegren JL; Fayad ZA; Fuster V, 2016, 'Family-Based Approaches to Cardiovascular Health Promotion', Journal of the American College of Cardiology, 67, pp. 1725 - 1737, http://dx.doi.org/10.1016/j.jacc.2016.01.036

Jeong D; Yang DK; Kho C; Oh JG; Lee A; Chen J; Liang L; Mitsuyama S; D'Escamard V; Kovacic JC; Hajjar RJ; Lee MA; Li Y; Hong G; Song MH; Park WJ; LaRocca TJ; Kwak TH, 2016, 'Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis', Journal of the American College of Cardiology, 67, pp. 1556 - 1568, http://dx.doi.org/10.1016/j.jacc.2016.01.030

Talukdar HA; Foroughi Asl H; Jain RK; Ermel R; Ruusalepp A; Franzén O; Kidd BA; Readhead B; Giannarelli C; Kovacic JC; Ivert T; Dudley JT; Civelek M; Lusis AJ; Schadt EE; Skogsberg J; Michoel T; Björkegren JLM, 2016, 'Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease', Cell Systems, 2, pp. 196 - 208, http://dx.doi.org/10.1016/j.cels.2016.02.002

Wiley BM; Kovacic JC; Basnet S; Makoto A; Chaudhry FA; Kini AS; Sharma SK; Sengupta PP, 2016, 'Intraprocedural TAVR Annulus Sizing Using 3D TEE and the “Turnaround Rule”', JACC: Cardiovascular Imaging, 9, pp. 213 - 215, http://dx.doi.org/10.1016/j.jcmg.2015.02.018

Kiando S; Tucker N; Katz A; Tréard C; Desca-Mard V; Castro-Vega L; Barlasina C; Cusi D; Galan P; Empana J; Olin J; Gornik H; Plouin P; Kullo I; Milan D; Ganesh S; Boutouyrie P; Kovacic J; Jeunemaitre X; Bouatia-Naji N, 2015, 'CO-43: Genetic study identifies common variation in phactr1 to associate with fibromuscular dysplasia', Annales de Cardiologie et d'Angeiologie, 64, pp. S20, http://dx.doi.org/10.1016/S0003-3928(16)30043-9

Senguttuvan NB; Ellozy S; Tejani F; Kovacic J; Kini AS; Sharma SK; Dangas GD, 2015, 'TAVR Through Heavily Calcified Aorta Following Atheroma Retrieval with the "elevator" Technique', Journal of Invasive Cardiology, 27, pp. E216 - E219

Christodoulidis G; Yu J; Kini A; Dangas GD; Baber U; Melissa A; Sartori S; Theodoropoulos K; Bhat A; Kovacic J; Moreno P; Krishnan P; Mehran R; Sharma S, 2015, 'Gender-specific outcomes after balloon aortic valvuloplasty: Inhospital and long-term outcomes', American Heart Journal, 170, pp. 180 - 186, http://dx.doi.org/10.1016/j.ahj.2015.03.013

Kovacic JC, 2015, 'Unlocking the many secrets of noncoding RNA', Journal of the American College of Cardiology, 65, pp. 2538 - 2541, http://dx.doi.org/10.1016/j.jacc.2015.04.014

Kini AS; Motoyama S; Vengrenyuk Y; Feig JE; Pena J; Baber U; Bhat AM; Moreno P; Kovacic JC; Narula J; Sharma SK, 2015, 'Multimodality Intravascular Imaging to Predict Periprocedural Myocardial Infarction During Percutaneous Coronary Intervention', JACC: Cardiovascular Interventions, 8, pp. 937 - 945, http://dx.doi.org/10.1016/j.jcin.2015.03.016

Kovacic JC; Fuster V, 2015, 'Cell therapy for patients with acute myocardial infarction: ACCRUEd evidence to date', Circulation Research, 116, pp. 1287 - 1290, http://dx.doi.org/10.1161/CIRCRESAHA.115.306323

