By Dr Tom Peat

Journal articles

Ahmed FH; Liu JW; Royan S; Warden AC; Esquirol L; Pandey G; Newman J; Scott C; Peat TS, 2024, 'Structural insights into the enzymatic breakdown of azomycin-derived antibiotics by 2-nitroimdazole hydrolase (NnhA)', Communications Biology, 7, http://dx.doi.org/10.1038/s42003-024-07336-6

Eldehna WM; Fares M; Bonardi A; Avgenikos M; Baselious F; Schmidt M; Al-Warhi T; Abdel-Aziz HA; Rennert R; Peat TS; Supuran CT; Wessjohann LA; Ibrahim HS, 2024, '4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells', Journal of Medicinal Chemistry, 67, pp. 20438 - 20454, http://dx.doi.org/10.1021/acs.jmedchem.4c01894

Fulford TS; Soliman C; Castle RG; Rigau M; Ruan Z; Dolezal O; Seneviratna R; Brown HG; Hanssen E; Hammet A; Li S; Redmond SJ; Chung A; Gorman MA; Parker MW; Patel O; Peat TS; Newman J; Behren A; Gherardin NA; Godfrey DI; Uldrich AP, 2024, 'Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers', Nature Immunology, 25, pp. 1355 - 1366, http://dx.doi.org/10.1038/s41590-024-01892-z

Joho Y; Royan S; Caputo AT; Newton S; Peat TS; Newman J; Jackson C; Ardevol A, 2024, 'Enhancing PET Degrading Enzymes: A Combinatory Approach', Chembiochem, 25, http://dx.doi.org/10.1002/cbic.202400084

Yi X; Kleinbeck F; Ching C; Boghospor L; Gomes S; Alvizo O; Allmendinger T; Fell J; Subramanian N; Li M; Garcia R; Riggins J; Entwistle D; Richter Y; Gschwend D; Lauener L; Peat TS; Lebhar H; Schlama T; Ruch T, 2024, 'Enhancing the Imine Reductase Activity of a Promiscuous Glucose Dehydrogenase for Scalable Manufacturing of a Chiral Neprilysin Inhibitor Precursor', ACS Catalysis, 14, pp. 7087 - 7096, http://dx.doi.org/10.1021/acscatal.3c05615

Esquirol L; Newman J; Nebl T; Scott C; Vickers C; Sainsbury F; Peat TS, 2024, 'Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii', Acta Crystallographica Section D Structural Biology, 80, pp. 203 - 215, http://dx.doi.org/10.1107/S2059798324001360

Sharma S; Chung CY; Uryu S; Petrovic J; Cao J; Rickard A; Nady N; Greasley S; Johnson E; Brodsky O; Khan S; Wang H; Wang Z; Zhang Y; Tsaparikos K; Chen L; Mazurek A; Lapek J; Kung PP; Sutton S; Richardson PF; Greenwald EC; Yamazaki S; Jones R; Maegley KA; Bingham P; Lam H; Stupple AE; Kamal A; Chueh A; Cuzzupe A; Morrow BJ; Ren B; Carrasco-Pozo C; Tan CW; Bhuva DD; Allan E; Surgenor E; Vaillant F; Pehlivanoglu H; Falk H; Whittle JR; Newman J; Cursons J; Doherty JP; White KL; MacPherson L; Devlin M; Dennis ML; Hattarki MK; De Silva M; Camerino MA; Butler MS; Dolezal O; Pilling P; Foitzik R; Stupple PA; Lagiakos HR; Walker SR; Hediyeh-Zadeh S; Nuttall S; Spall SK; Charman SA; Connor T; Peat TS; Avery VM; Bozikis YE; Yang Y; Zhang M; Monahan BJ; Voss AK; Thomas T; Street IP; Dawson SJ; Dawson MA; Lindeman GJ; Davis MJ; Visvader JE; Paul TA, 2023, 'Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer', Cell Chemical Biology, 30, pp. 1191 - 1210.e20, http://dx.doi.org/10.1016/j.chembiol.2023.07.005

Satta A; Esquirol L; Ebert BE; Newman J; Peat TS; Plan M; Schenk G; Vickers CE, 2022, 'Molecular characterization of cyanobacterial short-chain prenyltransferases and discovery of a novel GGPP phosphatase', FEBS Journal, 289, pp. 6672 - 6693, http://dx.doi.org/10.1111/febs.16556

Ahmed FH; Caputo AT; French NG; Peat TS; Whitfield J; Warden AC; Newman J; Scott1 C, 2022, 'Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed', Acta Crystallographica Section D Structural Biology, 78, pp. 599 - 612, http://dx.doi.org/10.1107/S2059798322002625

