By Dr Matthew Perry

Book Chapters

Vandenberg JI; Ng CA; Mann SA; Perry MD, 2014, 'Voltage-Gated Potassium Channels (Kv10-Kv12)', in Reference Module in Biomedical Research, http://dx.doi.org/10.1016/B978-0-12-801238-3.04809-1

Perry M; Sanguinetti M, 2012, 'Kv10, Kv11 and Kv12 channels', in Ion Channels: From Structure to Function, http://dx.doi.org/10.1093/acprof:oso/9780199296750.003.0002

Sanguinetti MC; Perry M, 2011, 'hERG1 Channel Blockers and Cardiac Arrhythmia', in Heart Rate and Rhythm, Springer Berlin Heidelberg, pp. 611 - 625, http://dx.doi.org/10.1007/978-3-642-17575-6_34

Mitcheson J; Perry M; Stansfeld P; Sanguinetti MC; Witchel H; Hancox J, 2005, 'Structural determinants for high-affinity block of hERG potassium channels', in , pp. 136 - 150

Journal articles

Thorpe J; Perry MD; Contreras O; Hurley E; Parker G; Harvey RP; Hill AP; Vandenberg JI, 2023, 'Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia', Stem Cell Research and Therapy, 14, http://dx.doi.org/10.1186/s13287-023-03405-5

Lee W; Ng B; Mangala MM; Perry MD; Subbiah RN; Vandenberg JI; Hill AP, 2023, 'Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs with Potential to Prolong Cardiac Repolarization', Circulation: Arrhythmia and Electrophysiology, 16, pp. 399 - 410, http://dx.doi.org/10.1161/CIRCEP.122.011574

Shuttleworth JG; Lok Lei C; Windley M; Hill AP; Perry MD; Preston S; Mirams GR, 2023, 'Using many different voltage protocols to characterise discrepancy in mathematical ion channel models', Biophysical journal, 122, http://dx.doi.org/10.1016/j.bpj.2022.11.1415

TeBay C; McArthur JR; Mangala M; Kerr N; Heitmann S; Perry MD; Windley MJ; Vandenberg JI; Hill AP, 2022, 'Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation', British Journal of Pharmacology, 179, pp. 2631 - 2646, http://dx.doi.org/10.1111/bph.15757

Ballouz S; Mangala MM; Perry MD; Heitmann S; Gillis JA; Hill AP; Vandenberg JI, 2021, 'Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events', Cardiovascular Research, 117, pp. 2216 - 2227, http://dx.doi.org/10.1093/cvr/cvaa280

Ng CA; Farr J; Young P; Windley MJ; Perry MD; Hill AP; Vandenberg JI, 2021, 'Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-Throughput automated patch clamp electrophysiology', Biology Methods and Protocols, 6, pp. 1 - 9, http://dx.doi.org/10.1093/biomethods/bpab003

Ross S; Holliday M; Lim S; Mangala M; Perry M; Gray B; Fraser S; Hill A; Hudson J; Semsarian C, 2021, 'Functional Analysis of a Novel Heterozygous Variant in CASQ2 as a Distinct Cause of Catecholaminergic Polymorphic Ventricular Tachycardia', Heart, Lung and Circulation, 30, pp. S96 - S96, http://dx.doi.org/10.1016/j.hlc.2021.06.016

Ng C-A; Farr J; Young P; Windley M; Perry M; Hill A; Vandenberg J, 2021, 'HeterozygousKCNH2variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology', , http://dx.doi.org/10.1101/2021.02.02.427891

Perry MD; Ng CA; Mangala MM; Ng TYM; Hines AD; Liang W; Xu MJO; Hill AP; Vandenberg JI, 2020, 'Pharmacological activation of IKrin models of long QT Type 2 risks overcorrection of repolarization', Cardiovascular Research, 116, pp. 1434 - 1445, http://dx.doi.org/10.1093/cvr/cvz247

Ng CA; Perry MD; Liang W; Smith NJ; Foo B; Shrier A; Lukacs GL; Hill AP; Vandenberg JI, 2020, 'High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants', Heart Rhythm, 17, pp. 492 - 500, http://dx.doi.org/10.1016/j.hrthm.2019.09.020

Lee W; Windley MJ; Perry MD; Vandenberg JI; Hill AP, 2019, 'Protocol-dependent differences in IC50 values measured in human ether-á-go-go–related gene assays occur in a predictable way and can be used to quantify state preference of drug binding', Molecular Pharmacology, 95, pp. 537 - 550, http://dx.doi.org/10.1124/mol.118.115220

Lee W; Mangala M; Windley M; Perry M; Vandenberg J; Hill A, 2018, 'Novel Pre–Clinical Risk Prediction of Acquired Long QT Syndrome', Heart, Lung and Circulation, 27, pp. S180 - S180, http://dx.doi.org/10.1016/j.hlc.2018.06.309

