By Dr Tertia Deborah Purves-Tyson

Journal articles

Debs SR; Rothmond DA; Zhu Y; Weickert CS; Purves-Tyson TD, 2024, 'Molecular evidence of altered stress responsivity related to neuroinflammation in the schizophrenia midbrain', Journal of Psychiatric Research, 177, pp. 118 - 128, http://dx.doi.org/10.1016/j.jpsychires.2024.07.004

Debs SR; Conn I; Navaneethan B; Penklis AG; Meyer U; Killcross S; Weickert CS; Purves-Tyson TD, 2024, 'Maternal immune activation and estrogen receptor modulation induce sex-specific dopamine-related behavioural and molecular alterations in adult rat offspring', Brain, Behavior, and Immunity, 118, pp. 236 - 251, http://dx.doi.org/10.1016/j.bbi.2024.02.034

Brown SJ; Brown AM; Purves-Tyson TD; Huang XF; Shannon Weickert C; Newell KA, 2023, 'GRIN2B gene expression is increased in the anterior cingulate cortex in major depression', Journal of Psychiatric Research, 160, pp. 204 - 209, http://dx.doi.org/10.1016/j.jpsychires.2023.02.017

Petty A; Glass LJ; Rothmond DA; Purves-Tyson T; Sweeney A; Kondo Y; Kubo S; Matsumoto M; Weickert CS, 2022, 'Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia', Journal of Neuroinflammation, 19, http://dx.doi.org/10.1186/s12974-022-02541-8

O'Donnell M; Teasdale S; Chua X-Y; Hardman J; Wu N; Curtis J; Samaras K; Bolton P; Morris M; Shannon-Weickert C; Purves-Tyson T; El-Assaad F; Jiang X; Hold G; El-Omar E; Wu N, 2022, 'The role of the microbiome in the metabolic health of people with schizophrenia and related psychoses: cross-sectional and pre-post lifestyle intervention analyses', Pathogens, 11, pp. 1279, http://dx.doi.org/10.3390/pathogens11111279

Zhu Y; Owens SJ; Murphy CE; Ajulu K; Rothmond D; Purves-Tyson T; Middleton F; Webster MJ; Weickert CS, 2022, 'Inflammation-related transcripts define “high” and “low” subgroups of individuals with schizophrenia and bipolar disorder in the midbrain', Brain, Behavior, and Immunity, 105, pp. 149 - 159, http://dx.doi.org/10.1016/j.bbi.2022.06.012

Brown AM; Conn I; Boerrigter D; Shannon Weickert C; Purves-Tyson TD, 2022, 'Maternal immune activation with high molecular weight poly(I:C) in Wistar rats leads to elevated immune cell chemoattractants', Journal of Neuroimmunology, 364, http://dx.doi.org/10.1016/j.jneuroim.2022.577813

Brown SJ; Brown AM; Purves-Tyson TD; Huang XF; Shannon Weickert C; Newell KA, 2022, 'Alterations in the kynurenine pathway and excitatory amino acid transporter-2 in depression with and without psychosis: Evidence of a potential astrocyte pathology', Journal of Psychiatric Research, 147, pp. 203 - 211, http://dx.doi.org/10.1016/j.jpsychires.2021.12.039

Rahman T; Purves-Tyson T; Geddes AE; Huang XF; Newell KA; Weickert CS, 2022, 'N-Methyl-D-Aspartate receptor and inflammation in dorsolateral prefrontal cortex in schizophrenia', Schizophrenia Research, 240, pp. 61 - 70, http://dx.doi.org/10.1016/j.schres.2021.11.045

Purves-Tyson TD; Brown AM; Weissleder C; Rothmond DA; Shannon Weickert C, 2021, 'Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia', Molecular Brain, 14, pp. 96, http://dx.doi.org/10.1186/s13041-021-00805-7

Purves-Tyson TD; Weber-Stadlbauer U; Richetto J; Rothmond DA; Labouesse MA; Polesel M; Robinson K; Shannon Weickert C; Meyer U, 2021, 'Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation', Molecular Psychiatry, 26, pp. 849 - 863, http://dx.doi.org/10.1038/s41380-019-0434-0

Ji E; Weickert CS; Purves-Tyson T; White C; Handelsman DJ; Desai R; O'Donnell M; Liu D; Galletly C; Lenroot R; Weickert TW, 2021, 'Cortisol-dehydroepiandrosterone ratios are inversely associated with hippocampal and prefrontal brain volume in schizophrenia', Psychoneuroendocrinology, 123, http://dx.doi.org/10.1016/j.psyneuen.2020.104916

Rahman T; Weickert CS; Harms L; Meehan C; Schall U; Todd J; Hodgson DM; Michie PT; Purves-Tyson T, 2020, 'Effect of Immune Activation during Early Gestation or Late Gestation on Inhibitory Markers in Adult Male Rats', Scientific Reports, 10, pp. 1982, http://dx.doi.org/10.1038/s41598-020-58449-x

