By Dr Tertia Deborah Purves-Tyson

Book Chapters

Weickert CS; Rothmond DA; Purves-Tyson TD, 2018, 'Considerations for optimal use of postmortem human brains for molecular psychiatry: lessons from schizophrenia', in Handbook of Clinical Neurology, pp. 221 - 235, http://dx.doi.org/10.1016/B978-0-444-63639-3.00016-5

Journal articles

Debs SR; Rothmond DA; Zhu Y; Weickert CS; Purves-Tyson TD, 2024, 'Molecular evidence of altered stress responsivity related to neuroinflammation in the schizophrenia midbrain', Journal of Psychiatric Research, 177, pp. 118 - 128, http://dx.doi.org/10.1016/j.jpsychires.2024.07.004

Debs SR; Conn I; Navaneethan B; Penklis AG; Meyer U; Killcross S; Weickert CS; Purves-Tyson TD, 2024, 'Maternal immune activation and estrogen receptor modulation induce sex-specific dopamine-related behavioural and molecular alterations in adult rat offspring', Brain, Behavior, and Immunity, 118, pp. 236 - 251, http://dx.doi.org/10.1016/j.bbi.2024.02.034

Brown SJ; Brown AM; Purves-Tyson TD; Huang XF; Shannon Weickert C; Newell KA, 2023, 'GRIN2B gene expression is increased in the anterior cingulate cortex in major depression', Journal of Psychiatric Research, 160, pp. 204 - 209, http://dx.doi.org/10.1016/j.jpsychires.2023.02.017

Petty A; Glass LJ; Rothmond DA; Purves-Tyson T; Sweeney A; Kondo Y; Kubo S; Matsumoto M; Weickert CS, 2022, 'Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia', Journal of Neuroinflammation, 19, http://dx.doi.org/10.1186/s12974-022-02541-8

O'Donnell M; Teasdale S; Chua X-Y; Hardman J; Wu N; Curtis J; Samaras K; Bolton P; Morris M; Shannon-Weickert C; Purves-Tyson T; El-Assaad F; Jiang X; Hold G; El-Omar E; Wu N, 2022, 'The role of the microbiome in the metabolic health of people with schizophrenia and related psychoses: cross-sectional and pre-post lifestyle intervention analyses', Pathogens, 11, pp. 1279, http://dx.doi.org/10.3390/pathogens11111279

Zhu Y; Owens SJ; Murphy CE; Ajulu K; Rothmond D; Purves-Tyson T; Middleton F; Webster MJ; Weickert CS, 2022, 'Inflammation-related transcripts define “high” and “low” subgroups of individuals with schizophrenia and bipolar disorder in the midbrain', Brain, Behavior, and Immunity, 105, pp. 149 - 159, http://dx.doi.org/10.1016/j.bbi.2022.06.012

Brown AM; Conn I; Boerrigter D; Shannon Weickert C; Purves-Tyson TD, 2022, 'Maternal immune activation with high molecular weight poly(I:C) in Wistar rats leads to elevated immune cell chemoattractants', Journal of Neuroimmunology, 364, http://dx.doi.org/10.1016/j.jneuroim.2022.577813

Brown SJ; Brown AM; Purves-Tyson TD; Huang XF; Shannon Weickert C; Newell KA, 2022, 'Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: Evidence of a potential astrocyte pathology', Journal of Psychiatric Research, 147, pp. 203 - 211, http://dx.doi.org/10.1016/j.jpsychires.2021.12.039

Rahman T; Purves-Tyson T; Geddes AE; Huang XF; Newell KA; Weickert CS, 2022, 'N-Methyl-D-Aspartate receptor and inflammation in dorsolateral prefrontal cortex in schizophrenia', Schizophrenia Research, 240, pp. 61 - 70, http://dx.doi.org/10.1016/j.schres.2021.11.045

Purves-Tyson TD; Brown AM; Weissleder C; Rothmond DA; Shannon Weickert C, 2021, 'Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia', Molecular Brain, 14, pp. 96, http://dx.doi.org/10.1186/s13041-021-00805-7

Purves-Tyson TD; Weber-Stadlbauer U; Richetto J; Rothmond DA; Labouesse MA; Polesel M; Robinson K; Shannon Weickert C; Meyer U, 2021, 'Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation', Molecular Psychiatry, 26, pp. 849 - 863, http://dx.doi.org/10.1038/s41380-019-0434-0

