By Dr Jason Ciril Kovacic

Preprints

Schaniel C; Dhanan P; Hu B; Xiong Y; Raghunandan T; Gonzalez DM; Dariolli R; D’Souza SL; Yadaw AS; Hansen J; Jayaraman G; Mathew B; Machado M; Berger SI; Tripodi J; Najfeld V; Garg J; Miller M; Lynch CS; Michelis KC; Tangirala NC; Weerahandi H; Thomas DC; Beaumont KG; Sebra R; Mahajan M; Schadt E; Vidovic D; Schürer SC; Goldfarb J; Azeloglu EU; Birtwistle MR; Sobie EA; Kovacic JC; Dubois NC; Iyengar R, A Library of Induced Pluripotent Stem Cells from Clinically Well-Characterized, Diverse Healthy Human Individuals, http://dx.doi.org/10.1101/2020.10.29.360909

Turner AW; Hu S; Mosquera JV; Feng W; Hodonsky CJ; Wong D; Auguste G; Sol-Church K; Farber E; Kundu S; Kundaje A; Lopez NG; Ma L; Ghosh SKB; Onengut-Gumuscu S; Ashley EA; Quertermous T; Finn AV; Leeper NJ; Kovacic JC; Björkgren JLM; Zang C; Miller CL, Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk, http://dx.doi.org/10.1101/2021.06.07.447388

Zhang M; McGrath-Cadell L; Hesselson S; Shen C; Gharleghi R; Collins N; Muller DW; Kovacic JC; Graham RM; Beier S, CT Coronary Angiography Identifies a Shear-Stress Signature of Spontaneous Coronary Artery Dissection: A Case–Control Study, http://dx.doi.org/10.64898/2026.08.12.26360329

Zhang Z; Cheng H; Hong X; Di Narzo AF; Franzen O; Peng S; Ruusalepp A; Kovacic JC; Bjorkegren JL; Wang X; Hao K, EnsembleCNV: An ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data, http://dx.doi.org/10.1101/356667

Trivieri MG; Robson PM; Vergani V; LaRocca G; Romero-Daza AM; Abgral R; Karakatsanis NA; Parikh A; Panagiota C; Palmisano A; DePalo L; Chang HL; Rothstein JH; Fayad RA; Miller MA; Fuster V; Narula J; Dweck MR; Jacobi A; Padilla M; Kovacic JC; Fayad ZA, Evaluating the association between hybrid magnetic resonance positron emission tomography and cardiac-related outcomes in cardiac sarcoidosis, http://dx.doi.org/10.1101/2022.01.13.22269230

Wong D; Auguste G; Cardenas CLL; Turner AW; Chen Y; Ma L; Perry RN; Aherrahrou R; Kuppusamy M; Yang C; Mosquera JV; Dube CJ; Khan MD; Palmore M; Kavousi M; Peyser PA; Matic L; Hedin U; Manichaikul A; Sonkusare SK; Civelek M; Kovacic JC; Björkegren JLM; Malhotra R; Miller CL, FHL5 controls vascular disease-associated gene programs in smooth muscle cells, http://dx.doi.org/10.1101/2022.07.23.501247

Georges A; Yang M-L; Berrandou T-E; Bakker M; Dikilitas O; Kiando SR; Ma L; Satterfield BA; Sengupta S; Yu M; Deleuze J-F; Dupré D; Hunker KL; Kyryachenko S; Liu L; Amar L; Brummett CM; Coleman DM; d’Escamard V; de Leeuw P; Fendrikova-Mahlay N; Kadian-Dodov D; Li JZ; Lorthioir A; Pappaccogli M; Prejbisz A; Smigielski W; Stanley JC; Zawistowski M; Zhou X; Zoellner S; investigators F; group ISGCIAW; Megastroke ; De Buyzere ML; Debette S; Dobrowolski P; Drygas W; Gornik HL; Olin JW; Piwonski J; Rietzschel ER; Ruigrok Y; Vikkula M; Celinska EW; Januszewicz A; Kullo IJ; Azizi M; Jeunemaitre X; Persu A; Kovacic JC; Ganesh SK; Bouatia-Naji N, Genetic association studies of fibromuscular dysplasia identify new risk loci and shared genetic basis with more common vascular diseases, http://dx.doi.org/10.1101/2020.09.16.20195701

Adlam D; Berrandou T-E; Georges A; Nelson CP; Giannoulatou E; Henry J; Ma L; Blencowe M; Turley TN; Yang M-L; Braund PS; Sadeg-Sayoud I; Iismaa SE; Kosel ML; Zhou X; Hamby SE; Cheng J; Liu L; Tarr I; Muller DWM; d’Escamard V; King A; Brunham LR; Baranowska-Clarke AA; Debette S; Amouyel P; Olin JW; Patil S; Hesselson SE; Junday K; Kanoni S; Aragam K; Butterworth AS; CARDIoGRAMPlusC4D ; MEGASTROKE ; group ISGCIAW; Tweet MS; Gulati R; Combaret N; investigators DR; Kadian-Dodov D; Kalman J; Fatkin D; Saw J; Webb TR; Hayes SN; Yang X; Ganesh SK; Olson TM; Kovacic JC; Graham RM; Samani NJ; Bouatia-Naji N, Genome-wide association meta-analysis of spontaneous coronary artery dissection reveals common variants and genes related to artery integrity and tissue-mediated coagulation, http://dx.doi.org/10.1101/2022.07.05.22277238

