By Dr Jason Ciril Kovacic

Journal articles

Brojakowska A; Bisserier M; Eskandari A; Jagana V; Khlgatian MK; Arakelyan A; Fogarty J; Kovacic JC; Goukassian DA, 2026, 'Cardiovascular risks and hazards associated with deep space exploration', Communications Medicine, 6, http://dx.doi.org/10.1038/s43856-026-01728-x

Wolhuter K; Ma L; Bryce NS; Contreras O; Mellett N; Zhong L; Thekkedam C; Iismaa SE; Giles C; Harvey RP; Hennessy T; Fouracre C; Bradley D; Meikle PJ; Björkegren JLM; Kovacic JC, 2026, 'Multi-omic analysis of human PHACTR1 signaling networks', Communications Biology, 9, http://dx.doi.org/10.1038/s42003-026-09542-w

Le Grande MR; Rogerson MC; Jackson AC; Hesselson S; Iismaa SE; Graham RM; Kovacic JC; Clarke ST; Murphy BM, 2026, 'Psychological recovery after SCAD: Identifying protective and vulnerability factors using cluster analysis', European Journal of Cardiovascular Nursing, pp. zvag201, http://dx.doi.org/10.1093/eurjcn/zvag201

Wolhuter K; Nedkoff L; Miller MR; Kovacic JC, 2026, 'Breathing Fire', Journal of the American College of Cardiology, 88, pp. 962 - 964, http://dx.doi.org/10.1016/j.jacc.2026.02.5104

Clarke ST; Murphy BM; Le Grande MR; Rogerson MC; Kovacic JC; Hesselson S; Iismaa SE; Graham RM; Hester R; Jackson AC, 2026, 'The impact of fear of recurrence and progression on mental health after spontaneous coronary artery dissection: the role of illness uncertainty', European Journal of Cardiovascular Nursing, 25, pp. 1210 - 1218, http://dx.doi.org/10.1093/eurjcn/zvag090

Fanous N; Zubrzycki N; Weir L; Mohammed F; Pomeroy A; Meredith T; Roy D; Roy A; Kovacic J; Muller D; Feneley M; Elmariah S; Namasivayam M, 2026, 'Delay and attrition in severe aortic stenosis: a four-checkpoint systematic review of pathway bottlenecks and interventions', European Heart Journal - Quality of Care and Clinical Outcomes, pp. qcag123, http://dx.doi.org/10.1093/ehjqcco/qcag123

Trevor C; Kells E; Weddell J; Murphy BM; Hesselson S; Jackson AC; Graham RM; Iismaa SE; Neubeck L; Hanson CL; Zaman S; Maiorana A; Queenan J; Kelly J; Kovacic JC; Thom J; Hollings M, 2026, 'Patient Perspectives on Cardiac Rehabilitation and Exercise After Spontaneous Coronary Artery Dissection', Heart Lung and Circulation, 35, pp. 1123 - 1129, http://dx.doi.org/10.1016/j.hlc.2026.06.022

von Scheidt M; Kovacic JC, 2026, 'Human coronary atherosclerosis: biological insights and implications for prevention', European Heart Journal, 47, pp. 3857 - 3859, http://dx.doi.org/10.1093/eurheartj/ehag221

Liou L; García-González J; Wu HM; Namba S; Vaura F; Okada Y; Kovacic JC; O’Reilly PF, 2026, 'Polygenic Prediction of Non-Goal Response to Statin Therapy', Circulation Genomic and Precision Medicine, pp. e005666 - e005666, http://dx.doi.org/10.1161/circgen.125.005666

Ganesh SK; Mace P; Kovacic JC, 2026, 'ALIGN-FMD Leducq funded network: Demystifying Fibromuscular Dysplasia', European Heart Journal, pp. ehag413, http://dx.doi.org/10.1093/eurheartj/ehag413

