By Dr John George Lock

Book Chapters

Wei W; Haidinger S; Lock J; Meijering E, 2021, 'Deep Representation Learning for Image-Based Cell Profiling', in Machine Learning in Medical Imaging, pp. 487 - 497, http://dx.doi.org/10.1007/978-3-030-87589-3_50

Strömblad S; Lock JG, 2018, 'Using systems microscopy to understand the emergence of cell migration from cell organization', in Cell Migration: Methods and Protocols, Springer, pp. 119 - 134, http://dx.doi.org/10.1007/978-1-4939-7701-7_10

Journal articles

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Neumann DP; Zheng Y; Rouaen JRC; Jue TR; Michniewicz FT; Schadel P; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Cazzoli R; Brettle M; Slapetova I; Kasherman M; Whan R; Souza-Fonseca-Guimaraes F; Vahdat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2023, 'Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer', Cell and Bioscience, 13, http://dx.doi.org/10.1186/s13578-023-01083-7

Davoudi F; Moradi A; Becker TM; Lock JG; Abbey B; Fontanarosa D; Haworth A; Clements J; Ecker RC; Batra J, 2023, 'Genomic and Phenotypic Biomarkers for Precision Medicine Guidance in Advanced Prostate Cancer', Current Treatment Options in Oncology, 24, pp. 1451 - 1471, http://dx.doi.org/10.1007/s11864-023-01121-z

Gunawan I; Vafaee F; Meijering E; Lock JG, 2023, 'An introduction to representation learning for single-cell data analysis', Cell Reports Methods, 3, http://dx.doi.org/10.1016/j.crmeth.2023.100547

Khan T; Lock JG; Ma Y; Harman DG; de Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, 'Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-20079-w

Burkhardt DB; San Juan BP; Lock JG; Krishnaswamy S; Chaffer CL, 2022, 'Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning', Cancer Discovery, 12, pp. 1847 - 1859, http://dx.doi.org/10.1158/2159-8290.CD-21-0282

Khan T; Scott KF; Becker TM; Lock J; Nimir M; Ma Y; De Souza P, 2020, 'The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?', Prostate Cancer, 2020, http://dx.doi.org/10.1155/2020/7938280

Bryce NS; Failes TW; Stehn JR; Baker K; Zahler S; Arzhaeva Y; Bischof L; Lyons C; Dedova I; Arndt GM; Gaus K; Goult BT; Hardeman EC; Gunning PW; Lock JG; Arndt G, 2019, 'High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained', Cell Systems, 9, pp. 496 - 507.e5, http://dx.doi.org/10.1016/j.cels.2019.09.002

Bryce NS; Hardeman EC; Gunning PW; Lock JG, 2019, 'Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening', Current Opinion in Chemical Biology, 51, pp. 40 - 47, http://dx.doi.org/10.1016/j.cbpa.2019.02.013

Lock JG; Baschieri F; Jones MC; Humphries JD; Montagnac G; Strömblad S; Humphries MJ, 2019, 'Clathrin-containing adhesion complexes', Journal of Cell Biology, 218, pp. 2086 - 2095, http://dx.doi.org/10.1083/jcb.201811160

Lock JG; Jones MC; Askari JA; Gong X; Oddone A; Olofsson H; Göransson S; Lakadamyali M; Humphries MJ; Strömblad S, 2018, 'Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis', Nature Cell Biology, 20, pp. 1290 - 1302, http://dx.doi.org/10.1038/s41556-018-0220-2

Gong X; Didan Y; Lock JG; Strömblad S, 2018, 'KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration', EMBO Journal, 37, http://dx.doi.org/10.15252/embj.201898994

Moshksayan K; Kashaninejad N; Warkiani ME; Lock JG; Moghadas H; Firoozabadi B; Saidi MS; Nguyen NT, 2018, 'Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture', Sensors and Actuators, B: Chemical, 263, pp. 151 - 176, http://dx.doi.org/10.1016/j.snb.2018.01.223

Spiess M; Hernandez-Varas P; Oddone A; Olofsson H; Blom H; Waithe D; Lock JG; Lakadamyali M; Strömblad S, 2018, 'Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions', Journal of Cell Biology, 217, pp. 1929 - 1940, http://dx.doi.org/10.1083/jcb.201707075

Lock J; Jones M; Askari J; Gong X; Oddone A; Olofsson H; Göransson S; Lakadamyali M; Humphries M; Strömblad S, 2017, 'Reticular adhesions: A new class of adhesion complex that mediates cell-matrix attachment during mitosis', , http://dx.doi.org/10.1101/234237

Shafqat-Abbasi H; Kowalewski JM; Kiss A; Gong X; Hernandez-Varas P; Berge U; Jafari-Mamaghani M; Lock JG; Stromblad S, 2016, 'An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes', ELIFE, 5, http://dx.doi.org/10.7554/eLife.11384

Kowalewski JM; Shafqat-Abbasi H; Jafari-Mamaghani M; Ganebo BE; Gong X; Stromblad S; Lock JG, 2015, 'Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions', PLOS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0135204