Björkegren JLM; Kovacic JC; Dudley JT; Schadt EE, 2015, 'Genome-wide significant loci: How important are they?: Systems genetics to understand heritability of coronary artery disease and other common complex disorders', Journal of the American College of Cardiology, 65, pp. 830 - 845, http://dx.doi.org/10.1016/j.jacc.2014.12.033

Sengupta PP; Wiley BM; Basnet S; Rajamanickman A; Kovacic JC; Fischer GW; Kini AS; Sharma SK, 2015, 'Transthoracic echocardiography guidance for TAVR under monitored anesthesia care', JACC: Cardiovascular Imaging, 8, pp. 379 - 380, http://dx.doi.org/10.1016/j.jcmg.2015.01.002

Kovacic JC; Kini A; Banerjee S; Dangas G; Massaro J; Mehran R; Popma J; O'Neill WW; Sharma SK, 2015, 'Patients with 3-vessel coronary artery disease and impaired ventricular function undergoing PCI with Impella 2.5 hemodynamic support have improved 90-day outcomes compared to intra-aortic balloon pump: A sub-study of the PROTECT II trial', Journal of Interventional Cardiology, 28, pp. 35 - 40, http://dx.doi.org/10.1111/joic.12166

Dohi T; Maehara A; Moreno PR; Baber U; Kovacic JC; Limaye AM; Ali ZA; Sweeny JM; Mehran R; Dangas GD; Xu K; Sharma SK; Mintz GS; Kini AS, 2015, 'The relationship among extent of lipid-rich plaque, lesion characteristics, and plaque progression/regression in patients with coronary artery disease: a serial near-infrared spectroscopy and intravascular ultrasound study', European heart journal cardiovascular Imaging, 16, pp. 81 - 87, http://dx.doi.org/10.1093/ehjci/jeu169

Meelu OA; Tomey MI; Sartori S; Kherada N; Mennuni MG; Theodoropoulos KN; Sayeneni S; Baber U; Pyo RT; Kovacic JC; Moreno P; Krishnan P; Mehran R; Dangas GD; Kini AS; Sharma SK, 2014, 'Comparison of provisional 1-stent and 2-stent strategies in diabetic patients with true bifurcation lesions: The EES bifurcation study', Journal of Invasive Cardiology, 26, pp. 619 - 623

Theodoropoulos K; Yu J; Aquino M; Baber U; Roy S; Kovacic J; Sweeny J; Mehran R; Sharma S; Kini A, 2014, 'Abstract 17007: Does Age Modify Gender-based Differences in Clinical Outcomes Following Percutaneous Coronary Intervention (PCI)', Circulation, 130, http://dx.doi.org/10.1161/circ.130.suppl_2.17007

Michelis KC; Boehm M; Kovacic JC, 2014, 'New vessel formation in the context of cardiomyocyte regeneration - the role and importance of an adequate perfusing vasculature', Stem Cell Research, 13, pp. 666 - 682, http://dx.doi.org/10.1016/j.scr.2014.04.009

Narula J; Kovacic JC, 2014, 'Putting TCFA in clinical perspective', Journal of the American College of Cardiology, 64, pp. 681 - 683, http://dx.doi.org/10.1016/j.jacc.2014.06.1163

Fuster V; Kovacic JC, 2014, 'Acute coronary syndromes: Pathology, diagnosis, genetics, prevention, and treatment', Circulation Research, 114, pp. 1847 - 1851, http://dx.doi.org/10.1161/CIRCRESAHA.114.302806

Garcia-Garcia HM; Jang IK; Serruys PW; Kovacic JC; Narula J; Fayad ZA, 2014, 'Imaging plaques to predict and better manage patients with acute coronary events', Circulation Research, 114, pp. 1904 - 1917, http://dx.doi.org/10.1161/CIRCRESAHA.114.302745