Ji E; Weickert CS; Purves-Tyson T; White C; Handelsman DJ; Desai R; O'Donnell M; Liu D; Galletly C; Lenroot R; Weickert TW, 2021, 'Cortisol-dehydroepiandrosterone ratios are inversely associated with hippocampal and prefrontal brain volume in schizophrenia', Psychoneuroendocrinology, 123, http://dx.doi.org/10.1016/j.psyneuen.2020.104916

Rahman T; Weickert CS; Harms L; Meehan C; Schall U; Todd J; Hodgson DM; Michie PT; Purves-Tyson T, 2020, 'Effect of Immune Activation during Early Gestation or Late Gestation on Inhibitory Markers in Adult Male Rats', Scientific Reports, 10, pp. 1982, http://dx.doi.org/10.1038/s41598-020-58449-x

Purves-Tyson TD; Robinson K; Brown AM; Boerrigter D; Cai HQ; Weissleder C; Owens SJ; Rothmond DA; Shannon Weickert C, 2020, 'Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia', Frontiers in Immunology, 11, pp. 2002, http://dx.doi.org/10.3389/fimmu.2020.02002

Purves-Tyson T; Cai H; Boerrigter D; Rothmond D; Shannon Weickert C, 2020, 'O11.2. ELEVATION OF MACROPHAGE-RELATED TRANSCRIPTS IN THE MIDBRAIN IN SCHIZOPHRENIA', Schizophrenia Bulletin, 46, pp. S27 - S28, http://dx.doi.org/10.1093/schbul/sbaa028.062

Owens SJ; Purves-Tyson TD; Webster MJ; Shannon Weickert C, 2019, 'Evidence for enhanced androgen action in the prefrontal cortex of people with bipolar disorder but not schizophrenia or major depressive disorder', Psychiatry Research, 280, http://dx.doi.org/10.1016/j.psychres.2019.112503

Owens SJ; Weickert TW; Purves-Tyson TD; Ji E; White C; Galletly C; Liu D; O'Donnell M; Shannon Weickert C, 2019, 'Sex-Specific Associations of Androgen Receptor CAG Trinucleotide Repeat Length and of Raloxifene Treatment with Testosterone Levels and Perceived Stress in Schizophrenia.', Mol Neuropsychiatry, 5, pp. 28 - 41, http://dx.doi.org/10.1159/000495062

Purves-Tyson T, 2018, '40. NEW INSIGHTS ON THE ROLE OF NEUROINFLAMMATION IN SCHIZOPHRENIA PATHOPHYSIOLOGY FROM POST MORTEM AND ANIMAL STUDIES', Schizophrenia Bulletin, 44, pp. S64 - S64, http://dx.doi.org/10.1093/schbul/sby014.163

Purves-Tyson T; Rothmond D; Weickert CS, 2018, '40.1 INFLAMMATORY CYTOKINES ARE ELEVATED IN THE MIDBRAIN IN SCHIZOPHRENIA', Schizophrenia Bulletin, 44, pp. S64 - S64, http://dx.doi.org/10.1093/schbul/sby014.164

Owens SJ; Murphy CE; Purves-Tyson TD; Weickert TW; Shannon Weickert C, 2018, 'Considering the role of adolescent sex steroids in schizophrenia', Journal of Neuroendocrinology, 30, http://dx.doi.org/10.1111/jne.12538

Rahman T; Zavitsanou K; Purves-Tyson T; Harms LR; Meehan C; Schall U; Todd J; Hodgson DM; Michie PT; Weickert CS, 2017, 'Effects of immune activation during early or late gestation on N-Methyl-D-Aspartate receptor measures in adult rat offspring', Frontiers in Psychiatry, 8, pp. 77, http://dx.doi.org/10.3389/fpsyt.2017.00077

Newton-Mann E; Finney C; Purves-Tyson T; Gogos A, 2017, 'Estrogen receptors: Mechanism of action and relevance to schizophrenia', Current Psychiatry Reviews, 13, pp. 55 - 64, http://dx.doi.org/10.2174/1573400513666170414102145

Purves-Tyson TD; Owens SJ; Rothmond DA; Halliday GM; Double KL; Stevens J; McCrossin T; Shannon Weickert C, 2017, 'Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain', Translational Psychiatry, 7, pp. e1003 - e1003, http://dx.doi.org/10.1038/tp.2016.257