Guo Z; Smutok O; Johnston WA; Walden P; Ungerer JPJ; Peat TS; Newman J; Parker J; Nebl T; Hepburn C; Melman A; Suderman RJ; Katz E; Alexandrov K, 2021, 'Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-27184-w

Caputo AT; Eder OM; Bereznakova H; Pothuis H; Ardevol A; Newman J; Nuttall S; Peat TS; Adams TE, 2021, 'Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-84551-9

Gumus A; Bozdag M; Angeli A; Peat TS; Carta F; Supuran CT; Selleri S, 2021, 'Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors', Bioorganic and Medicinal Chemistry Letters, 49, http://dx.doi.org/10.1016/j.bmcl.2021.128309

Mueller SL; Chrysanthopoulos PK; Halili MA; Hepburn C; Nebl T; Supuran CT; Nocentini A; Peat TS; Poulsen SA, 2021, 'The glitazone class of drugs as carbonic anhydrase inhibitors—a spin-off discovery from fragment screening', Molecules, 26, http://dx.doi.org/10.3390/molecules26103010

Newman J; Nebl T; Van H; Peat TS, 2020, 'The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein', Acta Crystallographica Section F Structural Biology Communications, 76, pp. 583 - 589, http://dx.doi.org/10.1107/S2053230X20015216

Dennis ML; Newman J; Dolezal O; Hattarki M; Surjadi RN; Nuttall SD; Pham T; Nebl T; Camerino M; Khoo PS; Monahan BJ; Peat TS, 2020, 'Crystal structures of human ENPP1 in apo and bound forms', Acta Crystallographica Section D Structural Biology, 76, pp. 889 - 898, http://dx.doi.org/10.1107/S2059798320010505

Berrino E; Angeli A; Zhdanov DD; Kiryukhina AP; Milaneschi A; De Luca A; Bozdag M; Carradori S; Selleri S; Bartolucci G; Peat TS; Ferraroni M; Supuran CT; Carta F, 2020, 'Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors', Journal of Medicinal Chemistry, 63, pp. 7392 - 7409, http://dx.doi.org/10.1021/acs.jmedchem.0c00636

Angeli A; Peat TS; Selleri S; Saleh Alfawaz Altamimi A; Supuran CT; Carta F, 2020, 'X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX', Bioorganic Chemistry, 97, http://dx.doi.org/10.1016/j.bioorg.2020.103669

Fares M; Eldehna WM; Bua S; Lanzi C; Lucarini L; Masini E; Peat TS; Abdel-Aziz HA; Nocentini A; Keller PA; Supuran CT, 2020, 'Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action', Journal of Medicinal Chemistry, 63, pp. 3317 - 3326, http://dx.doi.org/10.1021/acs.jmedchem.9b02090

MacPherson L; Anokye J; Yeung MM; Lam EYN; Chan YC; Weng CF; Yeh P; Knezevic K; Butler MS; Hoegl A; Chan KL; Burr ML; Gearing LJ; Willson T; Liu J; Choi J; Yang Y; Bilardi RA; Falk H; Nguyen N; Stupple PA; Peat TS; Zhang M; de Silva M; Carrasco-Pozo C; Avery VM; Khoo PS; Dolezal O; Dennis ML; Nuttall S; Surjadi R; Newman J; Ren B; Leaver DJ; Sun Y; Baell JB; Dovey O; Vassiliou GS; Grebien F; Dawson SJ; Street IP; Monahan BJ; Burns CJ; Choudhary C; Blewitt ME; Voss AK; Thomas T; Dawson MA, 2020, 'HBO1 is required for the maintenance of leukaemia stem cells', Nature, 577, pp. 266 - 270, http://dx.doi.org/10.1038/s41586-019-1835-6

Esquirol L; Peat TS; Sugrue E; Balotra S; Rottet S; Warden AC; Wilding M; Hartley CJ; Jackson CJ; Newman J; Scott C, 2020, 'Bacterial catabolism of s-triazine herbicides: biochemistry, evolution and application', Advances in Microbial Physiology, 76, pp. 129 - 186, http://dx.doi.org/10.1016/bs.ampbs.2020.01.004

Kaczmarski JA; Hong NS; Mukherjee B; Wey LT; Rourke L; Förster B; Peat TS; Price GD; Jackson CJ, 2019, 'Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the PII-like Protein, SbtB, from Cyanobium sp. PCC7001', Biochemistry, 58, pp. 5030 - 5039, http://dx.doi.org/10.1021/acs.biochem.9b00880

Dennis ML; Morrow BJ; Dolezal O; Cuzzupe AN; Stupple AE; Newman J; Bentley J; Hattarki M; Nuttall SD; Foitzik RC; Street IP; Stupple PA; Monahan BJ; Peat TS, 2019, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', Structural Dynamics, 6, http://dx.doi.org/10.1063/1.5122849