Kherada NI; Sartori S; Tomey MI; Mennuni MG; Meelu OA; Roy S; Mohanty BD; Baber U; Pyo R; Kovacic JC; Sweeny J; Moreno P; Krishnan P; Dangas GD; Mehran R; Sharma SK; Kini AS, 2014, 'Dedicated two-stent technique in complex bifurcation percutaneous coronary intervention with use of everolimus-eluting stents: The EES-bifurcation study', International Journal of Cardiology, 174, pp. 13 - 17, http://dx.doi.org/10.1016/j.ijcard.2014.03.029

Tomey MI; Narula J; Kovacic JC, 2014, 'Advances in the understanding of plaque composition and treatment options: Year in review', Journal of the American College of Cardiology, 63, pp. 1604 - 1616, http://dx.doi.org/10.1016/j.jacc.2014.01.042

Cooley BC; Nevado J; Mellad J; Yang D; St. Hilaire C; Negro A; Fang F; Chen G; San H; Walts AD; Schwartzbeck RL; Taylor B; Lanzer JD; Wragg A; Elagha A; Beltran LE; Berry C; Feil R; Virmani R; Ladich E; Kovacic JC; Boehm M, 2014, 'TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling', Science Translational Medicine, 6, http://dx.doi.org/10.1126/scitranslmed.3006927

Kovacic JC; Mehran R; Sweeny J; Li JR; Moreno P; Baber U; Krishnan P; Badimon JJ; Hulot JS; Kini A; Sharma SK, 2014, 'Clustering of acute and subacute stent thrombosis related to the introduction of generic clopidogrel', Journal of Cardiovascular Pharmacology and Therapeutics, 19, pp. 201 - 208, http://dx.doi.org/10.1177/1074248413510605

Lipskaia L; Bobe R; Chen J; Turnbull IC; Lopez JJ; Merlet E; Jeong D; Karakikes I; Ross AS; Liang L; Mougenot N; Atassi F; Lompré AM; Tarzami ST; Kovacic JC; Kranias E; Hajjar RJ; Hadri L, 2014, 'Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca²⁺-ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells', Circulation, 129, pp. 773 - 785, http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002565

Dangas GD; Maehara A; Evrard SM; Sartori S; Li JR; Chirumamilla AP; Nomura-Kitabayashi A; Gukathasan N; Hassanin A; Baber U; Fahy M; Fuster V; Mintz GS; Kovacic JC, 2014, 'Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: A three-dimensional intravascular ultrasound study', European Heart Journal Cardiovascular Imaging, 15, pp. 201 - 209, http://dx.doi.org/10.1093/ehjci/jet139

Hulot JS; Stillitano F; Salem JE; Kovacic JC; Fuster V; Hajjar RJ, 2014, 'Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes', Stem Cell Research and Therapy, 5, http://dx.doi.org/10.1186/scrt390

Giannarelli C; Alique M; Rodriguez DT; Yang DK; Jeong D; Calcagno C; Hutter R; Millon A; Kovacic JC; Weber T; Faries PL; Soff GA; Fayad ZA; Hajjar RJ; Fuster V; Badimon JJ, 2014, 'Alternatively spliced tissue factor promotes plaque angiogenesis through the activation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling', Circulation, 130, pp. 1274 - 1286, http://dx.doi.org/10.1161/CIRCULATIONAHA.114.006614

Roleder T; Kovacic JC; Ali Z; Sharma R; Cristea E; Moreno P; Sharma SK; Narula J; Kini AS, 2014, 'Combined NIRS and IVUS imaging detects vulnerable plaque using a single catheter system: A head-to-head comparison with OCT', EuroIntervention, 10, pp. 303 - 311, http://dx.doi.org/10.4244/EIJV10I3A53

Michelis KC; Olin JW; Kadian-Dodov D; D'Escamard V; Kovacic JC, 2014, 'Coronary artery manifestations of fibromuscular dysplasia', Journal of the American College of Cardiology, 64, pp. 1033 - 1046, http://dx.doi.org/10.1016/j.jacc.2014.07.014

