By Dr Lucy Coupland

Journal articles

Coupland LA; Pai KG; Pye SJ; Butorac MT; Miller JJ; Crispin PJ; Rabbolini DJ; Stewart AHL; Aneman A, 2024, 'Protracted fibrinolysis resistance following cardiac surgery with cardiopulmonary bypass: A prospective observational study of clinical associations and patient outcomes', Acta Anaesthesiologica Scandinavica, 68, pp. 772 - 780, http://dx.doi.org/10.1111/aas.14409

Coupland LA; Spiro C; Quah BJ-C; Orlov A; Browne A; O'Meara CH; Kang C-W; Frost S; Schulz L; Lombardo L; Parish CR; Aneman A, 2024, 'Plasma dynamics of neutrophil extracellular traps and cell-free DNA in septic and non-septic vasoplegic shock: a prospective comparative observational cohort study.', Shock, http://dx.doi.org/10.1097/SHK.0000000000002396

Coupland LA; Rabbolini DJ; Schoenecker JG; Crispin PJ; Miller JJ; Ghent T; Medcalf RL; Aneman AE, 2023, 'Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study', Critical Care, 27, http://dx.doi.org/10.1186/s13054-023-04329-5

Crispin PJ; Coupland LA; Gardiner EE, 2023, 'Achieving haemostasis in thrombocytopenia in remote settings: an in vitro comparison of frozen and lyophilized products', Blood Transfusion, 21, pp. 289 - 295, http://dx.doi.org/10.2450/2022.0128-22

Kang CW; Blackburn AC; Loh AHP; Hong KC; Goh JY; Hein N; Drygin D; Parish CR; Hannan RD; Hannan KM; Coupland LA, 2023, 'Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies', Biomedicines, 11, http://dx.doi.org/10.3390/biomedicines11041133

Mohamed E; Coupland L; Gibson S; Crispin P; Nisbet D; Tsuzuki T, 2022, 'Strong influence of morphology on the hemostatic performance of nanofibers irrespective of surface charge', Materials Letters, 327, http://dx.doi.org/10.1016/j.matlet.2022.133023

Mohamed E; Wang Y; Crispin PJ; Fitzgerald A; Dahlstrom JE; Fowler S; Nisbet DR; Tsuzuki T; Coupland LA, 2022, 'Superior Hemostatic and Wound-Healing Properties of Gel and Sponge Forms of Nonoxidized Cellulose Nanofibers: In Vitro and In Vivo Studies', Macromolecular Bioscience, 22, http://dx.doi.org/10.1002/mabi.202200222

O'Connor JH; McNamara HA; Cai Y; Coupland LA; Gardiner EE; Parish CR; McMorran BJ; Ganusov VV; Cockburn IA, 2022, 'Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8+ T Cell Localization in the Murine Liver', Journal of Immunology, 208, pp. 2738 - 2748, http://dx.doi.org/10.4049/jimmunol.2101037

Kang CW; Hannan KM; Blackburn AC; Loh AHP; Hong KC; Yuan GJ; Hein N; Drygin D; Hannan RD; Coupland LA, 2022, 'The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma', Investigational New Drugs, 40, pp. 529 - 536, http://dx.doi.org/10.1007/s10637-022-01222-w

Popp SK; Vecchio F; Brown DJ; Fukuda R; Suzuki Y; Takeda Y; Wakamatsu R; Sarma MA; Garrett J; Giovenzana A; Bosi E; Lafferty ARA; Brown KJ; Gardiner EE; Coupland LA; Thomas HE; Chong BH; Parish CR; Battaglia M; Petrelli A; Simeonovic CJ, 2022, 'Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice', JCI Insight, 7, http://dx.doi.org/10.1172/jci.insight.153993

Crispin P; Hicks S; Coupland LA; Ali S; Gardiner EE, 2022, 'Cryoprecipitate as an alternative to platelet transfusion in thrombocytopenia.', EJHaem, 3, pp. 80 - 85, http://dx.doi.org/10.1002/jha2.358

