By Dr John Walter Frew

Book Chapters

Grand D; Frew JW; Hawkes JE, 2023, '17 Epigenetics', in Atopic Dermatitis : Inside Out Or Outside in, Elsevier, pp. 168 - 178, http://dx.doi.org/10.1016/b978-0-323-84744-5.00017-6

Pham JP; Frew JW, 2023, 'Management of Immunosuppressed Dermatology Patients During COVID-19', in Updates in Clinical Dermatology, Springer Nature Switzerland, pp. 109 - 120, http://dx.doi.org/10.1007/978-3-031-45586-5_11

Grand D; Frew JW; Hawkes JE, 2022, 'Epigenetics', in Atopic Dermatitis: Inside Out or Outside In, pp. 168 - 178, http://dx.doi.org/10.1016/B978-0-323-84744-5.00017-6

Frew JW, 2022, 'Follicular Occlusion and Inflammation', in A Comprehensive Guide to Hidradenitis Suppurativa, pp. 89 - 99, http://dx.doi.org/10.1016/B978-0-323-77724-7.00010-3

Lasschuit JWJ; Snaith JR; Frew JW, 2021, 'The skin and diabetes', in Skin and the Heart, pp. 283 - 298, http://dx.doi.org/10.1007/978-3-030-54779-0_18

Lasschuit JWJ; Snaith JR; Frew JW, 2021, 'The skin and diabetes', in Skin and the Heart, pp. C1, http://dx.doi.org/10.1007/978-3-030-54779-0_29

Lasschuit JWJ; Snaith JR; Frew JW, 2021, 'Correction to: The Skin and Diabetes', in Skin and the Heart, Springer International Publishing, pp. C1 - C1, http://dx.doi.org/10.1007/978-3-030-54779-0_29

Grand D; Navrazhina K; Frew JW; Hawkes JE, 2021, 'Research Pipeline I: Oral Therapeutics for Psoriasis', in Advances in Psoriasis, Springer International Publishing, pp. 291 - 302, http://dx.doi.org/10.1007/978-3-030-54859-9_23

Frew JW; Navrazhina K; Krueger JG, 2020, 'Hidradenitis Suppurativa (HS) and other disorders of ‘follicular occlusion’', in Stiehm's Immune Deficiencies: Inborn Errors of Immunity, pp. 773 - 786, http://dx.doi.org/10.1016/B978-0-12-816768-7.00033-8

Frew JW; Murrell DF, 2015, 'Autoimmune Blistering Diseases and Corticosteroid Use: A Review of the Evidence', in Blistering Diseases: Clinical Features, Pathogenesis, Treatment, Springer Link, pp. 459 - 468, http://dx.doi.org/10.1007/978-3-662-45698-9_46

Frew JW; Chams Davatchi C; Murrell DF, 2015, 'Cyclophosphamide in Autoimmune Blistering Diseases: Safety, Efficacy and Evidence Base', in Blistering Diseases: Clinical Features, Pathogenesis, Treatment, Springer Link, pp. 507 - 513, http://dx.doi.org/10.1007/978-3-662-45698-9_51

Murrell DF; Frew JW, 2015, 'Living with Epidermolysis Bullosa: Reviewing the Impact on Individuals' Quality of Life', in Blistering Diseases: Clinical Features, Pathogenesis, Treatment, Springer Link, pp. 711 - 717, http://dx.doi.org/10.1007/978-3-662-45698-9_74

Journal articles

Pham J; Frew JW, 2025, 'Hidradenitis Suppurativa: Pathogenesis and Inflammatory Pathways', Dermatologic Clinics, 43, pp. 179 - 191, http://dx.doi.org/10.1016/j.det.2024.12.004

Frew J; Smith A; Penas PF; Ellis E; Foley P; Rubel D; McMeniman E; Marshman G; Saunders H; Veysey E; Nicolopolous J; Spelman L; Gebauer K, 2025, 'Australasian hidradenitis suppurativa management guidelines', Australasian Journal of Dermatology, 66, pp. 75 - 89, http://dx.doi.org/10.1111/ajd.14388

Westerkam LL; Santiago-Soltero K; Charrow A; Frew JW; Sayed CJ, 2025, 'Biologic Safety and Efficacy in Patients with Down Syndrome and Hidradenitis Suppurativa: A Retrospective Cohort Study.', Clin Exp Dermatol, http://dx.doi.org/10.1093/ced/llaf090

