Select Publications
Journal articles
2017, 'Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer', Nature, 551, pp. S12 - S16, http://dx.doi.org/10.1038/nature24462
,2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, 8, pp. 84635 - 84636, http://dx.doi.org/10.18632/oncotarget.21468
,2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
,2017, 'Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?', Molecular and Cellular Oncology, 4, http://dx.doi.org/10.1080/23723556.2017.1333973
,2017, 'Cell scientist to watch – Paul Timpson', Journal of Cell Science, 130, pp. 2949 - 2951, http://dx.doi.org/10.1242/JCS.207878
,2017, 'Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors', Methods, 128, pp. 78 - 94, http://dx.doi.org/10.1016/j.ymeth.2017.04.014
,2017, 'SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer', Oncogene, 36, pp. 4288 - 4298, http://dx.doi.org/10.1038/onc.2017.63
,2017, 'Annexin A6—A multifunctional scaffold in cell motility', Cell Adhesion and Migration, 11, pp. 288 - 304, http://dx.doi.org/10.1080/19336918.2016.1268318
,2017, 'Lost in translation: Returning germline genetic results in genome-scale cancer research', Genome Medicine, 9, pp. 41, http://dx.doi.org/10.1186/s13073-017-0430-4
,2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9, http://dx.doi.org/10.1126/scitranslmed.aai8504
,2017, 'Annexin A6 - a multifunctional scaffold in cell motility.', Cell Adh Migr, http://dx.doi.org/10.1080/19336918.2016.1268318
,2017, 'A biosensor mouse to predict the dissociation and spread of pancreatic cancer', CANCER RESEARCH, 77, http://dx.doi.org/10.1158/1538-7445.EPSO16-PR07
,2017, 'Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression', Oncotarget, 8, pp. 42901 - 42916, http://dx.doi.org/10.18632/oncotarget.17160
,2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, 8, pp. 26066 - 26078, http://dx.doi.org/10.18632/oncotarget.15257
,2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-016-0781-6
,2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, 11, pp. e0168203, http://dx.doi.org/10.1371/journal.pone.0168203
,2016, 'The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2', Oncogene, 35, pp. 4981 - 4989, http://dx.doi.org/10.1038/onc.2016.45
,2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29, http://dx.doi.org/10.36866/pn.104.27
,2016, 'Effect of biglycan on melanoma invasiveness via increased tissue stiffness and integrin-β1 expression.', Journal of Clinical Oncology, 34, pp. 11526 - 11526, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.11526
,2016, 'Novel therapeutics and preclinical imaging for pancreatic cancer - View from the lab', Cancer Forum, 40, pp. 16 - 22
,2016, 'Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration', Nature Communications, 7, http://dx.doi.org/10.1038/ncomms10664
,2016, 'Annexin A6 and late endosomal cholesterol modulate integrin recycling and cell migration', Journal of Biological Chemistry, 291, pp. 1320 - 1335, http://dx.doi.org/10.1074/jbc.M115.683557
,2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020
,2016, 'Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression.', F1000Research, 5, http://dx.doi.org/10.12688/F1000RESEARCH.8090.1
,2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330
,2015, 'A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis', Developmental Cell, 35, pp. 759 - 774, http://dx.doi.org/10.1016/j.devcel.2015.11.026
,2015, 'Alternate RASSF1 transcripts control SRC activity, E-cadherin contacts, and YAP-mediated invasion', Current Biology, 25, pp. 3019 - 3034, http://dx.doi.org/10.1016/j.cub.2015.09.072
,2015, 'The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis', Cancer Cell, 28, pp. 155 - 169, http://dx.doi.org/10.1016/j.ccell.2015.07.003
,2015, 'Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: Inhibition of LOX abrogates metastasis and enhances drug efficacy', EMBO Molecular Medicine, 7, pp. 1063 - 1076, http://dx.doi.org/10.15252/emmm.201404827
,2015, 'High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium', Breast Cancer Research, 17, http://dx.doi.org/10.1186/s13058-015-0592-1
,2015, 'Intravital microscopy of cancer: New insights into the spatiotemporal dynamics of the disease', AACR Education book, 2015, pp. 31 - 36, http://dx.doi.org/10.1158/aacr.edb-15-8637
,2015, 'Imaging fibrosis in pancreatic cancer using second harmonic generation', Pancreatology, 15, pp. 200 - 201, http://dx.doi.org/10.1016/j.pan.2015.02.004
,2015, 'The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking', Science Signaling, 8, http://dx.doi.org/10.1126/scisignal.2005547
,2015, 'FAK signaling in human cancer as a target for therapeutics', Pharmacology & therapeutics, 146, pp. 132 - 149, http://dx.doi.org/10.1016/j.pharmthera.2014.10.001
,2015, 'Rho-associated kinase signalling and the cancer microenvironment: Novel biological implications and therapeutic opportunities', Expert Reviews in Molecular Medicine, 17, http://dx.doi.org/10.1017/erm.2015.17
,2015, 'The cross-talk of LDL-cholesterol with cell motility: Insights from the niemann pick type C1 mutation and altered integrin trafficking', Cell Adhesion and Migration, 9, pp. 384 - 391, http://dx.doi.org/10.1080/19336918.2015.1019996
,2015, 'The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment', Small GTPases, 6, pp. 123 - 133, http://dx.doi.org/10.4161/21541248.2014.973749
,2015, 'There are four dynamically and functionally distinct populations of E-cadherin in cell junctions', Biology Open, 4, pp. 1481 - 1489, http://dx.doi.org/10.1242/bio.014159
,2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486, http://dx.doi.org/10.4161/19336918.2014.970004
,2014, 'Functions of TAp63 and p53 in restraining the development of metastatic cancer', British Dental Journal, 217, pp. 3325 - 3333, http://dx.doi.org/10.1038/onc.2013.287
,2014, 'The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues', Cell Reports, 6, pp. 1153 - 1164, http://dx.doi.org/10.1016/j.celrep.2014.02.024
,2014, 'Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries', Cell Reports, 7, pp. 883 - 897, http://dx.doi.org/10.1016/j.celrep.2014.03.043
,2014, 'CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer', Journal of Cell Science, 127, pp. 3893 - 3901, http://dx.doi.org/10.1242/jcs.135947
,2014, 'Developments in preclinical cancer imaging: Innovating the discovery of therapeutics', Nature Reviews Cancer, 14, pp. 314 - 328, http://dx.doi.org/10.1038/nrc3724
,2014, 'Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment', Carcinogenesis, 35, pp. 1671 - 1679, http://dx.doi.org/10.1093/carcin/bgu108
,2013, 'Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue', FEBS Journal, 280, pp. 5177 - 5197, http://dx.doi.org/10.1111/febs.12348
,2013, 'Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer', Cancer Research, 73, pp. 4674 - 4686, http://dx.doi.org/10.1158/0008-5472.CAN-12-4545
,2013, 'ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation', Cell Stem Cell, 12, pp. 761 - 773, http://dx.doi.org/10.1016/j.stem.2013.04.006
,2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', Journal of Clinical Oncology, 31, pp. e15029 - e15029, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e15029
,2013, 'Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion', Oncogene, 32, pp. 1252 - 1265, http://dx.doi.org/10.1038/onc.2012.148
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