Mohamed E; Coupland LA; Crispin PJ; Fitzgerald A; Nisbet DR; Tsuzuki T, 2021, 'Non-oxidized cellulose nanofibers as a topical hemostat: In vitro thromboelastometry studies of structure vs function', Carbohydrate Polymers, 265, http://dx.doi.org/10.1016/j.carbpol.2021.118043

Meara CHO; Coupland LA; Kordbacheh F; Quah BJC; Chang CW; Simon Davis DA; Bezos A; Browne AM; Freeman C; Hammill DJ; Chopra P; Pipa G; Madge PD; Gallant E; Segovis C; Dulhunty AF; Arnolda LF; Mitchell I; Khachigian LM; Stephens RW; von Itzstein M; Parish CR, 2020, 'Neutralizing the pathological effects of extracellular histones with small polyanions', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-20231-y

Harris MA; Shekhar TM; Coupland LA; Miles MA; Hawkins CJ, 2020, 'Transient NK Cell Depletion Facilitates Pulmonary Osteosarcoma Metastases after Intravenous Inoculation in Athymic Mice', Journal of Adolescent and Young Adult Oncology, 9, pp. 667 - 671, http://dx.doi.org/10.1089/jayao.2019.0172

Vulliamy P; Montague SJ; Gillespie S; Chan MV; Coupland LA; Andrews RK; Warner TD; Gardiner EE; Brohi K; Armstrong PC, 2020, 'Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients', Blood Advances, 4, pp. 2623 - 2630, http://dx.doi.org/10.1182/bloodadvances.2020001776

Montague SJ; Hicks SM; Lee CSM; Coupland LA; Parish CR; Lee WM; Andrews RK; Gardiner EE, 2020, 'Fibrin exposure triggers αIIbβ3-independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge-dependent manner', Journal of Thrombosis and Haemostasis, 18, pp. 1447 - 1458, http://dx.doi.org/10.1111/jth.14797

Hicks SM; Coupland LA; Jahangiri A; Choi PY; Gardiner EE, 2020, 'Novel scientific approaches and future research directions in understanding ITP', Platelets, 31, pp. 315 - 321, http://dx.doi.org/10.1080/09537104.2020.1727871

Yoon J; Parish CR; Coupland LA, 2020, 'A rapid and accurate bioluminescence-based migration assay permitting analysis of tumor cell/stromal cell interactions', Methods and Protocols, 3, pp. 1 - 12, http://dx.doi.org/10.3390/mps3010010

Yoon J; Parish CR; Blackburn AC; Coupland LA, 2020, 'Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas', Platelets, pp. 1 - 9, http://dx.doi.org/10.1080/09537104.2020.1792433

Tian DD; Bennett SK; Coupland LA; Forwood K; Lwin Y; Pooryousef N; Tea I; Truong TT; Neeman T; Crispin P; D’Rozario J; Blackburn AC, 2019, 'GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial', Pharmacology Research and Perspectives, 7, http://dx.doi.org/10.1002/prp2.526

Jing W; Yabas M; Bröer A; Coupland L; Gardiner EE; Enders A; Bröer S, 2019, 'Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets', Blood Advances, 3, pp. 219 - 229, http://dx.doi.org/10.1182/bloodadvances.2018023473

Simes J; Robledo KP; White HD; Espinoza D; Stewart RA; Sullivan DR; Zeller T; Hague W; Nestel PJ; Glasziou PP; Keech AC; Elliott J; Blankenberg S; Tonkin AM, 2018, 'D-dimer predicts long-term cause-specific mortality, cardiovascular events, and cancer in patients with stable coronary heart disease LIPID study', Circulation, 138, pp. 712 - 723, http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029901

Kordbacheh F; O'Meara CH; Coupland LA; Lelliott PM; Parish CR, 2017, 'Extracellular histones induce erythrocyte fragility and anemia', Blood, 130, pp. 2884 - 2888, http://dx.doi.org/10.1182/blood-2017-06-790519

Stewart RAH; Colquhoun DM; Marschner SL; Kirby AC; Simes J; Nestel PJ; Glozier N; O'Neil A; Oldenburg B; White HD; Tonkin AM, 2017, 'Persistent psychological distress and mortality in patients with stable coronary artery disease', Heart, 103, pp. 1860 - 1866, http://dx.doi.org/10.1136/heartjnl-2016-311097