Frew JW, 2025, 'Unravelling the complex pathogenesis of hidradenitis suppurativa', British Journal of Dermatology, 192, pp. i3 - i14, http://dx.doi.org/10.1093/bjd/ljae238

Johns M; Kunst H; Tng V; Frew J; Kok C; Lee S; Bonilla GM, 2025, 'Comparison of Keratinocyte Cancer Tumour and Defect Sizes Treated by Mohs Micrographic Surgery: Sydney Versus Outside Metropolitan Sydney', Australasian Journal of Dermatology, http://dx.doi.org/10.1111/ajd.14453

Greenlund L; Herzog C; Wendland Z; Rypka K; Frew JW; Kirby JS; Alavi A; Khalid B; Lowes MA; Garg A; Marzano AV; Zouboulis CC; Tzellos T; Jaleel T; Goldfarb N, 2025, 'Discrepancies in hidradenitis suppurativa lesion characterization by providers and patients', Journal of the European Academy of Dermatology and Venereology, 39, pp. 210 - 220, http://dx.doi.org/10.1111/jdv.19999

Wortsman X; Alfageme F; Dini V; García-Martínez FJ; Caposiena Caro RD; Frew J; Gonzalez C; Hamzavi IH; Kohli I; Krajewski PK; Kuyumllian M; Liu J; Mandava A; Nazzaro G; O'Brien E; Oranges T; Pelizzari M; Rezende J; Romani J; Sigrist R; Taleb E; Zattar L; Zavariz J; Martorell A, 2025, 'International consensus statement on the use of ultrasound in hidradenitis suppurativa', Journal of the European Academy of Dermatology and Venereology, http://dx.doi.org/10.1111/jdv.20600

Sholji T; Islam R; Pham J; Kok C; Frew JW, 2025, 'Malignancy risk differs between hidradenitis suppurativa and pilonidal sinus disease', Journal of the American Academy of Dermatology, http://dx.doi.org/10.1016/j.jaad.2025.01.076

Sampath AJ; Westerkam LL; Blum FR; Alhusayen R; Bechara FG; Caffrey J; Carmona-Rivera C; Chandran NS; George R; Goldberg SR; Gudjonsson JE; Hansen SL; Ingram JR; Kirby B; Marzano AV; Matusiak Ł; Orgill DP; Prens E; van der Zee HH; van Straalen KR; Zouboulis CC; Byrd AS; Frew JW; Lowes MA; Naik HB; Sokumbi O; Mi QS; Miedema JR; Googe PB; Sayed CJ, 2025, 'Standardized Protocols for Clinical and Histopathological Characterization of Hidradenitis Suppurativa Tissue Specimens', Journal of Investigative Dermatology, 145, pp. 50 - 55, http://dx.doi.org/10.1016/j.jid.2024.02.041

Frew JW, 2024, 'Intrinsic factors in the pathogenesis of hidradenitis suppurativa: Genetics, hormones, and the microbiome', Journal of the American Academy of Dermatology, 91, pp. S12 - S16, http://dx.doi.org/10.1016/j.jaad.2024.08.052

Pham J; Sholji T; Guttman L; Allan T; Frew JW, 2024, 'Predictors of wound healing after surgical deroofing in Hidradenitis Suppurativa', Australasian Journal of Dermatology, 65, pp. 636 - 641, http://dx.doi.org/10.1111/ajd.14375

Wu K; Larney C; Marshman G; Spelman L; Rubel D; Mcmeniman E; Veysey E; Saunders H; Frew JW, 2024, 'Quality-of-life evaluation in hidradenitis suppurativa in Australia: Validation and outcomes of the HiSQOL questionnaire', Australasian Journal of Dermatology, 65, pp. 630 - 635, http://dx.doi.org/10.1111/ajd.14370

Pham J; Flora A; Guttman L; Allan T; Chandran NS; Frew JW, 2024, 'Response to adalimumab in Caucasian and Asian patients with hidradenitis suppurativa: A retrospective cohort study of an Australian cohort stratified by patient-reported ethnicity', Australasian Journal of Dermatology, 65, pp. 560 - 566, http://dx.doi.org/10.1111/ajd.14343

van As N; Griffin C; Tree A; Patel J; Ostler P; van der Voet H; Loblaw A; Chu W; Ford D; Tolan S; Jain S; Camilleri P; Kancherla K; Frew J; Chan A; Naismith O; Armstrong J; Staffurth J; Martin A; Dayes I; Wells P; Price D; Williamson E; Pugh J; Manning G; Brown S; Burnett S; Hall E, 2024, 'Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer', NEW ENGLAND JOURNAL OF MEDICINE, 391, pp. 1413 - 1425, http://dx.doi.org/10.1056/NEJMoa2403365