Ma F; Liu Y; Xu Y; Liu W; Gupta N; Zhu Y; Xiao L; Swee S; Adam I; Zheng E; Ping P; Traylor JG; Rom O; Kovacic JC; Fidler TP; Yurdagul A; Singh R; Orr AW; Huang X; Cai B, 2026, 'Macrophage EHD1 Promotes Inflammation and Stabilizes Sortilin to Accelerate Atherosclerosis', Circulation Research, 139, http://dx.doi.org/10.1161/CIRCRESAHA.125.327751

Malik TH; Daniel D; Lee J; Al-Taie Z; Devarakonda K; Khan S; Le V; Loffler K; Anderson C; Baumert M; Kovacic J; Kundel VN; Mcalpine C; Nadkarni G; Cohen O; Suárez-Fariñas M; Shah NA, 2026, 'C100-02 Prototyping OSA: A New Framework for Predicting Cardiovascular Outcomes and CPAP Benefit', American Journal of Respiratory and Critical Care Medicine, 212, pp. aamag162.6442, http://dx.doi.org/10.1093/ajrccm/aamag162.6442

Murphy BM; Le Grande MR; Clarke ST; Hesselson S; Rogerson MC; Ford S; Iismaa SE; Kovacic JC; Graham RM; Jackson AC, 2026, 'Development and Validation of a Measure of Psychological Distress After Spontaneous Coronary Artery Dissection: The Spontaneous Coronary Artery Dissection Distress Inventory', Journal of the American Heart Association, 15, http://dx.doi.org/10.1161/JAHA.125.047498

Hall IF; Aikawa E; Sluimer J; Baker AH; Kovacic JC, 2026, 'Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives', European Heart Journal, 47, pp. 1144 - 1158, http://dx.doi.org/10.1093/eurheartj/ehaf670

Graham RM; Hayes SN; McGrath-Cadell L; Iismaa SE; Giannoulatou E; Kovacic JC, 2026, 'On the provenance of spontaneous coronary artery dissection', European Heart Journal Open, 6, http://dx.doi.org/10.1093/ehjopen/oeag066

Von Scheidt M; Adkar SS; Krefting J; Hoermann G; Meggendorfer M; Bauer S; Mitchell S; Pugach I; Friess C; Ma A; Hao K; Steigerwald S; Wahle M; Kessler T; Schwab M; Voll F; Mokry M; Sofokleous C; Palm KCA; Bongiovanni D; Fleig J; Oldenbuettel L; Chen Z; Hecker JS; Bassermann F; Maegdefessel L; Graw M; Ruusalepp A; Hilgendorf I; Leuschner F; Sager HB; Heimlich JB; Koenig W; Cremer S; Leistner DM; Abplanalp WT; Dimmeler S; Zeiher AM; Van der Laan SW; Pasterkamp G; Braun C; Jaiswal S; Kovacic JC; Kern W; Haferlach C; Mann M; Cassese S; Kastrati A; Haferlach T; Leeper NJ; Björkegren JLM; Schunkert H, 2026, 'Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease', European Heart Journal, 47, pp. 453 - 469, http://dx.doi.org/10.1093/eurheartj/ehaf602

Tam LM; Naderi S; Chi G; Gornik HL; Wells BJ; Kadian-Dodov D; Grodzinsky A; Taylor AM; Hess CN; Lewey J; Henkin S; Orford JL; Lindley KJ; Wells GL; Mauricio R; Ouellette ML; Trost J; Koczo A; Saucier S; Crousillat DR; Tolani S; Kovacic JC; Gibson CM; Leon KK; Wood MJ; Kim ESH, 2026, 'Sex Differences in Spontaneous Coronary Artery Dissection: A Report of the iSCAD Registry', Journal of the American Heart Association, 15, http://dx.doi.org/10.1161/JAHA.125.042773

Goodall LS; Lennon MJ; Sachdev PS; Gorelick PB; Kovacic JC; Samaras K, 2026, 'Current and Emerging Therapeutic Approaches for Vascular Cognitive Impairment and Dementia', Journal of the American College of Cardiology, 87, pp. 77 - 100, http://dx.doi.org/10.1016/j.jacc.2025.09.1502