Coupland L; Hindmarsh E; Gardiner E; Parish C, 2017, 'The influence of platelet membranes on tumour cell behaviour', Cancer and Metastasis Reviews, 36, pp. 215 - 224, http://dx.doi.org/10.1007/s10555-017-9671-3

Tonkin AM; Blankenberg S; Kirby A; Zeller T; Colquhoun DM; Funke-Kaiser A; Hague W; Hunt D; Keech AC; Nestel P; Stewart R; Sullivan DR; Thompson PL; West M; White HD; Simes J, 2015, 'Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study', International Journal of Cardiology, 201, pp. 499 - 507, http://dx.doi.org/10.1016/j.ijcard.2015.07.080

Pang JH; Coupland LA; Freeman C; Chong BH; Parish CR, 2015, 'Activation of tumour cell ECM degradation by thrombin-activated platelet membranes: potentially a P-selectin and GPIIb/IIIa-dependent process', Clinical and Experimental Metastasis, 32, pp. 495 - 505, http://dx.doi.org/10.1007/s10585-015-9722-5

Fraser ST; Midwinter RG; Coupland LA; Kong S; Berger BS; Yeo JH; Andrade OC; Cromer D; Suarna C; Lam M; Maghzal GJ; Chong BH; Parish CR; Stocker R, 2015, 'Heme oxygenase-1 deficiency alters erythroblastic Island formation, steady-state erythropoiesis and red blood cell lifespan in mice', Haematologica, 100, pp. 601 - 610, http://dx.doi.org/10.3324/haematol.2014.116368

Yabas M; Coupland LA; Cromer D; Winterberg M; Teoh NC; D'rozario J; Kirk K; Bröer S; Parish CR; Enders A, 2014, 'Mice deficient in the putative phospholipid flippase Atp11c exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span', Journal of Biological Chemistry, 289, pp. 19531 - 19537, http://dx.doi.org/10.1074/jbc.C114.570267

Funke-Kaiser A; Mann K; Colquhoun D; Zeller T; Hunt D; Simes J; Sullivan D; Sydow K; West M; White H; Blankenberg S; Tonkin AM, 2014, 'Midregional proadrenomedullin and its change predicts recurrent major coronary events and heart failure in stable coronary heart disease patients: The LIPID study', International Journal of Cardiology, 172, pp. 411 - 418, http://dx.doi.org/10.1016/j.ijcard.2014.01.064

White HD; Tonkin A; Simes J; Stewart R; Mann K; Thompson P; Colquhoun D; West M; Nestel P; Sullivan D; Keech AC; Hunt D; Blankenberg S, 2014, 'Association of contemporary sensitive troponin i levels at baseline and change at 1 year with long-term coronary events following myocardial infarction or unstable angina: Results from the LIPID study (Long-Term Intervention with Pravastatin in Ischaemic Disease)', Journal of the American College of Cardiology, 63, pp. 345 - 354, http://dx.doi.org/10.1016/j.jacc.2013.08.1643

Coupland LA; Parish CR, 2014, 'Platelets, selectins, and the control of tumor metastasis', Seminars in Oncology, 41, pp. 422 - 434, http://dx.doi.org/10.1053/j.seminoncol.2014.04.003

White HD; Simes J; Stewart RAH; Blankenberg S; Barnes EH; Marschner IC; Thompson P; West M; Zeller T; Colquhoun DM; Nestel P; Keech AC; Sullivan DR; Hunt D; Tonkin A, 2013, 'Changes in lipoprotein-associated phospholipase A2 activity predict coronary events and partly account for the treatment effect of pravastatin: Results from the long-term intervention with pravastatin in ischemic disease study', Journal of the American Heart Association, 2, pp. 1 - 13, http://dx.doi.org/10.1161/JAHA.113.000360

Coupland LA; Chong BH; Parish CR, 2013, 'Beware of NK cells in pre-clinical metastasis models', Clinical and Experimental Metastasis, 30, pp. 945 - 947, http://dx.doi.org/10.1007/s10585-013-9582-9