Alavi A; Prens EP; Kimball AB; Frew JW; Krueger JG; Mukhopadhyay S; Gao H; Ranganathan U; Ivanoff NB; Hernandez Daly AC; Zouboulis CC, 2024, 'Proof-of-concept study exploring the effect of spesolimab in patients with moderate-to-severe hidradenitis suppurativa: A randomized double-blind placebo-controlled clinical trial', British Journal of Dermatology, 191, pp. 508 - 518, http://dx.doi.org/10.1093/bjd/ljae144

Stewart TJ; Farrell J; Frew JW, 2024, 'A systematic review of case–control studies of cytokines in blister fluid and skin tissue of patients with Stevens Johnson syndrome and toxic epidermal necrolysis', Australasian Journal of Dermatology, 65, pp. 491 - 504, http://dx.doi.org/10.1111/ajd.14329

Pham JP; Rosenø NAL; Roccuzzo G; Saal RC; Egeberg A; Ring HC; Frew JW, 2024, 'Drug survival of biologics in hidradenitis suppurativa: A systematic review and meta-analysis', Journal of the American Academy of Dermatology, 91, pp. 170 - 172, http://dx.doi.org/10.1016/j.jaad.2024.03.028

Gu Y; Shih STF; Geevasinga N; Chan L; Frew JW; Sebaratnam DF, 2024, 'Economic Evaluation of HLA-B*15:02 Genotyping for Asian Australian Patients with Epilepsy', JAMA Dermatology, 160, pp. 631 - 640, http://dx.doi.org/10.1001/jamadermatol.2024.1037

Nebo ID; Frew JW; Gudjonsson JE; Petukhova L, 2024, 'Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies', Proceedings of the National Academy of Sciences of the United States of America, 121, http://dx.doi.org/10.1073/pnas.2404503121

Kozera EK; Porter M; Paek SY; Mintoff D; Mcmeniman E; Oon HH; Chandran NS; Glasenhardt K; Ring HC; Frew JW, 2024, 'Infectious Disease Screening prior to Systemic Immunomodulatory Therapy in Hidradenitis Suppurativa: Consensus Guidelines from the Asia-Pacific Hidradenitis Suppurativa Foundation', Dermatology, 240, pp. 494 - 506, http://dx.doi.org/10.1159/000534575

Williams SC; Garcet S; Hur H; Miura S; Gonzalez J; Navrazhina K; Yamamura-Murai M; Yamamura K; Li X; Frew J; Fischetti VA; Sela U; Krueger JG, 2024, 'Gram-negative anaerobes elicit a robust keratinocytes immune response with potential insights into HS pathogenesis', Experimental Dermatology, 33, http://dx.doi.org/10.1111/exd.15087

Pham JP; Staeger R; Frew JW, 2024, 'More data are needed to confirm the utility of screening for atypical fibroxanthoma and pleomorphic dermal sarcoma recurrence', Journal of the American Academy of Dermatology, 90, pp. e171 - e173, http://dx.doi.org/10.1016/j.jaad.2023.11.064

Pham JP; Flora A; Frew JW, 2024, 'Understanding multi-kinase inhibitor-associated cutaneous ulcers may provide molecular insights into the aetiology of pyoderma gangrenosum: A comment on Jeon et al.', Australasian Journal of Dermatology, 65, pp. e81 - e84, http://dx.doi.org/10.1111/ajd.14221

Flora A; Jepsen R; Pham J; Frew JW, 2024, 'Alterations to the Hidradenitis Suppurativa Serum Proteome with Spleen Tyrosine Kinase Antagonism: Proteomic Results from a Phase 2 Clinical Trial', Journal of Investigative Dermatology, 144, pp. 786 - 793.e1, http://dx.doi.org/10.1016/j.jid.2023.10.005

Pham JP; Jepsen R; Frew JW, 2024, 'Comment on Kridin et al.—Considering both relative and absolute risk differences in infection risk between biologics classes in patients with psoriasis', Journal of the European Academy of Dermatology and Venereology, 38, pp. e351 - e353, http://dx.doi.org/10.1111/jdv.19615