Tanini D; Ricci L; Capperucci A; Di Cesare Mannelli L; Ghelardini C; Peat TS; Carta F; Angeli A; Supuran CT, 2019, 'Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity', European Journal of Medicinal Chemistry, 181, http://dx.doi.org/10.1016/j.ejmech.2019.111586

Dennis ML; Esquirol L; Nebl T; Newman J; Scott C; Peat TS, 2019, 'The evolving story of AtzT, a periplasmic binding protein', Acta Crystallographica Section D Structural Biology, 75, pp. 995 - 1002, http://dx.doi.org/10.1107/S2059798319013883

Angeli A; Di Cesare Mannelli L; Ghelardini C; Peat TS; Bartolucci G; Menicatti M; Carta F; Supuran CT, 2019, 'Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects', European Journal of Medicinal Chemistry, 177, pp. 188 - 197, http://dx.doi.org/10.1016/j.ejmech.2019.05.058

Newman J; Caron K; Nebl T; Peat TS, 2019, 'Structures of the transcriptional regulator BgaR, a lactose sensor', Acta Crystallographica Section D Structural Biology, 75, pp. 639 - 646, http://dx.doi.org/10.1107/S2059798319008131

Esquirol L; Peat TS; Wilding M; Hartley CJ; Newman J; Scott C, 2018, 'A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. Strain ADP', Plos One, 13, http://dx.doi.org/10.1371/journal.pone.0206949

Liang YL; Khoshouei M; Deganutti G; Glukhova A; Koole C; Peat TS; Radjainia M; Plitzko JM; Baumeister W; Miller LJ; Hay DL; Christopoulos A; Reynolds CA; Wootten D; Sexton PM, 2018, 'Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor', Nature, 561, pp. 492 - 497, http://dx.doi.org/10.1038/s41586-018-0535-y

Mujumdar P; Bua S; Supuran CT; Peat TS; Poulsen SA, 2018, 'Synthesis, structure and bioactivity of primary sulfamate-containing natural products', Bioorganic and Medicinal Chemistry Letters, 28, pp. 3009 - 3013, http://dx.doi.org/10.1016/j.bmcl.2018.04.038

Baell JB; Leaver DJ; Hermans SJ; Kelly GL; Brennan MS; Downer NL; Nguyen N; Wichmann J; McRae HM; Yang Y; Cleary B; Lagiakos HR; Mieruszynski S; Pacini G; Vanyai HK; Bergamasco MI; May RE; Davey BK; Morgan KJ; Sealey AJ; Wang B; Zamudio N; Wilcox S; Garnham AL; Sheikh BN; Aubrey BJ; Doggett K; Chung MC; de Silva M; Bentley J; Pilling P; Hattarki M; Dolezal O; Dennis ML; Falk H; Ren B; Charman SA; White KL; Rautela J; Newbold A; Hawkins ED; Johnstone RW; Huntington ND; Peat TS; Heath JK; Strasser A; Parker MW; Smyth GK; Street IP; Monahan BJ; Voss AK; Thomas T, 2018, 'Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth', Nature, 560, pp. 253 - 257, http://dx.doi.org/10.1038/s41586-018-0387-5

Angeli A; di Cesare Mannelli L; Lucarini E; Peat TS; Ghelardini C; Supuran CT, 2018, 'Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects', European Journal of Medicinal Chemistry, 154, pp. 210 - 219, http://dx.doi.org/10.1016/j.ejmech.2018.05.026

Esquirol L; Peat TS; Wilding M; Liu JW; French NG; Hartley CJ; Onagi H; Nebl T; Easton CJ; Newman J; Scott C, 2018, 'An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme', Journal of Biological Chemistry, 293, pp. 7880 - 7891, http://dx.doi.org/10.1074/jbc.RA118.001996

Angeli A; Di Cesare Mannelli L; Trallori E; Peat TS; Ghelardini C; Carta F; Supuran CT, 2018, 'Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology', ACS Medicinal Chemistry Letters, 9, pp. 462 - 467, http://dx.doi.org/10.1021/acsmedchemlett.8b00076

Dennis ML; Lee MD; Harjani JR; Ahmed M; DeBono AJ; Pitcher NP; Wang ZC; Chhabra S; Barlow N; Rahmani R; Cleary B; Dolezal O; Hattarki M; Aurelio L; Shonberg J; Graham B; Peat TS; Baell JB; Swarbrick JD, 2018, '8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase', Chemistry A European Journal, 24, pp. 1922 - 1930, http://dx.doi.org/10.1002/chem.201704730

Esquirol L; Peat TS; Wilding M; Lucent D; French NG; Hartley CJ; Newman J; Scott C, 2018, 'Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841', Plos One, 13, http://dx.doi.org/10.1371/journal.pone.0192736