Coupland L; Chong BH; Parish CR, 2012, 'Platelets and P-selectin control tumor metastasis in an organ-specific manner and independently of NK cells. Cancer Research', Cancer Research, 72, pp. 4662 - 4671, http://dx.doi.org/10.1158/0008-5472.CAN-11-4010

Coupland LA; Cromer D; Davenport MP; Parish CR, 2010, 'A novel fluorescent-based assay reveals that thrombopoietin signaling and Bcl-X(L) influence, respectively, platelet and erythrocyte lifespans', Experimental Hematology, 38, pp. 453 - 461

Soderberg S; Colquhoun D; Keech A; Yallop J; Barnes EH; Pollicino C; Simes J; Tonkin AM; Nestel P, 2009, 'Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study', INTERNATIONAL JOURNAL OF OBESITY, 33, pp. 123 - 130, http://dx.doi.org/10.1038/ijo.2008.224

West MJ; Nestel PJ; Kirby AC; Schnabel R; Sullivan D; Simes RJ; Pollicino C; Lubos E; Münzel TF; White HD; Tonkin AM; Bickel C; Tiret L; Blankenberg S, 2008, 'The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study', European Heart Journal, 29, pp. 923 - 931, http://dx.doi.org/10.1093/eurheartj/ehn007

Coupland LA; Brun M; Jammu V; D'Rozario JM, 2006, 'A variant chronic B-cell lymphoma characterized by villous cells with novel immunophenotypic and cytogenetic profiles', Leukemia and Lymphoma, 47, pp. 129 - 134, http://dx.doi.org/10.1080/10428190500277126

Stewart RAH; White HD; Kirby AC; Heritier SR; Simes RJ; Nestel PJ; West MJ; Colquhoun DM; Tonkin AM, 2005, 'White blood cell count predicts reduction in coronary heart disease mortality with pravastatin', CIRCULATION, 111, pp. 1756 - 1762, http://dx.doi.org/10.1161/01.CIR.0000160924.73417.26

Colquhoun D; Keech A; Hunt D; Marschner I; Simes J; Glaszlou P; White H; Barter P; Tonkin A, 2004, 'Effects of pravastatin on coronary events in 2073 patients with low levels of both low-density lipoprotein cholesterol and high-density lipoprotein cholesterol: Results from the LIPID study', European Heart Journal, 25, pp. 771 - 777, http://dx.doi.org/10.1016/j.ehj.2004.03.013

Keech A; Colquhoun D; Best J; Kirby A; Simes RJ; Hunt D; Hague W; Beller E; Arulchelvam M; Baker J; Tonkin A, 2003, 'Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes of impaired fasting glucose: Results from the LIPID trial', Diabetes Care, 26, pp. 2713 - 2721, http://dx.doi.org/10.2337/diacare.26.10.2713

Hague W; Forder P; Simes J; Hunt D; Tonkin A, 2003, 'Prevention and rehabilitation - Effect of pravastatin on cardiovascular events and mortality in 1516 women with coronary heart disease: Results from the Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) study', AMERICAN HEART JOURNAL, 145, pp. 643 - 651, http://dx.doi.org/10.1067/mhj.2003.1

Simes RJ; Hunt D; Kirby A; Tonkin A; Keech A; Aylward P; Colquhoun D; Glasziou P; Hague W; MacMahon S; Thompson P; West M; White H, 2002, 'Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations: The LIPID trial follow-up', Lancet, 359, pp. 1379 - 1387, http://dx.doi.org/10.1016/S0140-6736(02)08351-4

Simes RJ; Marschner IC; Hunt D; Colquhoun D; Sullivan D; Stewart RAH; Hague W; Keech A; Thompson P; White H; Shaw J; Tonkin A, 2002, 'Relationship between lipid levels and clinical outcomes in the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) trial: To what extent is the reduction in coronary events with pravastatin explained by on-study lipid levels?', Circulation, 105, pp. 1162 - 1169, http://dx.doi.org/10.1161/hc1002.105136