Kini A; Yu J; Cohen MG; Mehran R; Baber U; Sartori S; Vlachojannis GJ; Kovacic JC; Pyo R; O'Neill B; Singh V; Jacobs E; Poludasu S; Moreno P; Kim MC; Krishnan P; Sharma SK; Dangas GD, 2014, 'Effect of bivalirudin on aortic valve intervention outcomes study: A two-centre registry study comparing bivalirudin and unfractionated heparin in balloon aortic valvuloplasty', EuroIntervention, 10, pp. 312 - 319, http://dx.doi.org/10.4244/EIJV10I3A54

Chaanine AH; Nonnenmacher M; Kohlbrenner E; Jin D; Kovacic JC; Akar FG; Hajjar RJ; Weber T, 2014, 'Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure', Gene Therapy, 21, pp. 379 - 386, http://dx.doi.org/10.1038/gt.2014.7

Kovacic JC; Castellano JM; Farkouh ME; Fuster V, 2014, 'The relationships between cardiovascular disease and diabetes: Focus on pathogenesis', Endocrinology and Metabolism Clinics of North America, 43, pp. 41 - 57, http://dx.doi.org/10.1016/j.ecl.2013.09.007

O'Neill B; Singh V; Kini A; Mehran R; Jacobs E; Knopf D; Alfonso CE; Martinez CA; Martinezclark P; O'Neill W; Heldman AW; Yu J; Baber U; Kovacic JC; Dangas G; Sharma S; Sartori S; Cohen MG, 2014, 'The use of vascular closure devices and impact on major bleeding and net adverse clinical events (NACEs) in balloon aortic valvuloplasty: A sub-analysis of the BRAVO study', Catheterization and Cardiovascular Interventions, 83, pp. 148 - 153, http://dx.doi.org/10.1002/ccd.24892

Kovacic JC; Limaye AM; Sartori S; Lee P; Patel R; Chandela S; Trost B; Roy S; Harari R; Narechania B; Karajgikar R; Kim MC; Krishnan P; Moreno P; Baber U; Mehran R; Dangas G; Kini AS; Sharma SK, 2013, 'Comparison of six risk scores in patients with triple vessel coronary artery disease undergoing PCI: Competing factors influence mortality, myocardial infarction, and target lesion revascularization', Catheterization and Cardiovascular Interventions, 82, pp. 855 - 868, http://dx.doi.org/10.1002/ccd.25008

Ali ZA; Roleder T; Narula J; Mohanty BD; Baber U; Kovacic JC; Mintz GS; Otsuka F; Pan S; Virmani R; Sharma SK; Moreno P; Kini AS, 2013, 'Increased thin-cap neoatheroma and periprocedural myocardial infarction in drug-eluting stent restenosis multimodality intravascular imaging of drug-eluting and bare-metal stents', Circulation: Cardiovascular Interventions, 6, pp. 507 - 517, http://dx.doi.org/10.1161/CIRCINTERVENTIONS.112.000248

Yang W; Kovacic JC; Cromwell C; Grosskreutz C; Mascarenhas J, 2013, 'Myocardial infarction in a young man receiving chemotherapy for acute lymphoblastic leukemia', Clinical Advances in Hematology and Oncology, 11, pp. 672 - 675

Mennuni M; Moreno P; Krishnan P; Sharma SK; Sartori S; Kovacic J; Pyo R; Dangas G; Yu J; Kini A, 2013, 'Impact of vascular closure with the pre-closure technique on adverse events in patients undergoing transfemoral balloon aortic valvuloplasty: results from a single-center registry', European Heart Journal, 34, pp. P2208 - P2208, http://dx.doi.org/10.1093/eurheartj/eht308.p2208

Wood KC; Cortese-Krott MM; Kovacic JC; Noguchi A; Liu VB; Wang X; Raghavachari N; Boehm M; Kato GJ; Kelm M; Gladwin MT, 2013, 'Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis', Arteriosclerosis, Thrombosis, and Vascular Biology, 33, pp. 1861 - 1871, http://dx.doi.org/10.1161/ATVBAHA.112.301068

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