Sachdev PS; Bentvelzen AC; Gustafson D; Hansra GK; Hosoki S; Jiang J; Lennon MJ; Moro MA; Saks DG; Samaras K; Kovacic JC; Kalaria R, 2026, 'Vascular Cognitive Impairment and Dementia: Clinical Features, Neuropathology, and Biomarkers', Journal of the American College of Cardiology, 87, pp. 52 - 76, http://dx.doi.org/10.1016/j.jacc.2025.11.008

Kovacic JC; Reynolds HR; Alasnag M; Blakeman JR; Ijioma NN; Kim ESH; Sandner S; Sanghavi M; Saw J; Tamis-Holland JE, 2026, 'Acute Coronary Syndromes in Premenopausal Women: A Scientific Statement From the American Heart Association', Circulation, http://dx.doi.org/10.1161/CIR.0000000000001416

Mohammed F; Meredith T; Adams H; Pomeroy A; Moran TP; Barbieri S; Meijering E; Roy DA; Kovacic JC; Hayward CS; Muller DWM; Feneley MP; Namasivayam M, 2026, '26-A-15088-ACC CLASSIFICATION OF AORTIC STENOSIS SEVERITY USING AUTOMATED LEAFLET TRACKING: INTERNAL AND EXTERNAL VALIDATION', Journal of the American College of Cardiology, 87, pp. a907, http://dx.doi.org/10.1016/j.jacc.2026.02.2238

Fanous N; Weir L; Zubrzycki N; Mohammed F; Pomeroy A; Meredith T; Roy D; Roy A; Kovacic J; Muller D; Feneley M; Elmariah S; Namasivayam M, 2026, '82001 | Reducing Time-to-TAVI: System-Level Interventions to Address Bottlenecks in Severe Aortic Stenosis', Structural Heart, 10, pp. 100867, http://dx.doi.org/10.1016/j.shj.2026.100867

Zhang M; McGrath-Cadell L; Hesselson S; Shen C; Gharleghi R; Collins N; Muller D; Kovacic J; McLachlan C; Graham R; Beier S, 2026, 'Anatomical and Haemodynamic Determinants of Spontaneous Coronary Artery Dissection Identified by Computed Tomography Coronary Angiography', Heart Lung and Circulation, 35, pp. s116 - s117, http://dx.doi.org/10.1016/j.hlc.2026.07.081

Godinho M; McNeill S; Archer O; Nicholls S; Kovacic J; Neal B; Donnan G; Brown A; Barr E; Taggart R; Carey K; Kularathna P; Chow C, 2026, 'Australian Cardiovascular Disease Innovation: What Does 40 Years of Patent Activity tell us?', Heart Lung and Circulation, 35, pp. s608 - s609, http://dx.doi.org/10.1016/j.hlc.2026.07.965

Xu Y; Jarrah S; Zhang S; Khlgatian MK; Brojakowska A; Du Y; Eskandari A; D'Escamard V; Kovacic JC; Goukassian DA, 2026, 'Space radiation impairs long‐term endothelial integrity and may promote atherosclerosis in ApoE‐deficient mice', Clinical and Translational Medicine, 16, pp. e70774, http://dx.doi.org/10.1002/ctm2.70774

Kells E; Trevor C; Weddell J; Murphy B; Hesselson S; Rogerson M; Jackson A; Graham R; Iismaa S; Kovacic J; Neubeck L; Hanson C; Zaman S; Maiorana A; Queenan J; Kelly J; Thom J; Hollings M, 2026, 'Support or Setback? How Healthcare Support can Make or Break Exercise Engagement After Spontaneous Coronary Artery Dissection', Heart Lung and Circulation, 35, pp. s108, http://dx.doi.org/10.1016/j.hlc.2026.07.064