Coupland LA; Jammu V; Pidcock ME, 2002, 'Partial deletion of chromosome 1 in a case of acute myelocytic leukemia', Cancer Genetics and Cytogenetics, 139, pp. 60 - 62, http://dx.doi.org/10.1016/S0165-4608(02)00597-6

Khurana OK; Coupland LA; Shelden MC; Howitt SM, 2000, 'Homologous mutations in two diverse sulphate transporters have similar effects', FEBS Letters, 477, pp. 118 - 122, http://dx.doi.org/10.1016/S0014-5793(00)01783-X

Coupland LA; Cooke-Yarborough CM; Dalla-Pozza L, 1999, 'The New Children's Hospital Tumour Bank [2]', Medical Journal of Australia, 170, pp. 284 - 285, http://dx.doi.org/10.5694/j.1326-5377.1999.tb127765.x

Tonkin A; Alyward P; Colquhoun D; Glasziou P; Harris P; Hunt D; Keech A; MacMahon S; Magnus P; Newel D; Nestel P; Sharpe N; Shaw J; Simes RJ; Thompson P; Thompson A; West M; White H; Simes S; Hague W; Caleo S; Hall J; Martin A; Mulray S; Barter P; Beilin L; Collins R; McNeil J; Meier P; Willimott H; Smithers D; Wallace P; Baker J; Hobbs M; Sullivan D; Anderson N; Hankey G; Watson J; Arulchelvam M; Chup S; Daly J; Hanna J; Leach A; Lee M; Loughhead J; Lundie-Jenkin H; Morrison J; Netting S; Nguyen A; Pater H; Philip R; Pinna G; Rattos D; Ryerson S; Sazhin V; Walsh R; Claque A; Mackie M; Yallop J; Boss K; Shepard M; Leach J; Gandy M; Joughin J; Seabrook J; Abraham R; Allen J; Bates F; Beinart I; Breed E; Brown D; Bunyan N; Calvert D; Campbell T; Condon-Paoloni D; Conway B; Coupland L; Crowe J; Cunio N; Cuthbert B; Cuthbert N; D'Arcy S; Davidson P; Dwyer B; England J; Friend C; Fulcher G; Grant S; Hellestrand K; Kava M; Kritharides L; McGill D; McKee H; McLean A; Neaverson M; Nelson G; O'Neill M; Onuma C; O'Reilly F, 1998, 'Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels', New England Journal of Medicine, 339, pp. 1349 - 1357, http://dx.doi.org/10.1056/NEJM199811053391902

Tonkin A; Aylward P; Colquhoun D; Glasziou P; Harris P; Hunt D; MacMahon S; Nestel P; Sharpe N; Símes J; Thompson P; Thomson A; West M; White H; Shaw J; Ablett M; MacAskill M; Turner R; Magnus P; Wallace P; Keech A; Newell D; Raupach H; Hague W; Hall J; Mulray S; Wiseman V; Davies P; Smithers D; Baker J; Hobbs M; Sullivan D; Daly J; Lundie-Jenkins H; Morrison J; Pater H; Philip R; Ryerson S; Simes S; Sazhin V; Martin A; Nguyen A; Drew J; Rattos D; Clague A; Hall A; Mackie M; Yallop J; Boss K; Barter P; Beilin L; Collins R; McNeil J; Meier P; Willimott H; Whiting M; Shepard M; Leach J; Gandy M; Joughan J; Seabrook J; Coupland L; McGill D; Tarimer P; Beinart I; McKee H; Abraham R; Parnell G; England J; Viles A; Bunyan N; Grant S; O'Neill M; Wikramanayake R; Brown-Paul P; Crowe J; Waites J; Walker R; Allen J; Marel M; Pawsey C; Wyndham R; Bates F; Brown D; Thomas J; Woods J; Hellestrand K; Paterson S; Calvert D; Condon-Paoloni D; Owensby A; Owensby D; Ryan J; Silberberg J; Taylor M; Onuma S; Wee K; Kava M; McLean A; Quinn K, 1995, 'Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: A randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris', The American Journal of Cardiology, 76, pp. 474 - 479, http://dx.doi.org/10.1016/S0002-9149(99)80133-7

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