By Dr John Walter Frew

Journal articles

Bouazzi D; Nielsen SM; Hagan PG; Botvid S; Hove LS; Prens EP; Christensen R; Jemec GBE; Knecht-Gurwin K; Szepietowski JC; Anaba EL; Chehad AS; Zobiri S; Serradj A; Bhuiyan MSI; Noor T; Guillem P; Parvizi MM; Saki N; Alpsoy E; Vardar C; Kanni T; Giamarellos-Bourboulis EJ; Frew JW; Al Maharbi WHA; Van Huijstee JC; Aarts P; Dewi ST; Febriana SA; Indrastuti N; Suryawati N; Pangastuti M; Adji A; Akhyar G; Nopriyati N; Hazlianda CP; Reyes-Baraona F; Matas C; Saeed H; Moodley A; Binamer Y; Kamil MAA; Jocic I; Mijuskovic Z; Mallawaarachchi K; Gangani C; Tusheva I; Boshkovski VB; Hu D; Geng S; Medianfar CE; Saunte DML; Chandran NS; Van Der Zee HH; Zouboulis CC; Benhadou F; Villumsen B; Alavi A; Ibekwe PU; Hamzavi IH; Ingram JR; Naik HB; Garg A; Boer J, 2025, 'Prevalence of Hidradenitis Suppurativa A Meta-Analysis of Global Hidradenitis Suppurativa Atlas Studies', JAMA Dermatology, 161, pp. 1022 - 1028, http://dx.doi.org/10.1001/jamadermatol.2025.2373

Byrd AS; Moreau JM; Petukhova L; Frew J, 2025, 'Differentiating the Role of Inflammation in Hidradenitis Suppurativa from that in other Inflammatory Skin Diseases', Journal of Investigative Dermatology, 145, pp. 2417 - 2427, http://dx.doi.org/10.1016/j.jid.2025.04.009

Aghajani M; Maye E; Burrell K; Kok C; Frew JW, 2025, 'Evaluating the quality and readability of online information about hidradenitis suppurativa: a systematic review', Clinical and Experimental Dermatology, 50, pp. 1937 - 1944, http://dx.doi.org/10.1093/ced/llaf236

Lam T; Gruzmark F; Ondreyka J; Lenczowski J; Harris-Tryon TA; Frew J; Lev-Tov H, 2025, 'Food as Medicine in Hidradenitis Suppurativa: A Review of Dietary Effects on Hidradenitis Suppurativa Pathogenesis', Integrative and Complementary Therapies, 31, pp. 181 - 191, http://dx.doi.org/10.1177/27683192251376656

Sholji T; Islam R; Pham J; Burrell K; Kok C; Frew JW, 2025, 'Quantifying time to medical and/or surgical therapy after diagnosis of hidradenitis suppurativa and pilonidal sinus disease: A propensity-matched real-world cohort analysis', Journal of the European Academy of Dermatology and Venereology, 39, pp. e671 - e672, http://dx.doi.org/10.1111/jdv.20494

Westerkam LL; Santiago-Soltero K; Charrow A; Frew JW; Sayed CJ, 2025, 'Safety and efficacy of biologics in patients with Down syndrome and hidradenitis suppurativa: A retrospective cohort study', Clinical and Experimental Dermatology, 50, pp. 1431 - 1433, http://dx.doi.org/10.1093/ced/llaf090

Sholji T; Islam R; Pham J; Kok C; Frew JW, 2025, 'Malignancy risk differs between hidradenitis suppurativa and pilonidal sinus disease', Journal of the American Academy of Dermatology, 92, pp. 1381 - 1382, http://dx.doi.org/10.1016/j.jaad.2025.01.076

Flora A; Pham J; Woods JA; Radzeika M; Dickson H; Malone M; Frew JW, 2025, 'The Clinical and Molecular Response of Pyoderma Gangrenosum to IL-23 Blockade: Result from a Proof-of-Concept Open-Label Clinical Trial', Journal of Investigative Dermatology, 145, pp. 1396 - 1406.e6, http://dx.doi.org/10.1016/j.jid.2024.10.602