Tardo DT; Cortes-Canteli M; Fuster V; Sachdev PS; Kovacic JC, 2025, 'The Heart-Brain-Metabolism Axis in Cardiovascular and Neurologic Disease', Journal of the American College of Cardiology, 86, pp. 2663 - 2686, http://dx.doi.org/10.1016/j.jacc.2025.09.1602

Meredith T; Mohammed F; Pomeroy A; Barbieri S; Meijering E; Jorm L; Roy D; Hayward C; Kovacic JC; Muller DWM; Feneley MP; Namasivayam M, 2025, 'Aortic valve leaflet motion for diagnosis and classification of aortic stenosis using single view echocardiography', Journal of Cardiovascular Imaging, 33, http://dx.doi.org/10.1186/s44348-025-00051-8

Hall IF; Kishta F; Kovacic JC, 2025, 'Endothelial to mesenchymal transition, Ets2 and the aging heart', Cardiovascular Research, 121, pp. 2820 - 2821, http://dx.doi.org/10.1093/cvr/cvaf273

Liou L; Gonzalez JG; Wu HM; Kovacic J; OReilly P, 2025, 'Abstract 4357525: Utility of Polygenic Risk Scores at Identifying Subgroup with Greater Benefit From Statins', Circulation, 152, pp. a4357525 - a4357525, http://dx.doi.org/10.1161/circ.152.suppl_3.4357525

Gensemer C; Petrucci T; Beck T; Daylor V; Griggs M; Griggs C; Weintraub A; Byerly K; Guo L; Morningstar J; Kornblau I; Biggs R; Moore K; Koren N; Hastings C; Oberlies E; Zientara ER; Devey E; Dooley S; Stayer K; Fenner R; Singleton K; Luzbetak S; Bear D; Byrd R; Weninger J; Bistran E; Beeson G; Kerns J; Osterhaus M; Fleck E; Schnaudigel J; Butler S; Severance S; Kendall W; Delaney JR; Judge DP; Chen P; Yao H; Guz J; Awgulewitsch A; Kautz SA; Mukherjee R; Price R; Henderson F; Shapiro S; Francomano CA; Kovacic JC; Lavallee M; Kontorovich AR; Berrandou TE; Slaugenhaupt SA; Milan D; Maitland A; Patel S; Bouatia-Naji N; Norris RA, 2025, 'KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome', Iscience, 28, http://dx.doi.org/10.1016/j.isci.2025.113343

Chow AM C; Kovacic J; Neal B; Donnan AO G; Brown A; Maple-Brown L; Carey K; Taggart R; Kularathna P; McNeill S; Nicholls S, 2025, 'Can Australia Tackle its Failure in Research Translation to Reduce Cardiovascular Disease, Improve Equity and Deliver Better Health and Economic Outcomes?', Heart Lung and Circulation, 34, pp. 877 - 882, http://dx.doi.org/10.1016/j.hlc.2025.04.095

Ma L; Tamis‑Holland JE; Mocci G; Wolhuter K; Bryce NS; Sajja S; Amadori L; Pradhan P; Chong PS; Sukhavasi K; Cheng H; Li L; Pang S; Schadt EE; Schunkert H; von Scheidt M; Ruusalepp A; Moreno PR; Hao K; Giannarelli C; Miller CL; Kovacic JC; Björkegren JLM, 2025, 'A macrophage gene-regulatory network linked to clinical severity of coronary artery disease: The STARNET and NGS-PREDICT primary blood macrophage studies', Basic Research in Cardiology, 120, pp. 799 - 814, http://dx.doi.org/10.1007/s00395-025-01105-0

Tweet MS; Kovacic JC, 2025, 'The Australian–New Zealand SCAD observational cohort study: major adverse cardiovascular events are associated with ticagrelor combined with aspirin, FMD, and history of stroke', European Heart Journal, 46, pp. 2024 - 2026, http://dx.doi.org/10.1093/eurheartj/ehaf127

