Researcher

Dr Lisa Nivison-Smith

My Expertise

Optometry, Ophthalmology, Vision Science, Eye disease, Retina, Macular Degeneration, Retinitis Pigmentosa

Field of Research (FoR)

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Biography

 

ABOUT ME:

My research interests lie in the fundamental biology of the healthy and diseased retina. I specifically focus on anatomical and neurochemical modifications which occur in the early stages of disease prior to permanent vision loss. I study retinal neurobiology in two ways: (1) I use clinical approach, assessing data obtained from patients attending the Centre For Eye Health on the UNSW campus and (2) I use a basic science approach,...view more

 

ABOUT ME:

My research interests lie in the fundamental biology of the healthy and diseased retina. I specifically focus on anatomical and neurochemical modifications which occur in the early stages of disease prior to permanent vision loss. I study retinal neurobiology in two ways: (1) I use clinical approach, assessing data obtained from patients attending the Centre For Eye Health on the UNSW campus and (2) I use a basic science approach, assessing rodent models of retinal disease at different stages. This research is highly significant as it focuses on early disease, allowing us to potentially determine the underlying mechanism/s of disease. In addition, many interventions for blinding diseases such as the bionic eye or stem cell transplantation, depend on accurate knowledge of the retinal architecture in retinal disease. This research can provide these modified anatomical and functional roadmaps of the diseased retina as well as discover new intervention points for new therapeutics. 

For further information on my research, please visit the Retinal Networks Laboratory or my Facebook page  

 

BASIC SCIENCE RESEARCH

My basic science research involves

  • animal models of inherited retinal dystrophies (rd1 mouse, P23H rat),
  • carriers of retinal dystrophies (heterozygous rd1 mouse)
  • animal models for retinal metabolic conditions (ischaemia model via elevated IOP).
  • a range of techniques to assess the retina including histology, immunocytochemistry, microscopy, rodent electroretinography (ERG), metabolic assays and glutamate receptor functional mapping

Current basic science student projects

CLINICAL RESEARCH

My clinical research involves
  • investigating major retinal diseases which cause blindness such as age-related macular degeneration (AMD) and Retinitis Pigmentosa
  • performing image analysis from a range of advanced modalities including optical coherence tomography (OCT), multi-spectral imaging, fundus autofluorscence, infra-red imaging and ultra wide field imaging
  • assessing pathological retinal function using psychophyiscal tests and electrophysiology

 

 Current clinical student projects

 

 

 

 


My Grants

  • 2019-20 Rebecca L Cooper Foundation: "Novel techniques to improve classification of individuals with macular degeneration" Value: $100K
  • 2019 UNSW RIS Grant: "COMPASS Microperimeter" Value: $55K
  • 2017 UNSW RIS Grant: "Spectralis OCTA" Value: $99K
  • 2016-17 UNSW Early Career Research Grant : “Late-stage remodelling in retinal degeneration” Value: $8.5K
  • 2015-16 UNSW Early Career Research Grant : “The metabolic actions of vinpocetine in the treatment of ocular ischaemia” Value: $11K
  • 2015-16 UNSW MREII Grant: "Tissue Culture Facility" Value: $96K
  • 2014-15 UNSW Early Career Research Grant : “Transneuronal degradation in the visual cortex of rodents with retinal damage” Value: $10K
  • 2013-14 UNSW Faculty Research Grant: “Glutamate receptor functionality of bipolar cells in ocular disease” Value: $21K

My Qualifications

  • PhD in Cell Biology/Tissue Engineering (University of Sydney, 2011)
  • BSc Hons in Molecular Biology and Genetics (University of Sydney, 2006)

 

 

PROFESSIONAL AFFILIATIONS AND SERVICE POSITIONS

  • 2018 - Current: Editor-in-Chief, International Journal of Orientation and Mobility
  • 2017 - Current: Associate Editor, Clinical and Experimental Optometry
  • 2016 - Current: Member, International Society of Eye Research
  • 2016 - Current: Member, American Academy of Optometry
  • 2014 - Current: Member, Association for Research in Vision and Ophthamology
  • 2011- 2016: Member, Australasian Neuroscience Society
  • 2011 - Current: Expert reviewer for Optometry journals (please see Publons for details)
  • 2008 - 2010:  Member, Australian Society of Tissue Engineering and Biomaterials

My Awards

  • 2016: Ian Potter travel award, American Academy of Optometry, Anaheim, USA
  • 2015: CASS travel award, Association for Research in Vision and Ophthamology, Seattle, USA
  • 2010: Travel Award, Australian Biomaterials and Tissue Engineering Conference, QLD, AUSTRALIA
  • 2010: Poster Prize, Elastin and Elastic Fibers Gordon Research Conference, Biddeford, MA
  • 2008: Poster Prize, Bosch Scientific Meeting, University of Sydney, NSW, AUSTRALIA
  • 2008: Travel Award, Lorne Proteins Conference, VIC, AUSTRALIA
  • 2007: Australian Postgraduate Award
  • 2006: University Medal, University of Sydney, NSW, AUSTRALIA
  • 2006: Roslyn Flora Galston Prize for Biochemistry, University of Sydney, NSW, AUSTRALIA
  • 2006: Honours Scholarship, University of Sydney, NSW, AUSTRALIA

My Research Supervision


Supervision keywords


Areas of supervision

Vision Science

Retinal disease Biology

Retinal neurochemistry

Photoreceptor degenerations (age-related macular degeneration; Retinitis Pigmentosa)

 

Available supervision: PhD, Masters, M(Optom), Honours, ILP, vacation scholarships


Currently supervising

Phd: Ms Agnes Choi

ILP: Mr Glenn Teo

 


My Teaching

VISN2111

OPTM3205

OPTM5171/OPTM5271

 

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Location

Office: Centre for Eye Health, Rupert Myers Building Sth
Lab: Rm 2.031, Rupert Myers Building Nth

Contact

+61 2 8115 0791
+61 2 8115 0799