Select Publications
Journal articles
, 2013, 'Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion', Current Biology, 23, pp. 107 - 117, http://dx.doi.org/10.1016/j.cub.2012.11.059
, 2012, 'Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions', Biochemical Journal, 448, pp. 35 - 42, http://dx.doi.org/10.1042/BJ20112206
, 2012, 'N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods', Journal of Cell Biology, 199, pp. 527 - 544, http://dx.doi.org/10.1083/jcb.201203025
, 2012, 'Inhibition of autophagy impairs tumor cell invasion in an organotypic model', Cell Cycle, 11, pp. 2022 - 2029, http://dx.doi.org/10.4161/cc.20424
, 2012, 'Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells', Oncogene, 31, pp. 1781 - 1793, http://dx.doi.org/10.1038/onc.2011.376
, 2012, 'Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression', Developmental Cell, 22, pp. 131 - 145, http://dx.doi.org/10.1016/j.devcel.2011.11.008
, 2011, 'P-Rex1 is required for efficient melanoblast migration and melanoma metastasis', Nature Communications, 2, http://dx.doi.org/10.1038/ncomms1560
, 2011, 'Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context.', Journal of visualized experiments : JoVE
, 2011, 'Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context', Journal of Visualized Experiments, http://dx.doi.org/10.3791/3089-v
, 2011, 'Imaging molecular dynamics in vivo - from cell biology to animal models', Journal of Cell Science, 124, pp. 2877 - 2890, http://dx.doi.org/10.1242/jcs.085191
, 2011, 'Live cell in vitro and in vivo imaging applications: Accelerating drug discovery', Pharmaceutics, 3, pp. 141 - 170, http://dx.doi.org/10.3390/pharmaceutics3020141
, 2011, 'Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53', Cancer Research, 71, pp. 747 - 757, http://dx.doi.org/10.1158/0008-5472.CAN-10-2267
, 2011, 'Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth', Cancer Cell, 19, pp. 776 - 791, http://dx.doi.org/10.1016/j.ccr.2011.05.008
, 2011, 'FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion', Small GTPases, 2, pp. 239 - 244, http://dx.doi.org/10.4161/sgtp.2.4.17275
, 2010, 'Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: Effects on e-cadherin dynamics', Cancer Research, 70, pp. 9413 - 9422, http://dx.doi.org/10.1158/0008-5472.CAN-10-1454
, 2010, 'Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma', Gastroenterology, 139, pp. 292 - 303, http://dx.doi.org/10.1053/j.gastro.2010.03.034
, 2010, 'Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 246 - 251, http://dx.doi.org/10.1073/pnas.0908428107
, 2009, 'Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.', Cell adhesion & migration, 3, pp. 351 - 354
, 2009, 'Real-time study of E-cadherin and membrane dynamics in living animals: Implications for disease modeling and drug development', Cancer Research, 69, pp. 2714 - 2719, http://dx.doi.org/10.1158/0008-5472.CAN-08-4308
, 2009, 'Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo', Cell Adhesion and Migration, 3, http://dx.doi.org/10.4161/cam.3.4.9460
, 2009, 'Annexin A6 inhibits Ras signalling in breast cancer cells', Oncogene, 28, pp. 363 - 377, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18850003
, 2009, 'The docking protein and proto-oncogene product Gab2 is regulated via a novel negative feedback mechanism mediated by 14-3-3 binding.', Cell communication and signaling : CCS, 7, pp. A12 - A12, http://dx.doi.org/10.1186/1478-811X-7-S1-A12
, 2008, 'Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein', European Molecular Biology Organization, 27, pp. 2305 - 2316
, 2008, 'Protein kinase C delta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin', Molecular Biology of the Cell, 19, pp. 17 - 29
, 2007, 'Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib', Cancer research, 67, pp. 9304 - 9314
, 2006, 'Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex', Cell Motility and the Cytoskeleton, 63, pp. 6 - 13, http://dx.doi.org/10.1002/cm.20101
, 2005, 'Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor', Cancer research, 65, pp. 3273 - 3280
, 2005, 'Distinction at the leading edge of the cell', BioEssays, 27, pp. 349 - 352
, 2004, 'A role for the actin cytoskeleton in cell death and aging in yeast', Journal of Cell Biology, 164, pp. 803 - 809, http://dx.doi.org/10.1083/jcb.200310148
, 2001, 'Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity', Current Biology, 11, pp. 1836 - 1846, http://dx.doi.org/10.1016/S0960-9822(01)00583-8
, 1997, 'Cryptosporidium parvum in environmental samples in the Sligo area, Republic of Ireland: A preliminary report', Letters in Applied Microbiology, 25, pp. 380 - 384, http://dx.doi.org/10.1046/j.1472-765X.1997.00248.x
, 1996, 'Characterization of rainbow trout, Oncorhynchus mykiss (Walbaum), serum creatine kinase isoenzymes and isoforms by means of electrophoresis and isoelectric focusing', Journal of Fish Diseases, 19, pp. 441 - 447, http://dx.doi.org/10.1111/j.1365-2761.1996.tb00384.x