McGrath-Cadell L; Hesselson S; Tarr I; Rath EM; Troup M; Gao Y; Junday K; Bax M; Iismaa SE; Collins N; Muller DWM; Kovacic JC; Giannoulatou E; Graham RM, 2025, 'Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study', Journal of the American Heart Association, 14, http://dx.doi.org/10.1161/JAHA.124.037921

Sukhavasi K; Mocci G; Ma L; Hodonsky CJ; Diez Benevante E; Muhl L; Liu J; Gustafsson S; Buyandelger B; Koplev S; Lendahl U; Vanlandewijck M; Singha P; Örd T; Beter M; Selvarajan I; Laakkonen JP; Väli M; den Ruijter HM; Civelek M; Hao K; Ruusalepp A; Betsholtz C; Järve H; Kovacic JC; Miller CL; Romanoski C; Kaikkonen MU; Björkegren JLM, 2025, 'Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques', Nature Cardiovascular Research, 4, pp. 412 - 432, http://dx.doi.org/10.1038/s44161-025-00628-y

Meredith T; Mohammed F; Pomeroy A; Barbieri S; Meijering E; Jorm L; Roy D; Kovacic J; Feneley M; Hayward C; Muller D; Namasivayam M, 2025, 'Machine learning cluster analysis identifies increased 12-month mortality risk in transcatheter aortic valve replacement recipients', Frontiers in Cardiovascular Medicine, 12, pp. 1444658, http://dx.doi.org/10.3389/fcvm.2025.1444658

Liou L; García-González J; Wu HM; Wang Z; Hoggart CJ; Kontorovich AR; Kovacic JC; O'reilly PF, 2025, 'Clinical and Genomic Prediction of Coronary Artery Disease Subtypes', Arteriosclerosis Thrombosis and Vascular Biology, 45, pp. 90 - 103, http://dx.doi.org/10.1161/ATVBAHA.124.321846

Kovacic JC; Skelding KA; Arya S; Ballard-Hernandez J; Goyal M; Ijioma NN; Kicielinski K; Takahashi EA; Ujueta F; Dangas G, 2025, 'Radial Access Approach to Peripheral Vascular Interventions: A Scientific Statement From the American Heart Association', Circulation Cardiovascular Interventions, 18, pp. e000094, http://dx.doi.org/10.1161/HCV.0000000000000094

Brisnovali N; dos Santos BG; Haney C; Ganbold K; de Urturi DS; Hathaway E; Madani W; Ma L; Murray S; Rajbhandari P; Björkegren J; Kovacic J; Goedeke L, 2025, 'Abstract Or130: Inhibition of MMAB Protects Against Diet-Induced Obesity and Atherosclerosis', Arteriosclerosis Thrombosis and Vascular Biology, 45, pp. aor130 - aor130, http://dx.doi.org/10.1161/atv.45.suppl_1.or130

Meredith T; Mohammed F; Pomeroy A; Barbieri S; Meijering E; Jorm L; Roy D; Kovacic J; Muller D; Feneley M; Namasivayam M, 2025, 'TCT-593 Aortic Valve Leaflet Motion for Diagnosis and Classification of Aortic Stenosis Using Single View Echocardiography', Journal of the American College of Cardiology, 86, pp. b258, http://dx.doi.org/10.1016/j.jacc.2025.09.733

Podgorski A; Tardo D; Cherrett C; Lavee O; Kovacic JC, 2024, 'Infiltrative Myocardial T-Cell Lymphoma', Jacc Case Reports, 29, http://dx.doi.org/10.1016/j.jaccas.2024.102831

Crousillat D; Sarma A; Wood M; Naderi S; Leon K; Gibson CM; Aday A; Grodzinsky A; Izard K; Kovacic JC; Lindsay ME; Phelan D; Rodriguez-Lozano PF; Scott NS; Scherer M; Sharma A; Sweis R; Sumner JA; Kim ESH, 2024, 'Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel', Jacc Advances, 3, http://dx.doi.org/10.1016/j.jacadv.2024.101385