Purves-Tyson TD; Allen K; Fung S; Rothmond D; Noble PL; Handelsman DJ; Shannon Weickert C, 2015, 'Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex', Schizophrenia Research, 168, pp. 661 - 670, http://dx.doi.org/10.1016/j.schres.2015.05.040

Allen KM; Purves-Tyson TD; Shannon Weickert C, 2015, 'Reproductive hormones and schizophrenia', Schizophrenia Research, 168, pp. 601 - 602, http://dx.doi.org/10.1016/j.schres.2015.07.034

Morris RW; Purves-Tyson TD; Weickert CS; Rothmond D; Lenroot R; Weickert TW, 2015, 'Testosterone and reward prediction-errors in healthy men and men with schizophrenia', Schizophrenia Research, 168, pp. 649 - 660, http://dx.doi.org/10.1016/j.schres.2015.06.030

Purves-Tyson TD; Boerrigter D; Allen K; Zavitsanou K; Karl T; Djunaidi V; Double KL; Desai R; Handelsman DJ; Weickert CS, 2015, 'Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats', Hormones and Behavior, 70, pp. 73 - 84, http://dx.doi.org/10.1016/j.yhbeh.2015.02.005

Allen KM; Purves-Tyson TD; Fung SJ; Shannon Weickert C, 2015, 'The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: Relationship with cell proliferation', BMC Neuroscience, 16, pp. 4, http://dx.doi.org/10.1186/s12868-015-0142-x

Purves-Tyson TD; Owens SJ; Double KL; Desai R; Handelsman DJ; Weickert CS, 2014, 'Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway', PLoS ONE, 9, pp. e91151, http://dx.doi.org/10.1371/journal.pone.0091151

Zavitsanou K; Lim CK; Purves-Tyson T; Karl T; Kassiou M; Banister SD; Guillemin GJ; Weickert CS, 2014, 'Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition', Brain, Behavior, and Immunity, 41, pp. 173 - 181, http://dx.doi.org/10.1016/j.bbi.2014.05.011

Sinclair D; Purves-Tyson TD; Allen KM; Weickert CS, 2014, 'Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain', Psychopharmacology, 231, pp. 1581 - 1599, http://dx.doi.org/10.1007/s00213-013-3415-z

Purves-Tyson TD; Handelsman D; Double KL; Bustamante S; owens SJ; Shannon Weickert C, 2012, 'Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra', BMC Neuroscience, 13, pp. 95, http://dx.doi.org/10.1186/1471-2202-13-95

Lee GL; Purves-Tyson TD, 2009, 'P5.6 Neuritin message is increased by testosterone in cultured rat pelvic autonomic neurons but is unchanged in pelvic ganglia in experimental diabetes', Autonomic Neuroscience, 149, pp. 104 - 105, http://dx.doi.org/10.1016/j.autneu.2009.05.196

Purves-Tyson TD; Arshi M; Handelsman D; Cheng Y; Keast JR, 2007, 'Androgen and estrogen receptor-mediated mechanisms of testosterone action in male rat pelvic autonomic ganglia', Neuroscience, 148, pp. 92 - 104

Fernyhough P; Smith DR; Schapansky J; Van Der Ploeg R; Gardiner NJ; Tweed CW; Kontos A; Freeman L; Purves-Tyson TD; Glazner GW, 2005, 'Activation of nuclear factor-κB via endogenous tumor necrosis factor α regulates survival of axotomized adult sensory neurons', Journal of Neuroscience, 25, pp. 1682 - 1690, http://dx.doi.org/10.1523/JNEUROSCI.3127-04.2005

Purves-Tyson TD; Keast JR, 2004, 'Rapid actions of estradiol on cyclic amp response-element binding protein phosphorylation in dorsal root ganglion neurons', Neuroscience, 129, pp. 629 - 637, http://www.sciencedirect.com/science/article/B6T0F-4DGW2WD-4/2/e7073c58cb765b52366a170f7a5c2a93

Price SA; Hounsom L; Purves-Tyson TD; Fernyhough P; Tomlinson DR, 2003, 'Activation of JNK in Sensory Neurons Protects against Sensory Neuron Cell Death in Diabetes and on Exposure to Glucose/Oxidative Stress in Vitro', Annals of the New York Academy of Sciences, 1010, pp. 95 - 99, http://dx.doi.org/10.1196/annals.1299.015

