By Dr John George Lock

Preprints

Steindl AJ; Rocha JF; Di Bassinga BT; Warren Z; Scicluna M; Córdova CMV; Gupta S; Torices L; Neumann D; Mann TJ; Gunawan I; Bhaskar D; Lock JG; Chaffer CL; Wolf G; Krishnaswamy S, 2026, scShapeBench: Discovering geometry from high dimensional scRNAseq data, http://dx.doi.org/10.48550/arxiv.2605.12662

Lock J; Jones M; Askari J; Gong X; Oddone A; Olofsson H; Göransson S; Lakadamyali M; Humphries M; Strömblad S, 2017, Reticular adhesions: A new class of adhesion complex that mediates cell-matrix attachment during mitosis, http://dx.doi.org/10.1101/234237

Latham SL; O’Donnell YE; Girgis-Cook O; Clearwater MS; Bryce NS; Mok ET; Lynn SA; Ni J; Alfred S; Leong H; Quek L-E; Murphy KJ; Pantarelli C; Dragutinovic I; Naeini MM; Thiel C; Cadell A; Phimmachanh M; Sharma R; Millar E; Han JZ; Hastings JF; Köhler M; Brummer T; Young A; O’Toole S; Oakes SR; Hardeman E; Lock J; Kolch W; Taft MH; Nobis M; Goldstein L; Timpson P; Parker BL; Holst J; Gunning PW; Cox TR; Morris JC; Croucher DR, A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade, http://dx.doi.org/10.1101/2025.04.16.649243

Silvani G; Kopecky C; Romanazzo S; Rodriguez V; Das A; Pandzic E; Lock JG; Chaffer C; Poole K; Kilian KA, Capillary constrictions prime cancer cell tumorigenicity through PIEZO1, http://dx.doi.org/10.1101/2025.07.22.666218

Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, http://dx.doi.org/10.21203/rs.3.rs-1602818/v1

Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, http://dx.doi.org/10.21203/rs.3.rs-1602818/v2

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Zheng Y; Rouaen J; Jue TR; Michniewicz FT; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Valli E; Brettle M; Whan R; Vahadat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer, http://dx.doi.org/10.1101/2022.10.03.510707

Mann TJ; Zheng Y; Khan T; Huang T; Nindra U; Ma Y; James A; Neumann DP; Kohane FV; Gunawan I; Vafaee F; Chua W; de Souza P; Roberts TL; Becker TM; Lock JG, Deep multiplexed 50-marker imaging of circulating tumor cells expands actionable biomarker profiling for precision oncology, http://dx.doi.org/10.1101/2025.10.23.684075

Kohane FV; Johnstone C; Neumann DP; Gunawan I; Huang T; Vafaee F; Chaffer CL; Lock JG, Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation, http://dx.doi.org/10.1101/2025.07.05.658545

Allan KM; Zhang S; Wong SL; Capraro A; McCarron A; Skinner D; Kardia E; Zheng Y; Zhong L; Ng C-A; Bell JL; Farrow N; Umashankar B; Banks C; Herbert C; Kilian KA; Pandzic E; Vittorio O; Vandenberg JI; Lock JG; Jaffe A; Donnelley M; Parsons D; Woodworth BA; Cho D-Y; Waters SA, Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model, http://dx.doi.org/10.1101/2025.07.21.666023

Gunawan I; Dey M; Neumann DP; Kohane FV; He Y; Meijering E; Lock JG, Generative semantic multiplexing (SemaPlex) for accessible and scalable multiplexed fluorescence imaging, http://dx.doi.org/10.1101/2025.09.15.676186

Gunawan I; Marsh RJ; Aggarwal N; Meijering E; Cox S; Lock JG; Culley S, Image quality metrics fail to accurately represent biological information in fluorescence microscopy, http://dx.doi.org/10.1101/2025.08.05.668508

Contreras O; Smith GD; Santiago C; Dey M; Thekkedam C; Chand R; González-Rajal Á; Zhong L; Lock JG; Wong E; Fatkin D; Harvey RP, Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia, http://dx.doi.org/10.64898/2026.01.11.698907

Krishnaswamy S; Tong A; Kuchroo M; Gupta S; Venkat A; Juan BS; Rangel L; Zhu B; Lock J; Chaffer C, Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport, http://dx.doi.org/10.21203/rs.3.rs-3605296/v1

Sun X; Gupta S; Tong A; Kuchroo M; Bhaskar D; Liu C; Venkat A; San Juan BP; Rangel L; Rodriguez V; Lock JG; Chaffer CL; Krishnaswamy S, Revealing dynamic temporal trajectories and underlying regulatory networks with Cflows, http://dx.doi.org/10.1101/2023.03.28.534644

Lock J; Gunawan I; Kohane F; Nguyen K; Zheng Y; Neumann D; Vafaee F; Meijering E, Seeing more with less: Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data, http://dx.doi.org/10.21203/rs.3.rs-4872456/v1

San Juan BP; Hediyeh-Zadeh S; Rangel L; Milioli HH; Rodriguez V; Bunkum A; Kohane FV; Purcell CA; Bhuva DD; Kurumlian A; Castillo L; Lim E; Gill AJ; Ganju V; Dear R; O’Toole S; Vargas AC; Hickey TE; Goldstein LD; Lock JG; Davis MJ; Chaffer CL, Targeting phenotypic plasticity prevents metastasis and the development of chemotherapy-resistant disease, http://dx.doi.org/10.1101/2022.03.21.22269988

Heydari MJ; Lye B; Mansouri P; Marsland T; Pamulapati K; Vary R; Allen H; Simpson KJ; Lock JG; McKenna J; Vafaee F, Uncertainty-Aware Deep Learning for Multi-Metric and Dose-Specific Prediction of Drug Synergy, http://dx.doi.org/10.1101/2025.11.05.686895

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