Wainman HE; Chandran NS; Frew JW; Garg A; Gibbons A; Gierbolini A; Horvath B; Jemec GB; Kirby B; Kirby J; Lowes MA; Martorell A; McGrath BM; Naik HB; Oon HH; Prens E; Sayed CJ; Thorlacius L; Van Der Zee HH; Villumsen B; Ingram JR, 2024, 'Global consensus process to establish a core dataset for hidradenitis suppurativa registries', British Journal of Dermatology, 190, pp. 510 - 518, http://dx.doi.org/10.1093/bjd/ljad454

Flora A; Pham J; Jepsen R; Frew JW, 2024, 'The serum proteome of pyoderma gangrenosum is more expansive than that of hidradenitis suppurativa', Journal of the European Academy of Dermatology and Venereology, 38, pp. e348 - e350, http://dx.doi.org/10.1111/jdv.19611

Krueger JG; Frew J; Jemec GBE; Kimball AB; Kirby B; Bechara FG; Navrazhina K; Prens E; Reich K; Cullen E; Wolk K, 2024, 'Hidradenitis suppurativa: New insights into disease mechanisms and an evolving treatment landscape', British Journal of Dermatology, 190, pp. 149 - 162, http://dx.doi.org/10.1093/bjd/ljad345

Flora A; Jepsen R; Pham J; Frew JW, 2024, 'Rapid Attenuation of B-Cell and IFN-γ–Associated Chemokines in Clinical Responders to Jak Inhibition with Upadacitinib in Hidradenitis Suppurativa', Journal of Investigative Dermatology, 144, pp. 416 - 419.e5, http://dx.doi.org/10.1016/j.jid.2023.07.023

Garcia-Doval I; Rajan N; Hunter H; Frew J; Naldi L; Mellerio JE; Hay R, 2024, 'Clinical reports: the overarching home for case series and case reports in the BJD', British Journal of Dermatology, 190, pp. 1 - 2, http://dx.doi.org/10.1093/bjd/ljad301

Stewart TJ; Chan CWJ; Shah H; Frew J, 2024, 'Infectious complications of Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis', International Journal of Dermatology, http://dx.doi.org/10.1111/ijd.17527

Navrazhina K; Garcet S; Williams SC; Gulati N; Kiecker F; Frew JW; Mitsui H; Krueger JG, 2024, 'Laser capture microdissection provides a novel molecular profile of human primary cutaneous melanoma', Pigment Cell and Melanoma Research, 37, pp. 81 - 89, http://dx.doi.org/10.1111/pcmr.13121

Flora A; Jepsen R; Kozera EK; Woods JA; Cains GD; Radzieta M; Jensen SO; Malone M; Frew JW, 2024, 'Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism', Experimental Dermatology, 33, http://dx.doi.org/10.1111/exd.14894

Sholji T; Islam R; Pham J; Burrell K; Kok C; Frew JW, 2024, 'Quantifying time to medical and/or surgical therapy after diagnosis of hidradenitis suppurativa and pilonidal sinus disease: A propensity-matched real-world cohort analysis', Journal of the European Academy of Dermatology and Venereology, http://dx.doi.org/10.1111/jdv.20494

Stewart TJ; Shah H; Frew J, 2024, 'Systematic review and meta-analysis of non-SCORTEN predictors of mortality in Stevens-Johnson syndrome and toxic epidermal necrolysis', International Journal of Dermatology, http://dx.doi.org/10.1111/ijd.17529

Flora A; Pham J; Woods JA; Radzeika M; Dickson H; Malone M; Frew JW, 2024, 'The Clinical and Molecular Response of Pyoderma Gangrenosum to IL-23 Blockade: Result from a Proof-of-Concept Open-Label Clinical Trial', Journal of Investigative Dermatology, http://dx.doi.org/10.1016/j.jid.2024.10.602

Kost R; Hashemi-Arend A; Gierbolini A; Samanoglu M; Mbye P; Shahriar F; Frew J; Lowes M, 2024, '276 Full Spectrum Town Hall Meetings - Advancing Clinician-Patient-Researcher Engagement for Hidradenitis Suppurativa (HS)', Journal of Clinical and Translational Science, 8, pp. 84 - 84, http://dx.doi.org/10.1017/cts.2024.252

Kimball AB; Alavi A; Prens E; Krueger JG; Frew JW; Garg A; Mukhopadhyay S; Wang H; Ivanoff NB; Hernandez Daly AC; Zouboulis CC, 2024, '52676 Safety and efficacy over one year of spesolimab treatment in patients with hidradenitis suppurativa (HS): Interim analysis of an open-label extension (OLE) study', Journal of the American Academy of Dermatology, 91, pp. AB83 - AB83, http://dx.doi.org/10.1016/j.jaad.2024.07.337

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