Johns M; Kunst H; Tng V; Frew J; Kok C; Lee S; Bonilla GM, 2025, 'Comparison of Keratinocyte Cancer Tumour and Defect Sizes Treated by Mohs Micrographic Surgery: Sydney Versus Outside Metropolitan Sydney', Australasian Journal of Dermatology, 66, pp. e148 - e154, http://dx.doi.org/10.1111/ajd.14453

Stewart TJ; Chan CWJ; Shah H; Frew J, 2025, 'Infectious complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis', International Journal of Dermatology, 64, pp. 830 - 848, http://dx.doi.org/10.1111/ijd.17527

Stewart TJ; Shah H; Frew J, 2025, 'Systematic review and meta-analysis of non-SCORTEN predictors of mortality in Stevens-Johnson syndrome and toxic epidermal necrolysis', International Journal of Dermatology, 64, pp. 849 - 860, http://dx.doi.org/10.1111/ijd.17529

Hashemi-Arend A; Lowes MA; Frew JW; Krueger J; Gierbolini A; Nayim M; Samanoglu M; Mbye PM; Shahriar F; Tobin JN; Kost RG, 2025, 'Full spectrum town halls for hidradenitis suppurativa: A model for advancing clinician-patient-researcher engagement in clinical and translational research', Journal of Clinical and Translational Science, 9, http://dx.doi.org/10.1017/cts.2025.62

Pham J; Frew JW, 2025, 'Hidradenitis Suppurativa: Pathogenesis and Inflammatory Pathways', Dermatologic Clinics, 43, pp. 179 - 191, http://dx.doi.org/10.1016/j.det.2024.12.004

Frew J; Smith A; Penas PF; Ellis E; Foley P; Rubel D; McMeniman E; Marshman G; Saunders H; Veysey E; Nicolopolous J; Spelman L; Gebauer K, 2025, 'Australasian hidradenitis suppurativa management guidelines', Australasian Journal of Dermatology, 66, pp. 75 - 89, http://dx.doi.org/10.1111/ajd.14388

Frew JW, 2025, 'Unravelling the complex pathogenesis of hidradenitis suppurativa', British Journal of Dermatology, 192, pp. i3 - i14, http://dx.doi.org/10.1093/bjd/ljae238

Greenlund L; Herzog C; Wendland Z; Rypka K; Frew JW; Kirby JS; Alavi A; Khalid B; Lowes MA; Garg A; Marzano AV; Zouboulis CC; Tzellos T; Jaleel T; Goldfarb N, 2025, 'Discrepancies in hidradenitis suppurativa lesion characterization by providers and patients', Journal of the European Academy of Dermatology and Venereology, 39, pp. 210 - 220, http://dx.doi.org/10.1111/jdv.19999

Sampath AJ; Westerkam LL; Blum FR; Alhusayen R; Bechara FG; Caffrey J; Carmona-Rivera C; Chandran NS; George R; Goldberg SR; Gudjonsson JE; Hansen SL; Ingram JR; Kirby B; Marzano AV; Matusiak Ł; Orgill DP; Prens E; van der Zee HH; van Straalen KR; Zouboulis CC; Byrd AS; Frew JW; Lowes MA; Naik HB; Sokumbi O; Mi QS; Miedema JR; Googe PB; Sayed CJ, 2025, 'Standardized Protocols for Clinical and Histopathological Characterization of Hidradenitis Suppurativa Tissue Specimens', Journal of Investigative Dermatology, 145, pp. 50 - 55, http://dx.doi.org/10.1016/j.jid.2024.02.041

Frew J; Flora A; Pham J; Woods J; Radzieta M; Dickson H; Malone M, 2025, '61257 The Clinical and Molecular Response of Pyoderma Gangrenosum to Interleukin 23 Blockade: Result from a proof-of-concept open-label clinical trial', Journal of the American Academy of Dermatology, 93, pp. AB313 - AB313, http://dx.doi.org/10.1016/j.jaad.2025.05.1236