Purves-Tyson TD; Robinson K; Brown AM; Boerrigter D; Cai HQ; Weissleder C; Owens SJ; Rothmond DA; Shannon Weickert C, 2020, 'Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia', Frontiers in Immunology, 11, pp. 2002, http://dx.doi.org/10.3389/fimmu.2020.02002

Purves-Tyson T; Cai H; Boerrigter D; Rothmond D; Shannon Weickert C, 2020, 'O11.2. ELEVATION OF MACROPHAGE-RELATED TRANSCRIPTS IN THE MIDBRAIN IN SCHIZOPHRENIA', Schizophrenia Bulletin, 46, pp. S27 - S28, http://dx.doi.org/10.1093/schbul/sbaa028.062

Owens SJ; Purves-Tyson TD; Webster MJ; Shannon Weickert C, 2019, 'Evidence for enhanced androgen action in the prefrontal cortex of people with bipolar disorder but not schizophrenia or major depressive disorder', Psychiatry Research, 280, http://dx.doi.org/10.1016/j.psychres.2019.112503

Owens SJ; Weickert TW; Purves-Tyson TD; Ji E; White C; Galletly C; Liu D; O'Donnell M; Shannon Weickert C, 2019, 'Sex-Specific Associations of Androgen Receptor CAG Trinucleotide Repeat Length and of Raloxifene Treatment with Testosterone Levels and Perceived Stress in Schizophrenia.', Mol Neuropsychiatry, 5, pp. 28 - 41, http://dx.doi.org/10.1159/000495062

Purves-Tyson T, 2018, '40. NEW INSIGHTS ON THE ROLE OF NEUROINFLAMMATION IN SCHIZOPHRENIA PATHOPHYSIOLOGY FROM POST MORTEM AND ANIMAL STUDIES', Schizophrenia Bulletin, 44, pp. S64 - S64, http://dx.doi.org/10.1093/schbul/sby014.163

Purves-Tyson T; Rothmond D; Weickert CS, 2018, '40.1 INFLAMMATORY CYTOKINES ARE ELEVATED IN THE MIDBRAIN IN SCHIZOPHRENIA', Schizophrenia Bulletin, 44, pp. S64 - S64, http://dx.doi.org/10.1093/schbul/sby014.164

Owens SJ; Murphy CE; Purves-Tyson TD; Weickert TW; Shannon Weickert C, 2018, 'Considering the role of adolescent sex steroids in schizophrenia', Journal of Neuroendocrinology, 30, http://dx.doi.org/10.1111/jne.12538

Rahman T; Zavitsanou K; Purves-Tyson T; Harms LR; Meehan C; Schall U; Todd J; Hodgson DM; Michie PT; Weickert CS, 2017, 'Effects of immune activation during early or late gestation on N-Methyl-D-Aspartate receptor measures in adult rat offspring', Frontiers in Psychiatry, 8, pp. 77, http://dx.doi.org/10.3389/fpsyt.2017.00077

Newton-Mann E; Finney C; Purves-Tyson T; Gogos A, 2017, 'Estrogen receptors: Mechanism of action and relevance to schizophrenia', Current Psychiatry Reviews, 13, pp. 55 - 64, http://dx.doi.org/10.2174/1573400513666170414102145

Purves-Tyson TD; Owens SJ; Rothmond DA; Halliday GM; Double KL; Stevens J; McCrossin T; Shannon Weickert C, 2017, 'Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain', Translational Psychiatry, 7, pp. e1003 - e1003, http://dx.doi.org/10.1038/tp.2016.257

Purves-Tyson TD; Allen K; Fung S; Rothmond D; Noble PL; Handelsman DJ; Shannon Weickert C, 2015, 'Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex', Schizophrenia Research, 168, pp. 661 - 670, http://dx.doi.org/10.1016/j.schres.2015.05.040

Allen KM; Purves-Tyson TD; Shannon Weickert C, 2015, 'Reproductive hormones and schizophrenia', Schizophrenia Research, 168, pp. 601 - 602, http://dx.doi.org/10.1016/j.schres.2015.07.034

Morris RW; Purves-Tyson TD; Weickert CS; Rothmond D; Lenroot R; Weickert TW, 2015, 'Testosterone and reward prediction-errors in healthy men and men with schizophrenia', Schizophrenia Research, 168, pp. 649 - 660, http://dx.doi.org/10.1016/j.schres.2015.06.030

Purves-Tyson TD; Boerrigter D; Allen K; Zavitsanou K; Karl T; Djunaidi V; Double KL; Desai R; Handelsman DJ; Weickert CS, 2015, 'Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats', Hormones and Behavior, 70, pp. 73 - 84, http://dx.doi.org/10.1016/j.yhbeh.2015.02.005

Allen KM; Purves-Tyson TD; Fung SJ; Shannon Weickert C, 2015, 'The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: Relationship with cell proliferation', BMC Neuroscience, 16, pp. 4, http://dx.doi.org/10.1186/s12868-015-0142-x