Ng T; Vandenberg J; Perry M, 2018, 'Pharmacological Activation of hERG Potassium Channels in Congenital Long QT Syndrome 2: Activator Compound ICA-105574 and its Effects on Mutant hERG Potassium Channels in Long QT Syndrome 2', Heart, Lung and Circulation, 27, pp. S61 - S61, http://dx.doi.org/10.1016/j.hlc.2018.06.039

Phan K; Ng CA; David E; Shishmarev D; Kuchel PW; Vandenberg JI; Perry MD, 2017, 'The S1 helix critically regulates the finely tuned gating of Kv11.1 channels', Journal of Biological Chemistry, 292, pp. 7688 - 7705, http://dx.doi.org/10.1074/jbc.M117.779298

Vandenberg JI; Perry MD; Hill AP, 2017, 'Recent advances in understanding and prevention of sudden cardiac death', F1000Research, 6, http://dx.doi.org/10.12688/f1000research.11855.1

Hill AP; Perry MD; Abi-Gerges N; Couderc JP; Fermini B; Hancox JC; Knollmann BC; Mirams GR; Skinner J; Zareba W; Vandenberg JI, 2016, 'Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century', Journal of Physiology, 594, pp. 6893 - 6908, http://dx.doi.org/10.1113/JP272015

Mann SA; Imtiaz M; Winbo A; Rydberg A; Perry MD; Couderc JP; Polonsky B; McNitt S; Zareba W; Hill AP; Vandenberg JI, 2016, 'Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes', Journal of Molecular and Cellular Cardiology, 100, pp. 25 - 34, http://dx.doi.org/10.1016/j.yjmcc.2016.09.011

Ng CA; Gravel AE; Perry MD; Arnold AA; Marcotte I; Vandenberg JI, 2016, 'Tyrosine residues from the s4-s5 linker of kv11.1 channels are critical for slow deactivation', Journal of Biological Chemistry, 291, pp. 17293 - 17302, http://dx.doi.org/10.1074/jbc.M116.729392

Perry MD; Ng CA; Phan K; David E; Steer K; Hunter MJ; Mann SA; Imtiaz M; Hill AP; Ke Y; Vandenberg JI, 2016, 'Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations', Journal of Physiology, 594, pp. 4031 - 4049, http://dx.doi.org/10.1113/JP271805

Perry MD; Rajendran VM; MacLennan KA; Sandle GI, 2016, 'Segmental differences in upregulated apical potassium channels in Mammalian colon during potassium adaptation', American Journal of Physiology - Gastrointestinal and Liver Physiology, 311, pp. G785 - G793, http://dx.doi.org/10.1152/ajpgi.00181.2015

Perry MD; Vandenberg JI, 2016, 'TECRL: Connecting sequence to consequence for a new sudden cardiac death gene', EMBO Molecular Medicine, 8, pp. 1364 - 1365, http://dx.doi.org/10.15252/emmm.201606967

Fonoudi H; Ansari H; Abbasalizadeh S; Larijani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw DS; Harvey RP; Aghdami N; Baharvand H, 2015, 'A universal and robust integrated platform for the scalable production of human cardiomyocytes from pluripotent stem cells', Stem Cells Translational Medicine, 4, pp. 1482 - 1494, http://dx.doi.org/10.5966/sctm.2014-0275

Perry MD; Ng CA; Mann SA; Sadrieh A; Imtiaz M; Hill AP; Vandenberg JI, 2015, 'Getting to the heart of hERG K⁺ channel gating', Journal of Physiology, 593, pp. 2575 - 2585, http://dx.doi.org/10.1113/JP270095

Brignell JL; Perry MD; Nelson CP; Willets JM; Challiss RAJ; Davies NW, 2015, 'Steady-state modulation of voltage-gated K⁺ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0121285

Vandenberg JI; Perry MD, 2014, 'Can many subunits make light work of ion channel inactivation?', Journal of Physiology, 592, pp. 4411 - 4412, http://dx.doi.org/10.1113/jphysiol.2014.281568

Ng CA; Phan K; Hill AP; Vandenberg JI; Perry MD, 2014, 'Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 25822 - 25832, http://dx.doi.org/10.1074/jbc.M114.558379

Ke Y; Hunter MJ; Ng CA; Perry MD; Vandenberg JI, 2014, 'Role of the cytoplasmic N-terminal cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels', Journal of Biological Chemistry, 289, pp. 13782 - 13791, http://dx.doi.org/10.1074/jbc.M113.531277

Sadrieh A; Domanski L; Pitt-Francis J; Mann SA; Hodkinson EC; Ng CA; Perry MD; Taylor JA; Gavaghan D; Subbiah RN; Vandenberg JI; Hill AP, 2014, 'Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2', Nature Communications, 5, http://dx.doi.org/10.1038/ncomms6069