Tomlinson DR; Purves T; Fernyhough P, 2002, 'Diabetic neuropathies', BRITISH JOURNAL OF PHARMACOLOGY, 136, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000176044800075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sayers NM; Purves TD; Fernyhough P, 2002, 'Neurofilament phosphorylation in sensory neurons in the streptozotocin (STZ)-Diabetic rat; Effect of neurotrophin-3 therapy', DIABETES, 51, pp. A195 - A195, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000175934600788&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Purves TD; Tomlinson DR, 2002, 'Are mitogen-activated protein kinases glucose transducers for diabetic neuropathies?', International Review of Neurobiology, 50, pp. 83 - 114, http://dx.doi.org/10.1016/s0074-7742(02)50074-x

Purves TD; Tomlinson DR, 2002, 'Diminished transcription factor survival signals in dorsal root ganglia in rats with streptozotocin-induced diabetes', Annals of the New York Academy of Sciences, 973, pp. 472 - 476, http://dx.doi.org/10.1111/j.1749-6632.2002.tb04686.x

Purves T; Middlemas A; Agthong S; Jude EB; Boulton AJM; Fernyhough P; Tomlinson DR, 2001, 'A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy', FASEB Journal, 15, pp. 2508 - 2514, http://dx.doi.org/10.1096/fj.01-0253hyp

Purves TD; Fernyhough P; Tomlinson DR, 2000, 'Activation of mitogen activated protein kinases (MAPKs) in response to cellular stress in adult primary sensory neurones.', EUROPEAN JOURNAL OF NEUROSCIENCE, 12, pp. 302 - 302, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088236601735&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Campbell WE; Gammon DW; Smith P; Abrahams M; Purves TD, 1997, 'Composition and antimalarial activity in vitro of the essential oil of Tetrodenia riparia', Planta Medica, 63, pp. 270 - 272, http://dx.doi.org/10.1055/s-2006-957672

Conference Papers

Brown S; Brown A; Purves-Tyson T; Huang X-F; Weickert CS; Newell K, 2020, 'Alterations in the Kynurenine Pathway in Depression With and Without Psychosis', in BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE INC, NY, New York, pp. S248 - S248, presented at 75th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry (SOBP), NY, New York, 30 April 2020 - 02 May 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000535308200603&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Purves-Tyson T; Cai H; Boerrigter D; Rothmond D; Weickert CS, 2020, 'ELEVATION OF MACROPHAGE-RELATED TRANSCRIPTS IN THE MIDBRAIN IN SCHIZOPHRENIA', in SCHIZOPHRENIA BULLETIN, OXFORD UNIV PRESS, ITALY, Florence, pp. S27 - S28, presented at Congress of the Schizophrenia-International-Research-Society (SRIS), ITALY, Florence, 04 April 2020 - 08 April 2020, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537751800059&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

O'Donnell M; Teasdale S; Curtis J; Samaras K; Bolton P; Weickert CS; Morris M; Hardman J; Purves-Tyson T; El-Assaad F; Jiang XT; Chua XY; El-Omar E, 2022, 'THE ROLE OF THE MICROBIOME AND METABOLIC SYNDROME IN SCHIZOPHRENIA AND EARLY PSYCHOSIS', in AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, SAGE PUBLICATIONS LTD, Vol. 56, pp. 189 - 189, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000792769900448&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Owens S; Weickert CS; Purves-Tyson T, 2019, 'Testosterone Modulation of Sex Steroid and Dopamine-Related mRNAs During Adolescence in the Mesolimbic Pathway', in BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE INC, IL, Chicago, Vol. 85, pp. S280 - S281, presented at 74th Annual Meeting of the Society-of-Biological-Psychiatry (SOBP), IL, Chicago, 16 May 2019 - 18 May 2019, http://dx.doi.org/10.1016/j.biopsych.2019.03.711

Purves-Tyson T; Rothmond D; Weickert CS, 2018, 'INFLAMMATORY CYTOKINES ARE ELEVATED IN THE MIDBRAIN IN SCHIZOPHRENIA', in SCHIZOPHRENIA BULLETIN, OXFORD UNIV PRESS, ITALY, Florence, Vol. 44, pp. S64 - S64, presented at 6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS), ITALY, Florence, 04 April 2018 - 08 April 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429541800166&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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