Purves-Tyson TD; Owens SJ; Double KL; Desai R; Handelsman DJ; Weickert CS, 2014, 'Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway', PLoS ONE, 9, pp. e91151, http://dx.doi.org/10.1371/journal.pone.0091151

Zavitsanou K; Lim CK; Purves-Tyson T; Karl T; Kassiou M; Banister SD; Guillemin GJ; Weickert CS, 2014, 'Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition', Brain, Behavior, and Immunity, 41, pp. 173 - 181, http://dx.doi.org/10.1016/j.bbi.2014.05.011

Sinclair D; Purves-Tyson TD; Allen KM; Weickert CS, 2014, 'Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain', Psychopharmacology, 231, pp. 1581 - 1599, http://dx.doi.org/10.1007/s00213-013-3415-z

Purves-Tyson TD; Handelsman D; Double KL; Bustamante S; owens SJ; Shannon Weickert C, 2012, 'Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra', BMC Neuroscience, 13, pp. 95, http://dx.doi.org/10.1186/1471-2202-13-95

Lee GL; Purves-Tyson TD, 2009, 'P5.6 Neuritin message is increased by testosterone in cultured rat pelvic autonomic neurons but is unchanged in pelvic ganglia in experimental diabetes', Autonomic Neuroscience, 149, pp. 104 - 105, http://dx.doi.org/10.1016/j.autneu.2009.05.196

Purves-Tyson TD; Arshi M; Handelsman D; Cheng Y; Keast JR, 2007, 'Androgen and estrogen receptor-mediated mechanisms of testosterone action in male rat pelvic autonomic ganglia', Neuroscience, 148, pp. 92 - 104

Fernyhough P; Smith DR; Schapansky J; Van Der Ploeg R; Gardiner NJ; Tweed CW; Kontos A; Freeman L; Purves-Tyson TD; Glazner GW, 2005, 'Activation of nuclear factor-κB via endogenous tumor necrosis factor α regulates survival of axotomized adult sensory neurons', Journal of Neuroscience, 25, pp. 1682 - 1690, http://dx.doi.org/10.1523/JNEUROSCI.3127-04.2005

Purves-Tyson TD; Keast JR, 2004, 'Rapid actions of estradiol on cyclic amp response-element binding protein phosphorylation in dorsal root ganglion neurons', Neuroscience, 129, pp. 629 - 637, http://www.sciencedirect.com/science/article/B6T0F-4DGW2WD-4/2/e7073c58cb765b52366a170f7a5c2a93

Price SA; Hounsom L; Purves-Tyson TD; Fernyhough P; Tomlinson DR, 2003, 'Activation of JNK in Sensory Neurons Protects against Sensory Neuron Cell Death in Diabetes and on Exposure to Glucose/Oxidative Stress in Vitro', Annals of the New York Academy of Sciences, 1010, pp. 95 - 99, http://dx.doi.org/10.1196/annals.1299.015

Tomlinson DR; Purves T; Fernyhough P, 2002, 'Diabetic neuropathies', BRITISH JOURNAL OF PHARMACOLOGY, 136, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000176044800075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sayers NM; Purves TD; Fernyhough P, 2002, 'Neurofilament phosphorylation in sensory neurons in the streptozotocin (STZ)-Diabetic rat; Effect of neurotrophin-3 therapy', DIABETES, 51, pp. A195 - A195, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000175934600788&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Purves TD; Tomlinson DR, 2002, 'Are mitogen-activated protein kinases glucose transducers for diabetic neuropathies?', International Review of Neurobiology, 50, pp. 83 - 114, http://dx.doi.org/10.1016/s0074-7742(02)50074-x

Purves TD; Tomlinson DR, 2002, 'Diminished transcription factor survival signals in dorsal root ganglia in rats with streptozotocin-induced diabetes', Annals of the New York Academy of Sciences, 973, pp. 472 - 476, http://dx.doi.org/10.1111/j.1749-6632.2002.tb04686.x

Purves T; Middlemas A; Agthong S; Jude EB; Boulton AJM; Fernyhough P; Tomlinson DR, 2001, 'A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy', FASEB Journal, 15, pp. 2508 - 2514, http://dx.doi.org/10.1096/fj.01-0253hyp

Purves TD; Fernyhough P; Tomlinson DR, 2000, 'Activation of mitogen activated protein kinases (MAPKs) in response to cellular stress in adult primary sensory neurones.', EUROPEAN JOURNAL OF NEUROSCIENCE, 12, pp. 302 - 302, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088236601735&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Campbell WE; Gammon DW; Smith P; Abrahams M; Purves TD, 1997, 'Composition and antimalarial activity in vitro of the essential oil of Tetrodenia riparia', Planta Medica, 63, pp. 270 - 272, http://dx.doi.org/10.1055/s-2006-957672

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