McGrath-Cadell L; Hesselson S; Muller DWM; Kovacic JC; Giannoulatou E; Graham RM, 2024, 'Understanding the Complex Genetics of Spontaneous Coronary Artery Dissection: A Guide for Clinicians', Circulation Genomic and Precision Medicine, 17, pp. e004800, http://dx.doi.org/10.1161/CIRCGEN.124.004800

Von Scheidt M; Adkar S; Krefting J; Hoermann G; Meggendorfer M; Bauer S; Pugach I; Friess C; Ma A; Hao K; Steigerwald S; Kessler T; Mokry M; Bongiovanni D; Fleig J; Oldenbuettel L; Chen Z; Hecker JS; Bassermann F; Maegdefessel L; Graw M; Ruusalepp A; Hilgendorf I; Leuschner F; Koenig W; Cremer S; Leistner D; Dimmeler S; Zeiher A; Braun C; Mitchell S; Jaiswal S; Kovacic J; Mann M; Kastrati A; Haferlach C; Haferlach T; Leeper N; Björkegren J; Schunkert H, 2024, 'Abstract 4145859: Clonal Hematopoiesis of Indeterminate Potential Increases Mortality Risk in Coronary Artery Disease', Circulation, 150, pp. a4145859 - a4145859, http://dx.doi.org/10.1161/circ.150.suppl_1.4145859

Figtree GA; Doyle K; Nedkoff L; Cadilhac DA; Kovacic J; Brieger D; Chant K; Chew D; Chow C; Gall S; Greaves K; Jennings G; Larson S; Levesque JF; McNeil K; Nicholls SJ; On ML; Redfern J; Verdicchio C; Vernon ST; Wainer Z, 2024, 'The national Cardiovascular Health Leadership Research Forum: a new data-driven model placing research at the centre of improving patient outcomes', Medical Journal of Australia, 221, pp. 452 - 456, http://dx.doi.org/10.5694/mja2.52482

La Gerche A; Paratz ED; Bray JE; Jennings G; Page G; Timbs S; Vandenberg JI; Abhayaratna W; Chow CK; Dennis M; Figtree GA; Kovacic JC; Maris J; Nehme Z; Parsons S; Pflaumer A; Puranik R; Stub D; Freitas E; Zecchin R; Cartledge S; Haskins B; Ingles J, 2024, 'A Call to Action to Improve Cardiac Arrest Outcomes: A Report From the National Summit for Cardiac Arrest', Heart Lung and Circulation, 33, pp. 1507 - 1522, http://dx.doi.org/10.1016/j.hlc.2024.09.001

Xu Y; Korayem A; Cruz-Solbes AS; Chandel N; Sakata T; Mazurek R; Mavropoulos SA; Kariya T; Aikawa T; Yamada KP; D'Escamard V; V'Gangula B; Baker AH; Ma L; Björkegren JLM; Fuster V; Boehm M; Fish KM; Tadros R; Ishikawa K; Kovacic JC, 2024, 'Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis', Cardiovascular Research, 120, pp. 1768 - 1779, http://dx.doi.org/10.1093/cvr/cvae157

Kovacic JC; Olin JW, 2024, 'Identifying a gene-regulatory network that drives fibromuscular dysplasia', Nature Cardiovascular Research, 3, pp. 1033 - 1034, http://dx.doi.org/10.1038/s44161-024-00534-9

d’Escamard V; Kadian-Dodov D; Ma L; Lu S; King A; Xu Y; Peng S; V′Gangula B; Zhou Y; Thomas A; Michelis KC; Bander E; Bouchareb R; Georges A; Nomura-Kitabayashi A; Wiener RJ; Costa KD; Chepurko E; Chepurko V; Fava M; Barwari T; Anyanwu A; Filsoufi F; Florman S; Bouatia-Naji N; Schmidt LE; Mayr M; Katz MG; Hao K; Weiser-Evans MCM; Björkegren JLM; Olin JW; Kovacic JC, 2024, 'Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia', Nature Cardiovascular Research, 3, pp. 1098 - 1122, http://dx.doi.org/10.1038/s44161-024-00533-w

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