Newman J; Sharp JA; Enjapoori AK; Bentley J; Nicholas KR; Adams TE; Peat TS, 2018, 'Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus', Acta Crystallographica Section F Structural Biology Communications, 74, pp. 39 - 45, http://dx.doi.org/10.1107/S2053230X17017708

Zabara A; Meikle TG; Trenker R; Yao S; Newman J; Peat TS; Separovic F; Conn CE; Call MJ; Call ME; Landau EM; Drummond CJ, 2017, 'Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis', Crystal Growth and Design, 17, pp. 5667 - 5674, http://dx.doi.org/10.1021/acs.cgd.7b00519

Angeli A; Tanini D; Peat TS; Di Cesare Mannelli L; Bartolucci G; Capperucci A; Ghelardini C; Supuran CT; Carta F, 2017, 'Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors', ACS Medicinal Chemistry Letters, 8, pp. 963 - 968, http://dx.doi.org/10.1021/acsmedchemlett.7b00280

Chrysanthopoulos PK; Mujumdar P; Woods LA; Dolezal O; Ren B; Peat TS; Poulsen SA, 2017, 'Identification of a New Zinc Binding Chemotype by Fragment Screening', Journal of Medicinal Chemistry, 60, pp. 7333 - 7349, http://dx.doi.org/10.1021/acs.jmedchem.7b00606

Fisher CR; Sutton HJ; Kaczmarski JA; McNamara HA; Clifton B; Mitchell J; Cai Y; Dups JN; D'Arcy NJ; Singh M; Chuah A; Peat TS; Jackson CJ; Cockburn IA, 2017, 'T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein', Plos Pathogens, 13, http://dx.doi.org/10.1371/journal.ppat.1006469

Peat TS; Balotra S; Wilding M; Hartley CJ; Newman J; Scott C, 2017, 'High-resolution X-ray structures of two functionally distinct members of the cyclic amide hydrolase family of Toblerone fold enzymes', Applied and Environmental Microbiology, 83, http://dx.doi.org/10.1128/AEM.03365-16

Davies C; Böttcher C; Boss PK; Peat T; Newman J, 2017, 'Understanding the control of grape berry ripening and developing opportunities for its manipulation', Acta Horticulturae, 1157, pp. 1 - 10, http://dx.doi.org/10.17660/ActaHortic.2017.1157.1

Zabara A; Meikle TG; Newman J; Peat TS; Conn CE; Drummond CJ, 2017, 'The nanoscience behind the art of: In-meso crystallization of membrane proteins', Nanoscale, 9, pp. 754 - 763, http://dx.doi.org/10.1039/c6nr07634c

Wilding M; Scott C; Newman J; Peat TS, 2017, 'Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC', Acta Crystallographica Section F Structural Biology Communications, 73, pp. 29 - 35, http://dx.doi.org/10.1107/S2053230X16019658

Wilding M; Peat TS; Kalyaanamoorthy S; Newman J; Scott C; Jermiin LS, 2017, 'Reverse engineering: Transaminase biocatalyst development using ancestral sequence reconstruction', Green Chemistry, 19, pp. 5375 - 5380, http://dx.doi.org/10.1039/c7gc02343j

Wilding M; Scott C; Peat TS; Newman J, 2017, 'X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC', Acta Crystallographica Section F Structural Biology Communications, 73, pp. 24 - 28, http://dx.doi.org/10.1107/S2053230X16020008

Brewster JL; McKellar JLO; Finn TJ; Newman J; Peat TS; Gerth ML, 2016, 'Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae', Scientific Reports, 6, http://dx.doi.org/10.1038/srep35198

Kryshtafovych A; Moult J; Baslé A; Burgin A; Craig TK; Edwards RA; Fass D; Hartmann MD; Korycinski M; Lewis RJ; Lorimer D; Lupas AN; Newman J; Peat TS; Piepenbrink KH; Prahlad J; van Raaij MJ; Rohwer F; Segall AM; Seguritan V; Sundberg EJ; Singh AK; Wilson MA; Schwede T, 2016, 'Some of the most interesting CASP11 targets through the eyes of their authors', Proteins Structure Function and Bioinformatics, 84, pp. 34 - 50, http://dx.doi.org/10.1002/prot.24942

Mujumdar P; Teruya K; Tonissen KF; Vullo D; Supuran CT; Peat TS; Poulsen SA, 2016, 'An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C', Journal of Medicinal Chemistry, 59, pp. 5462 - 5470, http://dx.doi.org/10.1021/acs.jmedchem.6b00443

Dennis ML; Pitcher NP; Lee MD; Debono AJ; Wang ZC; Harjani JR; Rahmani R; Cleary B; Peat TS; Baell JB; Swarbrick JD, 2016, 'Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli', Journal of Medicinal Chemistry, 59, pp. 5248 - 5263, http://dx.doi.org/10.1021/acs.jmedchem.6b00002

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