Frew J; Pham J; Sholji T; Guttman L; Allen T, 2025, '61380 Predictors of wound healing after surgical deroofing in Hidradenitis Suppurativa', Journal of the American Academy of Dermatology, 93, pp. AB72 - AB72, http://dx.doi.org/10.1016/j.jaad.2025.05.292

Porter ML; Kirby B; Krueger JG; Bechara FG; Frew JW; Sayed CJ; Pinter A; Szepietowski JC; Bertolini M; Reich K; Kimball AB, 2025, '62297 Resolution of deep dermal inflammatory lesions with the Nanobody sonelokimab in moderate-to-severe hidradenitis suppurativa (HS): preclinical results and outcomes from the Phase 2 MIRA trial', Journal of the American Academy of Dermatology, 93, pp. AB290 - AB290, http://dx.doi.org/10.1016/j.jaad.2025.05.1146

Sayed CJ; Kirby B; Frew JW; Porter ML; Ingram JR; Prens E; Charrow AP; Gooderham MJ; Savage L; Reich K; Bechara FG, 2025, '62305 IHS4-100 responses and other IHS4 outcomes with the IL-17A- and IL-17F-inhibiting Nanobody sonelokimab in patients with moderate-to-severe hidradenitis suppurativa (HS): Week 24 results from the Phase 2 MIRA trial', Journal of the American Academy of Dermatology, 93, pp. AB221 - AB221, http://dx.doi.org/10.1016/j.jaad.2025.05.878

Tzellos T; Sayed CJ; Gottlieb AB; Becherel P-A; Kirby B; Asai J; Frew JW; Pansar I; Rolleri R; Tilt N; Porter ML, 2025, '64414 Bimekizumab impact on draining tunnel reduction over 2 years in moderate to severe hidradenitis suppurativa: Results from BE HEARD EXT', Journal of the American Academy of Dermatology, 93, pp. AB137 - AB137, http://dx.doi.org/10.1016/j.jaad.2025.05.546

Tseng H; Frew J; Murrell D, 2025, '65 Statin Therapy Is Associated With a Reduced Risk of Autoimmune Blistering Diseases: A Global Retrospective Cohort Study of 172 Million Individuals', Journal of Investigative Dermatology, 145, pp. e42, http://dx.doi.org/10.1016/j.jid.2025.09.083

Frew JW, 2024, 'Intrinsic factors in the pathogenesis of hidradenitis suppurativa: Genetics, hormones, and the microbiome', Journal of the American Academy of Dermatology, 91, pp. S12 - S16, http://dx.doi.org/10.1016/j.jaad.2024.08.052

Pham J; Sholji T; Guttman L; Allan T; Frew JW, 2024, 'Predictors of wound healing after surgical deroofing in Hidradenitis Suppurativa', Australasian Journal of Dermatology, 65, pp. 636 - 641, http://dx.doi.org/10.1111/ajd.14375

Wu K; Larney C; Marshman G; Spelman L; Rubel D; Mcmeniman E; Veysey E; Saunders H; Frew JW, 2024, 'Quality-of-life evaluation in hidradenitis suppurativa in Australia: Validation and outcomes of the HiSQOL questionnaire', Australasian Journal of Dermatology, 65, pp. 630 - 635, http://dx.doi.org/10.1111/ajd.14370

Pham J; Flora A; Guttman L; Allan T; Chandran NS; Frew JW, 2024, 'Response to adalimumab in Caucasian and Asian patients with hidradenitis suppurativa: A retrospective cohort study of an Australian cohort stratified by patient-reported ethnicity', Australasian Journal of Dermatology, 65, pp. 560 - 566, http://dx.doi.org/10.1111/ajd.14343

Patel J; Ostler P; van der Voet H; Loblaw A; Chu W; Ford D; Tolan S; Camilleri P; Kancherla K; Frew J; Chan A; Naismith O; Armstrong J; Staffurth J; Martin A; Wells P; Price D; Williamson E; Pugh J; Manning G; Brown S; Burnett S; Griffin C; van As N; Tree A; Dayes I; Hall E; Jain S, 2024, 'Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer', The New England Journal of Medicine, 391, pp. 1413 - 1425, http://dx.doi.org/10.1056/nejmoa2403365