Hernandez-Varas P; Berge U; Lock JG; Stromblad S, 2015, 'A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime', NATURE COMMUNICATIONS, 6, http://dx.doi.org/10.1038/ncomms8524

Kiss A; Gong X; Kowalewski JM; Shafqat-Abbasi H; Stromblad S; Lock JG, 2015, 'Non-monotonic cellular responses to heterogeneity in talin protein expression-level', INTEGRATIVE BIOLOGY, 7, pp. 1171 - 1185, http://dx.doi.org/10.1039/c4ib00291a

Lock JG; Mamaghani MJ; Shafqat-Abbasi H; Gong X; Tyrcha J; Stromblad S, 2014, 'Plasticity in the Macromolecular-Scale Causal Networks of Cell Migration', PLOS ONE, 9, http://dx.doi.org/10.1371/journal.pone.0090593

Nguyen Hoang AT; Chen P; Björnfot S; Högstrand K; Lock JG; Grandien A; Coles M; Svensson M, 2014, 'Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.', J Leukoc Biol, 96, pp. 481 - 489, http://dx.doi.org/10.1189/jlb.3TA0513-303R

Nystrom S; Antoine DJ; Lundback P; Lock JG; Nita AF; Hogstrand K; Grandien A; Erlandsson-Harris H; Andersson U; Applequist SE, 2013, 'TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis', EMBO JOURNAL, 32, pp. 86 - 99, http://dx.doi.org/10.1038/emboj.2012.328

Nyström S; Antoine DJ; Lundbäck P; Lock JG; Nita AF; Högstrand K; Grandien A; Erlandsson-Harris H; Andersson U; Applequist SE, 2013, 'TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis', The EMBO journal, 32, pp. 172 - 172

Colo GP; Hernandez-Varas P; Lock J; Bartolome RA; Arellano-Sanchez N; Stromblad S; Teixido J, 2012, 'Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway', JOURNAL OF CELL SCIENCE, 125, pp. 5338 - 5352, http://dx.doi.org/10.1242/jcs.105270

An Z; Dobra K; Lock JG; Stromblad S; Hjerpe A; Zhang H, 2010, 'Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration', INTERNATIONAL JOURNAL OF CANCER, 127, pp. 1999 - 2008, http://dx.doi.org/10.1002/ijc.25223

Plantard L; Arjonen A; Lock JG; Nurani G; Ivaska J; Stromblad S, 2010, 'PtdIns(3,4,5)P-3 is a regulator of myosin-X localization and filopodia formation', JOURNAL OF CELL SCIENCE, 123, pp. 3525 - 3534, http://dx.doi.org/10.1242/jcs.069609

Li Z; Lock JG; Olofsson H; Kowalewski JM; Teller S; Liu Y; Zhang H; Stromblad S, 2010, 'Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin alpha v beta 5 Clustering and Turnover', MOLECULAR BIOLOGY OF THE CELL, 21, pp. 3317 - 3329, http://dx.doi.org/10.1091/mbc.E10-03-0245

Lock JG; Stromblad S, 2010, 'Systems microscopy: An emerging strategy for the life sciences', EXPERIMENTAL CELL RESEARCH, 316, pp. 1438 - 1444, http://dx.doi.org/10.1016/j.yexcr.2010.04.001

Lindberg K; Strom A; Lock JG; Gustafsson J-A; Haldosen L-A; Helguero LA, 2010, 'Expression of Estrogen Receptor beta Increases Integrin alpha 1 and Integrin beta 1 Levels and Enhances Adhesion of Breast Cancer Cells', JOURNAL OF CELLULAR PHYSIOLOGY, 222, pp. 156 - 167, http://dx.doi.org/10.1002/jcp.21932

Lieu ZZ; Lock JG; Hammond LA; La Gruta NL; Stow JL; Gleeson PA, 2008, 'A trans-Golgi network golgin is required for the 14 regulated secretion of TNF in activated macrophages in vivo', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, pp. 3351 - 3356, http://dx.doi.org/10.1073/pnas.0800137105

Lock JG; Wehrle-Haller B; Stroemblad S, 2008, 'Cell-matrix adhesion complexes: Master control machinery of cell migration', SEMINARS IN CANCER BIOLOGY, 18, pp. 65 - 76, http://dx.doi.org/10.1016/j.semcancer.2007.10.001

Souslova EA; Belousov VV; Lock JG; Stromblad S; Kasparov S; Bolshakov AP; Pinelis VG; Labas YA; Lukyanov S; Mayr LM; Chudakov DM, 2007, 'Single fluorescent protein-based Ca2+ sensors with increased dynamic range', BMC BIOTECHNOLOGY, 7, http://dx.doi.org/10.1186/1472-6750-7-37

Lock JG; Hammond LA; Houghton F; Gleeson PA; Stow JL, 2005, 'E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by Golgin-97', TRAFFIC, 6, pp. 1142 - 1156, http://dx.doi.org/10.1111/j.1600-0854.2005.00349.x

