Researcher

Keywords

Fields of Research (FoR)

Bioinformatics and computational biology, Genomics and transcriptomics, Evolutionary biology, Plant biology

Biography

Check out the lab website here ---> https://regrnalab.github.io/

Dr Fernandez is a genomic scientist & bioinformatician interested in understanding the role non-coding RNAs play in the evolution of gene regulatory landscapes within and across eukaryotes.

She is a Senior Lecturer RNA New Research Talent Program (Level C) funded by the UNSW RNA Institute. Her laboratory focuses on studying the evolution of long non-coding RNAs in various plants...view more

Location

School of Biotechnology and Biomolecular Sciences
Room 301D, Level 3, Biological Science South Building (E26)
UNSW Sydney
NSW 2052 Australia

Videos

Long non-coding RNAs (lncRNAs) are prominent regulators of gene expression in eukaryotes, including plants and animals. It has been challenging to assess the functionality of the majority of lncRNAs; their rates of sequence divergence are much higher than those of protein-coding mRNAs, making it difficult to identify lncRNA conservation using traditional sequence comparison methods. To help identify functional RNAs, Selene’s group characterized the splicing conservation of lncRNAs in plants, specifically in 16 Brassica species. Our analysis revealed that 17.9% (112/627) of all intergenic lncRNAs display splicing conservation in at least one exon, which is substantially higher to previous estimates of lncRNA conservation in this group. Their findings agree with similar studies in vertebrates, demonstrating that splicing conservation can be evidence of selection. They provide evidence for the existence of evolutionary deeply conserved lncRNAs in plants.
Women in Bioinformatics & Data Science LA - Splicing conservation signals in plant non-coding RNAs
Entretien avec la chercheuse Selene Lizbeth Fernandez Valverde (Public Sénat - in french)