Alavi A; Prens EP; Kimball AB; Frew JW; Krueger JG; Mukhopadhyay S; Gao H; Ranganathan U; Ivanoff NB; Hernandez Daly AC; Zouboulis CC, 2024, 'Proof-of-concept study exploring the effect of spesolimab in patients with moderate-to-severe hidradenitis suppurativa: A randomized double-blind placebo-controlled clinical trial', British Journal of Dermatology, 191, pp. 508 - 518, http://dx.doi.org/10.1093/bjd/ljae144

Kozera E; Elhage T; Cachia A; Frew JW, 2024, 'Lichenoid drug reaction to technicium-99: a case report and review of the literature', International Journal of Women S Dermatology, 10, http://dx.doi.org/10.1097/JW9.0000000000000179

Stewart TJ; Farrell J; Frew JW, 2024, 'A systematic review of case–control studies of cytokines in blister fluid and skin tissue of patients with Stevens Johnson syndrome and toxic epidermal necrolysis', Australasian Journal of Dermatology, 65, pp. 491 - 504, http://dx.doi.org/10.1111/ajd.14329

Frew J; Keyser N; Kim E; Paddock G; Toumbleston C; Wilson S; Tsikkou C, 2024, 'An analysis of a 2 × 2 Keyfitz–Kranzer type balance system with varying generalized Chaplygin gas', Physics of Fluids, 36, pp. 096132, http://dx.doi.org/10.1063/5.0231413

Pham JP; Rosenø NAL; Roccuzzo G; Saal RC; Egeberg A; Ring HC; Frew JW, 2024, 'Drug survival of biologics in hidradenitis suppurativa: A systematic review and meta-analysis', Journal of the American Academy of Dermatology, 91, pp. 170 - 172, http://dx.doi.org/10.1016/j.jaad.2024.03.028

Gu Y; Shih STF; Geevasinga N; Chan L; Frew JW; Sebaratnam DF, 2024, 'Economic Evaluation of HLA-B*15:02 Genotyping for Asian Australian Patients with Epilepsy', JAMA Dermatology, 160, pp. 631 - 640, http://dx.doi.org/10.1001/jamadermatol.2024.1037

Nebo ID; Frew JW; Gudjonsson JE; Petukhova L, 2024, 'Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies', Proceedings of the National Academy of Sciences of the United States of America, 121, http://dx.doi.org/10.1073/pnas.2404503121

Kozera EK; Porter M; Paek SY; Mintoff D; Mcmeniman E; Oon HH; Chandran NS; Glasenhardt K; Ring HC; Frew JW, 2024, 'Infectious Disease Screening prior to Systemic Immunomodulatory Therapy in Hidradenitis Suppurativa: Consensus Guidelines from the Asia-Pacific Hidradenitis Suppurativa Foundation', Dermatology, 240, pp. 494 - 506, http://dx.doi.org/10.1159/000534575

Williams SC; Garcet S; Hur H; Miura S; Gonzalez J; Navrazhina K; Yamamura-Murai M; Yamamura K; Li X; Frew J; Fischetti VA; Sela U; Krueger JG, 2024, 'Gram-negative anaerobes elicit a robust keratinocytes immune response with potential insights into HS pathogenesis', Experimental Dermatology, 33, http://dx.doi.org/10.1111/exd.15087

Pham JP; Staeger R; Frew JW, 2024, 'More data are needed to confirm the utility of screening for atypical fibroxanthoma and pleomorphic dermal sarcoma recurrence', Journal of the American Academy of Dermatology, 90, pp. e171 - e173, http://dx.doi.org/10.1016/j.jaad.2023.11.064

Pham JP; Flora A; Frew JW, 2024, 'Understanding multi-kinase inhibitor-associated cutaneous ulcers may provide molecular insights into the aetiology of pyoderma gangrenosum: A comment on Jeon et al.', Australasian Journal of Dermatology, 65, pp. e81 - e84, http://dx.doi.org/10.1111/ajd.14221