Ng CA; Ke Y; Perry MD; Tan PS; Hill AP; Vandenberg JI, 2013, 'C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels', PLoS ONE, 8, pp. e77032, http://dx.doi.org/10.1371/journal.pone.0077032

Perry MD; Wong S; Ng CA; Vandenberg JI, 2013, 'Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels', Journal of General Physiology, 142, pp. 275 - 288, http://dx.doi.org/10.1085/jgp.201310975

Tan PS; Perry MD; Ng C; Vandenberg JI; Hill A, 2012, 'Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels', Journal of General Physiology, 140, pp. 293 - 306, http://dx.doi.org/10.1085/jgp.201110761

Nelson CP; Rainbow RD; Brignell JL; Perry MD; Willets JM; Davies NW; Standen NB; Challiss RAJ, 2011, 'Principal role of adenylyl cyclase 6 in K ⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells', Cardiovascular Research, 91, pp. 694 - 702, http://dx.doi.org/10.1093/cvr/cvr137

Perry M; Sanguinetti M; Mitcheson J, 2010, 'Revealing the structural basis of action of hERG potassium channel activators and blockers', Journal of Physiology, 588, pp. 3157 - 3167, http://dx.doi.org/10.1113/jphysiol.2010.194670

Perry M; Sachse FB; Abbruzzese J; Sanguinetti MC, 2009, 'PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K⁺ conductance', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 20075 - 20080, http://dx.doi.org/10.1073/pnas.0906597106

Perry MD; Sandle GI, 2009, 'Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin', American Journal of Physiology - Gastrointestinal and Liver Physiology, 297, http://dx.doi.org/10.1152/ajpgi.00132.2009

Perry M; Sanguinetti MC, 2008, 'A single amino acid difference between ether-a-go-go-related gene channel subtypes determines differential sensitivity to a small molecule activator', Molecular Pharmacology, 73, pp. 1044 - 1051, http://dx.doi.org/10.1124/mol.107.043018

Perry M; Sachse FB; Sanguinetti MC, 2007, 'Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 13827 - 13832, http://dx.doi.org/10.1073/pnas.0703934104

Sandle GI; Perry MD; Mathialahan T; Linley JE; Robinson P; Hunter M; MacLennan KA, 2007, 'Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis', Journal of Pathology, 212, pp. 66 - 73, http://dx.doi.org/10.1002/path.2159

Perry M; Stansfeld PJ; Leaney J; Wood C; De Groot MJ; Leishman D; Sutcliffe MJ; Mitcheson JS, 2006, 'Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs', Molecular Pharmacology, 69, pp. 509 - 519, http://dx.doi.org/10.1124/mol.105.016741

Witchel HJ; Dempsey CE; Sessions RB; Perry M; Milnes JT; Hancox JC; Mitcheson JS, 2004, 'The low-potency, voltage-dependent herg blocker propafenone - Molecular determinants and drug trapping', Molecular Pharmacology, 66, pp. 1201 - 1212, http://dx.doi.org/10.1124/mol.104.001743

Perry M; De Groot MJ; Helliwell R; Leishman D; Tristani-Firouzi M; Sanguinetti MC; Mitcheson J, 2004, 'Structural determinants of HERG channel block by clofilium and ibutilide', Molecular Pharmacology, 66, pp. 240 - 249, http://dx.doi.org/10.1124/mol.104.000117

Mitcheson JS; Perry MD, 2003, 'Molecular determinants of high-affinity drug binding to HERG channels', Current Opinion in Drug Discovery and Development, 6, pp. 667 - 674

Conference Abstracts

TeBay C; MacArthur JR; Mangala M; Kerr N; Heitmann S; Perry MD; Windley MJ; Vandenberg JI; Hil AP, 2022, 'Comprehensive preclinical evaluation of how cardiac safety profiles of chloroquine and hydroxychloroquine are modified by disease associated factors', in JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER SCIENCE INC, Vol. 117, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000886335100044&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hill AP; Mann SA; Imtiaz MS; Perry MD; Vandenberg JI, 2014, 'Using Clinical Datasets to Optimize Models of Human Ventricular Electrophysiology: Implications for In Silico Drug Screening', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, Vol. 112, pp. 465A - 465A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014, http://dx.doi.org/10.1016/j.bpj.2016.11.2493

Tan PS; Perry M; Chai AN; Vandenberg JI; Hill AP, 2012, 'Bimodal Regulation of hERG Gating by the N-Terminal Tail Revealed by Voltage Clamp Fluorometry', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1800

Perry MD; Vandenberg JI, 2012, 'Critical Dual Role for the Pore Helix in Kv11.1 Channel Inactivation', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Diego, Vol. 102, pp. 328A - 328A, presented at 56th Annual Meeting of the Biophysical-Society, CA, San Diego, 25 February 2012 - 29 February 2012, http://dx.doi.org/10.1016/j.bpj.2011.11.1801

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