Mosquera JV; Auguste G; Wong D; Turner AW; Hodonsky CJ; Cardenas CLL; Theofilatos K; Bos M; Kavousi M; Peyser PA; Mayr M; Kovacic JC; Björkegren JLM; Malhotra R; van der Laan SW; Zang C; Sheffield NC; Miller CL, Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis, http://dx.doi.org/10.1101/2022.10.24.513520

von Scheidt M; Bauer S; Ma A; Hao K; Kessler T; Vilne B; Wang Y; Hodonsky CJ; Ghosh SKB; Mokry M; Gao H; Kawai K; Sakamoto A; Kaiser J; Bongiovanni D; Fleig J; Oldenbuettel L; Chen Z; Moggio A; Sager HB; Hecker JS; Bassermann F; Maegdefessel L; Miller CL; Koenig W; Zeiher AM; Dimmeler S; Graw M; Braun C; Ruusalepp A; Leeper NJ; Kovacic JC; Björkegren JLM; Schunkert H, Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques, http://dx.doi.org/10.1101/2023.07.22.23292754

Ma F; Liu Y; Xu Y; Liu W; Gupta N; Zhu Y; Xiao L; Traylor JG; Rom O; Kovacic JC; Fidler TP; Yurdagul A; Orr AW; Huang X; Cai B, Macrophage EHD1 promotes inflammation and stabilizes sortilin to accelerate atherosclerosis, http://dx.doi.org/10.1101/2025.10.27.684958

Mosquera JV; Tang I; Murach M; Auguste G; Kodali A; Hart P; Shaw DM; Li M; Turner AW; Hodonsky CJ; Dworak NM; de Oliveira AK; Sol-Church K; Jhee T; van der Sijs KIM; Adkar SS; Choi RB; Vacante F; Wu JC; Cheng P; Giannarelli C; Leeper NJ; Finn AV; Björkegren JLM; Kovacic JC; Yurdagul A; van der Laan SW; Miller CL, Multimodal atlas of human atherosclerosis links granular vascular cell states to coronary artery disease risk, http://dx.doi.org/10.64898/2026.05.24.26353986

Bankier S; Talukdar H; Khan M; Mocci G; Sukhavasi K; Hao K; Ma A; Ruusalepp A; Schadt EE; Kovacic JC; Michoel T; Björkegren JL, Plasma proteins are integral to gene-regulatory networks acting within and across blood cells, the arterial wall and major metabolic organs, http://dx.doi.org/10.1101/2025.01.22.25320723

Georges A; Albuisson J; Berrandou T; Dupré D; Lorthioir A; D’Escamard V; Di Narzo AF; Kadian-Dodov D; Olin JW; Warchol-Celinska E; Prejbisz A; Januszewicz A; Bruneval P; Baranowska AA; Webb TR; Hamby SE; Samani NJ; Adlam D; Fendrikova-Mahlay N; Hazen S; Wang Y; Yang M-L; Hunker K; Combaret N; Motreff P; Chédid A; Fiquet B; Plouin P-F; Mousseaux E; Azarine A; Amar L; Azizi M; Gornik HL; Ganesh SK; Kovacic JC; Jeunemaitre X; Bouatia-Naji N, Rare Loss-of-function Mutations of PTGIR Identified in Fibromuscular Dysplasia and Spontaneous Coronary Artery Dissection, http://dx.doi.org/10.1101/19012484

Yang D; Chen G; Gaurav S; de Jesus AA; Mehta AK; McNinch C; Miranda AX; Wei J; Kedei N; Hernandez MO; Zou J; Linask K; Lee C-C; Sukumar G; Zhang Y; Alehashemi S; Folio L; Yu Q; Lin B; Lang B; Buehring B; Dueckers G; Reinhardt A; Schulte G; Liptzin DR; Ozen S; Borzutzky A; Wong M; Tillo D; Dmitrieva NI; Mani H; Nathan SD; Kovacic JC; Dalgard C; Boehm M; Goldbach-Mansky R, STING–STAT3–SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis, http://dx.doi.org/10.64898/2026.03.23.713256

Schunkert H; Li L; Chen Z; Scheidt M; Steiner A; Güldener U; Koplev S; Ma A; Hao K; Pan C; Lusis A; Pang S; Kessler T; Ermel R; Sukhavasi K; Ruusalepp A; Gagneur J; Erdmann J; Kovacic J; Bjorkegren J, Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes, http://dx.doi.org/10.21203/rs.3.rs-678054/v1

Li L; Chen Z; von Scheidt M; Steiner A; Güldener U; Koplev S; Ma A; Hao K; Pan C; Lusis AJ; Pang S; Kessler T; Ermel R; Sukhavasi K; Ruusalepp A; Gagneur J; Erdmann J; Kovacic JC; Björkegren JLM; Schunkert H, Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes, http://dx.doi.org/10.1101/2021.07.21.453208

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