Flora A; Jepsen R; Pham J; Frew JW, 2024, 'Alterations to the Hidradenitis Suppurativa Serum Proteome with Spleen Tyrosine Kinase Antagonism: Proteomic Results from a Phase 2 Clinical Trial', Journal of Investigative Dermatology, 144, pp. 786 - 793.e1, http://dx.doi.org/10.1016/j.jid.2023.10.005

Pham JP; Jepsen R; Frew JW, 2024, 'Comment on Kridin et al.—Considering both relative and absolute risk differences in infection risk between biologics classes in patients with psoriasis', Journal of the European Academy of Dermatology and Venereology, 38, pp. e351 - e353, http://dx.doi.org/10.1111/jdv.19615

Wainman HE; Chandran NS; Frew JW; Garg A; Gibbons A; Gierbolini A; Horvath B; Jemec GB; Kirby B; Kirby J; Lowes MA; Martorell A; McGrath BM; Naik HB; Oon HH; Prens E; Sayed CJ; Thorlacius L; Van Der Zee HH; Villumsen B; Ingram JR, 2024, 'Global consensus process to establish a core dataset for hidradenitis suppurativa registries', British Journal of Dermatology, 190, pp. 510 - 518, http://dx.doi.org/10.1093/bjd/ljad454

Flora A; Pham J; Jepsen R; Frew JW, 2024, 'The serum proteome of pyoderma gangrenosum is more expansive than that of hidradenitis suppurativa', Journal of the European Academy of Dermatology and Venereology, 38, pp. e348 - e350, http://dx.doi.org/10.1111/jdv.19611

Krueger JG; Frew J; Jemec GBE; Kimball AB; Kirby B; Bechara FG; Navrazhina K; Prens E; Reich K; Cullen E; Wolk K, 2024, 'Hidradenitis suppurativa: New insights into disease mechanisms and an evolving treatment landscape', British Journal of Dermatology, 190, pp. 149 - 162, http://dx.doi.org/10.1093/bjd/ljad345

Flora A; Jepsen R; Pham J; Frew JW, 2024, 'Rapid Attenuation of B-Cell and IFN-γ–Associated Chemokines in Clinical Responders to Jak Inhibition with Upadacitinib in Hidradenitis Suppurativa', Journal of Investigative Dermatology, 144, pp. 416 - 419.e5, http://dx.doi.org/10.1016/j.jid.2023.07.023

Garcia-Doval I; Rajan N; Hunter H; Frew J; Naldi L; Mellerio JE; Hay R, 2024, 'Clinical reports: the overarching home for case series and case reports in the BJD', British Journal of Dermatology, 190, pp. 1 - 2, http://dx.doi.org/10.1093/bjd/ljad301

Navrazhina K; Garcet S; Williams SC; Gulati N; Kiecker F; Frew JW; Mitsui H; Krueger JG, 2024, 'Laser capture microdissection provides a novel molecular profile of human primary cutaneous melanoma', Pigment Cell and Melanoma Research, 37, pp. 81 - 89, http://dx.doi.org/10.1111/pcmr.13121

Flora A; Jepsen R; Kozera EK; Woods JA; Cains GD; Radzieta M; Jensen SO; Malone M; Frew JW, 2024, 'Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism', Experimental Dermatology, 33, http://dx.doi.org/10.1111/exd.14894

Kost R; Hashemi-Arend A; Gierbolini A; Samanoglu M; Mbye P; Shahriar F; Frew J; Lowes M, 2024, '276 Full Spectrum Town Hall Meetings - Advancing Clinician-Patient-Researcher Engagement for Hidradenitis Suppurativa (HS)', Journal of Clinical and Translational Science, 8, pp. 84 - 84, http://dx.doi.org/10.1017/cts.2024.252

Kimball AB; Alavi A; Prens E; Krueger JG; Frew JW; Garg A; Mukhopadhyay S; Wang H; Ivanoff NB; Daly ACH; Zouboulis CC, 2024, '52676 Safety and efficacy over one year of spesolimab treatment in patients with hidradenitis suppurativa (HS): Interim analysis of an open-label extension (OLE) study', Journal of the American Academy of Dermatology, 91, pp. ab83, http://dx.doi.org/10.1016/j.jaad.2024.07.337

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