Researcher

Dr Sj Shen

Keywords

Fields of Research (FoR)

Gastroenterology and hepatology, Tumour immunology, Immunology

Biography

Dr Sj Sijie Shen is a postdoctoral fellow in A/Prof Amany Zekry's group, based at Microbiome Research Centre, St George Clinical School, Kogarah NSW. His research investigates the intricate interactions between host immunity and gut microbiota, and how alterations in the gut contributes and modulates inflammation in the liver. By better understanding the mechanisms that underlie how this "gut-liver axis" impacts liver inflammation and disease,...view more

Dr Sj Sijie Shen is a postdoctoral fellow in A/Prof Amany Zekry's group, based at Microbiome Research Centre, St George Clinical School, Kogarah NSW. His research investigates the intricate interactions between host immunity and gut microbiota, and how alterations in the gut contributes and modulates inflammation in the liver. By better understanding the mechanisms that underlie how this "gut-liver axis" impacts liver inflammation and disease, he hopes to find how modifying the gut microbiota can prevent or halt the progression of liver cancer.

Dr Shen is a researcher in respiratory and gastrointestinal tract diseases, with a major focus on the interaction between host immunity and microbiota. He has a special interest in the role that diet plays in immune responses and disease progression and modification. Prior to his current role, Dr Shen trained as a postdoctoral fellow at UTS / Centenary Institute investigating the importance of microbiota in respiratory diseases.

Dr Shen completed his PhD at Monash University (2019) examining the interplay between the gut microbiota and neutrophils in a mouse model of colitis. His research topic during his 3rd year research project and Honours (Monash University) was examining the role of dietary fibre and short-chain fatty acids in a mouse models of lung inflammation (allergic airways disease and aspergillosis) and oesophagitis.


My Qualifications

2019 - Doctor of Philosophy (Medicine). Monash University / Monash Medical Centre

2014 - Bachelor of Biomedical Sciences (Honours). Monash University / Immunology


My Research Activities

Dr Shen is currently investigating the role of the gut microbiota and the gut-liver axis in the pathogenesis of liver cancer. By utilising mouse models, immune phenotyping techniques, molecular analysis and advanced imaging techniques, in addition to in vitro and ex vivo assays, he hopes to elucidate the mechanisms of how changes in the gut microbiota affects the progression of liver cancer.


My Research Supervision


Supervision keywords


Areas of supervision

Gut microbiota in gut homeostasis and inflammation

Gut microbiota in liver cancer

Gut-liver axis in liver cancer


Currently supervising

Honours student

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Location

Microbiome Research Centre
St George Hospital, Kogarah

Map reference (Google map)