Lock JG; Stow JL, 2005, 'Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin', MOLECULAR BIOLOGY OF THE CELL, 16, pp. 1744 - 1755, http://dx.doi.org/10.1091/mbc.E04-10-0867

Gleeson PA; Lock JG; Luke MR; Stow JL, 2004, 'Domains of the TGN: Coats, tethers and G proteins', TRAFFIC, 5, pp. 315 - 326, http://dx.doi.org/10.1111/j.1398-9219.2004.00182.x

Wylie FG; Lock JG; Jamriska L; Khromykh T; Brown DL; Stow JL, 2003, 'GAIP participates in budding of membrane carriers at the trans-Golgi network', TRAFFIC, 4, pp. 175 - 189, http://dx.doi.org/10.1034/j.1600-0854.2003.00106.x

Brown DL; Heimann K; Lock J; Kjer-Nielsen L; van Vliet C; Stow JL; Gleeson PA, 2001, 'The GRIP domain is a specific targeting sequence for a population of trans-Golgi network derived tubulo-vesicular carriers', TRAFFIC, 2, pp. 336 - 344, http://dx.doi.org/10.1034/j.1600-0854.2001.002005336.x

Bryce NS; Failes TW; Stehn JR; Baker K; Zahler S; Arzhaeva Y; Bischof L; Lyons C; Dedova I; Arndt GM; Gaus K; Goult BT; Hardeman EC; Gunning PW; Lock JG, 'The Limits of Phenotypic Plasticity in the Actin Cytoskeleton Revealed by Unbiased Chemical Perturbation', SSRN Electronic Journal, http://dx.doi.org/10.2139/ssrn.3299445

Conference Papers

Juan BPS; Hediyah-Zadeh S; Rangel L; Rodriguez V; Milioli HH; Kohane F; Purcell CA; Hickey TE; Goldstein LD; Lock JG; Davis MJ; Chaffer CL, 2022, 'The anti-androgen seviteronel sensitizes triple-negative breast cancer to chemotherapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, LA, New Orleans, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), LA, New Orleans, 08 April 2022 - 13 April 2022, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000892509505326&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Lock J; Filonik D; Lawther R; Pather N; Gaus K; Kenderdine S; Bednarz T, 2018, 'Visual Analytics of Single Cell Microscopy Data Using a Collaborative Immersive Environment', in Spencer SN (ed.), International Conference on Virtual Reality Continuum and its Applications in Industry (VRCAI '18), ACM, New York, Hachioji, Japan, pp. 1 - 4, presented at International Conference on Virtual Reality Continuum and its Applications in Industry (VRCAI '18), Hachioji, Japan, 02 December 2018 - 03 December 2018, http://dx.doi.org/10.1145/3284398.3284412

Conference Abstracts

Juan BPS; Hediyah-Zadeh S; Rangel L; Rodriguez V; Milioli HH; Kohane F; Purcell CA; Hickey TE; Goldstein LD; Lock JG; Davis MJ; Chaffer CL, 2022, 'Abstract 1029: The anti-androgen seviteronel sensitizes triple-negative breast cancer to chemotherapy', in Cancer Research, American Association for Cancer Research (AACR), Vol. 82, pp. 1029 - 1029, http://dx.doi.org/10.1158/1538-7445.am2022-1029

Preprints

Krishnaswamy S; Tong A; Kuchroo M; Gupta S; Venkat A; Juan BS; Rangel L; Zhu B; Lock J; Chaffer C, 2023, Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport, , http://dx.doi.org/10.21203/rs.3.rs-3605296/v1

Tong A; Kuchroo M; Gupta S; Venkat A; San Juan BP; Rangel L; Zhu B; Lock JG; Chaffer CL; Krishnaswamy S, 2023, Learning transcriptional and regulatory dynamics driving cancer cell plasticity using neural ODE-based optimal transport, , http://dx.doi.org/10.1101/2023.03.28.534644

Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, , http://dx.doi.org/10.21203/rs.3.rs-1602818/v2

Khan T; Lock J; Ma Y; Harman D; Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells, , http://dx.doi.org/10.21203/rs.3.rs-1602818/v1

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Zheng Y; Rouaen J; Jue TR; Michniewicz FT; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Valli E; Brettle M; Whan R; Vahadat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2022, Copper chelation inhibits TGF-βpathways and suppresses epithelial-mesenchymal transition in cancer, , http://dx.doi.org/10.1101/2022.10.03.510707

San Juan B; Hediyeh-Zadeh S; Rangel L; Milioli H; Rodriguez V; Bunkum A; Kohane F; Purcell C; Bhuva D; Kurumlian A; Castillo L; Lim E; Gill A; Ganju V; Dear R; O’Toole S; Vargas C; Hickey T; Goldstein L; Lock J; Davis M; Chaffer C, 2022, Targeting phenotypic plasticity prevents metastasis and the development of chemotherapy-resistant disease, , http://dx.doi.org/10.1101/2022.03.21.22269988

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